Download or read book Chirality from Dynamic Kinetic Resolution written by Hélène Pellissier and published by Royal Society of Chemistry. This book was released on 2011 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last 15 years have witnessed significant developments in the efficiency and scope of the application of DKR. These now offer a serious alternative to conventional methods for asymmetric synthesis. Indeed, impressive examples using new enzymes and major progress in the DKR of racemates have taken place over the past few years. The powerful combination of enzymes and metals has also been the subject of spectacular development. In addition, a new type of DKR, involving organocatalysts, has recently appeared. Although asymmetric catalysis has undergone development during the last two decades, the most common industrial process used to obtain enantiomerically pure compounds is still via resolution of racemic mixtures. This is despite the major disadvantage that only a maximum of 50% product yield can be obtained. It is not surprising that DKR, which solves the problem of the limitation in yield, has attracted an increasing amount of interest from both the industrial and the academic perspective. This book provides an up-date on the principle methods employed to obtain dynamic kinetic resolution (DKR) by either enzymatic or non-enzymatic methods. It also illustrates the diversity of useful chiral products that can be obtained through this powerful concept. Divided into three sections, the book deals successively with non-enzymatic methods, enzymatic methods, and the use of transition metals and enzymes in tandem.
Download or read book Separation of Enantiomers written by Matthew H. Todd and published by John Wiley & Sons. This book was released on 2014-07-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In one handy volume this handbook summarizes the most common synthetic methods for the separation of racemic mixtures, allowing an easy comparison of the different strategies described in the literature. Alongside classical methods, the authors also consider kinetic resolutions, dynamic kinetic resolutions, divergent reactions of a racemic mixture, and a number of "neglected" cases not covered elsewhere, such as the use of circularly polarized light, polymerizations, "ripening" processes, dynamic combinatorial chemistry, and several thermodynamic processes. The result is a thorough introduction to the field plus a long-needed, up-to-date overview of the chemical, biological, and physical methods and their applications. Newcomers to the field, students as well as experienced synthetic chemists will benefit from the highly didactic presentation: Every method is presented in detail, from relatively simple separation problems to advanced complex resolution methods.
Download or read book Future Directions in Biocatalysis written by Tomoko Matsuda and published by Elsevier. This book was released on 2017-08-11 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: Future Directions in Biocatalysis, Second Edition, presents the future direction and latest research on how to utilize enzymes, i.e., natural catalysts, to make medicines and other necessities for humans. It emphasizes the most important and unique research on biocatalysis instead of simply detailing the ABC’s on the topic. This book is an indispensable tool for new researchers in the field to help identify specific needs, start new projects that address current environmental concerns, and develop techniques based on green technology. It provides invaluable hints and clues for conducting new research on enzymes, with final sections outlining future directions in biocatalysis further expanding the science into new applications. Gives future directions in the area of biocatalysis research Presents research topics based on their uniqueness, originality, and novelty Includes many explanatory figures to demonstrate concepts to both organic chemists and biochemists Shows that there is no boundary between organic chemistry and biochemistry
Download or read book Hydrolases in Organic Synthesis written by Uwe Theo Bornscheuer and published by John Wiley & Sons. This book was released on 2006-05-12 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: From reviews to the first edtion: "Bornscheuer and Kazlauskas have set out, and succeeded, in producing a definitive manual on hydrolytic enzymes (especially lipases, esterases, and proteases) for organic chemists. This is quite simply the best book of its type and can be unreservedly recommended to organic chemists who have an interest in using hydrolytic enzymes in synthesis." (Nicholas J. Turner, University of Edinburgh) "The book is an indispensable source of information on the use of hydrolases in organic synthesis. The subject matter is very well set out, and the chapters are clearly written and presented from a critical viewpoint. Bornscheuer and Kazlauskas have succeeded admirably in describing the capabilities and limitations of the use of hydrolytic enzymes and in critically evaluating them. No library should be without the book." (Fritz Theil, WITEGA Angewandte Werkstoff-Forschung GmbH, Berlin) The second edition of this extremely successful and well-proven book presents recent developments in the use of hydrolases for organic synthesis, reflecting in particular the enormous progress made in enzyme discovery and optimization with a new chapter on "Protein Sources and Optimization of Biocatalyst Performance". The renowned authors survey the stereoselective reactions of hydrolases, especially lipases, esterases and proteases, giving researchers an overview of what has worked in the past so that they can judge how to solve their own synthetic problems. In total, the book contains over one thousand chemical structures, rounded off by some 1,800 invaluable references.
Download or read book Enantiomer Separation written by Fumio Toda and published by Springer Science & Business Media. This book was released on 2007-11-04 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: In spite of important advances in asymmetric synthesis, chiral compounds cannot all be obtained in a pure state by asymmetric synthesis. As a result, enantiomer separation remains an important technique for obtaining optically active materials. Although asymmetric synthesis is a once-only procedure, an enantiomer separation process can be repeated until the optically pure sample is obtained. This book discusses several new enantiomer separation methods using modern techniques developed by experts in the field. These methods consist mainly of the following three types: 1) Enantiomer separation by inclusion complexation with a chiral host compound 2) Enantiomer separation using biological methods 3) Enantiomer separation by HPLC chromatography using a column containing a chiral stationary phase. Separation of a racemic compound has been called “optical resolution” or simply “resolution”. Nowadays, the descriptions “enantiomer resolution” or “enantiomer separation” are also commonly used. Accordingly, “Enantiomer Separation” is used in the title of this book. The editor and all chapter contributors hope that this book is helpful for scientists and engineers working in this field.
Download or read book Fundamentals of Asymmetric Catalysis written by Patrick J. Walsh and published by University Science Books. This book was released on 2009-01-02 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work describes the essential aspects of enantioselective catalysis, with chapters organised by concept rather than by reaction type. Each concept is supported by examples to give the reader broad exposure to a wide range of catalysts, reactions and reaction mechanisms.
Download or read book Asymmetric Catalysis on Industrial Scale written by Hans Ulrich Blaser and published by John Wiley & Sons. This book was released on 2007-02-27 with total page 483 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by two of the experts in the field, the central aim is to show organic chemists working in process development that enantioselective catalysis is suitable for the large-scale production of enantioenriched intermediates. In so doing, it is equally a source of information and inspiration for academic research, and, with its contribution by Noble prizewinner W. S. Knowles, will also heighten the status of industrial catalyst specialists working in the exciting field of enantioselective catalysis. Some 25 contributions from top industrial researchers around the world present case studies on the development of the widest possible range of large-scale enantioselective processes, featuring stereoselective production processes of fine-chemicals, agrochemicals and pharmaceuticals. Clearly structured according to the nature of the task, this handbook adopts a problem-driven approach such that readers can easily find how colleagues have dealt with a similar situation.
Download or read book Dynamic Kinetic Resolution DKR and Dynamic Kinetic Asymmetric Transformations DYKAT written by Jan-E. Bäckvall and published by Georg Thieme Verlag. This book was released on 2022-12-07 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and applications of DKR and DYKAT DKR and DYKAT are of ever increasing importance in the synthesis of enantiomerically enriched compounds. The preparation of enantiomerically pure compounds is of great importance in society today, in particular in pharmaceutical chemistry and in the agrochemical sector. Kinetic resolution is a popular method for differentiating two enantiomers in a racemic mixture that react at different rates with a chiral catalyst or reagent. The drawback of kinetic resolution is that the yield of one pure enantiomer is limited to a maximum of 50%. To overcome this limitation, an in situ racemization of the starting material can be combined with a kinetic resolution. This combination leads to a so called “dynamic kinetic resolution” (DKR), where the two enantiomers are in equilibrium with one another. The slow-reacting enantiomer will continuously be converted into the fast-reacting one, when the latter is transformed into the enantiomerically pure product. Thus, a racemic starting material can be transformed in catalytic processes into a single isomer of a chiral compound in up to 100% yield. DKR only applies to the resolution of racemic mixtures and the involvement of enantiomers leads to simple kinetics. When diastereomers, either as starting materials or as diastereomeric intermediates, are involved in the resolution process under dynamic conditions (via equilibria between diastereomers), the kinetics is different from DKR. These reactions are classified as “dynamic kinetic asymmetric transformations” (DYKAT). This volume covers the principles of DKR and DYKAT and presents examples of organocatalytic, chemoenzymatic, and transition-metal catalyzed approaches, including applications in the synthesis of complex, biologically active compounds.
Download or read book Axially Chiral Compounds written by Bin Tan and published by John Wiley & Sons. This book was released on 2021-11-22 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Axially Chiral Compounds Explore this comprehensive and current volume summarizing the characteristics, synthesis, and applications of axial chirality Appearing widely in natural products, biologically active molecules, asymmetric chemistry, and material science, axially chiral motifs constitute the core backbones of the majority of chiral ligands and organocatalysts in asymmetric catalysis. In a new work of particular relevance to synthetic chemists, Axially Chiral Compounds: Asymmetric Synthesis and Applications delivers a clearly structured and authoritative volume covering the classification, characteristics, synthesis, and applications of axial chirality. A must read for every synthetic chemist practicing today, the book follows the development history, research status, and applications of axial chirality. An introductory chapter familiarizes the reader with foundational material before the distinguished authors describe the different classes and the synthesis of axial chiral compounds used in asymmetric synthesis. The book concludes with a focus on the applications of chiral ligands, chiral catalysts, and materials. Readers will also benefit from the inclusion of: A thorough introduction to asymmetric synthesis, including biaryls atropisomers, heterobiaryls atropisomers, and non-biaryls atropisomers Explorations of chiral allene, spiro skeletons, and natural products Practical discussions of asymmetric transformation, chiral ligands, and chiral catalysts An examination of miscellaneous applications of axially chiral compounds Perfect for organic chemists, chemists working with or on organometallics, catalytic chemists, and materials scientists, Axially Chiral Compounds: Asymmetric Synthesis and Applications will also earn a place in the libraries of natural products chemists who seek a one-stop reference for compounds exhibiting axial chirality.
Download or read book Dynamic Stereochemistry of Chiral Compounds written by Christian Wolf and published by Royal Society of Chemistry. This book was released on 2008 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive overview of fundamental concepts of asymmetric synthesis along with in-depth discussion. Recent developments that address important synthetic challenges are presented and highlighted with hundreds of examples.
Download or read book Chirality from Dynamic Kinetic Resolution written by Helene Pellissier and published by Royal Society of Chemistry. This book was released on 2011-04-04 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last 15 years have witnessed significant developments in the efficiency and scope of the application of DKR. These now offer a serious alternative to conventional methods for asymmetric synthesis. Indeed, impressive examples using new enzymes and major progress in the DKR of racemates have taken place over the past few years. The powerful combination of enzymes and metals has also been the subject of spectacular development. In addition, a new type of DKR, involving organocatalysts, has recently appeared. Although asymmetric catalysis has undergone development during the last two decades, the most common industrial process used to obtain enantiomerically pure compounds is still via resolution of racemic mixtures. This is despite the major disadvantage that only a maximum of 50% product yield can be obtained. It is not surprising that DKR, which solves the problem of the limitation in yield, has attracted an increasing amount of interest from both the industrial and the academic perspective. This book provides an up-date on the principle methods employed to obtain dynamic kinetic resolution (DKR) by either enzymatic or non-enzymatic methods. It also illustrates the diversity of useful chiral products that can be obtained through this powerful concept. Divided into three sections, the book deals successively with non-enzymatic methods, enzymatic methods, and the use of transition metals and enzymes in tandem.
Download or read book Kinetic Control in Synthesis and Self Assembly written by Munenori Numata and published by Academic Press. This book was released on 2018-11-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kinetic Control in Synthesis and Self-Assembly provides a unique overview of the fundamental principles, novel methods and practical applications for researchers across organic synthesis, supramolecular chemistry and materials sciences. The book examines naturally occurring molecular systems in which kinetic processes are more ubiquitous than thermodynamic processes, also exploring the control of reactions and molecular self-assemblies, through kinetic processes, in artificial systems. These methods currently play a crucial role for tuning materials functions. From organic synthesis, to supramolecular assemblies, and from restricted spaces, to material synthesis for hierarchical structures, the book offers valuable coverage for researchers across disciplines. Interesting topics include how to regulate kinetic pathways more precisely, essential molecular design for kinetic traps, and how molecular environments surrounding molecules (i.e., solvent, temperature, and pressure effects) influence kinetic control in reactions and self-assemblies.
Download or read book Practical Synthetic Organic Chemistry written by Stéphane Caron and published by John Wiley & Sons. This book was released on 2020-02-05 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a hands-on guide for the organic chemist. Focusing on the most reliable and useful reactions, the chapter authors provide the information necessary for a chemist to strategically plan a synthesis, as well as repeat the procedures in the laboratory. Consolidates all the key advances/concepts in one book, covering the most important reactions in organic chemistry, including substitutions, additions, eliminations, rearrangements, oxidations, reductions Highlights the most important reactions, addressing basic principles, advantages/disadvantages of the methodology, mechanism, and techniques for achieving laboratory success Features new content on recent advances in CH activation, photoredox and electrochemistry, continuous chemistry, and application of biocatalysis in synthesis Revamps chapters to include new and additional examples of chemistry that have been demonstrated at a practical scale
Download or read book Catalytic Asymmetric Synthesis written by Takahiko Akiyama and published by John Wiley & Sons. This book was released on 2022-05-27 with total page 798 pages. Available in PDF, EPUB and Kindle. Book excerpt: Catalytic Asymmetric Synthesis Seminal text presenting detailed accounts of the most important catalytic asymmetric reactions known today This book covers the preparation of enantiomerically pure or enriched chemical compounds by use of chiral catalyst molecules. While reviewing the most important catalytic methods for asymmetric organic synthesis, this book highlights the most important and recent developments in catalytic asymmetric synthesis. Edited by two well-qualified experts, sample topics covered in the work include: Metal catalysis, organocatalysis, photoredox catalysis, enzyme catalysis C–H bond functionalization reactions Carbon–carbon bond formation reactions, carbon–halogen bond formation reactions, hydrogenations, polymerizations, flow reactions Axially chiral compounds Retaining the best of its predecessors but now thoroughly up to date with the important and recent developments in catalytic asymmetric synthesis, the 4th edition of Catalytic Asymmetric Synthesis serves as an excellent desktop reference and text for researchers and students, from upper-level undergraduates all the way to experienced professionals in industry or academia.
Download or read book Dynamic Kinetic Resolution DKR and Dynamic Kinetic Asymmetric Transformations DYKAT written by K. Adriaensen and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Asymmetric Phase Transfer Catalysis written by Keiji Maruoka and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by the leading expert on the topic, this is the first book to present the latest developments in this exciting field. Alongside the theoretical aspects, the top contributors provide practical protocols to give readers additional important information otherwise unavailable. A must for every synthetic chemist in academia and industry.
Download or read book Organocatalytic Dynamic Kinetic Resolution written by Hélène Pellissier and published by Royal Society of Chemistry. This book was released on 2022-05-06 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: Collecting for the first time all the developments in the field of DKR, this book shows that a variety of organocatalysts allow excellent levels of stereocontrol and yields in many types of transformations.
