Download or read book Effects of Age on Neural Correlates of Episodic Encoding and Brain Structure and Their Relation to Cognitive Performance written by Eleanor Liu and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Episodic memory – memory for unique personal events – is essential to our daily life. Relative to other forms of memory, episodic memory declines disproportionately with advancing age. One prominent account of such decline proposes a reduction in the efficacy of episodic encoding in older individuals. Numerous studies have employed functional magnetic resonance imaging to investigate the neural correlates of episodic encoding in young and older adults with the “subsequent memory procedure”. With this procedure, encoding related neural activity is contrasted based on subsequent memory performance for the study items. These studies have consistently reported that neural activity during encoding is predictive of later memory performance. Such subsequent memory effects (SMEs) take two forms: positive SMEs, where enhanced neural activity is associated with study items later remembered relative to study items that are less well remembered or forgotten; and negative SMEs, that take the opposite pattern. Studies have generally reported age-invariant positive SMEs whereas negative effects tend to be attenuated in older adults. Of importance, neural activity preceding the onset of a study item has also been shown to predict subsequent memory. Few studies have examined the effect of age on such pre-stimulus subsequent memory effects (pre-stimulus SMEs). Experiment 1 (Chapter 2) describes findings on pre-stimulus neural activity in healthy young and older adults. The results revealed age-invariant and age-dependent pre-stimulus SMEs in different brain regions, although age differences were mostly quantitative rather than qualitative. In contrast to prior reports of pre-stimulus SMEs, the effects in the present study were negative in direction. They could reflect allocation of neural resources in preparation of the upcoming study event. The study reported in Chapter 3 combined data from 2 independent experiments to examine age differences in poststimulus SMEs. The 2 regions of a priori interest were the hippocampus and left inferior frontal gyrus (IFG). Positive and negative SMEs were evident in both age groups. Of importance, the hippocampal SMEs were equivalent across age groups; and there was no evidence of age-related right-frontal over-recruitment. There was an age-invariant relationship between hippocampal SMEs and memory performance, suggesting intact hippocampal encoding activity in healthy older adults, and consistent with the notion that hippocampal activity reflects the amount of information encoded. A positive relationship between left IFG SME and memory performance was observed in older adults only. The study in Chapter 4 took an integrated approach to examine the relationship between structural and functional measures, and memory performance in young and older adults. Consistent with the literature, robust age-related decline was evident in hippocampal volume and cortical thickness. Results from an integrated statistical model revealed that hippocampal encoding activity, but not hippocampal volume, was predictive of memory performance in both age groups. On the other hand, cortical thickness negatively correlated with performance in young adults, but positively correlated with performance in older adults. Both cortical thickness and cortical SMEs explained unique variance in memory performance. Of importance, IFG thickness-memory relationships were no longer significant after controlling for global thickness. In conclusion, both pre-stimulus and encoding-related neural activity can be resistant to the effects of age, although the left IFG acts as a ‘bottleneck’ in older adults. Age differences in pre-stimulus SMEs require a nuanced interpretation, rather than appeal to a generic construct. Moreover, age differences appear to be more robust in structural rather than in functional measures. Lastly, the age-dependent cortical thickness-memory relationship was general rather than region-specific.
Download or read book Cognitive Neuroscience of Aging written by Roberto Cabeza and published by Oxford University Press. This book was released on 2017 with total page 633 pages. Available in PDF, EPUB and Kindle. Book excerpt: A rapidly growing body of research has consituted a new discipline that may be called cognitive neuroscience of aging. This book offers an introduction to the topic, useful to both professionals & students in cognitive neuroscience, cognitive psychology, neuroscience, neuropsychology & neurology.
Download or read book Brain Aging written by David R. Riddle and published by CRC Press. This book was released on 2007-04-19 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur
Download or read book Neural Correlates of Successful Cognitive Aging written by and published by . This book was released on 2012 with total page 72 pages. Available in PDF, EPUB and Kindle. Book excerpt: Even in the absence of pathology such as Alzheimer's disease, aging is associated with cognitive decline. Nevertheless, some older individuals appear to maintain their cognitive abilities, raising the question of what neural factors might promote "successful" cognitive aging (SCA). From the current literature, it is unclear whether there are unique neural factors that give rise to individual differences in SCA, or whether the same neural factors relate to cognition across adulthood. Little is known about the relative importance of different aspects of neural integrity (i.e. brain structure, task-related functional response, and functional connectivity) to promoting SCA or how different neural factors interact in their contribution to SCA. We aimed to characterize the neural signature of SCA, defined by working memory performance. Sixty-four healthy adults, ages 23 to 78, underwent structural and functional magnetic resonance imaging during a working memory task. We focused on measuring the cortical thickness and surface area of the dorsolateral prefrontal cortex (DLPFC) and task-related activation within the DLPFC including laterality effects. We also focused on the "default-mode network" by measuring task-related deactivation in the medial prefrontal cortex (MPFC), functional connectivity between the MPFC and posterior cingulate (PC), and MPFC structure. We aimed to determine how these neural measures related to working memory and whether or not these brain-cognition relationships differed by age. We also explored the relative contribution of and inter-relationships between these neural measures in predicting SCA. Larger DLPFC surface area, greater left and right DLPFC activation, more bilateral DLPFC activation, and greater MPFC deactivation were each associated with better working memory performance. These brain-cognition relationships did not differ with age, thus SCA did not result from a unique neural signature but occurred when older adults maintained the same brain-cognition relationships present throughout adulthood. Results of multivariate analyses showed how different aspects of the neural system (i.e., brain structure and function) work together to achieve good cognitive function in aging. Right DLPFC activation and MPFC deactivation were the strongest contributors to SCA, suggesting that brain-based interventions should focus on preventing or reversing age-related alterations in those aspects of the neural system.
Download or read book Neural Plasticity and Memory written by Federico Bermudez-Rattoni and published by CRC Press. This book was released on 2007-04-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq
Download or read book Memory and Aging written by Moshe Naveh-Benjamin and published by Psychology Press. This book was released on 2012-05-04 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current demographical patterns predict an aging worldwide population. It is projected that by 2050, more than 20% of the US population and 40% of the Japanese population will be older than 65. A dramatic increase in research on memory and aging has emerged to understand the age-related changes in memory since the ability to learn new information and retrieve previously learned information is essential for successful aging, and allows older adults to adapt to changes in their environment, self-concept, and social roles. This volume represents the latest psychological research on different aspects of age-related changes in memory. Written by a group of leading international researchers, its chapters cover a broad array of issues concerning the changes that occur in memory as people grow older, including the mechanisms and processes underlying these age-related memory changes, how these changes interact with social and cultural environments, and potential programs intended to increase memory performance in old age. Similarly, the chapters draw upon diverse methodological approaches, including cross-cultural extreme group experimental designs, longitudinal designs assessing intra-participant change, and computational approaches and neuroimaging assessment. Together, they provide converging evidence for stability and change in memory as people grow older, for the underlying causes of these patterns, as well as for the heterogeneity in older adults’ performance. Memory and Aging is essential reading for researchers in memory, cognitive aging, and gerontology.
Download or read book The Cambridge Handbook of Cognitive Aging written by Ayanna K. Thomas and published by Cambridge University Press. This book was released on 2020-05-28 with total page 1019 pages. Available in PDF, EPUB and Kindle. Book excerpt: Decades of research have demonstrated that normal aging is accompanied by cognitive change. Much of this change has been conceptualized as a decline in function. However, age-related changes are not universal, and decrements in older adult performance may be moderated by experience, genetics, and environmental factors. Cognitive aging research to date has also largely emphasized biological changes in the brain, with less evaluation of the range of external contributors to behavioral manifestations of age-related decrements in performance. This handbook provides a comprehensive overview of cutting-edge cognitive aging research through the lens of a life course perspective that takes into account both behavioral and neural changes. Focusing on the fundamental principles that characterize a life course approach - genetics, early life experiences, motivation, emotion, social contexts, and lifestyle interventions - this handbook is an essential resource for researchers in cognition, aging, and gerontology.
Download or read book Cognitive Changes and the Aging Brain written by Kenneth M. Heilman and published by Cambridge University Press. This book was released on 2019-12-05 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the changes in the brain and in cognitive functions that occur with aging in the absence of a neurological, psychiatric, or medical disease. It discusses aging-related changes in many brain functions, including memory, language, sensory perception, motor function, creativity, attention, executive functions, emotions and mood. The neural mechanisms that may account for specific aging-related changes in cognition, perception and behavior are explored, as well as the means by which aging-related cognitive decrements can be managed and possibly ameliorated. Consequently, this book will be of value to clinicians, including neurologists, psychiatrists, geriatricians, primary care physicians, psychologists and speech-language pathologists. In addition, researchers and graduate students who want to learn about the aging brain will find this an indispensable guide.
Download or read book Investigating Age related Differences in Functional Brain Activity and Connectivity Underlying Source Memory written by Elizabeth Ankudowich and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Episodic memory encompasses an extraordinary range of diverse cognitive functions that are integral to daily functioning. Healthy aging is associated with declines in episodic memory, which may impair older adults' ability to remember the rich contextual details of previously experienced events. By the age of sixty, older individuals may have a reduced ability to remember spatial or temporal contextual features of past events (e.g., where or when you last took a prescription medication). Previous studies have focused on understanding the anatomical and functional neural correlates of episodic memory decline in young and older adulthood, but how these underlying mechanisms contribute to episodic memory to across the adult lifespan remains to be explored. In this series of studies, we aim to advance our understanding of the differences in episodic memory that develop across the adult lifespan and the neural basis of this age-related decline, as measured by functional magnetic resonance imaging (fMRI). Using a lifespan sample of young, middle-aged, and older adults, we employ a source memory paradigm to assess individuals' memory for the spatial and temporal contextual details of photographs of faces. In addition, we analyze fMRI data collected during both initial encoding and subsequent retrieval of contextual information in order to examine differential effects of age on encoding- and retrieval-specific processes. In Study 1, we demonstrate that declines in source memory may be discernible by midlife, extend into older adulthood, and are associated with reduced modulation of phase-specific activity in anterior prefrontal (PFC) and posterior ventral visual areas. We also show that older adulthood may be associated with increased phase-specific modulation, particularly in areas of lateral PFC and medial temporal lobes (MTL) at retrieval. In Study 2, we extend these findings to show how lifespan differences in phase-specific activity directly contribute to source memory performance. In particular, we find that older individuals engage dorsolateral PFC (DLPFC) to a greater extent at encoding and hippocampus (HC) to a greater extent at retrieval, during the phase when it does not seem to help performance across individuals. In Study 3, we address whether these age-related increases in encoding- or retrieval-specific activation might be related to differences in whole-brain connectivity. We examine whether age-related increases in DLPFC (Study 2 encoding) and posterior HC (Study 2 retrieval) differentially correlate with activity across the rest of the brain and with performance. In young adults, we demonstrate that connectivity between lateral PFC, parietal, and ventral visual cortical regions and our DLPFC seed relates to better performance. In older adults, these same regions show greater connectivity with posterior HC and relate to worse performance. Converging findings across studies suggests that activity and connectivity among fronto-parietal regions support the recollection of visual information and source memory performance in young adults, whereas aging may be associated with altered modulation of fronto-parietal activity and connectivity with posterior HC, which does not support source memory performance." --
Download or read book Investigations of Age related Effects on the Neural Correlates of Recollection and Familiarity written by Tracy Hsiang-Yi Wang and published by . This book was released on 2013 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present research investigated age-related differences in the neural correlates of two putative processes (recollection and familiarity) supporting recognition memory. Functional magnetic resonance imaging (fMRI) and electroencephalography (EEG) were utilized in concert with retrieval tasks that allow trials associated with recollection to be segregated from trials associated with familiarity. Some studies investigating age-related effects on the neural correlates of successful retrieval have reported that the neural correlates of retrieval are larger and more widespread in older subjects than in the young ('cortical over-recruitment'). These studies, however, vary widely in their methodologies, analyses, and even characterization of memory retrieval. The aim of the research described here is to elucidate the effects of age on the neural correlates of recognition memory. The second chapter of this dissertation describes an experiment that characterizes the neural correlates of episodic memory in subjects typically considered 'older' (between the ages of 63-77) and 'younger' (between the ages of 18-30) as indexed by functional magnetic resonance imaging (fMRI). The third chapter describes an analogous Event-related potential (ERP) study that investigated the electrophysiological correlates of recollection and familiarity in the same age groups as the study described in the second chapter. Finally, the fourth chapter describes the final experiment that investigated cortical reinstatement of material-specific recollection related effects in young and older subjects. This final study utilized univariate analysis to identify cortical reinstatement of material specific recollection-related activity, while using multivariate pattern analysis to quantify the amount of reinstatement in each age group. Overall, the findings provide evidence that there is no significant neural reorganization for the retrieval of episodic memory in the face of advancing age. Rather, the presented research suggests that under circumstances where encoding and retrieval are well controlled, the neural correlates of episodic retrieval remain largely invariant as a function of age.
Download or read book Neural Correlates of Cognitive Impairment in Aging written by Christine Wu Nordahl and published by . This book was released on 2004 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Brain Networks in Aging Reorganization and Modulation by Interventions written by Junfeng Sun and published by Frontiers Media SA. This book was released on 2018-02-22 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: Old adults undertake multiple reduced cognitive abilities in aging, which are accompanied with specific brain reorganization in forms of regional brain activity and brain tissues, inter-region connectivity, and topology of whole brain networks in both function and structure. The plasticity changes of brain activities in old adults are explained by the mechanisms of compensation and dedifferentiation. For example, older adults have been observed to have greater, usually bilateral, prefrontal activities during memory tasks compared to the typical unilateral prefrontal activities in younger adults, which was explained as a compensation for the reduced brain activities in visual processing cortices. Dedifferentiation is another mechanism to explain that old adults are with much less selective and less distinct activity in task-relevant brain regions compared with younger adults. A larger number of studies have examined the plasticity changes of brain from the perspective of regional brain activities. However, studies on only regional brain activities cannot fully elucidate the neural mechanisms of reduced cognitive abilities in aging, as multiple regions are integrated together to achieve advanced cognitive function in human brain. In recent years, brain connectivity/network, which targets how brain regions are integrated, have drawn increasing attention in neuroscience with the development of neuroimaging techniques and graph theoretical analysis. Connectivity quantifies functional association or neural fibers between two regions that may be spatially far separated, and graph theoretical analysis of brain network examines the complex interactions among multiple regions from the perspective of topology. Studies showed that compared to younger adults, older adults had altered strength of task-relevant functional connectivity between specific brain regions in cognitive tasks, and the alternation of connectivity are correlated to behavior performance. For example, older adults had weaker functional connectivity between the premotor cortex and a region in the left dorsolateral prefrontal cortex in a working memory task. Interventions like cognitive training and neuro-modulation (e.g., transcranial magnetic stimulation) have been shown to be promising in regaining or retaining the decreasing cognitive abilities in aging. However, only few neuroimaging studies have examined the influence of interventions to old adult’s brain activity, connectivity, and cognitive performance. This Research Topic calls for contributions on brain network of subjects in normal aging or with age-related diseases like mild cognitive impairment and Alzheimer’s disease. The studies are expected to be based on neuroimaging techniques including but not limited to functional magnetic resonance imaging, Electroencephalography, and diffusion tensor imaging, and contributions on the influence of interventions to brain networks in aging are highly encouraged. All these studies would enrich our understanding of neural mechanisms underlying aging, and offer new insights for developing possible interventions to retain cognitive abilities in aging subjects.
Download or read book Measuring the Mind written by John Duncan and published by . This book was released on 2005 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are the fundamental mechanisms of decision making, processing speed, memory and cognitive control? How do these give rise to individual differences, and how do they change as people age? How are these mechanisms implemented in neural unctions, in particular the functions of the frontal lobe? How do they relate to the demands of everyday, 'real life' behaviour? Over almost five decades, Pat Rabbitt has been among the most distinguished of British cognitive psychologists. His work has been widely influential in theories of mental speed, cognitive control and aging, influencing research in experimental psychology, neuropsychology and individual differences. This volume, dedicated to Pat Rabbitt, brings together a distinguished group of 16 contributors actively pursuing research in the fields of speed, memory, and control, and the application of these fields to individual differences and aging. With the latest work from senior figures in the field, and a focus on fundamental topics in both teaching and research, the book will be valuable to students and scientists in experimental psychology and cognitive neuroscience.
Download or read book Cognitive Aging written by Denise Park and published by Psychology Press. This book was released on 2012-12-06 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: As our society ages, the topic of cognitive aging is becoming increasingly important. This volume provides an accessible overview of how the cognitive system changes as a function of normal aging. Building on the successful first edition, this volume provide an even more comprehensive coverage of the major issues affecting memory, attention, language, speech and other aspects of cognitive functioning. The essential chapters from the first edition have been thoroughly revised and updated and new chapters have been introduced which draw in neuroscience studies and more applied topics. In addition, contributors were encouraged to ensure their chapters are accessible to students studying the topic for the first time. This therefore makes the volume appealing as a textbook on senior undergraduate and graduate courses.
Download or read book Imaging the Aging Brain written by William Jagust and published by . This book was released on 2009 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains chapters from experts in the fields of brain imaging, clinical neuroscience, and cognitive neuroscience who have studied the aging brain. Topics covered include technical factors in brain imaging, pathological basis of age-related structural and functional changes, neurochemistry and genetics of brain imaging in aging, and the use of imaging techniques in diagnosis, longitudinal testing, drug development and testing, and presymptomatic detection. The book is intended to be both a detailed review of the current status of brain imaging and aging and to serve as an introduction to the field for those who may be starting investigations using imaging techniques of PET, structural MRI, and functional MRI. It covers basic science approaches such as using fMRI to probe networks, as well as recent developments like amyloid imaging and the use of imaging as a biomarker in clinical trials.
Download or read book Lifespan Cognition written by Ellen Bialystok and published by Oxford University Press, USA. This book was released on 2006 with total page 411 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aims to create a bridge across cognitive development and cognitive aging. This volume studies the rise and fall of specific cognitive functions, such as attention, executive functioning, memory, working memory, representations, and individual differences to find ways in which the study of development and decline converge on common mechanisms.
Download or read book The Effects of Aging and Prefrontal Cortical Damage on the Neural Correlates of Recollection and Familiarity written by Audrey Laquita Duarte and published by . This book was released on 2004 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:
