Download or read book ECCENTRIC CONTRACTION INDUCED written by Wai Ella Yeung and published by Open Dissertation Press. This book was released on 2017-01-27 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Eccentric Contraction-induced Injury in Mammalian Skeletal Muscle" by Wai, Ella, Yeung, 楊慧, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled "Eccentric contraction-induced injury in mammalian skeletal muscle " submitted by Ella Wai YEUNG for the degree of Doctor of Philosophy at the University of Hong Kong in February, 2003 Eccentric contractions, in which muscles are lengthened during contraction, may injure skeletal muscle but the mechanism(s) for this remain uncertain. The hypothesis tested is that alterations in intracellular concentrations + + of ions such as Na or H may underlie some of the functional impairment. The initial phase of eccentric contraction-induced injury was investigated: the influence of eccentric contraction on developed force, intracellular pH, Na homeostasis and T-tubule morphology was examined; the roles of these changes in the development of muscle damage are discussed. Single fibres from the flexor brevis muscle of mice or small bundles of fibres from the soleus or extensor digitorum longus muscle of rats were dissected. Muscles underwent either 10 isometric tetani (controls) or 10 eccentric tetani, during which a 30 or 40 % stretch of the optimal length (L ) was applied. Eccentrically-contracted muscles showed 3 characteristic features of stretch- induced damage: (i) reduced maximal force, (ii) greater reduction of force at low stimulation frequencies, (iii) shift in L to a longer muscle length. Ten isometric o tetani or stretches of resting fibres reproduced none of these features. Intracellular pH ( pH ) was determined in rat soleus muscle with the fluorescent indicator BCECF. The resting pH was more acidic after eccentric contractions (6.80 0.06) than after isometric contractions (6.97 0.04). The rate of pH recovery following an acid load was reduced from 0.022 + 0.003 units i -1 -1 min following isometric contractions to 0.013 + 0.002 units min following eccentric contractions. The results suggested that the ability of the muscle to regulate pH was impaired after eccentric contractions, which may partially explain the reduction in force. T-tubule morphology and function were studied in single mouse muscle fibres with confocal microscopy. Following eccentric contractions, vacuoles connected to the T-tubules appeared, and the diffusion of an extracellular marker (sulforhodamine B) from the T-tubules was slowed to a half time 6.3 2.4 min, compared to 18 1 s in isometric controls. [Na ] measurements were performed with the fluorescent indicator SBFI or sodium green. Isometric tetani had no detectable effect on [Na ] (7.2 0.5 mM), whereas eccentric contraction increased [Na ] to 16.3 1.6 mM. Confocal i images showed a uniform increase in [Na ] after eccentric tetani with no localized elevations of [Na ]. Gadolinium, a blocker of stretch-sensitive channels prevented the rise of [Na ] and reduced the force deficit after eccentric damage. The slow extrusion of intracellular protons following eccentric contractions may be explained by the rise in [Na ] which would be expected to + + reduce the inward Na gradient and hence slow proton efflux. The Na may enter by very small and widely distributed membrane tears, or alternatively through stretch-sensitive channels which remain open for many minutes after eccentric contractions. The vacuoles may result from osmotic stresses involved in pumping out the excess Na . Th

Download or read book Eccentric Contraction induced Injury in Mammalian Skeletal Muscle written by Wai Yeung (Ella) and published by . This book was released on 2003 with total page 438 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Eccentric Contraction induced Skeletal Muscle Injury and Its Consequences for the Sarcolemma and the Associated Cytoskeleton written by Richard Michael Lovering and published by . This book was released on 2003 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Eccentric Contraction induced Injury in Skeletal Muscle written by Tina Jitendra Patel and published by . This book was released on 1998 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Fatigue written by Patricia A. Pierce and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes the current state of our knowledge on the neurobiology of muscle fatigue, with consideration also given to selected integrative cardiorespiratory mechanisms. Our charge to the authors of the various chapters was twofold: to provide a systematic review of the topic that could serve as a balanced reference text for practicing health-care professionals, teaching faculty, and pre-and postdoctoral trainees in the biomedi cal sciences; and to stimulate further experimental and theoretical work on neurobiology. Key issues are addressed in nine interrelated areas: fatigue of single muscle fibers, fatigue at the neuromuscular junction, fatigue of single motor units, metabolic fatigue studied with nuclear magnetic resonance, fatigue of the segmental motor system, fatigue involving suprasegmental mechanisms, the task dependency of fatigue mechanisms, integrative (largely cardiorespiratory) systems issues, and fatigue of adapted systems (due to aging, under-and overuse, and pathophysiology). The product is a volume that provides compre of processes that operate from the forebrain to the contractile proteins.

Download or read book Importance of Satellite Cells in Recovery from Eccentric Contraction induced Muscle Injury written by Christopher Ronald Rathbone and published by . This book was released on 2003 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Effects of Eccentric Contraction Induced Muscle Damage on Stretch shortening Cycle Function and Lower Limb Stiffness written by Gaffney (Simon David.) and published by . This book was released on 2001 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Contraction induced Injury written by Kam D. Hunter and published by . This book was released on 1997 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Effects of Anabolic Steroids on Eccentric Contraction Induced Muscle Damage written by Jason Lamar Rolling and published by . This book was released on 1996 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Quantification of Oscillatory Force Parameters that Affect Eccentric Contraction Induced Injury in an in Vivo Rodent written by and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Muscle Regeneration written by Alexander Mauro and published by Raven Press (ID). This book was released on 1979 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Relative Contributions of Neural and Muscular Mechanisms to the Repeated Bout Effect Associated with Eccentric Contraction induced Injury written by Rijuta Ashok Dhere and published by . This book was released on 2003 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Effect of a Calcium Channel Blocker on Eccentric Contraction induced Muscle Damage written by Louise J. Beaton and published by . This book was released on 2001 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Advances in Structural Biology written by S.K. Malhotra and published by Elsevier. This book was released on 1996-06-21 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present volume continues the trend established in previous volumes in this series on Advances in Structural Biology. As in the past, diverse topics of current importance relevant to the theme of the series are included in the fourth volume.

Download or read book Whole body Electromyostimulation A Training Technology to Improve Health and Performance in Humans written by Wolfgang Kemmler and published by Frontiers Media SA. This book was released on 2020-07-08 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Protein Degradation and Synthesis in Skeletal Muscle Following Eccentric Contraction induced Injury written by Dawn Annette Lowe and published by . This book was released on 1994 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Muscle Cell and Tissue written by Kunihiro Sakuma and published by BoD – Books on Demand. This book was released on 2018-10-10 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: In order to complete tissue regeneration, various cells (neuronal, skeletal and smooth) interact coordinately with each other. This book, Muscle Cell and Tissue - Current Status of Research Field, deals with current progress and perspectives in a variety of topics on the skeletal and smooth muscle, stem cells, regeneration, disease or therapeutics. Novel applications for cell and tissue engineering including cell therapy, tissue models and disease pathology modeling are introduced. This book also deals with the differentiation/de-differentiation process of vascular smooth muscle cells in health and disease. Furthermore, natural products to reverse metabolic syndromes are descriptively reviewed. These chapters can be interesting for graduate students, teachers, physicians, executives and researchers in the field of molecular biology and regenerative medicine.