Download or read book Early Markers in Parkinson s and Alzheimer s Diseases written by Philippe Dostert and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of Early Markers in Parkinson's and Alzheimer's Diseases is to provide the reader with updated data on various approaches whose investigation and development could contribute to the discovery of early diag- nostic markers of these two degenerative diseases. Concerning Parkinson's disease, some of the topics dealt with in the book will help update the information previously reported in Early Diagnosis and Preventive Therapy in Parkinson's Disease. Concerning Alzheimer's disease, the scope and limitations of electrophysiological and brain imaging techniques with regards to early detection of the disease are documented. Various biochemical parameters, such as brain energy metabolism, levels of choline, and platelet monoamine oxidase activity are envisaged as some of the starting points for the discovery of early diagnostic markers of Alzheimer's disease.
Download or read book Early Markers in Parkinson s and Alzheimer s Diseases written by P. Dostert and published by Springer. This book was released on 1990 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of Early Markers in Parkinson's and Alzheimer's Diseases is to provide the reader with updated data on various approaches whose investigation and development could contribute to the discovery of early diag- nostic markers of these two degenerative diseases. Concerning Parkinson's disease, some of the topics dealt with in the book will help update the information previously reported in Early Diagnosis and Preventive Therapy in Parkinson's Disease. Concerning Alzheimer's disease, the scope and limitations of electrophysiological and brain imaging techniques with regards to early detection of the disease are documented. Various biochemical parameters, such as brain energy metabolism, levels of choline, and platelet monoamine oxidase activity are envisaged as some of the starting points for the discovery of early diagnostic markers of Alzheimer's disease.
Download or read book Etiology of Parkinson s Disease written by Jonas H. Ellenberg and published by CRC Press. This book was released on 1995-03-01 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive reference provides a detailed overview of current concepts regarding the cause of Parkinson's disease-emphasizing the issues involved in the design, implementation, and analysis of epidemiological studies of parkinsonism.
Download or read book Early Diagnosis of Alzheimer s Disease written by Leonard F. M. Scinto and published by Springer Science & Business Media. This book was released on 2000-02-09 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drs. Leonard Scinto and Kirk Daffner provide a comprehensive survey of new diagnostic approaches to Alzheimer's disease. The authoritative contributors critically survey the most promising current research on early diagnostic markers for Alzheimer's disease, including the elucidation of changes in the brain revealed by structural and functional neuroimaging, as well as the characteristic patterns of cognitive decline that are documented by sensitive neuropsychological tests, various genetic markers, and biological assays. Early Diagnosis of Alzheimer's Disease illuminates the complex issues surrounding the search for early markers of this increasingly widespread disease. It will establish a new standard reference guide for all those working with Alzheimer's patients.
Download or read book Early Detection of Neurodegenerative Disorders Using Behavioral Markers and New Technologies New Methods and Perspectives written by Erika Rovini and published by Frontiers Media SA. This book was released on 2023-03-30 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Smell and Taste Disorders written by Christopher H. Hawkes and published by Cambridge University Press. This book was released on 2018-01-25 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a comprehensive and unique text that details the latest research on smell and taste disorders for use by clinicians and scientists.
Download or read book Biomarkers of Alzheimer s Disease The Present and the Future written by Sylvain Lehmann and published by Frontiers Media SA. This book was released on 2016-11-10 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alzheimer disease (AD) is a neurodegenerative disorder characterized by significant cognitive deficits, behavioral changes, sleep disorders and loss of functional autonomy. AD represents the main cause of dementia and has become a major public health issue. In addition, the number of patients suffering from AD is growing rapidly as the population ages worldwide. Memory impairment is usually the earliest clinical and core symptom of this disease. The diagnosis at a late clinical stage is relatively easy. However, a delay in the diagnosis is damageable for the handling of patients in terms of optimal medical and social care. The actual interest of the scientific head-ways is to optimize the diagnosis in prodromal stage of the disease and to propose personalized therapeutic solutions to individual patients. New revised AD diagnostic criteria include early alteration of cerebrospinal fluid (CSF) biomarkers: decrease of amyloïd peptides (Aβ42), and increase in tau and phosphorylated-tau (p-tau) protein concentration. This recognition of CSF biological biomarkers for the diagnosis of AD is a major step towards the “molecular” diagnosis and follow-up of the disease. Many issues are however still subject of debate. This e-book provides a comprehensive overview of the state of the art of fluid biomarkers for AD, e.g. which novel biomarkers should be implemented in clinical practice for diagnosis or for monitoring treatment or side effects, which ones are new for AD or related dementias or what is the potential of peripheral blood markers. Moreover, the e-Book provides practical guidelines how to optimally and efficiently develop and validate novel biomarker assays, and to document and control pre-analytical variation.
Download or read book Behold the Eye in Parkinson s Disease Alzheimer s Disease written by Ivan Bodis-Wollner and published by Frontiers Media SA. This book was released on 2020-01-20 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are increasing lines of evidence showing that neurodegeneration in Alzheimer’s disease (AD) and Parkinson’s disease (PD) is not limited to the brain but also occurs in the retina. Consequently, AD/PD patients can gradually develop vision problems. This neurological and ophthalmological disorder creates a pressing need for developing therapy to treat vision impairment in AD/PD. On the other hand, pathophysiological changes in the retina may reflect what might happen in the same diseases in the brain. Thus retinal studies may allow us to develop quantifiable measures for the diagnosis and prognosis of disease progression. Furthermore, parallel or early pathophysiological changes of the retina in AD/PD allow us to study retina-brain interactions.
Download or read book Immunotherapy and Biomarkers in Neurodegenerative Disorders written by Lars Lannfelt and published by . This book was released on 2016 with total page 289 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pathology Prevention and Therapeutics of Neurodegenerative Disease written by Sarika Singh and published by Springer. This book was released on 2018-09-24 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, written by a leading panel of experts in the field of neurosciences, provides a comprehensive overview of the pathology of neurodegenerative diseases as well as the preventive measures. Prevention is important due to the lack of early diagnostic markers and the limitations/ problems of treating neurodegenerative diseases
Download or read book Molecular Diagnostics in the Detection of Neurodegenerative Disorders written by Megha Agrawal and published by Frontiers Media SA. This book was released on 2017-07-04 with total page 92 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurodegeneration is characterized by the progressive loss of neural tissue that result in various neurodegeneration-initiated cerebral failures and complex diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease. All these medical conditions are accompanied by the disruption of blood-brain barrier (BBB). The BBB is an interface, separating the brain from the circulatory system and protecting the central nervous system from potentially harmful chemicals while regulating transport of essential molecules and maintaining a stable environment. Owing to the inability of the neurons to regenerate on their own after neurodegeneration or severe damage to the neural tissue, neurodegenerative disorders do not have natural cures on their own. Neuroregeneration is a viable way to curb neurodegeneration. One of the current approaches is stem cell-based therapy that has been shown to be potentially helpful for the application of neuronal cell replacement for neuroregeneration. It is vital that the neurodegenerative disorder being detected at an early stage as it can provide a chance for treatment that may be helpful to prevent further progression of the fatal disease. Thus, research has focused on developing effective non-invasive diagnostic methods for early detection of these disorders. Molecular diagnostics can provide a powerful method to detect and diagnose various neurological disorders. Such diagnosis can enhance early detection, provide subsequent medical counsel based on medical pathway, as well as to gain better insight of neurogenesis and hopefully eventual cure of the neurodegenerative diseases. With research reports, reviews, mini-reviews and commentary, this research topic covers a wide range of areas in neurodegeneration research, including diagnosis and prognosis; regulating central nervous system; biomarkers and brain injury induced neurobehavioral outcomes among other timely reports on neurodegeneration.
Download or read book Neurodegenerative Diseases Integrative PPPM Approach as the Medicine of the Future written by Silvia Mandel and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will compile a collection of chapters dedicated to varied aspects of PPPM in neuropsychiatric and neurodegenerative diseases. Among the topics to be covered are: Recent advances in ALS research News about Clinical aspects and advanced therapy approaches in personalized treatment of ALS Schizophrenia: New treatments and clinical aspects Predictive, Preventive and Personalised Medicine in aging macular degeneration Advances in Multiple Sclerosis Pharmacogenetics, Tailoring Treatment Efficacy, Safety and Regimen Selection Multiple sclerosis related biomarkers: perspectives for clinical application Preventive clinical trials in brain aging: new trends & the need of guidelines MCI_ clinical guidelines in early diagnosis of dementia Alzheimer's disease: diagnostics, prognostics and the road to prevention Biomarkers for early diagnosis of Parkinson's and Alzheimer's diseases Synucleinopathies, tauopathies, TDP-43 proteinopathies and amyloidosis PSP, MSA and other parkinsonisms
Download or read book Predicting Onset Progression And Clinical Subtypes Of Alzheimer s And Parkinson s Disease From Genomic And Longitudinal Clinical Data written by Faraz Faghri and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Background Parkinsonu2019s disease and Alzheimeru2019s Disease and Related Dementia (ADRD) are categories of aging disorders with complex and heterogeneous symptomatology. The clinical manifestations of these neurological disorders are characterized by heterogeneity in age at onset, disease duration, rate of progression, and constellation of cognitive, motor, and non-motor features. Due to these variable presentations, counseling of patients about their individual risks and prognosis is limited. There is an unmet need for predictive tests that facilitate early detection and characterization of distinct disease subtypes as well as improved, individualized predictions of the disease course. The emergence of machine learning to detect hidden patterns in complex, multi-dimensional datasets provides unparalleled opportunities to address this critical need. We have developed predictive models for Alzheimeru2019s and Parkinsonu2019s related disorders. Our efforts have focused on: (1) developing predictive models and identification of biomarkers which are multi-modal (clinical, biological, genetic, and imaging data), and (2) relying on unsupervised machine learning techniques to identify disease subtypes that are multidimensional. Methods and findings We used unsupervised and supervised machine learning approaches for subtype identification and prediction. We used machine learning methods on comprehensive, longitudinal clinical data from the Parkinson Disease Progression Marker Initiative (PPMI) (n=328 cases) and Alzheimer's Disease Neuroimaging Initiative (ADNI) (n= 248) to identify patient subtypes and to predict disease progression. The resulting models were validated in an independent, clinically well-characterized cohort from the Parkinson Disease Biomarker Program (PDBP) (n=112 cases). Our analysis distinguished three distinct disease subtypes with highly predictable progression rates, corresponding to slow, moderate and fast disease progressors, after 24, 48, and 72 months from baseline. We achieved highly accurate projections of disease progression four years after initial diagnosis with an average Area Under the Curve of 0.93 (95% CI: 0.96 u00b1 0.01 for PDvec1, 0.87 u00b1 0.03 for PDvec2, and 0.96 u00b1 0.02 for PDvec3). We have demonstrated robust replication of these findings in the independent validation cohort.Conclusion These data-driven results enable clinicians to deconstruct the heterogeneity within their patient cohorts. This knowledge could have immediate implications for clinical trials by improving the detection of significant clinical outcomes that might have been masked by cohort heterogeneity. We anticipate that machine learning models will improve patient counseling, clinical trial design, allocation of healthcare resources and ultimately individualized clinical care.
Download or read book Clinical use of biomarkers for neurodegenerative disorders written by Manuel Menéndez-González and published by Frontiers Media SA. This book was released on 2014-12-03 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: The prevalence of neurodegenerative disorders is increasing dramatically and one of the major challenges today is the need of early and accurate diagnosis, the other is the need of more effective therapies -in turn the development of such therapies also requires early and accurate diagnosis-. The main hope for an earlier and more accurate diagnosis comes from the use of biomarkers. Much research is being done trying to solve the many interrogates related to the role of biomarkers in clinical practice, including the early diagnosis, differential diagnosis and follow-up of neurodegenerative disorders. This is a field where translational research is intense enough to make this topic interesting for basic researchers and clinicians. Indeed, the amount and quality of articles received in response to the call for contributions was very good. This eBook contains a good amount of high quality articles devoted to diverse techniques across several neurodegenerative disorders from different perspectives, including original reports, reviews, methods reports and opinion letters on biochemical biomarkers in biological fluids, neuroimaging techniques and multidimensional approaches linking clinical findings with biomarkers. The disorders covered are also diverse: Alzheimer’s disease, Frontotemporal Dementia, Dementia with Lewy Bodies, Huntington’s disease, Parkinson’s disease among others. As we can learn from articles in this Research Topic, biomarkers are allowing us to expand the knowledge on the biological and anatomical basis of neurodegenerative diseases and to implement diagnostic techniques in clinical practice and clinical trials.
Download or read book Progress in Alzheimer s and Parkinson s Diseases written by Abraham Fisher and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 846 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book represents the fourth ina series of international conferences related to Alzheimer's (AD) and Parkinson's (PO) diseases. The first one took place in EHat, Israel in 1985; the second in Kyoto, Japan, in 1989; and the third in Chicago, IL, USA in 1993. This book incorporates the proceedings of the Fourth International Conference on Pro gress in Alzheimer's and Parkinson's Diseases, held in EHat, Israel, on May 18-23, 1997. This Conference was the 41st in the series of annual OHOLO Conferences sponsored by the Israel Institute for Biological Research (IIBR). It was also conducted under the aus pices of the Alzheimer's Association Ronald and Nancy Reagan Research Institute, USA. The Conference was attended by 550 participants from 28 countries, representing a broad spectrum of research interests; and included a well-balanced representation from aca demia, clinical institutions and pharmaceutical industry. The four-and-one-half day meeting served as an excellent medium for surveying the current preclinical and clinical develop ments in AD, PO, and other related disorders. The scientific program was divided into 24 oral sessions and daily poster sessions. The conference culminated in a round table discus sion. There were 122 talks and 161 posters. This book incorporates a combination of both.
Download or read book Advances in Alzheimer s and Parkinson s Disease written by Abraham Fisher and published by Springer Science & Business Media. This book was released on 2007-12-26 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of the 2005 ADPD conference and is unique in that it deals not only with issues related individually to Alzheimer’s disease and Parkinson’s disease, but also with the integration of these and other related diseases. The most up-to-date techniques and research findings are illustrated in this volume, which covering topics from immunology, neuroscience, and pharmacology to genetics and molecular biology. Possible future developments in the treatment of Alzheimer’s and Parkinson’s Diseases are also covered.
Download or read book Alzheimer s Early Detection Workbook written by John Nunez and published by John Nunez. This book was released on 2024-04-21 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Alzheimer's: Early Detection Workbook" This book is the result of my reflections after witnessing beloved family members and friends gradually succumb to this terrible disease, which remains incurable despite significant scientific advances. However, as you will see in this book, it takes a special kind of resilience to confront this torment that not only ends the lives of those who suffer from it but also profoundly impacts those around them. Let this serve as a tribute to Walter and Emilia. The Author. The e-book "Final Alzheimer's: Early Detection Workbook" serves as a comprehensive guide focused on the early detection and management of Alzheimer's disease. It covers a wide range of topics including the basics of Alzheimer's pathology, the importance of early detection, stages of the disease, risk factors, symptoms, and preventive measures. Here's a breakdown of the main elements: 1. Understanding Alzheimer's Disease: - The book begins with a detailed overview of Alzheimer’s disease, describing its characteristics such as the buildup of amyloid plaques and tau tangles, and its progression from mild cognitive impairments to severe dementia. 2. Importance of Early Detection: - A significant emphasis is placed on the advantages of early detection which includes enhanced treatment effectiveness, better management of symptoms, and planning for future care. Early detection is also highlighted as beneficial for advancing research and reducing healthcare costs. 3. Symptoms and Signs: - The text details the symptoms of Alzheimer’s, which are categorized into early signs (like memory loss affecting daily activities and challenges in problem-solving) and progressive signs (such as severe memory loss and physical decline). 4. Preventive Measures and Management: - Lifestyle factors that might impact the risk of developing Alzheimer's are discussed, including diet, physical activity, cognitive stimulation, and environmental factors. The book also explores strategies to manage the disease through cognitive tests, medical imaging, and emerging therapies. 5. Cognitive Tests and Early Detection Tools: - The workbook outlines various cognitive tests used for early detection, stressing their importance in identifying the onset of cognitive issues which can lead to tailored treatment plans and better management of the disease. 6. Living with Alzheimer’s: - Practical advice is provided for caregivers and families on managing daily life with a person who has Alzheimer’s, focusing on creating a safe environment, handling behavioral changes, and providing emotional support. The workbook is structured to educate and empower readers—patients, families, and caregivers—with the knowledge to recognize early signs of Alzheimer's, understand its progression, and implement effective management strategies. It combines scientific information with practical guidance, making it a valuable resource for anyone involved in the care of individuals with Alzheimer’s disease.
