Download or read book Drug Interactions in Infectious Diseases Mechanisms and Models of Drug Interactions written by Manjunath P. Pai and published by Springer. This book was released on 2018-03-05 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes – “Mechanisms and Models of Drug Interactions” and “Antimicrobial Drug Interactions”. This volume, “Mechanisms and Models of Drug Interactions,” delivers a text that enhances clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation. The book provides a comprehensive review of basic clinical pharmacology with a focus on metabolism and transporter-mediated drug interactions. The chapters address materials that cannot be retrieved easily in the medical literature, including materials focused on the complex interrelationship of acute infection, inflammation, and the risk of drug interactions in the Drug-Cytokine chapter. The Food-Drug and Herb-Drug interactions chapters remain definitive resources. A new chapter on in vitro modeling of drug interactions is included along with updates on design and data analysis of clinical drug interaction studies. Authoritative discussion of models for regulatory decision-making on drug-drug interactions provides the necessary framework to aid antimicrobial drug development. This concise review of the mechanisms and models of drug interactions provides important insights to health care practitioners as well as scientists in drug development.
Download or read book Drug Interactions in Infectious Diseases Antimicrobial Drug Interactions written by Manjunath P. Pai and published by Springer. This book was released on 2018-03-19 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 4th edition of Drug Interactions in Infectious Diseases is being split into two separate volumes – “Mechanisms and Models of Drug Interactions” and “Antimicrobial Drug Interactions”. This volume, “Antimicrobial Drug Interactions,” delivers a quick clinical resource that distills relevant drug interactions by antimicrobial drug class. The book provides informative tables on specific drug-drug interactions that include the degree and severity of the expected interaction. A mechanistic basis for drug-drug interactions is also provided to link observed interactions to pharmacologic characteristics of key drug classes. This complete resource is organized by major antibacterial, antimycobacterial, antiviral, antifungal, antimalarial, and antiprotozoal class. In line with current innovations in antimicrobial drug development, a distinct chapter on the pharmacologic management of drug interactions in hepatitis B virus (HBV) and hepatitis C virus (HCV)-related infections is included. Two new chapters are dedicated to the management of human immunodeficiency virus (HIV) drug-drug interactions given the breadth of antiretroviral class-specific effects. This comprehensive review of known drug interactions and strategies to manage them is an invaluable resource to all health care practitioners.
Download or read book Drug Interactions in Infectious Diseases written by Stephen C. Piscitelli and published by Springer Science & Business Media. This book was released on 2007-10-28 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past 25 years, the world’s population has witnessed an explosion in kno- edge about infectious diseases. The global population is coming to the realization that diseases long recognized to cause substantial suffering, such as malaria, tuberculosis, schistosomiasis, and hepatitis, can be diagnosed and treated, and that transmission can be prevented using tools that are available, and which may be becoming increasingly affordable. The global population is recognizing that few infections are local: the travel of humans, other animals, insects, and food transport pathogens around the world, often with astonishing rapidity. New pathogens are appearing, either newly recognized or newly developing, such as severe acute respiratory syndrome (SARS), avian inf- enza, metapneumovirus, or hepatitis C, which are causing human morbidity and m- tality. Finally, there is growing fear that dangerous pathogens may be intentionally introduced into human populations by deranged individuals or terrorist organizations. The potential to use drugs or biologic agents to treat and prevent infectious diseases has increased dramatically over the past quarter century as we have learned more about the biology of many of these agents, and as we have developed techniques to discover new agents by high throughput screening programs and by sophisticated drug design and synthesis.
Download or read book Drug Interactions written by Ivan H. Stockley and published by . This book was released on 1996 with total page 1018 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a source book of adverse drug reactions covering their clinical importance, mechanisms and management. This fourth edition has been revised from an extensive database. Major interaction mechanisms are followed by alphabetically-arranged material covering all the drug groups. As with prior editions, there is a series of monographs with a consistent plan devised to offer quick and easy reading. Both British and American drug names have been used throughout the book and bibliogrpahies are provided for those who wish to use the book as a reference source.
Download or read book Drug Interactions in Infectious Diseases written by Stephen C. Piscitelli and published by Springer Science & Business Media. This book was released on 2011-09-08 with total page 698 pages. Available in PDF, EPUB and Kindle. Book excerpt: The revised and up-to-date third edition of Drug Interactions in Infectious Diseases delivers a text that will enhance your clinical knowledge of the complex mechanisms, risks, and consequences of drug interactions associated with antimicrobials, infection, and inflammation. The third edition features five new chapters that cover material not addressed in previous editions. These new chapters describe interactions with a number of drug classes such as non-HIV antiviral, antimalarial, antiparasitic, antihelmintic, macrolide, azalide and ketolide agents. A novel chapter on probe cocktail studies has been included to highlight an important research tool for drug development. These chapters address material that cannot be retrieved easily in the medical literature. The highly acclaimed food-drug interactions as well as the study design and analysis chapters remain definitive references. The newly written drug-cytokine interaction highlights the need for our improved understanding of the complex interrelationship of acute infection, inflammation, and the risk of drug interactions. Informative tables on specific drug-drug interactions are provided throughout the chapters as a quick clinical resource. The Third Edition of Drug Interactions in Infectious Diseases is a distillation of relevant drug interactions associated with antimicrobials, infection, and inflammation. This concise review of the mechanisms and strategies to manage drug interactions should be valuable to all health care practitioners. Features • Definitive reference source of up-to-date information on antimicrobial drug interactions • Informative tables on the degree of interaction for specific antimicrobial agents • In-depth discussion of mechanisms and potential mechanistic pathways of interaction • New chapters on non-HIV antiviral, antimalarial, antiparasitic, and macrolide, azalide and ketolide agents • New chapter on probe-cocktail studies as a research tool to study drug-drug interactions • Inclusion of new antimicrobial agents and their associated drug interactions • First rate chapters on study design and analysis, and drug-food interactions • A fresh perspective on drug-cytokine interactions • Authoritative chapter on regulatory considerations of drug interactions during drug development
Download or read book Drug Drug Interactions for Therapeutic Biologics written by Honghui Zhou and published by John Wiley & Sons. This book was released on 2013-05-10 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Strategize, plan, and execute comprehensive drug-drug interaction assessments for therapeutic biologics Offering both theory and practical guidance, this book fully explores drug-drug interaction assessments for therapeutic biologics during the drug development process. It draws together and analyzes all the latest findings and practices in order to present our current understanding of the topic and point the way to new research. Case studies and examples, coupled with expert advice, enable readers to better understand the complex mechanisms of biologic drug-drug interactions. Drug-Drug Interactions for Therapeutic Biologics features contributions from leading international experts in all areas of therapeutic biologics drug development and drug-drug interactions. The authors' contributions reflect a thorough review and analysis of the literature as well as their own firsthand laboratory experience. Coverage includes such essential topics as: Drug-drug interaction risks in combination with small molecules and other biologics Pharmacokinetic and pharmacodynamic drug-drug interactions In vitro methods for drug-drug interaction assessment and prediction Risk-based strategies for evaluating biologic drug-drug interactions Strategies to minimize drug-drug interaction risk and mitigate toxic interactions Key regulations governing drug-drug interaction assessments for therapeutic biologics. Drug-Drug Interactions for Therapeutic Biologics is recommended for pharmaceutical and biotechnology scientists, clinical pharmacologists, medicinal chemists, and toxicologists. By enabling these readers to understand how therapeutic biologics may interact with other drugs, the book will help them develop safer, more effective therapeutic biologics.
Download or read book Drug Interactions and Their Mechanisms written by Ivan H. Stockley and published by . This book was released on 1973 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pharmacokinetic and Pharmacodynamic Drug Interactions Associated with Antiretroviral Drugs written by Tony K. L. Kiang and published by Springer. This book was released on 2016-12-21 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: Clinically-focussed, with easily accessible tables and chapter summaries suitable for clinicians and researchers, this comprehensive book provides a systematic, critical evaluation of the current literature. An updated clinical decision-making algorithm specifically tailored to the antiretroviral drugs is also provided. The identified interactions are interpreted in the context of known mechanisms derived from clinical, preclinical, and in vitro data. The clinical relevance of the interactions is systematically evaluated and gaps in literature discussed in the context of potential future experiments. In addition to the comprehensive summary of pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antiretroviral drugs on the market today (i.e. nucleotide reverse-transcriptase inhibitors, non-nucleoside reverse-transcriptase inhibitors, integrase inhibitors, and protease inhibitors), this book also provides detailed section summaries on the epidemiology of HIV infection, diagnosis and pharmacotherapy, basic pharmacology of the individual antiretrovirals, pertinent pre-clinical and in vitro molecular pharmacology, and in vitro drug interaction data available in the literature today.
Download or read book Handbook of Drug Interactions written by Ashraf Mozayani and published by Springer Science & Business Media. This book was released on 2003-10-15 with total page 662 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise compilation of the known interactions of the most commonly prescribed drugs, as well as their interaction with nonprescription compounds. The agents covered include CNS drugs, cardiovascular drugs, antibiotics, and NSAIDs. For each class of drugs the authors review the pharmacology, pharmacodynamics, pharmacokinetics, chemistry, metabolism, epidemiological occurrences, adverse reactions, and significant interactions. Environmental and social pharmacological issues are also addressed in chapters on food and alcohol drug interactions, nicotine and tobacco, and anabolic doping agents. Comprehensive and easy-to-use, Handbook of Drug Interactions: A Clinical and Forensic Guide provides physicians with all the information needed to avoid prescribing drugs with undesirable interactions, and toxicologists with all the data necessary to interpret possible interactions between drugs found simultaneously in patient samples.
Download or read book Pocket Guide to Evaluations of Drug Interactions written by Frederic J. Zucchero and published by American Pharmaceutical Association. This book was released on 1999 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: A condensed version of Evaluations of Drug Interactions, designed to facilitate quick access to the information most frequently needed by busy health practitioners. It contains 952 drug interaction monographs organized by drug class. Most monographs contain eight concise pieces of information and the volume is indexed by generic names.
Download or read book Handbook of Drug Interaction and the Mechanism of Interaction written by Qutaiba A. Ibrahim and published by Xlibris Corporation. This book was released on 2011-09-28 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook is offered as a general summary of information for physicians, pharmacists, nurses and other health professionals. Inappropriate administration of interacting drugs to patients can result in severe injury or death.
Download or read book Stockley s Drug Interactions written by Karen Baxter and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: First published over twenty years ago, Stockley's Drug Interactions is still the most indispensable and authoritative international source of drug interaction information. Based upon the many thousands of published clinical papers and reports, it provides a series of detailed yet concise monographs designed for quick and easy reference. Each monograph contains a summary, clinical evidence for the interaction under discussion, its probable mechanism, clinical importance and management. Individual interactions are assembled alphabetically into chapters, grouped therapeutically, pharmacologically or individually. Both Recommended International Nonproprietary Names (rlNN) and US Adopted Names (USAN) are used throughout the book
Download or read book Drug Interactions written by Joseph A. Albanese and published by McGraw-Hill Companies. This book was released on 1978 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Mechanisms of Drug Interactions written by Patrick F. D'Arcy and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the years a number of excellent books have classified and detailed drug drug interactions into their respective categories, e.g. interactions at plasma protein binding sites; those altering intestinal absorption or bioavailability; those involving hepatic metabolising enzymes; those involving competition or antagonism for receptor sites, and drug interactions modifying excretory mechanisms. Such books have presented extensive tables of interactions and their management. Although of considerable value to clinicians, such publica tions have not, however, been so expressive about the individual mechanisms that underlie these interactions. It is within this sphere of "mechanisms" that this present volume specialises. It deals with mechanisms of in vitro and in vivo, drug-drug, drug food and drug-herbals interactions and those that cause drugs to interfere with diagnostic laboratory tests. We believe that an explanation of the mechanisms of such interactions will enable practitioners to understand more fully the nature of the interactions and thus enable them to manage better their clinical outcome. If mechanisms of interactions are better understood, then it may be pos sible for the researcher to develop meaningful animal/biochemical/tissue cul ture or physicochemical models to which new molecules could be exposed during their development stages. The present position, which largely relies on patients experiencing adverse interactions before they can be established or documented, can hardly be regarded as satisfactory. This present volume is classified into two major parts; firstly, pharmacoki netic drug interactions and, secondly, pharmacodynamic drug interactions.
Download or read book Drug Drug Interactions written by Dong Hyun Kim and published by Mdpi AG. This book was released on 2021-09-17 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-drug interactions (DDIs) cause a drug to affect other drugs, leading to reduced drug efficacy or increased toxicity of the affected drug. Some well-known interactions are known to be the cause of adverse drug reactions (ADRs) that are life threatening to the patient. Traditionally, DDI have been evaluated around the selective action of drugs on specific CYP enzymes. The interaction of drugs with CYP remains very important in drug interactions but, recently, other important mechanisms have also been studied as contributing to drug interaction including transport- or UDP-glucuronyltransferase as a Phase II reaction-mediated DDI. In addition, novel mechanisms of regulating DDIs can also be suggested. In the case of the substance targeted for interaction, not only the DDIs but also the herb-drug or food-drug interactions have been reported to be clinically relevant in terms of adverse side effects. Reporting examples of drug interactions on a marketed drug or studies on new mechanisms will be very helpful for preventing the side effects of the patient taking these drugs. This Special Issue aims to highlight current progress in understanding both the clinical and nonclinical interactions of commercial drugs and the elucidation of the mechanisms of drug interactions.
Download or read book A Manual of Adverse Drug Interactions written by J.P. Griffin and published by Elsevier. This book was released on 1997-11-17 with total page 665 pages. Available in PDF, EPUB and Kindle. Book excerpt: For twenty years this book, now in its 5th edition, has provided information on adverse drug interactions that is unrivalled in coverage and scholarship.Adverse drug reactions, many of them ascribable to interactions with other drugs or with chemical substances in food or the environment, are thought to cause or complicate one in twenty of hospital admissions.The book is conveniently divided into two parts: Part 1 comments on drug interactions and their mechanisms, on a pharmacokinetic and pharmacodynamic level, while Part 2 consists of drug interaction tables, divided and subdivided into categories of disorders, and the drugs used in the treatment of these disorders.If safety in drugs is to improve, education of prescribers is vitally important. This book, with its up-to-date and coordinated approach, serves that purpose well. The real threat, as the authors remind us, is the ignorance of practitioners, not the drug itself. The volume is therefore an essential addition to the shelves of those responsible for the prescription of drugs, in order to prevent a potential backlash when used in combination with other drugs or chemical substances.
Download or read book Handbook of Drug Nutrient Interactions written by Joseph I. Boullata and published by Springer Science & Business Media. This book was released on 2004-04-17 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although there is agreat deal ofliterature regarding drug-nutrientinteractions (DNis ), there are limited sources of up-to-date comprehensive information. The Handbook of Drug-Nutrient Interactions admirably fills this gap. The editors, Dr. Joseph 1. Boullata and Dr. Vincent T. Armenti, ha ve a wealth of experience in this therapeutic ar ea and ha ve assembled a fine cadre of chapter authors who have individually contributed their high level of expertise. As treatment for many diseases becomes increasingly complex with multiple drug therapies scheduled at varying times, the need to identify clinically significant DNis is an essential part of medication management. This is a shared responsibility between health care professionals to interpret available data and individualize an approach to therapy that is compatible with the patient' s disease state, life stage, and dietary intake. Awareness ofthe significance of drug-food interactions is generally lacking. Although many texts contain lengthy lists of possible interactions, few data are provided for the clinician to gain an understanding of the mechanism of action of the interaction and subsequently apply the information to a particular patient or group of patients. For example, in the management of patients with HN -AIDS who are taking complex prescribed drug regimens, herbal products, and nutritional supplements, many of which are affected by dietary intake, careful attention to D Nls is a critic al component of therapy. Clinicians need to take account of not only the well-documented interactions between drugs and nutrients, but also the less obvious effects on drug-nutrient disposition and metabolism.
