Download or read book Disordered Minds written by Ian Hughes and published by John Hunt Publishing. This book was released on 2018-09-28 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disordered Minds offers a compelling and timely account of the dangers posed by narcissistic leaders, and provides a stark warning that the conditions in which this psychopathy flourishes - extremes of social inequality and a culture of hyper-individualism - are the hallmarks of our present age. 'An excellent account of how malignant narcissism is evident in the lives of the great dictators, and how the conditions in which this psychopathy flourishes have returned to haunt us.' Dr Kieran Keohane, editor of The Social Pathologies of Contemporary Civilization
Download or read book Mentally Disordered Offenders written by Robert Harris and published by Routledge. This book was released on 2002-01-04 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Topical theme of mentally disordered offenders. Reputation of Herschel Prins, Editors and Contributors.
Download or read book Intrinsically Disordered Proteins written by and published by Academic Press. This book was released on 2018-11-21 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intrinsically Disordered Proteins, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics of interest, including the Characterization of Structure-Function relationships in the intrinsically disordered protein complexin, Distances, distance distributions, and ensembles of IDPs from single-molecule FRET, Biophysical characterization of disordered protein liquid phases, The Use of Mass Spectrometry to Examine IDPs – Unique Insights and Caveats, Fluorescence Depolarization Kinetics to Study Conformational Preference, Structural Plasticity and Membrane Binding of Intrinsically Disordered Proteins, Characterizing the Function of Intrinsically Disordered Proteins in the Circadian Clock, and more. - Breadth of experimental approaches and systems that will be covered - The expertise of the contributors writing the articles
Download or read book Disordered Semiconductors Second Edition written by Anatoly Popov and published by CRC Press. This book was released on 2018-08-01 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt: Devices based on disordered semiconductors have wide applications. It is difficult to imagine modern life without printers and copiers, LCD monitors and TVs, optical disks, economical solar cells, and many other devices based on disordered semiconductors. However, nowadays books that discuss disordered (amorphous, nanocrystalline, microcrystalline)
Download or read book Disordered Materials written by S. K. Tripathi and published by Alpha Science Int'l Ltd.. This book was released on 2003 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the National Conference on "Recent Developments on Disordered Materials", held in Dept. of Physics, Panjab University, Chandigarh, on 15-16 March, 2001; contributed papers.
Download or read book The Disordered Mind written by Eric R. Kandel and published by Farrar, Straus and Giroux. This book was released on 2018-08-28 with total page 317 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Nobel Prize–winning neuroscientist’s probing investigation of what brain disorders can tell us about human nature Eric R. Kandel, the winner of the Nobel Prize in Physiology or Medicine for his foundational research into memory storage in the brain, is one of the pioneers of modern brain science. His work continues to shape our understanding of how learning and memory work and to break down age-old barriers between the sciences and the arts. In his seminal new book, The Disordered Mind, Kandel draws on a lifetime of pathbreaking research and the work of many other leading neuroscientists to take us on an unusual tour of the brain. He confronts one of the most difficult questions we face: How does our mind, our individual sense of self, emerge from the physical matter of the brain? The brain’s 86 billion neurons communicate with one another through very precise connections. But sometimes those connections are disrupted. The brain processes that give rise to our mind can become disordered, resulting in diseases such as autism, depression, schizophrenia, Parkinson’s, addiction, and post-traumatic stress disorder. While these disruptions bring great suffering, they can also reveal the mysteries of how the brain produces our most fundamental experiences and capabilities—the very nature of what it means to be human. Studies of autism illuminate the neurological foundations of our social instincts; research into depression offers important insights on emotions and the integrity of the self; and paradigm-shifting work on addiction has led to a new understanding of the relationship between pleasure and willpower. By studying disruptions to typical brain functioning and exploring their potential treatments, we will deepen our understanding of thought, feeling, behavior, memory, and creativity. Only then can we grapple with the big question of how billions of neurons generate consciousness itself.
Download or read book The Disordered Cosmos written by Chanda Prescod-Weinstein and published by Bold Type Books. This book was released on 2021-03-09 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: From a star theoretical physicist, a journey into the world of particle physics and the cosmos—and a call for a more liberatory practice of science. Winner of the 2021 Los Angeles Times Book Prize in Science & Technology A Finalist for the 2022 PEN/E.O. Wilson Literary Science Writing Award A Smithsonian Magazine Best Science Book of 2021 A Symmetry Magazine Top 10 Physics Book of 2021 An Entropy Magazine Best Nonfiction Book of 2020-2021 A Publishers Weekly Best Nonfiction Book of the Year A Kirkus Reviews Best Nonfiction Book of 2021 A Booklist Top 10 Sci-Tech Book of the Year In The Disordered Cosmos, Dr. Chanda Prescod-Weinstein shares her love for physics, from the Standard Model of Particle Physics and what lies beyond it, to the physics of melanin in skin, to the latest theories of dark matter—along with a perspective informed by history, politics, and the wisdom of Star Trek. One of the leading physicists of her generation, Dr. Chanda Prescod-Weinstein is also one of fewer than one hundred Black American women to earn a PhD from a department of physics. Her vision of the cosmos is vibrant, buoyantly nontraditional, and grounded in Black and queer feminist lineages. Dr. Prescod-Weinstein urges us to recognize how science, like most fields, is rife with racism, misogyny, and other forms of oppression. She lays out a bold new approach to science and society, beginning with the belief that we all have a fundamental right to know and love the night sky. The Disordered Cosmos dreams into existence a world that allows everyone to experience and understand the wonders of the universe.
Download or read book The Disordered Body written by Suzanne E. Hatty and published by State University of New York Press. This book was released on 1999-11-04 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Disordered Body presents a fascinating look at how three epidemics of the medieval and Early Renaissance period in Western Europe shaped and altered conceptions of the human body in ways that continue today. Authors Suzanne E. Hatty and James Hatty show the ways in which concepts of the disordered body relate to constructions of disease. In so doing, they establish a historical link between the discourses of the disordered body and the constructs of gender. The ideas of embodiment, contagion and social space are placed in historical context, and the authors argue that our current anxieties about bodies and places have important historical precedents. They show how the cultural practices of embodied social interaction have been shaped by disease, especially epidemics.
Download or read book Intrinsically Disordered Proteins written by Nicola Salvi and published by Academic Press. This book was released on 2019-06-14 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intrinsically Disordered Proteins: Dynamics, Binding, and Function thoroughly examines and ties together the fundamental biochemical functions of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs), including signaling, binding, and regulation, with the methodology for study and the associated pathways for drug design and therapeutic intervention. The role of new mechanistic, computational, and experimental approaches in IDP study are explored in depth, with methods for the characterization of IDP dynamics; models, simulations, and mechanisms of IDP and IDR binding; and biological and medical implications of IDP dynamics prominently featured. Written and edited by leading scientists in the field, this book explores groundbreaking areas such as ensemble descriptions of IDPs and IDRs, single-molecule studies of IDPs and IDRs, IDPs and IDRs in membraneless organelles, and molecular mechanisms of fibrillation of IDPs. Intrinsically Disordered Proteins provides students and researchers in biochemistry, molecular biology, and applied microbiology with a comprehensive and updated discussion of the complex dynamics of IDPs and IDRs. - Provides in-depth discussion of fundamental IDP and IDR dynamics, function, and binding, with mechanistic insight to support new drug development - Describes the role of new computational and experimental approaches in characterizing the binding of IDPs to their functional targets - Features chapter contributions from international experts in IDP and IDR biochemical function and methods of study
Download or read book Intrinsically Disordered Proteins written by Vladimir N. Uversky and published by Springer. This book was released on 2014-08-05 with total page 73 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this brief, Vladimir Uversky discusses the paradigm-shifting phenomenon of intrinsically disordered proteins (IDPs) and hybrid proteins containing ordered domains and functional IDP regions (IDPRs). Beginning with an introduction to the concept of protein intrinsic disorder, Uversky then goes on to describe the peculiar amino acid sequences of IDPs, their structural heterogeneity, typical functions and disorder-based binding modes. In the final sections, Uversky discusses IDPs in human diseases and as potential drug targets. This volume provides a snapshot to researchers entering the field as well as providing a current overview for more experienced scientists in related areas.
Download or read book The Wiley Blackwell Handbook of Disordered Gambling written by David C. S. Richard and published by John Wiley & Sons. This book was released on 2013-12-04 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Wiley-Blackwell Handbook of Disordered Gambling is a complete guide to the current empirical literature relating to the conceptualization, assessment, and treatment of disordered gambling. The international contributors are all experienced, practicing clinicians who discuss gambling within a global context. Best-practice guidelines for the clinical management of problem and disordered gambling Contains empirically derived findings that translate research into practical clinical applications that clinicians and counselors can use in understanding and treating problem gamblers Brings together a distinguished international group of scholars whose contributions discuss gambling as it occurs around the globe Clearly organized into sections that cover conceptualization, research, assessment, treatment, and special topics
Download or read book Dancing protein clouds Intrinsically disordered proteins in health and disease Part A written by and published by Academic Press. This book was released on 2019-09-12 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.
Download or read book Violence Crime and Mentally Disordered Offenders written by Sheilagh Hodgins and published by John Wiley & Sons. This book was released on 2000-06-08 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mentally disordered criminal is a public nightmare, and themanagement of these offenders can be driven as much by politicaland economic concerns as by scientific evidence and professionaljudgement within the fields of mental health and correctionservices. This book aims to provide a critical and focused reviewof knowledge and best practice in this field for mental health andcorrection professionals and for those concerned with policy andmanagement of services for these offenders. Mentally disordered offenders include offenders who suffer fromschizophrenia, major affective disorders, personality disorders(including psychopathy), brain damage, and mental retardation. Thetopic is of increasing importance because of the growth ofcommunity psychiatry, and the growing community programmes foroffenders, and also because of the growing pressures on thoseinstitutions which deal with offenders and care for the mentallydisordered or disabled. Professionals in these fields will welcomethis book which: * Provides a review of approaches to treatment, accessible to awide mental health and forensic readership * Relates treatment approaches to specific mental problems, andreviews evidence of effectiveness * features a truly international group of authors bringing togethera wide variety of approaches, scientific research, and practicalexperience of important programmes for treatment and prevention "Few recent texts provide both the depth and breadth necessary tounderstand the vexing behaviour of mentally disordered offenders.Drs Hodgins and Muller-Isberner, a remarkable pairing of researchand clinical expertise, have put together a highly readable andsuperb resource for anyone interested in this interface of seriousmental illness and criminal behavior. The authors of theconstituent chapters are leading authorities in their respectiveareas and have provided thoughtful commentary on the most recentinternational literature. This is a first-rate treatment of arapidly growing and fascinating field." Marvin Swartz, DukeUniversity, USA
Download or read book Structure and Function of Intrinsically Disordered Proteins written by Peter Tompa and published by CRC Press. This book was released on 2009-11-18 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: The existence and functioning of intrinsically disordered proteins (IDPs) challenge the classical structure-function paradigm that equates function with a well-defined 3D structure. Uncovering the disordered complement of proteomes and understanding their functioning can extend the structure-function paradigm to herald new breakthroughs in drug dev
Download or read book Disordered Thinking and the Rorschach written by James H. Kleiger and published by Routledge. This book was released on 2013-04-15 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Disordered Thinking and the Rorschach, James Kleiger provides a thoroughly up-to-date text that covers the entire range of clinical and diagnostic issues associated with the phenomenon of disordered thinking as revealed on the Rorschach. Kleiger guides the reader through the history of psychiatric and psychoanalytic conceptualizations of the nature and significance of different kinds of disordered thinking and their relevance to understanding personality structure and differential diagnosis. He then moves on to thorough reviews of the respective contributions of David Rapaport, Robert Holt, Philip Holzman, and John Exner in conceptualizing and scoring disordered thinking on the Rorschach. These synopses are followed by an equally fascinating examination of less well known research conceptualizations, which, taken together, help clarify the basic interpretive conundrums besetting the major systems. Finally, having brought the reader to a full understanding of systematic exploration to date, Kleiger enters into a detailed analysis of the phenomenological and psychodynamic aspects of disordered thinking per se. Even experienced clinicians will find themselves challenged to reconceptualize such familiar categories as confabulatory or combinative thinking in a manner that leads not only to new diagnostic precision, but also to a richer understanding of the varieties of thought disturbances with their equally variable therapeutic and prognostic implications. With Disordered Thinking and the Rorschach, Kleiger has succeeded in summarizing a wealth of experience pertaining to the rigorous empirical detection and classification of disordered thinking. Equally impressive, he has taken full advantage of the Rorschach as an assessment instrument able to capture the richness of personality and thus capable of providing a unique clinical window into those crucially important differences in the quality of thought that patients may evince.
Download or read book Physics of Disordered Materials written by David Adler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 835 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume and its two companion volumes, entitled Tetrahedrally-Bonded Amorphous Semiconductors and Localization and Metal-Insulator Transitions, are our way of paying special tribute to Sir Nevill Mott and to express our heartfelt wishes to him on the occasion of his eightieth birthday. Sir Nevill has set the highest standards as a physicist, teacher, and scientific leader. Our feelings for him include not only the respect and admiration due a great scientist, but also a deep affection for a great human being, who possesses a rare combination of outstanding personal qualities. We thank him for enriching our lives, and we shall forever carry cherished memories of this noble man. Scientists best express their thanks by contributing their thoughts and observations to a Festschrift. This one honoring Sir Nevill fills three volumes, with literally hundreds of authors meeting a strict deadline. The fact that contributions poured in from all parts of the world attests to the international cohesion of our scientific community. It is a tribute to Sir Nevill's stand for peace and understanding, transcending national borders. The editors wish to express their gratitude to Ghazaleh Koefod for her diligence and expertise in deciphering and typing many of the papers, as well as helping in numerous other ways. The blame for the errors that remain belongs to the editors.
Download or read book A First Principles Study of Highly Anharmonic and Dynamically Disordered Solids written by Johan Klarbring and published by Linköping University Electronic Press. This book was released on 2020-05-06 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis is a first-principles theoretical investigation of solid materials with high degrees of anharmonicity. These are systems where the dynamics of the constituent atoms is too complex to be well-described by a set of uncoupled harmonic oscillators. While theoretical studies of such systems pose a significant challenge, they are under increasing demand due to the prevalence of these sytems in next-generation technological applications. Indeed, very anharmonic systems are ubiquitous in envisioned materials for future solid-state batteries and fuel-cells, thermoelectrics and optoelectronics. In some of these cases, the anharmonicity is a “side-effect” that simply has to be dealt with in order to accurately model certain properties, while in other cases the anharmonicity is the origin of the high-performance of the material. There are two main parts to the thesis: The first is on materials with perovskite-related structures. This is a very large class of materials, members of which are typically highly anharmonic, not least in relation to a series of complex phase transformations between different structural modifications. In the thesis, I have studied a specific class of such phase-transformations that relate to tilting of the framework of octahedra that make up the structure. The oxide CaMnO3 and a set of inorganic halide perovskites were taken as model systems. The results shed some light on the experimentally observed differences between the local and average atomic structure in these systems. I have further studied Cs2AgBiBr6, a member of the so-called lead-free halide double perovskites. I rationalized its temperature induced phase transformation and found high degrees of anharmonicity and ultra-low thermal conductivity. Finally, I studied the influence of nuclear quantum effects, which are often ignored in computational modelling, on the structure and bonding in the hybrid organic-inorganic lead-halide perovskite, CH3NH3PbI3. The second part of the thesis deals with theoretical studies of the phase stability of dynamically disordered solids. These are solids which have some sort of time-averaged long-range order, characteristic of a crystalline solid, but where the anharmonicity is so strong that the basic concept of an equilibrium atomic position cannot be statically assigned to all atoms. Examples include certain solids with very fast ionic conduction, so called superionics, and solids with rotating molecular units. This absence of equilibrium atomic positions makes many standard computational techniques to evaluate phase-stability inapplicable. I outline a method to deal with this issue, which is based on a stress-strain thermodynamic integration on a deformation path from an ordered variant to the dynamically disordered phase itself. I apply the method to study the phase stability of the high-temperature ?-phase of Bi2O3, which is the fastest know solid oxide ion conductor, and to Li2C2, whose high temperature cubic phase contains rotating C2 dimers. The thesis exemplifies the need to go beyond many of the standard approximations used in first-principles computational materials science if accurate theoretical predictions are to be made. This is true, in particular, for many emerging material classes in the field of energy materials. I den konventionella teoretiska modellen för ett (kristallint) fast material antags varje atom kunna tillordnas en jämviktsposition. Rörelsen av atomerna runt dessa jämviktspositioner antags sedan ofta vara harmoniskt, d.v.s. hyfsat kunna beskrivs i termer av en samling (kvantmekaniska) fjädrar. Denna avhandling behandlar teori- och beräkningsstudier av material där ett eller båda av dessa antaganden inte är giltiga, så kallade anharmoniska material. En nogrann teoretisk behandling av sådana material är ofta ordentligt utmanande. I takt med en snabb teknologiska utveckling ställs allt mer specifika och stränga krav på de material som behövs för diverse applikationer. Inom flertalet områden dyker då denna typ av komplexa och anharmoniska material upp som potentiella kandidater. Till exempel som fastelektrolyter för batterier och bränsleceller eller som solcellsmaterial. Inom vissa applikationer är denna anharmonicitet en bieffekt som man helt enkelt måste ta hänsyn till för att kunna göra noggranna teoretiska förutsägelser om diverse materialegenskaper, i andra fall är anharmoniciteten själva ursprunget för materialets goda egenskaper. I den första delen av avhandlingen behandlar jag material som har, eller är nära relaterade till, den så kallade perovskitstrukturen. Detta är en väldigt stor klass av material, och strukturen dyker därför upp inom en mängd olika tillämpningar, inte minst i lovande solcellsmaterial. Dessa material är ofta mycket anharmoniska, vilket tar sig uttryck bland annat i en rad komplexa fastransformationer mellan olika typer av perovskitmodifikationer. I perovskitoxiden CaMnO3, samt i en samling halogenperovskiter, har jag har studerat en specifik typ av fastransformationer som tillkommer på grund av rotationer av de oktaedrar som utgör en del av strukturen. Jag har fortsatt studerat den väldigt kraftiga anharmoniciteten i den så kallade blyfria halogendubbelperovskiten Cs2AgBiBr6, och slutligen har jag studerat hur en kvantmekanisk behandling av atomkärnorna, något som oftast inte görs, påverkar materialegenskaper i CH3NH3PbI3, en så kallad hybrid organisk-inorganisk bly-halogenperovskit, som är ett extremt lovande solcellsmaterial. I den andra delen av avhandlingen studerar jag dynamiskt oordnade fasta material. I dessa material är atomernas rörelse för komplex för att varje atom ska kunna tilldellas en statisk jämviktsposition. Material i denna klass är, till exempel, lovande som fastelektrolyter i bränsleceller och batterier. Mer specifikt studerar jag en typ av fasövergång, från en ordnad fas till en fas med dynamisk oordning, som ofta sker när dessa material värms upp. Jag introducerar en beräkningsmetod för att utvärdera deras fasstabilitet. Metoden är baserad på en så kallad termodynamisk integration, utförd mellan en ordnad variant och den dynamiskt oordnade fasen själv. Metoden gör det möjligt att beräkna fastransformationstemperaturer i denna typ av material. Jag applicerar metoden på Bi2O3, som i sin ?-fas är det fasta material med högst känd syrejonledningsförmåga, samt på Li2C2 vars kubiska fas innehåller roterande C2 molekyler. Resultaten stämmer bra överens med kända experimentella mätningar.
