Download or read book Drug Evaluation in Angina Pectoris written by Gianluigi Ardissino and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although there are many books on angina, few are devoted to the important problem of how to evaluate drug efficacy in angina pectoris. Drug Evaluation in Angina Pectoris has two fundamental aims: the first is to review the methodological aspects of drug evaluation in stable and unstable angina pectoris; the second is to provide a logical and methodological background for future studies aimed at assessing the ability of medical treatment to improve prognosis. Part I updates the pathophysiology, clinical presentation and prognosis of angina pectoris. Part II aims to `put in numbers' the symptoms and signs of myocardial ischemia, starting from a revision of the currently used parameters. It is extremely important to quantify the variability of the disease for the correct design of clinical trial, a subject dealt with in Part III, which also discusses some clinico-pharmacological aspects of therapy. Part IV is a critical review of the drugs currently used for the treatment of stable and unstable angina, and particularly considers some important unresolved issues concerning their use. The current FDA and EC guidelines for the evaluation of antianginal drugs are briefly discussed in Part V, giving clinical investigators insight into how antianginal drugs are evaluated by regulatory agencies and what is considered as proof of a valid efficacy/tolerability ratio. Drug Evaluation in Angina Pectoris will assist discerning cardiologists, pharmacologists, and advanced students of cardiology as well as innovative pharmaceutical companies, all of whom need to understand what angina is, how to evaluate treatment, and how to judge the agents used in its treatment.

Download or read book Guidelines for the Clinical Evaluation of Anti anginal Drugs written by United States. Food and Drug Administration and published by . This book was released on 1977 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book An Evaluation of Beta blockers Calcium Antagonists Nitrates and Alternative Therapies for Stable Angina written by Paul A. Heidenreich and published by Agency for Healthcare Research & Quality. This book was released on 1999 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Unstable Angina written by Eugene Braunwald and published by DIANE Publishing. This book was released on 1997-07 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt: This clinical practice guideline was developed by a 19-member panel that included physicians, cardiovascular nurse specialists, a public health representative, & a consumer representative. Their recommendations outline a comprehensive care plan for patients with unstable angina, further refined by peer & pilot review. The guideline is written to be directly applicable to patient care & is intended for use by a broad range of health care practitioners, including cardiologists, cardiac surgeons, family practitioners, internists, & nurses. Charts, graphs, tables & glossary. Also includes a 20-page Patient & Family Guide, Managing Unstable Angina.Ó

Download or read book Coronary Microvascular Dysfunction written by Filippo Crea and published by Springer Science & Business Media. This book was released on 2013-08-15 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past two decades a number of studies have shown that abnormalities in the function and structure of coronary microcirculation can be detected in several cardiovascular diseases. On the basis of the clinical setting in which it occurs, coronary microvascular dysfunction (CMD) can be classified into four types: CMD in the absence of any other cardiac disease; CMD in myocardial diseases; CMD in obstructive epicardial coronary artery disease; and iatrogenic CMD. In some instances CMD represents an epiphenomenon, whereas in others it represents an important marker of risk or may contribute to the pathogenesis of myocardial ischemia, thus becoming a possible therapeutic target. This book provides an update on coronary physiology and a systematic assessment of microvascular abnormalities in cardiovascular diseases, in the hope that it will assist clinicians in prevention, detection and management of CMD in their everyday activity.

Download or read book Cardiovascular Disability written by Institute of Medicine and published by National Academies Press. This book was released on 2010-12-04 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Social Security Administration (SSA) uses a screening tool called the Listing of Impairments to identify claimants who are so severely impaired that they cannot work at all and thus immediately qualify for benefits. In this report, the IOM makes several recommendations for improving SSA's capacity to determine disability benefits more quickly and efficiently using the Listings.

Download or read book Differential Diagnosis of Chest Pain written by Umashankar Lakshmanadoss and published by BoD – Books on Demand. This book was released on 2020-07-01 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book aims to provide an excellent overview of the differential diagnosis and approach to chest pain in various clinical settings. This book is divided into two sections including the introduction and the approach to chest pain. Our introductory chapter starts with the basic principles of statistics and its application in various diagnostic modalities of heart disease. Our authors present a nice approach to patients presenting with chest pain in various scenarios. We have also included a chapter describing GERD, which could present as chest pain and another chapter describing aortic dissection, which is a life-threatening disease presenting with chest pain. We hope that this book will serve as an accessible handbook on the differential diagnosis of chest pain.

Download or read book Cardiovascular Drug Therapy written by Adam Schneeweiss and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: The· first meeting of the cardiovascular drug therapy forum took place on April 13-15, 1988 in Montreux, Switzerland. In this meeting, which was closed to the public, approximately 150 leading investigators in the field of cardiovascular drug therapy, both academics and from the pharmaceutical industry, discussed the state of the art and future trends of this rapidly expanding field. The discussions concentrated on four major topics: (1) ischemic heart disease; (2) heart failure; (3) hyper tension; (4) arrhythmias. These topics were discussed by four committees in parallel, and thereafter the main points were reviewed by the whole forum. This framework allowed both intensive and interdisciplinary discussions. This book, the first publication of selected topics from the meeting, focuses mainly on nitrate therapy in ischemic heart disease and heart failure. Adam Schneeweiss, MD Chairman v Contents Opening Remarks . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Presentation of the Sir Thomas Lauder Brunton Award for Outstanding Nitrate Research . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Origins of Symptoms in Heart Failure - Relevance in Evaluation of New Drugs . . . . . . . . . . . . . . . . . . . . 5 Mononitrates in Congestive Heart Failure . . . . . . . . . . . . . . . . . 9 Are There Differences Between the Various Formulations of Nitrates in Heart Failure? . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 11 Long-Term Nitrate Therapy - A Decade of Changing Concepts . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Nitrate Therapy in Angina Pectoris . . . . . . . . . . . . . . . . . . . . . . . . 23 Mononitrates . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 39 Transdermal Administration of Nitrates . . . . . . . . . . . . . . . . . . . 53 Nitrates in Angina Pectoris - Rationale of Use and Avoidance of Limitations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 67 Treatment of Congestive Heart Failure - Summary . . . . . . . .

Download or read book Clinical Pharmacology of Antianginal Drugs written by U. Abshagen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: When I was asked some years ago by the editors of the Handbook of Experimental Pharmacology to edit a new volume on Antianginal Drugs, I agreed on the condition that, in accordance with my scientific background, primary emphasis be given to clinical pharmacology and therapeutics. It soon turned out that, due to rapid developments in this field, nothing of the previous volume on Antianginal Drugs by Charlier (Vol. 31, 1971) could be retained apart from its basic idea of devoting considerable space to methodology. Since editors must operate within certain limits, I had to abstain from dealing with acute myocardial infarction in detail despite the well-known overlap between unstable angina, the preinfarction syndrome, and acute myocardial infarction. It was only possible for acute myocardial infarction and the concept of reduction of infarct size to be briefly discussed within the chapter on pathophysiology of acute coronary insufficiency. The chapter on invasive methods provided an opportunity to touch on new approaches to early intervention in acute myocardial infarction. Here, intracoronary streptokinase therapy and PTCA are considered, again with attention to the overlap between mechanical and pharmacological interventions.

Download or read book Davis s Drug Guide for Rehabilitation Professionals written by Charles D. Ciccone and published by F.A. Davis. This book was released on 2013-03-21 with total page 1217 pages. Available in PDF, EPUB and Kindle. Book excerpt: A one-of-a-kind guide specifically for rehabilitation specialists! A leader in pharmacology and rehabilitation, Charles Ciccone, PT, PhD offers a concise, easy-to-access resource that delivers the drug information rehabilitation specialists need to know. Organized alphabetically by generic name, over 800 drug monographs offer the most up-to-date information on drug indications, therapeutic effects, potential adverse reactions, and much more! A list of implications for physical therapy at the end of each monograph helps you provide the best possible care for your patients. It’s the perfect companion to Pharmacology in Rehabilitation, 4th Edition!

Download or read book Guidelines for the clinical evaluation of anti anginal drugs written by and published by . This book was released on 1977 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Angina Pectoris written by Desmond Gareth Julian and published by . This book was released on 1985 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Scientific Basis of Healthcare written by Colin R. Martin and published by CRC Press. This book was released on 2011-12-20 with total page 224 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practice and Procedures are continually changing with a corresponding improvement in healthcare. Concomitantly, the demand for comprehensive and focused evidenced-based text and scientific literature covering single areas of nursing and healthcare science or treatment has also increased. The volume on Angina covers, inter alia, epidemiology of angina, coronary plaque rupture, angina questionnaires,American College of Cardiology/American Heart Association guidelines for nursing care, non-invasive coronary angiography, drugs used in angina, thrombin inhibitors, and external counterpulsation therapy.

Download or read book The Clinical Evaluation of New Drugs written by Sholom Omi Waife and published by . This book was released on 1959 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Arzneimittel / Test / Klinik.

Download or read book The Evaluation of Beat Blocker and Calcium Antagonist Drugs written by J. Morganroth and published by Springer. This book was released on 1982-02-28 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the beginning of the 1980's it was becoming increasingly evident that the lack of approval of new cardiovascular agents for use by clinicians in the United States for the treatment of cardiovascular disorders was becoming a problem. Patients requiring medical therapy for hypertension, angina pectoris, arrhythmias, congestive heart failure, and vasospastic disorders of the coronary arteries could receive in the United States only a small number of the drugs available to physicians in the rest of the world. In fact, as the 1980's began, there was only one available beta blocking agent released by The Food and Drug Administration; and even as of this writing, no oral calcium antagonist agent. This lag, in part, has been due to the confusion of proper and expeditious methods to define safety and efficacy of such agents so that the United States regulatory agency (Food and Drug Administration) could approve the use of such agents by clinicians. The vast number of new beta blocker and calcium antagonist agents being developed, as well as the long-term use abroad of many new drugs, has raised important questions as to how relative safety and efficacy of such agents can be determined to facilitate availability in the United States.

Download or read book Clinical Methods written by Henry Kenneth Walker and published by Butterworth-Heinemann. This book was released on 1990 with total page 1128 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the techniques and analysis of clinical data. Each of the seventeen sections begins with a drawing and biographical sketch of a seminal contributor to the discipline. After an introduction and historical survey of clinical methods, the next fifteen sections are organized by body system. Each contains clinical data items from the history, physical examination, and laboratory investigations that are generally included in a comprehensive patient evaluation. Annotation copyrighted by Book News, Inc., Portland, OR

Download or read book Organic Nitrates written by P. Needleman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nitroglycerin and other organic nitrates have been used for over a century in the treatment of angina pectoris. Millions of patients, throughout the world, have placed nitroglycerin tablets under the tongue and have experienced rapid and dramatic relief from the chest pain that frequently occurs as a manifestation of disease of the coronary arteries. The empirical observation of the safe use of nitrates for tile alleviation of the symptoms of angina have led to their widespread medical acceptance. The use of organic nitrates preceded any knowledge of their mechanism of action or their ultimate metabolic fate. Thus, more simply stated, although sub lingual nitrates helped the patients, little was known concerning what these drugs do to the body or what the body does to the drugs. A substantial number of investigators have focused on these questions especially during the last two decades. We now have considerably more insight into the pathways of degradation of organic nitrates and the relationship of the metabolic processes to the biological action of these agents. Similarly, considerable effort has been expended in understanding the mechanism of action of these agents directly on vascular smooth muscle and on cardiac work and performance. Finally, there is a more substantive understanding of the physiology of the coronary circulation as well as the" pathophysiologic manifestations of myocardial disease.