Download or read book Ecological and Evolutionary Mechanisms for Emerging Infectious Diseases written by Nicole Nova and published by . This book was released on 2022 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: SARS. Ebola. Zika. COVID-19. The majority of all new infectious diseases discovered in the last decades are transmitted from animals to humans. More and more diseases have "spilled over" from wildlife to humans and escalated into pandemics, largely due to anthropogenic activities and global change, including climate change and land use change. Emerging diseases in wildlife can spill over from one species to another, decimating many vulnerable species. However, because human and wildlife systems are so complex, we still lack a clear understanding of the mechanisms driving disease emergence. My dissertation fills some critical gaps in our understanding of the ecological and evolutionary drivers of infectious diseases within and across species. In Chapter 1, I showed how temperature, rainfall and susceptible population size (ecological drivers) affect the (re)emerging mosquito-borne disease dengue. I used a data-driven approach for inferring causal relationships in nonlinear systems and demonstrated that suitable climate can only promote epidemics when the susceptible population is sufficiently large. In Chapter 2, I uncovered ecological and evolutionary drivers of pathogen sharing between different species using datasets of organisms and their pathogens, and their ecological and phylogenetic similarities, to understand how pathogens have adapted to multiple organisms. Here, I quantified the relative importance between ecological and evolutionary factors for predicting pathogen sharing by taxonomic level. Finally, Chapter 3 highlights a wildlife disease case study using genomic analyses of canine distemper virus (CDV) sampled from different carnivores in Alaska and Yellowstone to understand how viruses evolve in wildlife and what disease dynamics they cause. All these findings will help facilitate more effective preventative disease management strategies to improve human and animal health. In sum, my dissertation will help bridge the knowledge gap between ecological and evolutionary drivers of infectious diseases to better understand spillover and subsequent outbreaks. My research will help lay the foundation for future interdisciplinary studies in disease ecology and molecular evolution and will improve the effectiveness of both public health strategies and wildlife conservation.
Download or read book Ecology and Evolution of Infectious Diseases written by Benjamin Roche and published by Oxford University Press. This book was released on 2018-05-11 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, the ecology and evolution of infectious diseases has been studied extensively and new approaches to the study of host-pathogen interactions continue to emerge. At the same time, pathogen control in low-income countries has tended to remain largely informed by classical epidemiology, where the objective is to treat as many people as possible, despite recent research suggesting new opportunities for improved disease control in the context of limited economic resources. The need to integrate the scientific developments in the ecology and evolution of infectious diseases with public health strategy in low-income countries is now more important than ever. This novel text uniquely incorporates the latest research in ecology and evolutionary biology into the discussion of public health issues in low-income countries. It brings together an international team of experts from both universities and health NGOs to provide an up-to-date, authoritative, and challenging review of the ecology and evolution of infectious diseases, focusing on low-income countries for effective public health applications and outcomes. It discusses a range of public health threats including malaria, TB, HIV, measles, Ebola, tuberculosis, influenza and meningitis among others.
Download or read book Ecological and Evolutionary Perspectives on Infections and Morbidity written by Azeez, P.A. and published by IGI Global. This book was released on 2023-09-25 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: The management of infectious diseases demands a deeper understanding of the ecological and socio-economic drivers and needs a holistic and systematic system-thinking approach. Issues such as the ecological and social features of the source of the disease-causing organisms, the landscape, and how such organisms invade larger distribution ranges need to be sufficiently understood. The remedial measures must be handled from the perspectives of ecology, evolution, epidemiology, socioeconomics, forestry practices, and agriculture from the viewpoint of systems thinking and complex interactions. It is a paradigm shift from the current reductionist disease management. Ecological and Evolutionary Perspectives on Infections and Morbidity addresses human diseases from a holistic perspective by looking at morbidity from an ecological viewpoint and highlights the need for a wider perspective in healthcare that focuses on more than managing diseases and relieving the individual patients from suffering. Covering a range of topics such as antiviral research and human health, this reference work is ideal for healthcare professionals, academicians, policymakers, practitioners, scholars, researchers, instructors, and students.
Download or read book Evolutionary Mechanisms of Infectious Diseases written by Yufeng Wang and published by Frontiers Media SA. This book was released on 2021-07-08 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Microbial Evolution and Co Adaptation written by Institute of Medicine and published by National Academies Press. This book was released on 2009-05-10 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dr. Joshua Lederberg - scientist, Nobel laureate, visionary thinker, and friend of the Forum on Microbial Threats - died on February 2, 2008. It was in his honor that the Institute of Medicine's Forum on Microbial Threats convened a public workshop on May 20-21, 2008, to examine Dr. Lederberg's scientific and policy contributions to the marketplace of ideas in the life sciences, medicine, and public policy. The resulting workshop summary, Microbial Evolution and Co-Adaptation, demonstrates the extent to which conceptual and technological developments have, within a few short years, advanced our collective understanding of the microbiome, microbial genetics, microbial communities, and microbe-host-environment interactions.
Download or read book Genetics and Evolution of Infectious Diseases written by Michel Tibayrenc and published by Elsevier. This book was released on 2010-12-17 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetics and Evolution of Infectious Diseases is at the crossroads between two major scientific fields of the 21st century: evolutionary biology and infectious diseases. The genomic revolution has upset modern biology and has revolutionized our approach to ancient disciplines such as evolutionary studies. In particular, this revolution is profoundly changing our view on genetically driven human phenotypic diversity, and this is especially true in disease genetic susceptibility. Infectious diseases are indisputably the major challenge of medicine. When looking globally, they are the number one killer of humans and therefore the main selective pressure exerted on our species. Even in industrial countries, infectious diseases are now far less under control than 20 years ago. The first part of this book covers the main features and applications of modern technologies in the study of infectious diseases. The second part provides detailed information on a number of the key infectious diseases such as malaria, SARS, avian flu, HIV, tuberculosis, nosocomial infections and a few other pathogens that will be taken as examples to illustrate the power of modern technologies and the value of evolutionary approaches. Takes an integrated approach to infectious diseases Includes contributions from leading authorities Provides the latest developments in the field
Download or read book Indicators for Waterborne Pathogens written by National Research Council and published by National Academies Press. This book was released on 2004-06-19 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent and forecasted advances in microbiology, molecular biology, and analytical chemistry have made it timely to reassess the current paradigm of relying predominantly or exclusively on traditional bacterial indicators for all types of waterborne pathogens. Nonetheless, indicator approaches will still be required for the foreseeable future because it is not practical or feasible to monitor for the complete spectrum of microorganisms that may occur in water, and many known pathogens are difficult to detect directly and reliably in water samples. This comprehensive report recommends the development and use of a "tool box" approach by the U.S Environmental Protection Agency and others for assessing microbial water quality in which available indicator organisms (and/or pathogens in some cases) and detection method(s) are matched to the requirements of a particular application. The report further recommends the use of a phased, three-level monitoring framework to support the selection of indicators and indicator approaches.Â
Download or read book Evolutionary Mechanisms of Viral Cross species Transmission and Emergence written by Ian Eugene Huber Voorhees and published by . This book was released on 2020 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: For all viruses, replicative success is a balancing act. As obligate intracellular parasites, viruses must overcome or evade a gauntlet of host barriers and defenses while simultaneously maintaining many other required interactions. In instances of cross-species transmission, this balance is often disrupted as a foreign virus encounters a new suite of host-specific selective challenges and must reach a new equilibrium within the context of the biology and ecology of the recipient host species. Thus, the ultimate outcome of viral cross-species transmissions is determined by differential selective pressures and evolutionary changes. Understanding the evolutionary mechanisms that underlie viral transmission to and sustained circulation in a new host species is therefore critical for efforts towards managing ongoing viral epidemics and minimizing the threat of future emergence events. While much of scientific literature in this area focuses on viruses that have already caused significant epidemics or pandemics in humans, viral host-range shifts also occur in other animals. These events can provide tractable and informative models that reveal the critical underlying processes. In addition to their relevancy as companion animals, dogs serve as particularly useful host model systems for studying the drivers of viral emergence as they display many biological and ecological factors that are relevant to emerging infectious diseases in humans. Over the last half century, three viruses from two different families have emerged in dogs as a result of cross-species transmission events: two distinct canine influenza virus (CIV) subtypes - H3N8 and H3N2, and canine parvovirus (CPV). Using these viruses as case studies, this thesis explores the critical steps that occur in viral host-range shifts across multiple biological scales by utilizing new advances in viral full-genome sequencing and preforming sequence analyses informed by detailed epidemiological modeling and viral protein structural information. Among the CIVs, I find that contact heterogeneity within the United States dog population is likely a major barrier preventing sustained circulation. This barrier has proven to be insurmountable for the H3N8 CIV, which has now gone extinct. The circulation of H3N2 CIV appears to be similarly affected; however, my work reveals that multiple re-introductions of virus from Asia have driven repeated epidemic waves within the United States, suggesting that dog populations in Asia serve as a reservoir for this virus. In contrast, CPV is not as limited by host contact heterogeneity, likely due to its broad host range and ability to remain infectious for long periods of time in the environment, both features which increase the probability of exposure to new susceptible animals. However, there appear to be genetic constraints on the small ssDNA CPV genome since after 40 years of sustained pandemic circulation in dogs, I found very low levels of diversity at the intrahost and epidemiological scales. Interestingly, these genetic constraints may be overcome by structural flexibility in the CPV capsid and its interactions with the transferrin receptors from different host species, suggesting an alternative evolutionary strategy for overcoming host-specific barriers to infection. The results of this dissertation provide new information that is immediately relevant to significant ongoing epidemics of viral diseases in dogs and may inform vaccine development and biosecurity or outbreak management practices. In a more general sense, the results also provide a framework for better understanding the critical barriers associated with viral host-range shifts and how different viruses may overcome such barriers.
Download or read book Wildlife and Emerging Zoonotic Diseases The Biology Circumstances and Consequences of Cross Species Transmission written by James E. Childs and published by Springer. This book was released on 2007-08-13 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume offers an overview of the processes of zoonotic viral emergence, the intricacies of host/virus interactions, and the role of biological transitions and modifying factors. The themes introduced here are amplified and explored in detail by the contributing authors, who explore the mechanisms and unique circumstances by which evolution, biology, history, and current context have contrived to drive the emergence of different zoonotic agents by a series of related events.
Download or read book Under the Weather written by National Research Council and published by National Academies Press. This book was released on 2001-06-29 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the dawn of medical science, people have recognized connections between a change in the weather and the appearance of epidemic disease. With today's technology, some hope that it will be possible to build models for predicting the emergence and spread of many infectious diseases based on climate and weather forecasts. However, separating the effects of climate from other effects presents a tremendous scientific challenge. Can we use climate and weather forecasts to predict infectious disease outbreaks? Can the field of public health advance from "surveillance and response" to "prediction and prevention?" And perhaps the most important question of all: Can we predict how global warming will affect the emergence and transmission of infectious disease agents around the world? Under the Weather evaluates our current understanding of the linkages among climate, ecosystems, and infectious disease; it then goes a step further and outlines the research needed to improve our understanding of these linkages. The book also examines the potential for using climate forecasts and ecological observations to help predict infectious disease outbreaks, identifies the necessary components for an epidemic early warning system, and reviews lessons learned from the use of climate forecasts in other realms of human activity.
Download or read book Infectious Diseases of Humans written by Roy M. Anderson and published by Oxford University Press. This book was released on 1991 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book deals with infectious diseases -- viral, bacterial, protozoan and helminth -- in terms of the dynamics of their interaction with host populations. The book combines mathematical models with extensive use of epidemiological and other data. This analytic framework is highly useful for the evaluation of public health strategies aimed at controlling or eradicating particular infections. Such a framework is increasingly important in light of the widespread concern for primary health care programs aimed at such diseases as measles, malaria, river blindness, sleeping sickness, and schistosomiasis, and the advent of AIDS/HIV and other emerging viruses. Throughout the book, the mathematics is used as a tool for thinking clearly about fundamental and applied problems having to do with infectious diseases. The book is divided into two parts, one dealing with microparasites (viruses, bacteria and protozoans) and the other with macroparasites (helminths and parasitic arthropods). Each part begins with simple models, developed in a biologically intuitive way, and then goes on to develop more complicated and realistic models as tools for public health planning. The book synthesizes previous work in this rapidly growing field (much of which is scattered between the ecological and the medical literature) with a good deal of new material.
Download or read book Immunology and Evolution of Infectious Disease written by Steven A. Frank and published by Princeton University Press. This book was released on 2002-07-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Publisher Description
Download or read book The Social Ecology of Infectious Diseases written by Kenneth H. Mayer and published by Elsevier. This book was released on 2011-04-28 with total page 523 pages. Available in PDF, EPUB and Kindle. Book excerpt: Social Ecology of Infectious Diseases explores how human activities enable microbes to disseminate and evolve, thereby creating favorable conditions for the diverse manifestations of communicable diseases. Today, infectious and parasitic diseases cause about one-third of deaths and are the second leading cause of morbidity and mortality. The speed that changes in human behavior can produce epidemics is well illustrated by AIDS, but this is only one of numerous microbial threats whose severity and spread are determined by human behaviors. In this book, forty experts in the fields of infectious diseases, the life sciences and public health explore how demography, geography, migration, travel, environmental change, natural disaster, sexual behavior, drug use, food production and distribution, medical technology, training and preparedness, as well as governance, human conflict and social dislocation influence current and likely future epidemics. Provides essential understanding of current and future epidemics Presents a crossover perspective for disciplines in the medical and social sciences and public policy, including public health, infectious diseases, population science, epidemiology, microbiology, food safety, defense preparedness and humanitarian relief Creates a new perspective on ecology based on the interaction of microbes and human activities
Download or read book Oxford Bibliographies written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Infectious Disease Ecology written by Richard S. Ostfeld and published by Princeton University Press. This book was released on 2010-12-16 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: News headlines are forever reporting diseases that take huge tolls on humans, wildlife, domestic animals, and both cultivated and native plants worldwide. These diseases can also completely transform the ecosystems that feed us and provide us with other critical benefits, from flood control to water purification. And yet diseases sometimes serve to maintain the structure and function of the ecosystems on which humans depend. Gathering thirteen essays by forty leading experts who convened at the Cary Conference at the Institute of Ecosystem Studies in 2005, this book develops an integrated framework for understanding where these diseases come from, what ecological factors influence their impacts, and how they in turn influence ecosystem dynamics. It marks the first comprehensive and in-depth exploration of the rich and complex linkages between ecology and disease, and provides conceptual underpinnings to understand and ameliorate epidemics. It also sheds light on the roles that diseases play in ecosystems, bringing vital new insights to landscape management issues in particular. While the ecological context is a key piece of the puzzle, effective control and understanding of diseases requires the interaction of professionals in medicine, epidemiology, veterinary medicine, forestry, agriculture, and ecology. The essential resource on the subject, Infectious Disease Ecology seeks to bridge these fields with an ecological approach that focuses on systems thinking and complex interactions.
Download or read book The Evolution and Emergence of RNA Viruses written by Edward C. Holmes and published by Oxford University Press. This book was released on 2009-06-25 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the study of viral evolution has developed rapidly in the last 30 years, little attention has been directed toward linking the mechanisms of viral evolution to the epidemiological outcomes of these processes. This book intends to fill this gap by considering the patterns and processes of viral evolution at all its spatial and temporal scales.
Download or read book Infectious Disease Ecology of Wild Birds written by Jennifer C. Owen and published by Oxford University Press. This book was released on 2021-06-30 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Birds are the most diverse group of land vertebrates and have evolved to exploit almost every terrestrial niche on earth. They also serve as a natural reservoir for an array of different pathogens that pose serious health risks to human and domestic animal populations, including West Nile virus, highly pathogenic avian influenza viruses, Newcastle Disease virus, and numerous enteric pathogens. Avian diseases are also critically important to the conservation of endemic bird species in many places around the world. This accessible textbook focuses on the dynamics of infectious diseases for wild avian hosts across every level of ecological hierarchy, from the way pathogens interact with the physiology and behavior of individual hosts, the evolutionary and ecological dynamics of the host-parasite interactions occurring within populations, up to the complex biotic and abiotic interactions occurring within biological communities and ecosystems. Parasite-bird interactions are also increasingly occurring in rapidly changing global environments - thus, their ecology is also changing - and this shapes the complex ways by which parasites influence the inter-connected health of birds, humans, and shared ecosystems. Given the key role of birds in ecological communities more broadly, and as the primary host to so many zoonotic pathogens, an understanding of the ecological and evolutionary principles underlying the maintenance, amplification, transmission, and dispersal of these infectious agents is crucial to understanding how to mitigate the negative global impacts of the ever-increasing number of emerging infectious diseases. Although the topics and principles discussed in this book relate to birds, they have a far wider relevance and can also be applied to non-avian, wildlife host-pathogen systems. The COVID-19 pandemic has shown that understanding of disease ecology in wild animal populations is paramount to global health. Infectious Disease Ecology of Wild Birds is suitable for both senior undergraduate and graduate students taking courses in avian disease ecology, ecoimmunology, ecology, and conservation. It will also appeal to the many professional parasitologists, ecoimmunologists, ornithologists, behavioural ecologists, conservation biologists, and wildlife biologists requiring a concise overview of the topic.
