Download or read book Dynamic Clamp written by Alain Destexhe and published by Springer Science & Business Media. This book was released on 2009-03-11 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dynamic-clamp is a fascinating electrophysiology technique that consists of merging living neurons with computational models. The dynamic-clamp (also called “conductance injection”) allows experimentalists and theoreticians to challenge neurons (or any other type of cell) with complex conductance stimuli generated by a computer. The technique can be implemented from neural simulation environments and a variety of custom-made or commercial systems. The real-time interaction between the computer and cell also enables the design of recording paradigms with unprecedented accuracy via a computational model of the electrode. Dynamic-Clamp: From Principles to Applications contains contributions from leading researchers in the field, who investigate these paradigms at the cellular or network level, in vivo and in vitro, and in different brain regions and cardiac cells. Topics discussed include the addition of artificially-generated synaptic activity to neurons; adding, amplifying or neutralizing voltage-dependent conductances; creating hybrid networks with real and artificial cells; attaching simulated dendritic tree structures to the living cell; and connecting different neurons. This book will be of interest to experimental biophysicists, neurophysiologists, and cardiac physiologists, as well as theoreticians, engineers, and computational neuroscientists. Graduate and undergraduate students will also find up-to-date coverage of physiological problems and how they are investigated.
Download or read book Biohybrid Systems written by Ranu Jung and published by John Wiley & Sons. This book was released on 2011-11-30 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discipline of neurodesign is a highly interdisciplinary one, while at the same time in the process of maturing towards real-life applications. The breakthrough about to be achieved is to close the loop in communication between neural systems and electronic and mechatronic systems and actually let the nervous system adapt to the feedback from the man-made systems. To master this loop, scientists need a sound understanding of neurology, from the cellular to the systems scale, of man-made systems and how to connect the two. These scientists comprise medical scientists, neurologists and physiologists, engineers, as well as biophysicists. And they need the topics in a coherently written work with chapters building upon another.
Download or read book The Tools of Neuroscience Experiment written by John Bickle and published by Routledge. This book was released on 2021-12-31 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume establishes the conceptual foundation for sustained investigation into tool development in neuroscience. Neuroscience relies on diverse and sophisticated experimental tools, and its ultimate explanatory target—our brains and hence the organ driving our behaviors—catapults the investigation of these research tools into a philosophical spotlight. The chapters in this volume integrate the currently scattered work on tool development in neuroscience into the broader philosophy of science community. They also present an accessible compendium for neuroscientists interested in the broader theoretical dimensions of their experimental practices. The chapters are divided into five thematic sections. Section 1 discusses the development of revolutionary research tools across neuroscience’s history and argues to various conclusions concerning the relationship between new research tools and theory progress in neuroscience. Section 2 shows how a focus on research tools and their development in neuroscience transforms some traditional epistemological issues and questions about knowledge production in philosophy of science. Section 3 speaks to the most general questions about the way we characterize the nature of the portion of the world that this science addresses. Section 4 discusses hybrid research tools that integrate laboratory and computational methods in exciting new ways. Finally, Section 5 extends research on tool development to the related science of genetics. The Tools of Neuroscience Experiment will be of interest to philosophers and philosophically minded scientists working at the intersection of philosophy and neuroscience.
Download or read book Patch Clamp Methods and Protocols written by Peter Molnar and published by Springer Science & Business Media. This book was released on 2007 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patch Clamp Methods and Protocols surveys the typical patch clamp applications and advises scientists on identifying problems and selecting the best technique in each instance. The experiments described require a basic level of electrophysiological training and aid the researcher in pursuing new areas of electrophysiology and using the patch clamp technique effectively. Patch Clamp Methods and Protocols is divided into three sections that cover the major areas of patch clamp application: Pharmacology, Physiology, and Biophysics. The first section provides examples and step by step instructions on how to use whole-cell and single-channel patch clamp methods for testing drugs in industrial settings. The second section provides a wide selection of patch clamp applications in physiological studies. The last part focuses on the biophysical applications of the patch clamp method using single channel recordings or statistical analysis of whole-cell currents in order to obtain parameters that describe ion channel properties or transmitter release. Individual techniques are explored within the area that they are applied most often. Researchers will find Patch Clamp Methods and Protocols to be an invaluable aid in the design and execution of a wide variety of patch clamp experiments, both on their own and in conjunction with other state-of-the-art methodologies.
Download or read book Safety Pharmacology Risk Assessment QT Interval Prolongation and Beyond written by Esther Pueyo and published by Frontiers Media SA. This book was released on 2018-08-16 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of articles presenting new technological and conceptual advances, including refinement of ex vivo and in vitro assays, screens and models, and in silico approaches reflecting the increasing effort that has been put forward by regulatory agencies, industry, and academia to try and address the need of a more accurate, mechanistically-based paradigm of proarrhythmic potential of drugs. This Research Topic is dedicated to the memory of Dr. J. Jeremy Rice, our wonderful friend and colleague.
Download or read book Potassium Channels written by Simone Furini and published by Springer Nature. This book was released on with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Heart Rate and Rhythm written by Onkar N. Tripathi and published by Springer Science & Business Media. This book was released on 2011-05-02 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms. Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.
Download or read book Biomedical Engineering written by Carlos Mello and published by BoD – Books on Demand. This book was released on 2009-10-01 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Engineering can be seen as a mix of Medicine, Engineering and Science. In fact, this is a natural connection, as the most complicated engineering masterpiece is the human body. And it is exactly to help our “body machine” that Biomedical Engineering has its niche. This book brings the state-of-the-art of some of the most important current research related to Biomedical Engineering. I am very honored to be editing such a valuable book, which has contributions of a selected group of researchers describing the best of their work. Through its 36 chapters, the reader will have access to works related to ECG, image processing, sensors, artificial intelligence, and several other exciting fields.
Download or read book Methods and Models in Neurophysics written by and published by Elsevier. This book was released on 2004-12-11 with total page 863 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuroscience is an interdisciplinary field that strives to understand the functioning of neural systems at levels ranging from biomolecules and cells to behaviour and higher brain functions (perception, memory, cognition). Neurophysics has flourished over the past three decades, becoming an indelible part of neuroscience, and has arguably entered its maturity. It encompasses a vast array of approaches stemming from theoretical physics, computer science, and applied mathematics. This book provides a detailed review of this field from basic concepts to its most recent development.
Download or read book Mechanisms Symbols and Models Underlying Cognition written by José Mira and published by Springer Science & Business Media. This book was released on 2005-06-09 with total page 555 pages. Available in PDF, EPUB and Kindle. Book excerpt: The two-volume set LNCS 3561 and LNCS 3562 constitute the refereed proceedings of the First International Work-Conference on the Interplay between Natural and Artificial Computation, IWINAC 2005, held in Las Palmas, Canary Islands, Spain in June 2005. The 118 revised papers presented are thematically divided into two volumes; the first includes all the contributions mainly related with the methodological, conceptual, formal, and experimental developments in the fields of Neurophysiology and cognitive science. The second volume collects the papers related with bioinspired programming strategies and all the contributions related with the computational solutions to engineering problems in different application domains.
Download or read book Network Neuroscience written by Flavio Fröhlich and published by Academic Press. This book was released on 2016-09-20 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studying brain networks has become a truly interdisciplinary endeavor, attracting students and seasoned researchers alike from a wide variety of academic backgrounds. What has been lacking is an introductory textbook that brings together the different fields and provides a gentle introduction to the major concepts and findings in the emerging field of network neuroscience. Network Neuroscience is a one-stop-shop that is of equal use to the neurobiologist, who is interested in understanding the quantitative methods employed in network neuroscience, and to the physicist or engineer, who is interested in neuroscience applications of mathematical and engineering tools. The book spans 27 chapters that cover everything from individual cells all the way to complex network disorders such as depression and autism spectrum disorders. An additional 12 toolboxes provide the necessary background for making network neuroscience accessible independent of the reader’s background. Dr. Flavio Frohlich (www.networkneuroscientist.org) wrote this book based on his experience of mentoring dozens of trainees in the Frohlich Lab, from undergraduate students to senior researchers. The Frohlich lab (www.frohlichlab.org) pursues a unique and integrated vision that combines computer simulations, animal model studies, human studies, and clinical trials with the goal of developing novel brain stimulation treatments for psychiatric disorders. The book is based on a course he teaches at UNC that has attracted trainees from many different departments, including neuroscience, biomedical engineering, psychology, cell biology, physiology, neurology, and psychiatry. Dr. Frohlich has consistently received rave reviews for his teaching. With this book he hopes to make his integrated view of neuroscience available to trainees and researchers on a global scale. His goal is to make the book the training manual for the next generation of (network) neuroscientists, who will be fusing biology, engineering, and medicine to unravel the big questions about the brain and to revolutionize psychiatry and neurology. Easy-to-read, comprehensive introduction to the emerging field of network neuroscience Includes 27 chapters packed with information on topics from single neurons to complex network disorders such as depression and autism Features 12 toolboxes serve as primers to provide essential background knowledge in the fields of biology, mathematics, engineering, and physics
Download or read book Methods in Neuronal Modeling written by Christof Koch and published by MIT Press. This book was released on 1998 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: Kinetic Models of Synaptic Transmission / Alain Destexhe, Zachary F. Mainen, Terrence J. Sejnowski / - Cable Theory for Dendritic Neurons / Wilfrid Rall, Hagai Agmon-Snir / - Compartmental Models of Complex Neurons / Idan Segev, Robert E. Burke / - Multiple Channels and Calcium Dynamics / Walter M. Yamada, Christof Koch, Paul R. Adams / - Modeling Active Dendritic Processes in Pyramidal Neurons / Zachary F. Mainen, Terrence J. Sejnowski / - Calcium Dynamics in Large Neuronal Models / Erik De Schutter, Paul Smolen / - Analysis of Neural Excitability and Oscillations / John Rinzel, Bard Ermentrout / - Design and Fabrication of Analog VLSI Neurons / Rodney Douglas, Misha Mahowald / - Principles of Spike Train Analysis / Fabrizio Gabbiani, Christof Koch / - Modeling Small Networks / Larry Abbott, Eve Marder / - Spatial and Temporal Processing in Central Auditory Networks / Shihab Shamma / - Simulating Large Networks of Neurons / Alexander D. Protopapas, Michael Vanier, James M. Bower / ...
Download or read book Sensors Nanoscience Biomedical Engineering and Instruments written by Richard C. Dorf and published by CRC Press. This book was released on 2018-10-03 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: In two editions spanning more than a decade, The Electrical Engineering Handbook stands as the definitive reference to the multidisciplinary field of electrical engineering. Our knowledge continues to grow, and so does the Handbook. For the third edition, it has expanded into a set of six books carefully focused on a specialized area or field of study. Each book represents a concise yet definitive collection of key concepts, models, and equations in its respective domain, thoughtfully gathered for convenient access. Sensors, Nanoscience, Biomedical Engineering, and Instruments provides thorough coverage of sensors, materials and nanoscience, instruments and measurements, and biomedical systems and devices, including all of the basic information required to thoroughly understand each area. It explores the emerging fields of sensors, nanotechnologies, and biological effects. Each article includes defining terms, references, and sources of further information. Encompassing the work of the world’s foremost experts in their respective specialties, Sensors, Nanoscience, Biomedical Engineering, and Instruments features the latest developments, the broadest scope of coverage, and new material on multisensor data fusion and MEMS and NEMS.
Download or read book Neural Information Processing written by Derong Liu and published by Springer. This book was released on 2017-11-07 with total page 911 pages. Available in PDF, EPUB and Kindle. Book excerpt: The six volume set LNCS 10634, LNCS 10635, LNCS 10636, LNCS 10637, LNCS 10638, and LNCS 10639 constitues the proceedings of the 24rd International Conference on Neural Information Processing, ICONIP 2017, held in Guangzhou, China, in November 2017. The 563 full papers presented were carefully reviewed and selected from 856 submissions. The 6 volumes are organized in topical sections on Machine Learning, Reinforcement Learning, Big Data Analysis, Deep Learning, Brain-Computer Interface, Computational Finance, Computer Vision, Neurodynamics, Sensory Perception and Decision Making, Computational Intelligence, Neural Data Analysis, Biomedical Engineering, Emotion and Bayesian Networks, Data Mining, Time-Series Analysis, Social Networks, Bioinformatics, Information Security and Social Cognition, Robotics and Control, Pattern Recognition, Neuromorphic Hardware and Speech Processing.
Download or read book Phase Response Curves in Neuroscience written by Nathan W. Schultheiss and published by Springer Science & Business Media. This book was released on 2011-12-23 with total page 515 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will track advances in the application of phase response (PR) analysis to the study of electrically excitable cells, focusing on applications of PR analysis in the computational neurosciences. This proposal was motivated by discussions with colleagues at the 2007 meeting of the Organization for Computational Neuroscience (OCNS) and further motivated by the success of a workshop at the 2008 OCNS meeting this past July. At that meeting the editors hosted a workshop entitled A dialogue for theoreticians and experimentalists: What is phase response analysis, and what can it tell us about neurons and networks? Invited speakers used mathematical, modeling, and experimental results to illustrate how phase response analysis has been used to reveal or describe neuronal and neuronal population dynamics. This was the most well-attended workshop of the meeting and was standing room only.
Download or read book Cells Advances in Research and Application 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 4017 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cells—Advances in Research and Application / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cells. The editors have built Cells—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cells in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Cells—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Methods and applications in integrative physiology written by Ovidiu Constantin Baltatu and published by Frontiers Media SA. This book was released on 2023-01-04 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Research Topic is part of the Methods and Applications in Physiology series. Other titles in this series are: • Methods and Applications in Aquatic Physiology • Methods and Applications in Clinical and Translational Physiology • Methods and Applications in Computational Physiology and Medicine • Methods and Applications in Environmental, Aviation and Space Physiology • Methods and Applications in Exercise Physiology • Methods and Applications in Fractal Physiology • Methods and Applications in Invertebrate Physiology • Methods and Applications in Metabolic Physiology • Methods and Applications in Physio-logging • Methods and Applications in Striated Muscle Physiology • Methods and Applications in Respiratory Physiology • Methods and Applications in Vascular Physiology • New Methods for Red Blood Cell Research and Diagnosis, Volume II • Combining Computational and Experimental Approaches to Characterize Ion Channels and Transporters
