Download or read book Dual Discovery written by Zkharyeh Hofman and published by . This book was released on 2009 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Knowledge Discovery and Data Mining written by Takashi Washio and published by Springer Science & Business Media. This book was released on 2008-05-08 with total page 1125 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 12th Pacific-Asia Conference on Knowledge Discovery and Data Mining, PAKDD 2008, held in Osaka, Japan, in May 2008. The 37 revised long papers, 40 revised full papers, and 36 revised short papers presented together with 1 keynote talk and 4 invited lectures were carefully reviewed and selected from 312 submissions. The papers present new ideas, original research results, and practical development experiences from all KDD-related areas including data mining, data warehousing, machine learning, databases, statistics, knowledge acquisition, automatic scientific discovery, data visualization, causal induction, and knowledge-based systems.
Download or read book Discovery of the Presence of God written by David R. Hawkins, M.D., Ph.D. and published by Hay House, Inc. This book was released on 2021-02-16 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: This awe-inspiring sixth installment of the profound consciousness series by Dr. David R. Hawkins reveals the true essence of Enlightenment, from world-renowned author, psychiatrist, clinician, and spiritual teacher David R. Hawkins, M.D., Ph.D. A true instruction manual for the serious spiritual devotee, this masterpiece from Dr. David R. Hawkins reveals information only known by those who have transcended the ego to reach Divine Realization. Chapters Include: Devotional Nonduality The Inner Path Spiritual Practices The "Experiencer" The Razor's Edge Allness Versus Nothingness Spirituality and the World Teachers and Teachings The Devotee Transcending Identification with the Ego/Self Enlightenment: The Presence of Self Progressive States of Consciousness This spiritual book is the inner route from the self to the Self and an invitation into the profound depths of higher consciousness and enlightenment. It walks you through the path to divine consciousness through the fusion of psychology, philosophy, metaphysics, and spirituality. Immerse yourself in a devotional exploration of non-duality, a profound philosophy that bridges the gap between existential questions and spiritual answers. This transformative work will help you evolve spiritually by connecting to divine love. Dr. David Hawkins explains complex concepts with clarity, making them accessible and relatable for everyone, from spiritual seekers to business professionals seeking personal growth. His spiritual awakening guidance offers meditation techniques for inner peace and provides tools to transcend the confines of the mundane, illuminating the path to spiritual growth. Drawing on his profound understanding of spiritual liberation, Dr. David Hawkins' words guide us toward our spiritual evolution and higher consciousness. Through this journey, you will discover an empowering understanding of your divine consciousness, leading to a sense of inner peace and a heightened state of spiritual awareness.
Download or read book Introducing Routing and Switching in the Enterprise CCNA Discovery Learning Guide written by Allan Reid and published by Cisco Press. This book was released on 2008-04-25 with total page 1194 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the eBook of the printed book and may not include any media, website access codes, or print supplements that may come packaged with the bound book. Introducing Routing and Switching in the Enterprise, CCNA Discovery Learning Guide is the official supplemental textbook for the Introducing Routing and Switching in the Enterprise course in the Cisco® Networking Academy® CCNA® Discovery curriculum version 4. The course, the third of four in the new curriculum, familiarizes you with the equipment applications and protocols installed in enterprise networks, with a focus on switched networks, IP Telephony requirements, and security. It also introduces advanced routing protocols such as Enhanced Interior Gateway Routing Protocol (EIGRP) and Open Shortest Path First (OSPF) Protocol. Hands-on exercises include configuration, installation, and troubleshooting. The Learning Guide’s features help you focus on important concepts to succeed in this course: Chapter Objectives—Review core concepts by answering the focus questions listed at the beginning of each chapter. Key Terms—Refer to the lists of networking vocabulary introduced and highlighted in context in each chapter. The Glossary defines each key term. Summary of Activities and Labs—Maximize your study time with this complete list of all associated exercises at the end of each chapter. Check Your Understanding—Evaluate your readiness with the end-of-chapter questions that match the style of questions you see in the online course quizzes. The answer key explains each answer. Challenge Questions and Activities—Apply a deeper understanding of the concepts with these challenging end-of-chapter questions and activities. The answer key explains each answer. Hands-on Labs— Master the practical, hands-on skills of the course by performing all the tasks in the course labs and additional challenge labs included in Part II of the Learning Guide. This book is part of the Cisco Networking Academy Series from Cisco Press®. Books in this series support and complement the Cisco Networking Academy curriculum.
Download or read book Discovery of the North Pole written by James Martin Miller and published by . This book was released on 1909 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Blood Brain Barrier in Drug Discovery written by Li Di and published by John Wiley & Sons. This book was released on 2014-12-29 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focused on central nervous system (CNS) drug discovery efforts,this book educates drug researchers about the blood-brain barrier(BBB) so they can affect important improvements in one of the mostsignificant – and most challenging – areas of drugdiscovery. • Written by world experts to provide practicalsolutions to increase brain penetration or minimize CNSside-effects • Reviews state-of-the-art in silico, in vitro, and invivo tools to assess brain penetration and advanced CNS drugdelivery strategies • Covers BBB physiology, medicinal chemistry designprinciples, free drug hypothesis for the BBB, and transportmechanisms including passive diffusion, uptake/efflux transporters,and receptor-mediated processes • Highlights the advances in modelling BBBpharmacokinetics and dynamics relationships (PK/PD) andphysiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNSdrugs, lessons learned and paths to the market
Download or read book Machine Learning and Knowledge Discovery in Databases written by Toon Calders and published by Springer. This book was released on 2014-09-01 with total page 565 pages. Available in PDF, EPUB and Kindle. Book excerpt: This three-volume set LNAI 8724, 8725 and 8726 constitutes the refereed proceedings of the European Conference on Machine Learning and Knowledge Discovery in Databases: ECML PKDD 2014, held in Nancy, France, in September 2014. The 115 revised research papers presented together with 13 demo track papers, 10 nectar track papers, 8 PhD track papers, and 9 invited talks were carefully reviewed and selected from 550 submissions. The papers cover the latest high-quality interdisciplinary research results in all areas related to machine learning and knowledge discovery in databases.
Download or read book The Search for Antidepressants An Integrative View of Drug Discovery written by Andre F. Carvalho and published by Bentham Science Publishers. This book was released on 2017-07-10 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major depressive disorder (MDD) is a prevalent, chronic, and recurring mental disorder. This disorder is a leading source of disability worldwide, and is associated with excess mortality rates. Currently approved antidepressants primarily enhance, or otherwise modulate monoaminergic neurotransmission, without curing the disease. Evidence indicates that only one third of patients with MDD achieve remission after treatment with a first-line antidepressant agent. Research in the past two decades has provided valuable insights into the pathophysiological understanding of MDD. However, there is an acknowledged ‘translational gap’ in the field, and few genuinely novel antidepressants have been approved for the treatment of MDD. The Search for Anti Depressants provides readers an in-depth picture of the main pathophysiological mechanisms responsible for the development of MDD in patients. Chapters in the volume focus on possible strategies to spur the discovery of novel antidepressants. This book is an indispensable reference for mental health care providers, students at both under-graduate and graduate levels, and neuroscientists interested in the neurobiology of MDD and recent advances towards the discovery of next generation antidepressants.
Download or read book North Carolina Reports written by North Carolina. Supreme Court and published by . This book was released on 1984 with total page 1150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cases argued and determined in the Supreme Court of North Carolina.
Download or read book Polypharmacology in Drug Discovery written by Jens-Uwe Peters and published by John Wiley & Sons. This book was released on 2012-03-13 with total page 542 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential outline of the main facets of polypharmacology in drug discovery research Extending drug discovery opportunities beyond the "one drug, one target" philosophy, a polypharmacological approach to the treatment of complex diseases is emerging as a hot topic in both industry and academic research. Polypharmacology in Drug Discovery presents an overview of the various facets of polypharmacology and how it can be applied as an innovative concept for developing medicines for treating bacterial infections, epilepsy, cancer, psychiatric disorders, and more. Filled with a collection of instructive case studies that reinforce the material and illuminate the subject, this practical guide: Covers the two-sided nature of polypharmacology—its contribution to adverse drug reactions and its benefit in certain therapeutic drug classes Addresses the important topic of polypharmacology in drug discovery, a subject that has not been thoroughly covered outside of scattered journal articles Overviews state-of-the-art approaches and developments to help readers understand concepts and issues related to polypharmacology Fosters interdisciplinary drug discovery research by embracing computational, synthetic, in vitro and in vivo pharmacological and clinical aspects of polypharmacology A clear road map for helping readers successfully navigate around the problems involved with promiscuous ligands and targets, Polypharmacology in Drug Discovery provides real examples, in-depth explanations and discussions, and detailed reviews and opinions to spark inspiration for new drug discovery projects.
Download or read book Molecular Biology of the Gene written by James D. Watson and published by Benjamin-Cummings Publishing Company. This book was released on 2014 with total page 872 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now completely up-to-date with the latest research advances, the Seventh Edition retains the distinctive character of earlier editions. Twenty-two concise chapters, co-authored by six highly distinguished biologists, provide current, authoritative coverage of an exciting, fast-changing discipline.
Download or read book Machine Learning and Knowledge Discovery in Databases written by Annalisa Appice and published by Springer. This book was released on 2015-08-28 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: The three volume set LNAI 9284, 9285, and 9286 constitutes the refereed proceedings of the European Conference on Machine Learning and Knowledge Discovery in Databases, ECML PKDD 2015, held in Porto, Portugal, in September 2015. The 131 papers presented in these proceedings were carefully reviewed and selected from a total of 483 submissions. These include 89 research papers, 11 industrial papers, 14 nectar papers, and 17 demo papers. They were organized in topical sections named: classification, regression and supervised learning; clustering and unsupervised learning; data preprocessing; data streams and online learning; deep learning; distance and metric learning; large scale learning and big data; matrix and tensor analysis; pattern and sequence mining; preference learning and label ranking; probabilistic, statistical, and graphical approaches; rich data; and social and graphs. Part III is structured in industrial track, nectar track, and demo track.
Download or read book Advances in Chance Discovery written by Yukio Ohsawa and published by Springer. This book was released on 2012-08-01 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since year 2000, scientists on artificial and natural intelligences started to study chance discovery - methods for discovering events/situations that significantly affect decision making. Partially because the editors Ohsawa and Abe are teaching at schools of Engineering and of Literature with sharing the interest in chance discovery, this book reflects interdisciplinary aspects of progress: First, as an interdisciplinary melting pot of cognitive science, computational intelligence, data mining/visualization, collective intelligence, ... etc, chance discovery came to reach new application domains e.g. health care, aircraft control, energy plant, management of technologies, product designs, innovations, marketing, finance etc. Second, basic technologies and sciences including sensor technologies, medical sciences, communication technologies etc. joined this field and interacted with cognitive/computational scientists in workshops on chance discovery, to obtain breakthroughs by stimulating each other. Third, “time” came to be introduced explicitly as a significant variable ruling causalities - background situations causing chances and chances causing impacts on events and actions of humans in the future. Readers may urge us to list the fourth, fifth, sixth, ... but let us stop here and open this book.
Download or read book Structural Biology in Drug Discovery written by Jean-Paul Renaud and published by John Wiley & Sons. This book was released on 2020-01-09 with total page 1367 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the most comprehensive and up-to-date overview of structure-based drug discovery covering both experimental and computational approaches, Structural Biology in Drug Discovery: Methods, Techniques, and Practices describes principles, methods, applications, and emerging paradigms of structural biology as a tool for more efficient drug development. Coverage includes successful examples, academic and industry insights, novel concepts, and advances in a rapidly evolving field. The combined chapters, by authors writing from the frontlines of structural biology and drug discovery, give readers a valuable reference and resource that: Presents the benefits, limitations, and potentiality of major techniques in the field such as X-ray crystallography, NMR, neutron crystallography, cryo-EM, mass spectrometry and other biophysical techniques, and computational structural biology Includes detailed chapters on druggability, allostery, complementary use of thermodynamic and kinetic information, and powerful approaches such as structural chemogenomics and fragment-based drug design Emphasizes the need for the in-depth biophysical characterization of protein targets as well as of therapeutic proteins, and for a thorough quality assessment of experimental structures Illustrates advances in the field of established therapeutic targets like kinases, serine proteinases, GPCRs, and epigenetic proteins, and of more challenging ones like protein-protein interactions and intrinsically disordered proteins
Download or read book Analogue based Drug Discovery III written by János Fischer and published by John Wiley & Sons. This book was released on 2012-10-15 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most drugs are analogue drugs. There are no general rules how a new drug can be discovered, nevertheless, there are some observations which help to find a new drug, and also an individual story of a drug discovery can initiate and help new discoveries. Volume III is a continuation of the successful book series with new examples of established and recently introduced drugs. The major part of the book is written by key inventors either as a case study or a study of an analogue class. With its wide range across a variety of therapeutic fields and chemical classes, this is of interest to virtually every researcher in drug discovery and pharmaceutical chemistry, and -- together with the previous volumes -- constitutes the first systematic approach to drug analogue development.
Download or read book Knowledge Discovery with Support Vector Machines written by Lutz H. Hamel and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: An easy-to-follow introduction to support vector machines This book provides an in-depth, easy-to-follow introduction to support vector machines drawing only from minimal, carefully motivated technical and mathematical background material. It begins with a cohesive discussion of machine learning and goes on to cover: Knowledge discovery environments Describing data mathematically Linear decision surfaces and functions Perceptron learning Maximum margin classifiers Support vector machines Elements of statistical learning theory Multi-class classification Regression with support vector machines Novelty detection Complemented with hands-on exercises, algorithm descriptions, and data sets, Knowledge Discovery with Support Vector Machines is an invaluable textbook for advanced undergraduate and graduate courses. It is also an excellent tutorial on support vector machines for professionals who are pursuing research in machine learning and related areas.
Download or read book Machine Learning and Knowledge Discovery in Databases written by Hendrik Blockeel and published by Springer. This book was released on 2013-08-28 with total page 732 pages. Available in PDF, EPUB and Kindle. Book excerpt: This three-volume set LNAI 8188, 8189 and 8190 constitutes the refereed proceedings of the European Conference on Machine Learning and Knowledge Discovery in Databases, ECML PKDD 2013, held in Prague, Czech Republic, in September 2013. The 111 revised research papers presented together with 5 invited talks were carefully reviewed and selected from 447 submissions. The papers are organized in topical sections on reinforcement learning; Markov decision processes; active learning and optimization; learning from sequences; time series and spatio-temporal data; data streams; graphs and networks; social network analysis; natural language processing and information extraction; ranking and recommender systems; matrix and tensor analysis; structured output prediction, multi-label and multi-task learning; transfer learning; bayesian learning; graphical models; nearest-neighbor methods; ensembles; statistical learning; semi-supervised learning; unsupervised learning; subgroup discovery, outlier detection and anomaly detection; privacy and security; evaluation; applications; and medical applications.
