Download or read book Effects of Excess Dietary L histidine on the Synthesis of Cholesterol and Fatty Acids in Rat Liver written by Jirapa Khuankong Solomon and published by . This book was released on 1977 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book L histidine 2 C14 Its Synthesis and Some Aspects of Its Metabolism in Rats written by Milton Toporek and published by . This book was released on 1952 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Synergistic Effects of Cortisone and Insulin on Lipogenesis in the Perfused Rat Liver as Studied with alpha C14 acetate written by Kurt I. Altman and published by . This book was released on 1950 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Effect of Dietary Fiber and Short Chain Fatty Acids on Lipogenesis and Sterologenesis in Isolated Rat Hepatocytes written by Patsy Masae Nishina and published by . This book was released on 1988 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Effect of Simple Diets on Cholesterol Synthesis in Rat Liver written by Ernest B. Terrell and published by . This book was released on 1970 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Hormonal and Dietary Control of the Synthesis and Degradation of Rat Liver Fatty Acid Synthetase and Other Lipogenic Enzymes written by Margaret Corinne Craig and published by . This book was released on 1973 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Effect of Growth Hormone on Hepatic Lipogenesis and Cholesterol Synthesis written by John William Bauman and published by . This book was released on 1956 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The effects of alcohol and lovastatin on cholesterol and fatty acid synthesis in rat liver written by Gwendolyn Ann Bartek and published by . This book was released on 1995 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Effect of Increasing Dietary Fat on Certain Rat Liver Enzymes written by Charles Radanovics and published by . This book was released on 1965 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Nutrient Requirements of Laboratory Animals written by National Research Council and published by National Academies Press. This book was released on 1995-02-01 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the years since the third edition of this indispensable reference was published, a great deal has been learned about the nutritional requirements of common laboratory species: rat, mouse, guinea pig, hamster, gerbil, and vole. The Fourth Revised Edition presents the current expert understanding of the lipid, carbohydrate, protein, mineral, vitamin, and other nutritional needs of these animals. The extensive use of tables provides easy access to a wealth of comprehensive data and resource information. The volume also provides an expanded background discussion of general dietary considerations. In addition to a more user-friendly organization, new features in this edition include: A significantly expanded section on dietary requirements for rats, reporting substantial new findings. A new section on nutrients that are not required but that may produce beneficial results. New information on growth and reproductive performance among the most commonly used strains of rats and mice and on several hamster species. An expanded discussion of diet formulation and preparationâ€"including sample diets of both purified and natural ingredients. New information on mineral deficiency and toxicity, including warning signs. This authoritative resource will be important to researchers, laboratory technicians, and manufacturers of laboratory animal feed.

Download or read book Effects of Dietary Lipids Against Carbon Tetrachloride Induced Liver Fibrosis in Rats written by Hualin Wang and published by . This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Effects of Dietary Lipids Against Carbon Tetrachloride-induced Liver Fibrosis in Rats: a Proteomic Approach" by Hualin, Wang, 王华林, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Liver fibrosis is an important reversible stage in progress of most chronic liver diseases (CLDs). The excess hepatic wound healing response against chronic liver injury results in extracellular matrix proteins accumulation and fibrosis. Oxidative stress, liver inflammation and/or hepatic steatosis contribute to this process. Until now, little is known how dietary lipids can influence liver''s pathophysiology. The effects of lipids on CLD progression may depend on their amount and the quality of fatty acids as well as the degrees of saturation. The investigation of liver fibrosis will help to understand the pathogenesis of CLDs and develop potential nutritional therapeutic approaches. The specific aim of this study was to investigate the effects of different high fats consumption in liver fibrosis by feeding the normal and carbon tetrachloride (CCl4)-treated animals with the diets enriched with following oils: corn oil rich in ω-6 polyunsaturated fatty acids (PUFAs), extra virgin olive oil (EVOO) high in ω-9 monounsaturated fatty acids (MUFAs), and lard enriched with saturated fatty acids (SFAs) for 4 weeks. The differentially expressed liver proteins in this process were identified by two-dimensional gel electrophoresis based proteomics to explore the molecular mechanisms. The proteomic analysis revealed characteristic differences between (i) normal and fibrotic livers (Chapter 3), and between the fibrotic livers treated with (ii) low fat versus high fat (20% w/w corn oil, Chapter 4) and among the high fats, between the diet enriched with corn oil versus (iii) EVOO (Chapter 5) and lard (Chapter 6). Among the identified proteins, collagen synthesis related protein prolyl 4-hydroxylase, oxidative stress related protein alpha-1-antitrypsin, free radical scavenger Cu/Zn superoxide dismutase and Calcium homeostasis regulator calreticulin and regucalcin were found to involve in CCl4-induced liver fibrosis. The results show that corn oil enhanced the hepatic steatosis but had no significant effects on fibrogenesis; the expression of several stress proteins like heat shock protein 75 kDa, and lipid metabolism related protein enoyl-CoA hydratase domain-containing protein 3 were found increased in high corn oil consumption animals with CCl4-treatment. Histological evaluations showed that olive oil could attenuate, and lard oil aggravate the liver damage induced by CCl4. Compared to corn oil, high EVOO diet rich in MUFAs decreased the lipid peroxidation and collagen accumulation in liver. Several protein related to antioxidant effects, including peroxiredoxin-1, thiosulfate sulfurtransferase and thioredoxin domain-containing protein 12 were found have higher expression level in high EVOO intake animals. In contrast, lard rich in SFAs intake leaded to macrovesicular steatosis and advanced fibrosis, and decreased the expression of antioxidant related glutathione S-transferases. Interestingly, S-adenosylmethionine synthesis related enzyme methionine adenosyltransferase was found up-regulated in lard intake animals, suggests the modification of DNA methylation was implicated in lard fed animals, while the demethylation on the promoter of profibrogenic gene was found, confirmed the lard consumption has the epigenetic modification effects in liver injury. Together, these findings give further insight into the pathobiology of CLDs. The data

Download or read book Effects of Dietary Heated Fats and Cyclic Fatty Acid Monomers on Rat Liver Enzyme Activity written by Courdjo Lamboni and published by . This book was released on 1993 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The objective of this research was to evaluate the effects of dietary heated fats from a commercial deep-fat frying operation and of cyclic fatty acids (CFA) on rat liver enzyme activity. The fats were partially hydrogenated soybean oil (PHSBO) used 4 days (4-MH) and 7 days (7-DH) for frying foodstuffs. Balanced diets containing these used fats were fed to rats for 10 weeks. In a second experiment, rats were pair-fed diets containing graded doses of 7-DH. In a third, 0.15% CFA diet was fed to animals. In a fourth, rats were pair-fed diet containing the 7-DH treated (T-7DH) with magnesium silicate which removes some polymers from the used oil. All four sets of experiments were conducted with control rats fed non-heated PHSBO (NH) diet. All diets were isocaloric with 15% fat. Animals fed 7-DH diet either ad libitum or by pair-feeding, showed significant increased contents of cytochromes P$sb{450}$ and b$sb5$ as well as increased activity of (EC 1.6.2.4) NADPH-cytochrome P$sb{450}$ reductase when compared to controls. The 4-MH diet group showed the same trends for cytochromes contents and reductase activity in comparison to controls. Similar results were obtained with CFA diet. The activities of (EC 2.3.1.21) carnitine palmitoyltransferase-I; (EC 1.1.1.42) isocitrate dehydrogenase; were significantly decreased in each case either ad libitum or by pair-feeding in comparison to controls. Significantly depressed activity of (EC 1.1.1.49) glucose 6-phosphate dehydrogenase was also noticed for these animals when compared to NH. Similar results were recorded when fed CFA diet to rats. In addition, liver and microsomal protein were significantly increased when the used oils were fed to rats either ad libitum or by pair-feeding in comparison to NH. Enlarged and fatty livers were noted. Similar results were obtained when fed CFA diet. Liver glycogen was significantly decreased when fed the used oils or CFA diets in comparison to controls. However, when animals were fed T-7DH diet, the activities of the enzymes were significantly improved.

Download or read book The Effect of Long Chain Saturated Fatty Acids 12 0 14 0 16 0 18 0 on Hepatic Cholesterol Metabolism written by Jeong-Sook Lee Kim and published by . This book was released on 1997 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book A Comprehensive Overview of the Effects of Diet on the Hepatic Transcriptome and Translatome in Rat Liver written by Jaclyn Welles and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Consumption of excess calories is associated with alterations in lipid and carbohydrate metabolism in the liver, and often leads to development of metabolic diseases in the liver such as, non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), and diabetes. Even though hepatic lipid accumulation begins with as little as 1-wk of high-fat diet i.e. HFD consumption, previous studies searching for the mechanism(s) involved have focused almost universally on time points >=1 month. Moreover, no studies have assessed possible changes in mRNA translation as a mechanism involved in hepatic fatty acid accumulation, even though changes in mRNA translation have been shown to explain ~40% of alterations in protein expression. Thus, for the studies presented in this thesis, we hypothesized that the translation of specific mRNAs essential in the regulation of metabolic processes in the liver, may be detrimentally dysregulated, contributing to the onset and pathogenesis of metabolic diseases. In chapter 3 we hypothesized that short-term (i.e. 2-wk) consumption of a Western-diet (WD), high in saturated fat, sucrose, and cholesterol, significantly alters the translation of specific mRNA transcripts e.g. lipoprotein lipase (LPL), hormone sensitive lipase E (LIPE), and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3), in the liver, contributing to the onset of metabolic disorders such as NASH and NAFLD. Notably, the 5' and 3' untranslated region (UTR) of all 3 mRNAs contain regulatory motifs e.g., upstream open reading frames (uORF), internal ribosomal entry sites (IRES), terminal oligopyrimidine (TOP) motif, which may be modulating their translational control as observed in studies performed in chapter 3. Moreover, the expression of several mRNAs i.e. LPL, LIPE, glucokinase (GCK), and fibroblast growth factor 21 (FGF21), was significantly lower in the livers of both fasted and refed rats fed a WD, when compared to rats fed a CD. Overall, the results presented in chapter 3 suggest that alterations in liver metabolism occur rapidly after placing rats on a WD, and that such changes manifest as a consequence of alterations in gene expression occurring at both the transcriptional and translational levels. Surprisingly, feeding-induced phosphorylation of 4E-BP1 and S6, was blunted in WD-fed rats when compared to CD, suggesting that hepatic mTORC1 activity may be, at least in part, responsible for some of the translational changes observed in this study. Thus, the changes observed between fasted and refed CD and WD-fed rats, suggest that the results demonstrating modulations in the expression, and/or translation of several mRNAs, critical in function in the regulation of metabolic processes (i.e. glucose and lipid metabolism), may be occurring through a mechanism dependent oft hepatic mTORC1-activity. Interestingly, in studies performed in chapter 3, the expression of FGF21 mRNA was significantly upregulated in the livers of fasted rats when compared to refed rats, a finding previously demonstrated in studies found in the literature. Studies recently published by Cyphert et. al. demonstrated how the fasting secretagogue glucagon increased the secretion of FGF21 into the media in three hepatoma cell lines, without affecting total FGF21 mRNA abundance suggesting either translational or post-translational control of FGF21 mRNA translation in the liver. Notably, several studies have found that in cases of obesity, glucagon concentrations are significantly dysregulated, leading to glucagon-dependent changes, such as changes in liver weight, hepatic triglycerides, gluconeogenesis, and glycogenolysis. Moreover, in studies where mice lacking the expression of the glucagon receptor (GCGR), were challenged using diet-induced obesity (DIO) by HFD, or streptozotocin treatments to model Type 2 Diabetes, mice lacking GCGR expression, were protected against hyperglycemia, beta cell loss, and hepatic steatosis, directly associating glucagon activity with improvements in metabolic control (93). Together, these findings delineate glucagon as a potential therapeutic against diet-induced obesogenic pathologies. Thus, we hypothesized that FGF21 mRNA was being translationally upregulated by glucagon in the liver. Notably, results from studies performed in chapter 4 of this thesis, demonstrated how the translation and secretion of FGF21 was significantly upregulated by the peptide hormone, glucagon, in rat H4IIE hepatoma cells. Furthermore, glucagon also inhibited mTORC1 activity concurrently with upregulation of FGF21 mRNA secretion, suggesting a mechanism which may be dependent on mTORC1 activity in the liver. Finally, we also observed significant increases in the translation of FGF21 mRNA in the livers of fasted rats when compared to refed, changes independent of changes to total FGF21 mRNA abundance. All in all, results from these studies highlight mRNA translation, as a method of gene regulation, which may be influencing the onset and pathogenesis of metabolic diseases driven by the liver. Studies are currently underway exploring possible regulatory motifs in RNA e.g. uORFs; 5'-TOP; IRES; RNA binding, motifs that may be coordinating translational control of mRNAs identified in chapters 3 and 4.

Download or read book Dissertation Abstracts International written by and published by . This book was released on 1978 with total page 744 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Effect of Dietary Fats on the Incorporation of Various Fatty Acids Into Phospholipids and Triglycerides of Rat Liver written by Lumduan Savetamal and published by . This book was released on 1964 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Effects of Diets Containing Gelatin Gelatin L tryptophan Or L histidine on Serum and Hepatic Lipids in Rats written by Hing W. Char and published by . This book was released on 1984 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: