Download or read book Alphaherpesviruses written by Sandra Knowles Weller and published by Caister Academic Press Limited. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.

Download or read book Nutrition for Musculoskeletal Health written by Matteo Cesari and published by . This book was released on 2020-10-07 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: The maintenance of optimal musculoskeletal health is increasingly recognized as a key element for promoting overall health and fostering independent living in advanced age. Growing evidence indicates that nutrition, together with an active lifestyle, plays a central role in supporting musculoskeletal health both aging and in the setting of specific disease conditions. This Special Issue of Nutrients, entitled "Nutrition for Musculoskeletal Health", includes original research and review contributions highlighting the relevance of nutrition to musculoskeletal health during aging and in the context of specific diseases. The overarching theme of the Special Issue is addressed through a multidisciplinary set of articles embracing clinical, basic science, and translational studies.

Download or read book Organizational water footprint analyzing water use and mitigating water scarcity along global supply chains written by Forin, Silvia and published by Universitätsverlag der TU Berlin. This book was released on 2021-10-06 with total page 46 pages. Available in PDF, EPUB and Kindle. Book excerpt: Freshwater is a vital resource for humans and ecosystems but is scarce in many regions around the world. Organizations measure and manage direct water use at their premises but usually neglect the indirect water use associated with global supply chains – even though the latter can be higher by several orders of magnitude. As of 2015, there was no standardized life-cycle-based approach for analysing the water consumption of an organization. Against this background, the BMBF funded research project “Water Footprint for Organizations – Local Measures in Global Supply Chains (WELLE)” has been launched by TU Berlin, Evonik, German Copper Institute, Neoperl, thinkstep and Volkswagen. The project aims to support organizations in determining their complete Organizational Water Footprint, identifying local hotspots in global supply chains and taking action to reduce their water use and mitigate water stress at critical basins. Within the WELLE project a method for analysing an Organizational Water Footprint has been developed, which analyses an organization’s water use and resulting local impacts throughout its entire value chain. In other words, the Organizational Water Footprint considers not only the direct water use at production facilities, but also the water used indirectly for energy generation and raw material production (upstream in the supply chain) as well as water use during the use and end-of-life phases of products (downstream). The Organizational Water Footprint method builds on two environmental assessment frameworks which have been identified as suitable for the purpose of this project: Water Footprint (ISO 14046, 2014 and Organizational Life Cycle Assessment (UNEP 2015). To support stakeholders in conducting Organizational Water Footprint studies, this guidance document was developed, which presents the method in a clear and concise way by illustrating each step with a practical example. By analysing their Water Footprints, organizations can determine water use and resulting local impacts at premises and “beyond the fence” along global supply chains. In this way they can reduce water risks and contribute to a more sustainable use of the world’s limited freshwater resources. Süßwasser ist eine lebenswichtige Ressource für Menschen und Ökosysteme, ist aber in vielen Regionen der Welt knapp. Organisationen messen und managen den direkten Wasserverbrauch an ihrem Standort, vernachlässigen aber in der Regel den indirekten Wasserverbrauch, der mit globalen Lieferketten verbunden ist - obwohl Letzterer um mehrere Größenordnungen höher sein kann. Bis 2015 gab es keinen standardisierten lebenszyklusbasierten Ansatz, um den Wasserverbrauch einer Organisation zu analysieren. Vor diesem Hintergrund wurde das vom BMBF geförderte Forschungsprojekt "Water Footprint for Organizations - Local Measures in Global Supply Chains (WELLE)" von der TU Berlin, Evonik, dem Deutschen Kupferinstitut, Neoperl, thinkstep und Volkswagen gestartet. Das Projekt zielt darauf ab, Unternehmen dabei zu unterstützen, ihren kompletten organisatorischen Wasserfußabdruck zu bestimmen, lokale Hotspots in globalen Lieferketten zu identifizieren und Maßnahmen zu ergreifen, um ihren Wasserverbrauch zu reduzieren und den Wasserstress in wasserknappen Einzugsgebieten zu mindern. Im Rahmen des WELLE-Projekts wurde eine Methode zur Analyse eines Organisationsbezogenen Wasser Fußabdrucks entwickelt, die den Wasserverbrauch einer Organisation und die daraus resultierenden lokalen Auswirkungen entlang der gesamten Wertschöpfungskette analysiert. Das heißt, der organisationsbezogene Wasser Fußabdruck berücksichtigt nicht nur den direkten Wasserverbrauch in den Produktionsstätten, sondern auch den indirekten Wasserverbrauch für die Energieerzeugung und die Rohstoffproduktion (vorgelagert in der Lieferkette) sowie den Wasserverbrauch während der Nutzungs- und End-of-Life-Phase der Produktion (nachgelagert). Die Methode des organisationsbezogenen Wasser Fußabdrucks baut auf zwei Umweltbewertungsrichtlinien auf, die für den Zweck dieses Projekts als geeignet identifiziert wurden: Wasser Fußabdruck (ISO 14046, 2014) und organisationsbezogene Ökobilanzierung (UNEP 2015). Um Akteure bei der Durchführung von organisationsbezogenen Wasser Fußabdruck Studien zu unterstützen, wurde dieser Leitfaden entwickelt, der die Methode klar und übersichtlich darstellt und indem jeder Schritt mit einem praktischen Beispiel illustriert wird. Durch die Analyse ihres Wasser-Fußabdrucks können Organisationen den Wasserverbrauch und die daraus resultierenden lokalen Auswirkungen am Standort und entlang globaler Lieferketten ermitteln. Auf diese Weise können sie Wasserrisiken reduzieren und zu einem nachhaltigeren Umgang mit den begrenzten Süßwasserressourcen der Welt beitragen.

Download or read book The Effect of Hydrology on Soil Erosion written by Jesús Rodrigo-Comino and published by MDPI. This book was released on 2021-01-21 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Special Issue includes manuscripts about soil erosion and degradation processes and the accelerated rates due to hydrological processes and climate change. The new research included in this issue focuses on measurements, modeling, and experiments in field or laboratory conditions developed at different scales (pedon, hillslope, and catchment). This Special Issue received investigations from different parts of the world such as Ethiopia, Morocco, China, Iran, Italy, Portugal, Greece, and Spain, among others. We are happy to see that all papers presented findings characterized as unconventional, provocative, innovative, and methodologically new. We hope that the readers of the journal Water can enjoy and learn about hydrology and soil erosion using the published material, and share the results with the scientific community, policymakers, and stakeholders to continue this amazing adventure, facing plenty of issues and challenges.

Download or read book Integrated Water Resources Research written by Jason A. Hubbart and published by MDPI. This book was released on 2021-05-20 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anthropogenic and natural disturbances to freshwater quantity and quality are a greater issue for society than ever before. To successfully restore water resources requires understanding the interactions between hydrology, climate, land use, water quality, ecology, and social and economic pressures. This Special Issue of Water includes cutting edge research broadly addressing investigative areas related to experimental study designs and modeling, freshwater pollutants of concern, and human dimensions of water use and management. Results demonstrate the immense, globally transferable value of the experimental watershed approach, the relevance and critical importance of current integrated studies of pollutants of concern, and the imperative to include human sociological and economic processes in water resources investigations. In spite of the latest progress, as demonstrated in this Special Issue, managers remain insufficiently informed to make the best water resource decisions amidst combined influences of land use change, rapid ongoing human population growth, and changing environmental conditions. There is, thus, a persistent need for further advancements in integrated and interdisciplinary research to improve the scientific understanding, management, and future sustainability of water resources.

Download or read book Hydrological Extremes written by Ashish Pandey and published by Springer Nature. This book was released on 2020-11-07 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents quality technical papers representing the recent developments in the field of hydrological modeling, water management and water governance including practical applications. The content covers multifarious aspects of hydrology and water resources. It includes an application of the Hydrologic Modelling System (HEC-HMS) which has been successfully demonstrated for assessment of floods. The authors suggest an approach for the mitigation of cyclone disaster through a case study of the Phailin cyclone, whilst considering mitigating pluvial flooding, developing suitable management strategies. The book includes chapters discussing the detrended fluctuation analysis which is carried out for multifractal description of droughts. Drought characteristics are analyzed, and drought indices evolved for drought preparedness/management. The use of science in community planning under changing climate is also studied and discussed. The authors present and experimental study wherein hydraulic coefficients are calibrated by using vertical orifice. A cross flow hybrid hydrokinetic turbine is also evaluated for performance, and high head regulating radial gate designed and studied its sensitivity. This book will appeal to researchers, field practitioners, NGO and other Governmental as well as private water practitioners