Download or read book Effects of Nerve Growth Factor on TGF Smad TGF beta Smad Signal Transduction in PC12 Cells written by Marion Lutz and published by . This book was released on 2002 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Effects of Nerve Growth Factor on TGF beta Smad Signal Transduction in PC12 Cells written by Marion Lutz and published by . This book was released on 2002 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Effects of Nerve Growth Factor on TGF beta Smad TGF beta Smad Signal Transduction in PC12 Cells written by Marion Lutz and published by . This book was released on 2002 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The TGF beta Family written by Rik Derynck and published by CSHL Press. This book was released on 2008 with total page 1108 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transforming growth factor-[beta] (TGF-[beta]), identified nearly three decades ago, is a secreted polypeptide that functions in critical cell cycle processes, including cellular proliferation, differentiation, and development: It belongs to a large protein family that, in humans, contains 33 members, including activins, inhibins, bone morphogenetic proteins, growth and differentiation factors, and Mullerian inhibiting substance. This volume draws on the world's leading laboratories to comprehensively cover all aspects of the biology of TGF-[beta] and related factors. In addition to providing historical and background information, it describes the cell biology and signaling pathways of TGF-[beta] members in detail, including the roles of TGF-[beta] factors in the development and physiology of humans and model organisms. The last few chapters are devoted to the role of TGF-[beta] members in cancer and other diseases, as well as the possibilities for therapeutics based on knowledge of signaling pathways and macromolecular structures. It serves as a comprehensive reference work for both specialists and researchers less familiar with the field.

Download or read book Nerve Growth Factor dependent Signaling and Transcription in Neuronally Differentiated PC12 Cells written by Jay Hyuk Chang and published by . This book was released on 2005 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Transforming Growth Factor Beta Receptor Partitioning written by Sarah E. A. McLean and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The transforming growth factor beta (TGFbeta) pathway has been conserved throughout evolution and plays important roles in tissue homeostasis. Dysregulation of the TGFbeta pathway has been implicated in a number of disorders, including cancer, fibrosis, and vascular conditions. The signalling potential of the TGFbeta pathway is regulated by the route of internalization of its cell-surface receptors: Receptors internalized by clathrin-mediated endocytosis propagate signal transduction while those internalized by membrane rafts are targeted for degradation. Given the importance of trafficking of the TGFbeta receptors to signal propagation, this thesis focuses on evaluating proteins which direct TGFb receptor internalization and trafficking. Initial work in this thesis shows that the extracellular domain of the type II TGFbeta receptor (TbRII) and the glycosylation state of the cell are important factors in permitting membrane-raft localization of TbRII. Using this information I assessed the ability of TbRIII, a glycosylated cell surface protein, to direct TbRII internalization. I found that TbRIII increases membrane-raft independent internalization of TbRII, increases TbRII/TbRI complex half-life, and basal TGFbeta signalling. I next assessed the role of beta arrestin2, a protein which interacts with TbRIII, in regulating TbRII trafficking and signalling. I show that beta arrestin2 interacts with TbRII and traffics with TbRII to the early endosome to increase Smad-dependent signalling. Also, I show that depletion of beta arrestin2 increases Smad-independent signal transduction. In the last data chapter of this thesis, I evaluate the role of TGFbeta1 and TGFbeta3, to direct TGFbeta trafficking and signalling. I found that TGFbeta3 is less potent than TGFbeta1 at propagating TGFbeta signalling. I also show that TGFbeta3 induces a different binding ratio of TbRII/TbRI cell-surface complexes, which could explain its decreased potency. Overall my studies highlight the role of receptor-interacting proteins in directing TGFbeta receptor trafficking and signal transduction. Since this pathway is dysregulated in a number of pathologies, my studies suggest that TGFbeta receptor trafficking is an important avenue to modifying TGFbeta signal transduction.

Download or read book Modulation of Nerve Growth Factor Signal Transduction and Calcium Signaling by GM1 Ganglioside in PC12 Cells written by Brian Scott Hilbush and published by . This book was released on 1991 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Smad Signal Transduction written by Peter Dijke and published by Springer Science & Business Media. This book was released on 2007-05-10 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first comprehensive book on Smad signal transduction. Forward looking reviews of Smads are provided in a series of 22 cutting-edge chapters. The book is written for an audience with basic understanding of molecular and cell biology. This volume provides an in-depth review of a rapidly developing field and extensive cross-references between chapters are provided.

Download or read book Investigating SMAD Involvement in Transforming Growth Factor beta Signal Transduction written by Michael Benjamin Major and published by . This book was released on 2004 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Medicine Sciences and Bioengineering written by Mings Wang and published by CRC Press. This book was released on 2015-05-06 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt: This proceedings volume contains selected papers presented at the 2014 International Conference on Medicine Sciences and Bioengineering (ICMSB 2014), held August 16-17, 2014 in Kunming, Yunnan, China. ICMSB2014 was aimed at researchers, engineers, industrial professionals and academics, who were broadly welcomed to present their latest research res

Download or read book Proceedings of the 2015 International Conference on Medicine and Biopharmaceuticals written by and published by World Scientific. This book was released on 2016 with total page 1545 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This book provides an all-embracing review of each and every author's study on the related topics and areas. For instance, some author's study on Chinese Medicine, and some other researchers' survey on biomedical engineering. Moreover, there are also papers that focus on information based bioinformatics, pharmacy and medicinal chemistry and biopharmaceutical technology."--

Download or read book Turkish Journal of Biology written by and published by . This book was released on 2003 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Download or read book Proceedings of the 2015 International Conference on Sustainable Development written by Liandong Zhu and published by World Scientific. This book was released on 2016 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Since the emergence of climate and global warming onto the international agenda, research in sustainability has been underpinned by the development in energy and environmental science. Highlighted 30 years ago by the Brundtland Commission, "sustainable development" was defined as: meeting the needs of the present without compromising the ability of future generations to meet their own needs. This has very much defined the scope and aims of this conference. This conference proceedings book contains the selected papers presented in the 2015 International Conference on Sustainable Development (ICSD2015) held in September 25-27, 2015, in Wuhan, Hubei, China. The conference positions itself as an international forum for researchers all over the world to come together to share and discuss their findings and contributions in all aspects of sustainability; including theory, methodology and applications covering a wide spectrum of topics and issues. The conference proceedings put together a total of 119 papers in sustainable development, covering issues in environmental, energy, and economical aspects of the subjects."--Provided by publisher

Download or read book Chemical Abstracts written by and published by . This book was released on 2002 with total page 2692 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Journal of Cell Science written by and published by . This book was released on 2001 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Tgf beta Family written by Rik Derynck and published by . This book was released on 2017-04-30 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Members of the transforming growth factor β (TGFβ) family, which include activins and bone morphogenetic proteins (BMPs), are essential intercellular signaling molecules that control of cell proliferation and embryonic development. This book provides a comprehensive view of the different members of the TGFβ family and their receptors, as well as their roles in normal physiology and development and pathological conditions such as cancer"--