Download or read book Drug Resistance and Selectivity Biochemical and Cellular Basis written by Enrico Mihich and published by . This book was released on 1973 with total page 554 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1997 with total page 1058 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Antitumor Drug Resistance written by Brian W. Fox and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 742 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of tumour resistance to anticancer drugs has been the subject of many publications since the initial discovery of the phenomenon by J. H. Burchenal and colleagues in 1950. Many papers have been published since then reporting development of resistance to most of the well-known anticancer agents in many different animal tumour systems, both in vivo and in vitro. Many different mechanisms of resistance have been described, and it is clear that the tumour cell has a wide diversity of options in overcoming the cell-killing activity of these agents. Definition of the magnitude of the phenomenon in the clinic is, however, much more problematical, and it is with this in mind that the initial chapter, seeks to out line the problem as the clinicians see it. It appears that the phenomenon of true resistance to a drug, as the biochemist would recognise it, is an important cause of the failure which clinicians experience in treating the disease. The extent of the contribution of this phenomenon to the failure of treatment cannot easily be evaluated at the present time, but it is hoped that the development and application of new and more sophisticated techniques for the analysis of cellular sub populations may help to give a more exact estimate and to shed some light on the causes of failure of many of the present therapeutic techniques.
Download or read book Journal written by National Cancer Institute (U.S.) and published by . This book was released on 1977 with total page 1084 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cancer Treatment Reports written by and published by . This book was released on 1984 with total page 606 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Anthracycline Antibiotics in Cancer Therapy written by Franco M. Muggia and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: F. M. MUGGIA When faced with the inadequacies of current cancer treatment, we prefer to look at what the future may hold. Quite often, we take for granted the past, preferring research into totally new areas. However, the persistent development of fertile soil may yield surprising rewards for those who choose to build on the knowledge of the past--hence, this symposium on anthracycline antibiotics. Although the anthracycline antibiotics represent much of the present and future of cancer treatment, their actual use c stretches back barely two decades to the pioneering efforts of Aurelio Di Marco, who characterized the antitumor properties of daunomycin and adriamycin. * The clinical application of these two compounds heralded a decade of excitement among oncologists dealing with pediatric tumors, breast cancer, leukemias, and lymphomas, and opened new hope for patients afflicted with sar comas and a variety of other tumors that had been deemed - sistant to chemotherapy. These successes were tempered with the realization that the antitumor effect of anthracyclines could be achieved at times only at the very high price of risking cardiac decompensation and, almost invariably, with the occurrence of alopecia and other acute toxicities. This record of past achievements and problems has slowly given way to a present increasingly illuminated by our ability to modify the distressing toxicities of these agents. Detailed clinical studies supplemented by ingenious laboratory models have gradually elucidated mechanisms and risk factors im plicated in the cardiomyopathy.
Download or read book Drug Design written by E. J. Ariëns and published by Elsevier. This book was released on 2013-10-22 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Design, Volume V covers the fundamental approaches to the development of bioactive compounds. The book discusses the utilization of operational schemes for analog synthesis in drug design; the design of enzyme inhibitors (transition state analogs); and the significance of structure-absorption-distribution relationships for drug design. The text describes the role of charge-transfer processes in the action of bioactive materials, as well as the approaches to the rational combination of antimetabolites for cancer chemotherapy. The physicochemical, quantum chemical, and other theoretical techniques for the understanding of the mechanism of action of central nervous system (CNS) agents, such as psychoactive drugs, narcotics, and narcotic antagonists and anesthetics, are also encompassed. Chemists, biochemists, pharmacologists, and people involved in drug design will find the book invaluable.
Download or read book Medical Research in the Veteran s Administration written by United States. Veterans Administration and published by . This book was released on 1976 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cancer Chemotherapy Reports written by and published by . This book was released on 1973 with total page 1154 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drugs and Immune Responsiveness written by J.L. Turk and published by Springer. This book was released on 1979-06-17 with total page 258 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biological Responses in Cancer written by Enrico Mihich and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series of volumes entitled Biological Responses in Cancer provides information on approaches through which the interaction between neoplas tic and normal cells may be modified. Topics discussed in various volumes include immunological and host defense systems, control mechanisms of cell and population growth, cell differentiation, and cell transformation. This volume is specifically concerned with various aspects of cell interactions and regulation within heterogeneous tumor cell populations, and their role in tumor progression and metastasis. Knowledge in this area is likely to provide new leads toward the exploitation of novel cellular sites and mech anisms in the development of new types of therapies of cancer. Several topics are discussed within these general areas of consideration. The possibly unique characteristics and mechanisms of tumor vascularization and the potential sites of interference with angiogenesis that might have therapeutic impli cations are critically evaluated. Tumor cell-normal tissue interactions in volved in different phases of the growth and metastatic processes are dis cussed in two chapters dealing with mechanisms of tumor invasion and with the role of collagen in mammary tumor growth; here again potential leads are identified that may be exploited toward the development of new thera peutic approaches. The evolution of phenotypic diversity as a phenomenon complicating the biology of tumor metastasis and consequently affecting the opportunities offered by chemotherapy is also critically considered.
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1973 with total page 1256 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book The Chemotherapy Source Book written by Michael Clinton Perry and published by Lippincott Williams & Wilkins. This book was released on 1996 with total page 1552 pages. Available in PDF, EPUB and Kindle. Book excerpt: The updated Third Edition of The Chemotherapy Source Book is the most current and comprehensive reference on cancer chemotherapy. It brings together pharmacologic and patient management information in one source that practitioners can consult for any question encountered in the delivery of chemotherapy. This edition features increased information on the expanding use of high-dose therapy for various cancers, including breast cancer, leukemias, multiple myeloma, Hodgkin's disease, non-Hodgkin's lymphoma, lung cancer, and ovarian cancer. Coverage also includes new material on monoclonal antibodies, monoclonal antibody therapy, and breast, colon, and lung cancers, and information on five new drugs approved since the Second Edition. A Brandon-Hill recommended title.
Download or read book Advances in Applied Microbiology written by and published by Academic Press. This book was released on 1974-02-08 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Applied Microbiology offers intensive reviews of the latest techniques and discoveries in this rapidly moving field. The editors are recognized experts and the format is comprehensive and instructive. Published since 1959, Advances in Applied Microbiology continues to be one of the most widely read and authoritative review sources in microbiology. Recent areas covered include bacterial diversity in the human gut, protozoan grazing of freshwater biofilms, metals in yeast fermentation processes and the interpretation of host-pathogen dialogue through microarrays.
Download or read book Mechanism of Action of Antieukaryotic and Antiviral Compounds written by Fred E. Hahn and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: When Antibiotics I was published in 1967, the teleological view was held by some that" antibiotics" were substances elaborated by certain microorgan isms for the purpose of competing with other microorganisms for survival in mixed ecological environments. However, not only had J. EHRLICH and his associates shown 15 years earlier that chloramphenicol was produced by Strepto myces venezuelae in cultures of sterilized soils but not in parallel cultures of the same soils which were not sterilized, but operationally, the search for anti cancer antibiotics was actively under way (Antibiotics I reporting on numerous such substances), although the concept of antibiosis could not logically justify such undertakings. This editor hesitates to accept the use of the term "antibiotic" for anti microbial agents of non microbiological origins which is sometimes encountered, but neither does he subscribe to the view that antibiotics are in some fundamental manner different from chemotherapeutic substances of other origins. Modes and mechanisms of action of chemotherapeutic compounds are not systematic functions of their origins nor of the taxonomical position of the target organisms. Consequently, in the selection of topics for Antibiotics III (published in 1975), synthetic drugs and natural products of higher plants (alkaloids) were represented, along with antibiotics in the strict sense of the definition. We now present Antibiotics V, for whose assembly the same selection criteria were applied as for Antibiotics Ill. The aggregate length of the contributions rendered it impractical to place the entire text between the covers of one book.
Download or read book The Effects on Human Health of Subtherapeutic Use of Antimicrobials in Animal Feeds written by National Research Council and published by National Academies Press. This book was released on 1980-02-01 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt:
