Download or read book Effect of Intranasal Delivery of Carbon Dioxide on Trigeminal Ganglion Neurons written by Stanka Kankipati (M. K.) and published by . This book was released on 2008 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: The data from recent clinical trails [sic] have reported that intranasal administration of non-inhaled 100% medical grade CO2 is an effective and safe treatment for migraine and allergic rhinosinusitis, but the exact mechanism of action of CO2 in treating these diseases is not well understood. Activation of trigeminal nerves, release of CGRP, and neuron-glia interactions through gap junctions in trigeminal ganglion are implicated in the pathology of migraine and allergic rhinosinusitis. The goal of this study was to determine whether administration of 100% CO2 to the nasal mucosa of rats inhibits trigeminal ganglion neuron-glia signaling and neuronal cell secretion. Increased signaling via gap junctions between trigeminal neurons and satellite glial cells was seen 2 hrs after capsaicin injection into the whisker pad. This gap junction communication was greatly reduced in animals treated with CO2 prior to capsaicin stimulation. CO2 treatment also blocked the stimulatory effect of capsaicin on Cx 26, S100B and CGRP expression. In addition, CO2 caused a decrease in levels of SNAP-25, a protein involved in controlling CGRP release from trigeminal nerves. Results from this in vivo study provide the first evidence of a unique regulatory mechanism by which CO2 inhibits sensory nerve activation, neuron-glial cell signaling, and subsequent neuropeptide release.
Download or read book Differential Regulation of Calcitonin Gene related Peptide Secretion from Trigeminal Ganglion Neurons by Carbon Dioxide written by Carrie Vause and published by . This book was released on 2006 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Headache written by Giuseppi Nappi and published by Elsevier. This book was released on 2010-11-30 with total page 860 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Clinical Neurology: Headache covers various aspects of headaches. It covers up-to-date information about the cultural developments and the scientific advances in the field of neurological science. One of the most frequent symptoms that people encounter is migraine or other type of headaches. At least 40% of neurological consultations are headache-related. With this, significant advances in basic and applied brain sciences have emerged in the field of headache-related problems. Divided into six sections, the book discusses the socioeconomic aspects of headaches, the contribution of biological sciences to the study of the pathophysiology of headache, and the management of headache and other related problems. It also deals with headache-related issues, such as pathogenic (chronobiological, endocrinological, and neuroimaging correlates), nosographic (i.e., migraine, vertigo, and headache in children), and treatment-related issues. The book will serve as a reference for researchers, clinical physicians, and other readers who want additional knowledge about the clinical features of headaches.
Download or read book Springer Handbook of Odor written by Andrea Büttner and published by Springer. This book was released on 2017-02-28 with total page 1155 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Springer Handbook of Odor is the definitive guide to all aspects related to the study of smell and their impact on human life. For the first time, this handbook aligns the senso-chemo-analytical characterization of everyday smells encountered by mankind, with the elucidation of perceptual, hedonic, behavioral and physiological responses of humans to such odors. From birth onwards we learn to interact with our environment using our sense of smell. Moreover, evolutionary processes have engendered a multi-faceted communication that is supported – even dominated – by olfaction. This compilation examines the responses of humans to odors at different stages of life, thereby building a foundation for a widely overseen area of research with broader ramifications for human life. The expert international authors and editor align aspects, concepts, methodologies and perspectives from a broad range of different disciplines related to the science of smell. These include chemistry, physiology, psychology, material sciences, technology but also disciplines related to linguistics, culture, art and design. This handbook, edited by an internationally renowned aroma scientist with the support of an outstanding team of over 60 authors, is an authoritative reference for researchers in the field of odors both in academia and in industry and is also a useful reference for newcomers to the area.
Download or read book Direct Nose to Brain Drug Delivery written by Chandrakantsing Pardeshi and published by Academic Press. This book was released on 2021-06-16 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Direct Nose-to-Brain Drug Delivery provides the reader with precise knowledge about the strategies and approaches for enhanced nose-to-brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration and includes an overview on the toxicity aspects of the various materials used to develop the direct nose-to-brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. This book is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems and novel drug administration devices for the treatment of neuro-ailments. Explains the targeting approaches for enhanced brain targeting following intranasal drug administration Explores the various nanocarriers developed to date for neurotherapeutic delivery via nose-to-brain Discusses pharmaceutical and biomedical applications after nose-to-brain delivery of therapeutic pharmaceuticals and biologicals
Download or read book CSA Neurosciences Abstracts written by and published by . This book was released on 1994 with total page 918 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nasal Physiology and Pathophysiology of Nasal Disorders written by Özlem Önerci Celebi and published by Springer Nature. This book was released on 2023-02-20 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fully revised and expanded second edition provides a comprehensive and up-to-date overview of nasal physiology and pathophysiology. With the help of numerous tables, schematic drawings, and color photographs, it helps readers gain a better understanding of the impact of structural changes and the process of disease development, and to make treatment decisions. Each chapter has been written by a leading expert in the field and addresses one important aspect in an accessible way. Covering all four functions of the nose: respiration, defense, olfaction and cosmesis, the book discusses the various techniques for the clinical evaluation of nasal function as well as current trends and future directions in nasal physiologic research. This second edition also includes additional chapters on rhinomanometry, local nasal inflammation, T cells and B cells, and artificial intelligence for the nose. Given its scope, the book is a valuable resource for both experienced otorhinolaryngologists and novices in the field.
Download or read book Handbook of Trigeminal Neuralgia written by Girija Prasad Rath and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all aspects of trigeminal neuralgia (TGN) which is a common yet very painful condition of face and scalp. Chapters include historical perspective of the condition, clinical presentations, diagnosis, management strategy, drug therapy, different interventional techniques utilized, and non-invasive modalities offered. The book has ample images to explain three main percutaneous procedures carried out for this condition such as radiofrequency thermocoagulation, glycerol rhizolysis and balloon microcompression in detail. It also covers open neurosurgical procedures including microvascular decompression and certain non-conventional and non-invasive methods. This book provides assistance to pain physicians to have a comprehensive knowledge of trigeminal neuralgia. It is also relevant to neurosurgeons, neurologists, anesthesiologists, dental surgeons and resident doctors.
Download or read book Core Topics in Neuroanaesthesia and Neurointensive Care written by Basil F. Matta and published by Cambridge University Press. This book was released on 2011-10-13 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: Core Topics in Neuroanesthesia and Neurointensive Care is an authoritative and practical clinical text that offers clear diagnostic and management guidance for a wide range of neuroanesthesia and neurocritical care problems. With coverage of every aspect of the discipline by outstanding world experts, this should be the first book to which practitioners turn for easily accessible and definitive advice. Initial sections cover relevant anatomy, physiology and pharmacology, intraoperative and critical care monitoring and neuroimaging. These are followed by detailed sections covering all aspects of neuroanesthesia and neurointensive care in both adult and pediatric patients. The final chapter discusses ethical and legal issues. Each chapter delivers a state-of-the art review of clinical practice, including outcome data when available. Enhanced throughout with numerous clinical photographs and line drawings, this practical and accessible text is key reading for trainee and consultant anesthetists and critical care specialists.
Download or read book Abstracts Society for Neuroscience written by Society for Neuroscience and published by . This book was released on 1994 with total page 972 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Neurobiology of Olfaction written by Anna Menini and published by CRC Press. This book was released on 2009-11-24 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Overview of Advances in OlfactionThe common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely
Download or read book Anesthesia for Otolaryngologic Surgery written by Basem Abdelmalak and published by Cambridge University Press. This book was released on 2012-10-18 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: Anesthesia for Otolaryngologic Surgery offers a comprehensive synopsis of the anesthetic management options for otolaryngologic and bronchoscopic procedures. Authored by world authorities in the fields of anesthesiology and otolaryngology, both theoretical concepts and practical issues are addressed in detail, providing literature-based evidence wherever available and offering expert clinical opinion where rigorous scientific evidence is lacking. A full chapter is dedicated to every common surgical ENT procedure, as well as less common procedures such as face transplantation. Clinical chapters are enriched with case descriptions, making the text applicable to everyday practice. Chapters are also enhanced by numerous illustrations and recommended anesthetic management plans, as well as hints and tips that draw on the authors' extensive experience. Comprehensively reviewing the whole field, Anesthesia for Otolaryngologic Surgery is an invaluable resource for every clinician involved in the care of ENT surgical patients, including anesthesiologists, otolaryngologists and pulmonologists.
Download or read book Comparative Medicine written by and published by . This book was released on 2000 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Index Medicus written by and published by . This book was released on 2003-07 with total page 2036 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Holland Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1979 with total page 892 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pain Neurosurgery written by Dr. Oren Sagher and published by Oxford University Press. This book was released on 2019-07-08 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: Part of the Neurosurgery by Example series, this volume on pain neurosurgery presents exemplary cases in which renowned authors guide readers through the assessment and planning, decision making, surgical procedure, after care, and complication management of common and uncommon disorders. The cases explore the spectrum of clinical diversity and complexity within pain neurosurgery, including trigeminal neuralgia, postherpetic neuralgia, occipital neuralgia, percutaneous cordotomy for cancer-associated pain, chronic lumbar radiculopathy, and more. Each chapter also contains 'pivot points' that illuminate changes required to manage patients in alternate or atypical situations, and pearls for accurate diagnosis, successful treatment, and effective complication management. Containing a focused review of medical evidence and expected outcomes, Pain Neurosurgery is appropriate for neurosurgeons who wish to learn more about a subspecialty, and those preparing for the American Board of Neurological Surgery oral examination.
