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Book Effects of Omega 3 Fatty Acids on Arrhythmogenic Mechanisms in Animal and Isolated Organ Cell Culture Studies

Download or read book Effects of Omega 3 Fatty Acids on Arrhythmogenic Mechanisms in Animal and Isolated Organ Cell Culture Studies written by U.s. Department of Health and Human Services and published by CreateSpace. This book was released on 2014-06-27 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This evidence report is one of three prepared by the Tufts-New England Medical Center Evidence-based Practice Center (EPC) concerning the health benefits of omega-3 fatty acids on cardiovascular diseases. The aim of these reports is to summarize the current evidence of the health effects of omega-3 fatty acids on: cardiovascular diseases, cancer, child and maternal health, eye health, gastrointestinal/renal diseases, asthma, autoimmune diseases, immune-mediated diseases, transplantation, mental health, and neurological diseases and conditions. The focus of this report is on arrhythmogenic mechanisms in animal and isolated organ and cell culture studies. Arrhythmias are thought to be the cause of “sudden death” in heart disease. Animal studies have suggested that omega-3 long-chain polyunsaturated fatty acids (LC PUFAs), such as eicosapentaenoic acid (EPA, 20:5 n-3) and docosahexaenoic acid (DHA, 22:6 n-3), engage in multiple cytoprotective activities that may contribute to antiarrhythmic mechanisms. In this report, we examine evidence that omega-3 fatty acids affect cell organelles—such as cardiac ion channels, pumps, or exchange mechanisms—that are involved in cardiac electrophysiology or electrogenesis. The key questions addressed by this report are: 1) What is the evidence from whole animal studies that omega-3 fatty acids affect arrhythmogenic outcomes (and intermediate outcomes)? 2) What is the evidence from cell culture and tissue studies (including animal and human cardiac tissue) that omega-3 fatty acids directly affect cell organelles such as cardiac ion channels, pumps, or exchange mechanisms involved in electrogenesis? In whole animal studies examined for this report, omega-3 fatty acids were fed to whole, intact animals as part of their diet or were infused intravenously. Outcomes examined by these studies include induced arrhythmia, ventricular ectopic beats, and ventricular and atrial fibrillation. In whole animal isolated organ and cell studies, omega-3 fatty acids were fed to whole, intact animals as part of their diet, and organs or cell tissues were subsequently excised from the animal to study outcomes such as arrhythmia, and myocyte contraction and beating rate. In “pure” isolated organ and cell studies, omega-3 fatty acids were applied directly to mammalian tissues or cultured cell lines or incorporated into the membrane of the mammalian tissues or cultured cell lines. Outcomes examined in these studies include induced arrhythmia, myocyte contraction and beating rate, and any other arrhythmogenic outcomes. In examining studies for this report, we focused on several potential arrhythmogenic mechanisms, including contractile parameters, basoelectromechanical parameters, ion pumps, ion channels, and membrane currents.

Book Omega 3 Fatty Acids in Health and Disease

Download or read book Omega 3 Fatty Acids in Health and Disease written by Lindsay Brown and published by MDPI. This book was released on 2018-09-27 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Omega-3 Fatty Acids in Health and Disease" that was published in JCM

Book Index Medicus

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2002 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Book Novel Therapeutic Targets for Antiarrhythmic Drugs

Download or read book Novel Therapeutic Targets for Antiarrhythmic Drugs written by George Edward Billman and published by John Wiley & Sons. This book was released on 2010-01-07 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: PROFILES POTENTIAL TREATMENT APPROACHES FOR CARDIAC ARRHYTHMIAS Cardiac arrhythmias of ventricular origin are responsible for the deaths of nearly half a million Americans each year while atrial fibrillation accounts for about 2.3 million cases per year, a rate that is projected to increase 2.5 fold over the next half century. Effectively managing these cardiac rhythm disorders remains a major challenge for both caregivers and the pharmaceutical industry. Filling a gap in the current literature, Novel Therapeutic Targets for Antiarrhythmic Drugs presents the latest treatments for cardiac arrhythmias alongside comprehensive presentations of basic cardiac physiology and pharmacology. Written by leading experts in their research areas, this invaluable resource offers both practitioners and researchers a one-stop guide that brings together previously dispersed information. The text consists of four sections: Section One comprehensively reviews basic cardiac electrophysiology, the mechanisms responsible for arrhythmias in the setting of ischemia, and basic pharmacology of antiarrhythmic drugs. Section Two addresses safety pharmacology, including the concept of "repolarization reserve," safety challenges, and regulatory issues for the development of novel antiarrhythmic drugs. Section Three describes several novel pharmacological targets for antiarrhythmic drugs, including both ion channel and non-ion channel targets. Section Four describes promising non-pharmacological antiarrhythmic interventions including selective cardiac neural disruption or nerve stimulation, aerobic exercise training, and diet (omega-3 fatty acids). Offering an unparalleled look at the current state and future direction of cardiac arrhythmia treatment, Novel Therapeutic Targets for Antiarrhythmic Drugs provides an important resource to advanced students, working researchers, and busy professionals alike.

Book Studies on the Effects of Omega 3 and Omega 6 Fatty Acids on Tumor Cell Viability and Macrophage Function in Cell Culture and in Animal Models

Download or read book Studies on the Effects of Omega 3 and Omega 6 Fatty Acids on Tumor Cell Viability and Macrophage Function in Cell Culture and in Animal Models written by John Mark Black and published by . This book was released on 1991 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Pharmacotherapeutics For Advanced Practice Nurse Prescribers

Download or read book Pharmacotherapeutics For Advanced Practice Nurse Prescribers written by Teri Moser Woo and published by F.A. Davis. This book was released on 2015-08-03 with total page 1417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This exceptional text builds your knowledge of pharmacology by first providing an overview of pharmacologic principles and then teaching you how to apply those principles to clinical practice. Focusing on applying pharmacologic scientific knowledge to clinical practice, it explains diagnostic and treatment reasoning and rational drug selection, while providing useful clinical pearls from experienced practitioners.

Book Present Knowledge in Nutrition

Download or read book Present Knowledge in Nutrition written by John W. Erdman, Jr. and published by John Wiley & Sons. This book was released on 2012-05-30 with total page 2062 pages. Available in PDF, EPUB and Kindle. Book excerpt: Present Knowledge in Nutrition, 10th Edition provides comprehensive coverage of all aspects of human nutrition, including micronutrients, systems biology, immunity, public health, international nutrition, and diet and disease prevention. This definitive reference captures the current state of this vital and dynamic science from an international perspective, featuring nearly 140 expert authors from 14 countries around the world. Now condensed to a single volume, this 10th edition contains new chapters on topics such as epigenetics, metabolomics, and sports nutrition.The remaining chapters have been thoroughly updated to reflect recent developments. Suggested reading lists are now provided for readers wishing to delve further into specific subject areas. An accompanying website provides book owners with access to an image bank of tables and figures as well as any updates the authors may post to their chapters between editions. Now available in both print and electronic formats, the 10th edition will serve as a valuable reference for researchers, health professionals, and policy experts as well as educators and advanced nutrition students.

Book Research Activities

Download or read book Research Activities written by and published by . This book was released on 2004 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Omega 3 Fatty Acids  the Brain and Retina

Download or read book Omega 3 Fatty Acids the Brain and Retina written by Artemis P. Simopoulos and published by Karger Medical and Scientific Publishers. This book was released on 2009-01-01 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on omega-3 fatty acids has come a long way since its beginnings in the middle 70's. Starting with studies on the role of omega-3 fatty acids in the secondary prevention of cardiovascular disease, interest soon turned to the mechanisms of and the need to balance the omega-6 to the omega-3 ratio for homeostasis and normal development. Today, it is widely accepted that docosahexaenoic acid (DHA) and arachidonic acid are essential for brain development during pregnancy, lactation and throughout the life cycle. It is also no longer controversial that DHA can affect brain function, mental health and behavior, and studies on supplemental DHA in age-related macular degeneration have revealed significant Interactions between DHA and genetic variants. Featuring contributions by leading scientists in the field, this publication discusses not only the role of omega-3 fatty acids in maintaining homeostasis, but also their importance in the prevention and management of neurodegenerative diseases associated with the aging process or genetic predisposition. It is thus not only of interest to nutritionists, dieticians or policy makers, but also to psychologists, physiologists, neuroscientists, psychiatrists, ophthalmologists, geneticists, neurologists, pedlatrlclans, obstetricians and geriatricians.

Book Vitamins and Minerals

Download or read book Vitamins and Minerals written by Zina Kroner and published by Bloomsbury Publishing USA. This book was released on 2011-04-08 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insightful, objective, and evidence-based, this overview of the most commonly used supplements dispels misinformation and provides facts from a qualified physician's point of view. An endless array of vitamin and mineral supplements are available to health-conscious consumers today, and an increasing number of individuals have incorporated these supplements into their daily routines. Unfortunately, their use is often inspired by rumor rather than sound medical advice. The results of clinical research on these supplements' effectiveness are often inconclusive while some studies have even shown negative health effects from overuse. Instead of relying on media hype and often-conflicting "word-of-mouth" information, people who take nutritional supplements need an authoritative, evidence-based reference text about self-medication with vitamins and minerals. Dr. Zina Kroner has provided exactly that. Vitamins and Minerals is an eye-opening guide that separates truth from myth about dozens of today's common and popular supplements. It covers the effects of the deficiency of each nutrient, its primary uses, dosages, food sources, potential side effects, and mechanism of action, helping readers make informed decisions about use of these under-regulated, over-the-counter "nutraceuticals."

Book Seafood Choices

    Book Details:
  • Author : Institute of Medicine
  • Publisher : National Academies Press
  • Release : 2007-04-09
  • ISBN : 0309102189
  • Pages : 737 pages

Download or read book Seafood Choices written by Institute of Medicine and published by National Academies Press. This book was released on 2007-04-09 with total page 737 pages. Available in PDF, EPUB and Kindle. Book excerpt: The fragmented information that consumers receive about the nutritional value and health risks associated with fish and shellfish can result in confusion or misperceptions about these food sources. Consumers are therefore confronted with a dilemma: they are told that seafood is good for them and should be consumed in large amounts, while at the same time the federal government and most states have issued advisories urging caution in the consumption of certain species or seafood from specific waters. Seafood Choices carefully explores the decision-making process for selecting seafood by assessing the evidence on availability of specific nutrients (compared to other food sources) to obtain the greatest nutritional benefits. The book prioritizes the potential for adverse health effects from both naturally occurring and introduced toxicants in seafood; assesses evidence on the availability of specific nutrients in seafood compared to other food sources; determines the impact of modifying food choices to reduce intake of toxicants on nutrient intake and nutritional status within the U.S. population; develops a decision path for U.S. consumers to weigh their seafood choices to obtain nutritional benefits balanced against exposure risks; and identifies data gaps and recommendations for future research. The information provided in this book will benefit food technologists, food manufacturers, nutritionists, and those involved in health professions making nutritional recommendations.

Book The OMEGA 3 Miracle

Download or read book The OMEGA 3 Miracle written by Garry Gordon, M.D., D.O., M.D. (H.) and published by SCB Distributors. This book was released on 2010-04-20 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Omega-3 Miracle is the secret to longevity. The people of Iceland have less heart disease, high blood pressure and stroke than those of any other country. In fact, they outlive all other nationalities. Their longevity is a direct result of their daily intake of omega3 rich fish oils. The American Heart Association recommends omega3 fatty acids to help prevent cardiovascular disease and stroke. Omega3s inhibit plaque and blood clots and dramatically improve cholesterol levels. They also increase brain function by promoting neurotransmission in the brain. With research from over 20 leading medical and scientific journals, Drs. Garry Gordon and Herb JoinerBey reveal how the good fats found in omega3s from fish and pharmaceuticalgrade supplements are essential to maintaining optimum health. The only way your body can get these vital essential fatty acids is through proper nutrition and supplementation. The Omega3 Miracle shows you how. Clinical and scientific studies in both Europe and the U.S. show that omega3 fatty acids benefit a wide range of conditions including: Cardiovascular Disease High Cholesterol Lowering Triglycerides High Blood Pressure Arthritis Diabetes Bipolar Disorder ADHD Chronic Inflammation Cancer This is your definitive guide on how to maximize your health and longevity with omega3.