Download or read book Electrochemically assisted Functionalization of a 316L Stainless Steel Surface with Fibronectin written by Hesam Dadafarin and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Cardiovascular disease (CVD) is reported to be the single largest cause of death in developed countries. Among different types of CVD, a common and prevalent disorder is atherosclerosis, which is characterized mostly by the formation of a plaque resulting in considerable narrowing (stenosis) and hardening of the arteries. Approximately one third of atherosclerosis patients are treated by angioplasty and stenting. However, all current stents offer low biocompatibility, which results in occurrence of in-stent thrombosis and restenosis in up to ca. 30% patients, and the need for further medical treatment. Various stent-surface modification approaches have been employed in order to minimize in-stent restenosis, but none of them has proven to give long-term satisfactory benefits. The aim of this work was to develop a new method for the stent surface modification, in an attempt to decrease the in-stent restenosis rate. The ultimate aim of the project was to functionalize 316L stainless steel, CoCr and NiTi surfaces with a chemically-bound extracellular matrix protein fibronectin (Fn), in order to control and mediate endothelial cell (EC) and smooth muscle cell (SMC) / surface (Fn) interactions. In this PhD project, a novel electrochemistry-based method for the immobilization of Fn on 316L stainless steel, CoCr and NiTi surface was developed. The method is based on the formation of a stable alkanethiol monolayer ("linker") on the alloy surface, which was further chemically modified to allow covalent attachment of Fn. Polarization modulation infrared reflection absorption spectroscopy (PM-IRRAS) revealed that the formed alkanethiol monolayer is relatively ordered and well-packed. X-ray photoelectron spectroscopy (XPS) demonstrated that monolayer is attached to the 316L stainless steel surface through the sulfur atom. It was further confirmed that the monolayer remained stable over a period of seven days of constant immersion in a corrosive phosphate buffered saline solution. Long-term electrochemical impedance spectroscopy experiments demonstrated that the formed monolayer also provided a diffusion barrier for aggressive / corrosive ions, yielding a high (ca. 94%) corrosion protection efficiency for 316L stainless steel. It was determined that the covalent attachment of Fn to the alkanethiol monolayer pre-formed on 316L stainless steel, CoCr and NiTi surfaces resulted in the formation of a very stable protein layer. PM-IRRAS indicated that the covalent attachment of Fn resulted in a change of the protein's secondary structure. Scanning electron microscopy (SEM) and energy dispersive X-Ray (EDX) analysis of Fn molecules immobilized on a surface of a commercial 316L stainless steel cardiovascular stent revealed that a relative homogenous spatial distribution of Fn was achieved and the molecule spacing was appropriate for cell adhesion.The effect of Fn immobilization on a 316L stainless steel surface on cell/surface behavior was further investigated by examining the interaction with platelets, ECs and SMCs. Lower platelet adhesion and aggregation was observed on Fn-modified surfaces, in comparison to the naked (unmodified) surface, which implies a lower thrombogenicity of the Fn-modified surface. It was shown that the presence of Fn on the surface significantly enhanced EC attachment, while no detectable improvement in SMC attachment was observed. Higher proliferation rate of both ECs and SMCs was achieved on the Fn-modified surface. The comparative study of EC and SMC attachment revealed that Fn-modified surfaces can selectively attract more ECs than SMCs. This indicates a higher biocompatibility of the Fn-modified surface for coronary stent applications." --

Download or read book Modern Surface Technology written by Friedrich-Wilhelm Bach and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This translation of a successful German title provides a broad and fundamental overview of current coating technology. Edited by experts from one of the largest research centers for this field in Germany, this valuable reference combines research and industrial perspectives, treated by authors from academia and industry alike. They discuss the potential of the many innovations introduced into industrial application in recent years, allowing materials scientists and engineers to find the appropriate solution for their own specific coating problems. Thus, with the aid of this book, it is possible to make coating technology an integral part of R&D, construction and production.

Download or read book Biomaterials written by S.V. Bhat and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: As biomaterials are used in medical devices, meeting needs in such diverse surgical disciplines as ophthalmology, cardiology, neuromuscular surgery, orthopaedics, dentistry, etc., they must have intimate contact with patient's tissue or body fluids, providing a real physical interface which seriously restricts developments. This book is written for those who would like to advance their knowledge of biomaterials. The subject matter of the book is divided into twelve chapters dealing with the structure and relationship of biological and man-made biomaterials. The application of these materials for various medical devices, and recent developments in tissue engineering, are also discussed.

Download or read book Laser Surface Engineering written by Jonathan R. Lawrence and published by Elsevier. This book was released on 2014-10-02 with total page 719 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lasers can alter the surface composition and properties of materials in a highly controllable way, which makes them efficient and cost-effective tools for surface engineering. This book provides an overview of the different techniques, the laser-material interactions and the advantages and disadvantages for different applications. Part one looks at laser heat treatment, part two covers laser additive manufacturing such as laser-enhanced electroplating, and part three discusses laser micromachining, structuring and surface modification. Chemical and biological applications of laser surface engineering are explored in part four, including ways to improve the surface corrosion properties of metals. Provides an overview of thermal surface treatments using lasers, including the treatment of steels, light metal alloys, polycrystalline silicon and technical ceramics Addresses the development of new metallic materials, innovations in laser cladding and direct metal deposition, and the fabrication of tuneable micro- and nano-scale surface structures Chapters also cover laser structuring, surface modification, and the chemical and biological applications of laser surface engineering

Download or read book Metals for Biomedical Devices written by Mitsuo Niinomi and published by Elsevier. This book was released on 2010-03-31 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite recent advances in medical devices using other materials, metallic implants are still one of the most commercially significant sectors of the industry. Given the widespread use of metals in medical devices, it is vital that the fundamentals and behaviour of this material are understood. Metals in biomedical devices reviews the latest techniques in metal processing methods and the behaviour of this important material. Initial chapters review the current status and selection of metals for biomedical devices. Chapters in part two discuss the mechanical behaviour, degradation and testing of metals with specific chapters on corrosion, wear testing and biocompatibility of biomaterials. Part three covers the processing of metals for biomedical applications with chapters on such topics as forging metals and alloys, surface treatment, coatings and sterilisation. Chapters in the final section discuss clinical applications of metals such as cardiovascular, orthopaedic and new generation biomaterials. With its distinguished editor and team of expert contributors, Metals for biomedical devices is a standard reference for materials scientists, researchers and engineers working in the medical devices industry and academia. Reviews the latest techniques in metal processing methods including surface treatment and sterilisation Examines metal selection for biomedical devices considering biocompatibility of various metals Assesses mechanical behaviour and testing of metals featuring corrosion, fatigue and wear

Download or read book Advanced Coating Materials written by Liang Li and published by John Wiley & Sons. This book was released on 2018-12-06 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive, yet practical source of reference, and excellent foundation for comparing the properties and performance of coatings and selecting the most suitable materials based on specific service needs and environmental factors. Coating technology has developed significant techniques for protecting existing infrastructure from corrosion and erosion, maintaining and enhancing the performance of equipment, and provided novel functions such as smart coatings greatly benefiting the medical device, energy, automotive and construction industries. The mechanisms, usage, and manipulation of cutting-edge coating methods are the focus of this book. Not only are the working mechanisms of coating materials explored in great detail, but also craft designs for further optimization of more uniform, safe, stable, and scalable coatings. A group of leading experts in different coating technologies demonstrate their main applications, identify the key bottlenecks, and outline future prospects. Advanced Coating Materials broadly covers the coating techniques, including cold spray, plasma vapor deposition, chemical vapor deposition, sol–gel method, etc., and their significant applications in microreactor technology, super(de)wetting, joint implants, electrocatalyst, etc. Numerous kinds of coating structures are addressed, including nanosize particles, biomimicry structures, metals and complexed materials, along with the environmental and human compatible biopolymers resulting from microbial activities. This state-of-the-art book is divided into three parts: (1) Materials and Methods: Design and Fabrication, (2) Coating Materials: Nanotechnology, and (3) Advanced Coating Technology and Applications.

Download or read book Handbook of Nanoelectrochemistry written by Mahmood Aliofkhazraei and published by Springer. This book was released on 2015-11-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited book is devoted to different electrochemical aspects of nano materials. This comprehensive reference text is basically divided in 3 parts: electrochemical synthesis routes for nanosized materials, electrochemical properties of nano materials and electrochemical characterization methods for nanostructures. The Handbook is a reference work to chemists and materials scientists interested in the nano aspects of electrochemistry. The chapters are written by a number of international experts in the field and the content will assist members of both electrochemical and materials communities to keep abreast of developments in the field.

Download or read book An Introduction to Tissue Biomaterial Interactions written by Kay C. Dee and published by John Wiley & Sons. This book was released on 2003-04-14 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Introduction to Tissue-Biomaterial Interactions acquaints an undergraduate audience with the fundamental biological processes that influence these sophisticated, cutting-edge procedures. Chapters one through three provide more detail about the molecular-level events that happen at the tissue-implant interface, while chapters four through ten explore selected material, biological, and physiological consequences of these events. The importance of the body’s wound-healing response is emphasized throughout. Specific topics covered include:Structure and properties of biomaterials Proteins Protein-surface interactions Blood-biomaterial interactions Inflammation and infection The immune system Biomaterial responses to implantation Biomaterial surface engineering Intimal hyperplasia and osseointegration as examples of tissue-biomaterial interactions The text also provides extensive coverage of the three pertinent interfaces between the body and the biomaterial, between the body and the living cells, and between the cells and the biomaterial that are critical in the development of tissue-engineered products that incorporate living cells within a biomaterial matrix. Ideal for a one-semester, biomedical engineering course, An Introduction to Tissue-Biomaterial Interactions provides a solid framework for understanding today’s and tomorrow’s implantable biomedical devices.

Download or read book Hydroxyapatite and Other Calcium Orthophosphates written by Sergey V. Dorozhkin and published by Nova Science Publishers. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the inorganic constituents of skeletons, dentine and the enamel of teeth in all vertebrates, as well as antlers of male deer, calcium orthophosphates (CaPO4) appear to be the key materials to sustain all life on Earth. Therefore, biologically relevant CaPO4 possess all the necessary features of the biomaterials, such as biocompatibility, bioactivity, bioresorbability, osteoconductivity, osteoinductivity, and appear to be non-toxic, non-inflammatory and non-immunogenic. In this book, the author presents current state-of-the-art applications of CaPO4 as bioceramics, deposits (coatings, films and layers) and in dentistry. Topics discussed include chemical composition and preparation, forming and shaping, sintering and firing for CaPO4-based bioceramics, chemical composition and preparation, pre- and post-deposition treatments for CaPO4-based deposits, followed by the detailed description of their major properties, biomedical applications and in vivo behavior. The detailed description of current CaPO4 applications in dentistry both for dental caries prevention and as various types of dental treatments is given in the last section of this book.

Download or read book Materials Development and Processing for Biomedical Applications written by Savaş Kaya and published by CRC Press. This book was released on 2022-04-06 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Materials Development and Processing for Biomedical Applications focuses on various methods of manufacturing, surface modifications, and advancements in biomedical applications. This book examines in detail about five different aspects including, materials properties, development, processing, surface coatings, future perspectives and fabrication of advanced biomedical devices. Fundamental aspects are discussed to better understand the processing of various biomedical materials such as metals, ceramics, polymers, composites, etc. A wide range of surface treatments are covered in this book that will be helpful for the readers to understand the importance of surface treatments and their future perspectives. Additional Features Include: Examines various properties of biomedical materials at the beginning in several chapters which will enrich the fundamental knowledge of the readers. Discusses advancements in various fields of biomedical applications. Provides a glimpse of characterization techniques for the evaluation of material properties. Addresses biocompatibility, biocorrosion, and tribocorrosion. This book explores new and novel strategies for the development of materials and their biomedical applications. It will serve as a comprehensive resource for both students and scientists working in materials and biomedical sciences.

Download or read book Biomaterials and Medical Devices written by Ferdyansyah Mahyudin and published by Springer. This book was released on 2016-02-26 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an introduction to biomaterials with the focus on the current development and future direction of biomaterials and medical devices research and development in Indonesia. It is the first biomaterials book written by selected academic and clinical experts experts on biomaterials and medical devices from various institutions and industries in Indonesia. It serves as a reference source for researchers starting new projects, for companies developing and marketing products and for governments setting new policies. Chapter one covers the fundamentals of biomaterials, types of biomaterials, their structures and properties and the relationship between them. Chapter two discusses unconventional processing of biomaterials including nano-hybrid organic-inorganic biomaterials. Chapter three addresses biocompatibility issues including in vitro cytotoxicity, genotoxicity, in vitro cell models, biocompatibility data and its related failure. Chapter four describes degradable biomaterial for medical implants, which include biodegradable polymers, biodegradable metals, degradation assessment techniques and future directions. Chapter five focuses on animal models for biomaterial research, ethics, care and use, implantation study and monitoring and studies on medical implants in animals in Indonesia. Chapter six covers biomimetic bioceramics, natural-based biocomposites and the latest research on natural-based biomaterials in Indonesia. Chapter seven describes recent advances in natural biomaterial from human and animal tissue, its processing and applications. Chapter eight discusses orthopedic applications of biomaterials focusing on most common problems in Indonesia, and surgical intervention and implants. Chapter nine describes biomaterials in dentistry and their development in Indonesia.

Download or read book Biomaterials Science written by William R Wagner and published by Academic Press. This book was released on 2020-05-23 with total page 1612 pages. Available in PDF, EPUB and Kindle. Book excerpt: The revised edition of the renowned and bestselling title is the most comprehensive single text on all aspects of biomaterials science from principles to applications. Biomaterials Science, fourth edition, provides a balanced, insightful approach to both the learning of the science and technology of biomaterials and acts as the key reference for practitioners who are involved in the applications of materials in medicine.This new edition incorporates key updates to reflect the latest relevant research in the field, particularly in the applications section, which includes the latest in topics such as nanotechnology, robotic implantation, and biomaterials utilized in cancer research detection and therapy. Other additions include regenerative engineering, 3D printing, personalized medicine and organs on a chip. Translation from the lab to commercial products is emphasized with new content dedicated to medical device development, global issues related to translation, and issues of quality assurance and reimbursement. In response to customer feedback, the new edition also features consolidation of redundant material to ensure clarity and focus. Biomaterials Science, 4th edition is an important update to the best-selling text, vital to the biomaterials’ community. The most comprehensive coverage of principles and applications of all classes of biomaterials Edited and contributed by the best-known figures in the biomaterials field today; fully endorsed and supported by the Society for Biomaterials Fully revised and updated to address issues of translation, nanotechnology, additive manufacturing, organs on chip, precision medicine and much more. Online chapter exercises available for most chapters

Download or read book Hydroxyapatite and Other Calcium Orthophosphates written by Sergey V. Dorozhkin and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: As the inorganic constituents of skeletons, dentine and the enamel of teeth in all vertebrates, as well as antlers of male deer, calcium orthophosphates (CaPO4) appear to be the key materials to sustain all life on Earth. Therefore, biologically relevant CaPO4 possess all the necessary features of the biomaterials, such as biocompatibility, bioactivity, bioresorbability, osteoconductivity, osteoinductivity, and appear to be non-toxic, non-inflammatory and non-immunogenic. In this book, the author presents current state-of-the-art applications on three popular types of CaPO4: nano-scaled (nano-dimensional), multiphasic (polyphasic) and amorphous CaPO4. Topics discussed include the preparation, structure, composition, properties and biomedical applications of these types of CaPO4 combined with the specific information for each type. Namely, occurrence in the calcified tissue of mammals is discussed for both nano-scaled and amorphous types of CaPO4; both known and potential formulations, as well as their stability are discussed for multiphasic CaPO4, while both the morphology and the available knowledge on amorphous-to-crystalline transformations are discussed for amorphous CaPO4.

Download or read book Emerging Nanotechnologies in Dentistry written by Karthikeyan Subramani and published by . This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: New nanomaterials are leading to a range of emerging dental treatments that utilize more biomimetic materials that more closely duplicate natural tooth structure (or bone, in the case of implants). The use of nanostructures that will work in harmony with the body's own regenerative processes (eg, to restore tooth structure or alveolar bone) are moving into clinical practice. This book brings together an international team of experts from the fields of nanomaterials, biomedical engineering and dentistry, to cover the new materials and techniques with potential for use intra-orally or extra-orally for the restoration, fixation, replacement, or regeneration of hard and soft tissues in and about the oral cavity and craniofacial region. New dental nanotechnologies include the use of advanced inorganic and organic materials, smart and biomimetic materials, tissue engineering and drug delivery strategies. Book prepared by an interdisciplinary and international group of bio-nanomaterial scientists and dental/oral biomedical researchers Comprehensive professional reference for the subject covering materials fabrication and use of materials for all major diagnostic and therapeutic dental applications - repair, restoration, regeneration, implants and prevention Book focuses in depth on the materials manufacturing processes involved with emphasis on pre-clinical and clinical applications, use and biocompatibility.

Download or read book Green Approaches in Medicinal Chemistry for Sustainable Drug Design written by Bimal Krishna Banik and published by Elsevier. This book was released on 2024-05-31 with total page 699 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensive experimentation and high failure rates are a well-recognized downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry 2e reveals how medicinal chemistry can play a direct role in addressing this issue. After providing essential context to the growth of green chemistry in relation to drug discovery, the book goes on to identify a broad range of practical techniques and useful insights, revealing how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process. Drawing on the knowledge of a global team of experts, Sustainable and Green Approaches in Medicinal Chemistry, Second Edition encourages the growth of green medicinal chemistry, and supports medicinal chemists, drug discovery researchers, pharmacologists and all those in related fields across both academia and industry in integrating these approaches into their own work. This second volume of the second edition includes the development of nanoparticles and nanocomposites, as well as the application of ultrasound and microwave-induced methods; studies solventless synthesis; defines the role of steroids; studies reactions in aqueous solution; identifies enzyme-mediated reactions; investigates ionic liquids and deep eutectic solvents; explores natural products; investigates solid supports; realizes the effects of salts; focuses on combinatorial chemistry; develops one-pot methods; analyzes multi-component reactions; investigates dipole moment values; and examines computer-assisted methods. Highlights the need for adoption of sustainable and green chemistry pathways in drug development Reveals risk factors associated with the drug development process and the ways sustainable approaches can help address these Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability

Download or read book Fundamental Biomaterials Metals written by Sabu Thomas and published by Woodhead Publishing. This book was released on 2018-07-19 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamental Biomaterials: Metals provides current information on the development of metals and their conversion from base materials to medical devices. Chapters analyze the properties of metals and discuss a range of biomedical applications, with a focus on orthopedics. While the book will be of great use to researchers and professionals in the development stages of design for more appropriate target materials, it will also help medical researchers understand, and more effectively communicate, the requirements for a specific application. With the recent introduction of a number of interdisciplinary bio-related undergraduate and graduate programs, this book will be an appropriate reference volume for students. It represents the second volume in a three volume set, each of which reviews the most important and commonly used classes of biomaterials, providing comprehensive information on materials properties, behavior, biocompatibility and applications. Provides current information on metals and their conversion from base materials to medical devices Includes analyses of types of metals, discussion of a range of biomedical applications, and essential information on corrosion, degradation and wear and lifetime prediction of metal biomaterials Explores both theoretical and practical aspects of metals in biomaterials

Download or read book Biological Performance of Materials written by Jonathan Black and published by CRC Press. This book was released on 2005-12-20 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioengineers need a thorough grounding in biocompatibility - the biological performance of materials. Until now, there were no publications suitable for a neophyte in the field; prior publications were either not comprehensive or focused on rather narrow interests. Drawing on the author's 35 years of experience as a teacher, researcher, and consult