Download or read book Chronicles of Drug Discovery written by Jasjit S. Bindra and published by Wiley-Interscience. This book was released on 1993 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Knowledge Discovery with Support Vector Machines written by Lutz H. Hamel and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 211 pages. Available in PDF, EPUB and Kindle. Book excerpt: An easy-to-follow introduction to support vector machines This book provides an in-depth, easy-to-follow introduction to support vector machines drawing only from minimal, carefully motivated technical and mathematical background material. It begins with a cohesive discussion of machine learning and goes on to cover: Knowledge discovery environments Describing data mathematically Linear decision surfaces and functions Perceptron learning Maximum margin classifiers Support vector machines Elements of statistical learning theory Multi-class classification Regression with support vector machines Novelty detection Complemented with hands-on exercises, algorithm descriptions, and data sets, Knowledge Discovery with Support Vector Machines is an invaluable textbook for advanced undergraduate and graduate courses. It is also an excellent tutorial on support vector machines for professionals who are pursuing research in machine learning and related areas.

Download or read book History of the United States of America written by George Bancroft and published by . This book was released on 1883 with total page 660 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Discovery of the Third World written by Christoph Kalter and published by Cambridge University Press. This book was released on 2016-09-12 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the emergence of 'Third Worldism' as a new intellectual movement during the era of decolonisation and the Cold War.

Download or read book Drug Discovery written by Walter Sneader and published by John Wiley & Sons. This book was released on 2005-06-23 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edition provides expanded coverage of pre-20th century drugs, including emphasis on setting chapters in a wide historical and social context.

Download or read book Models of Discovery and Creativity written by Joke Meheus and published by Springer Science & Business Media. This book was released on 2009-10-08 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the origin of the modern sciences, our views on discovery and creativity had a remarkable history. Originally, discovery was seen as an integral part of methodology and the logic of discovery as algorithmic or nearly algorithmic. During the nineteenth century, conceptions in line with romanticism led to the famous opposition between the context of discovery and the context of justification, culminating in a view that banned discovery from methodology. The revival of the methodological investigation of discovery, which started some thirty years ago, derived its major impetus from historical and sociological studies of the sciences and from developments within cognitive psychology and artificial intelligence. Today, a large majority of philosophers of science agrees that the classical conception as well as the romantic conception are mistaken. Against the classical conception, it is generally accepted that truly novel discoveries are not the result of simply applying some standardized procedure. Against the romantic conception, it is rejected that discoveries are produced by unstructured flashes of insight. An especially important result of the contemporary study concerns the availability of (descriptive and normative) models for explaining discoveries and creative processes. Descriptive models mainly aim at explaining the origin of novel products; normative models moreover address the question how rational researchers should proceed when confronted with problems for which a standard procedure is missing. The present book provides an overview of these models and of the important changes they induced within methodology. As appears from several papers, the methodological study of discovery and creativity led to profound changes in our conceptions of justification and acceptance, of rationality, of scientific change, and of conceptual change. The book contains contributions from both historians and philosophers of science. All of them, however, are methodological in the contemporary sense of the term. The central values of this methodology are empirical accurateness, clarity and precision, and rationality. The different contributions realize these values by their interdisciplinary nature. Some philosophically oriented papers rely on historical case studies and results from the cognitive sciences, others on recent results from the computer sciences and/or non-standard logics. The historically oriented papers address central philosophical questions and hypotheses.

Download or read book Carney V Union Pacific Railroad Company written by and published by . This book was released on 2015 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Data Mining written by Krzysztof J. Cios and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 601 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive textbook on data mining details the unique steps of the knowledge discovery process that prescribes the sequence in which data mining projects should be performed, from problem and data understanding through data preprocessing to deployment of the results. This knowledge discovery approach is what distinguishes Data Mining from other texts in this area. The book provides a suite of exercises and includes links to instructional presentations. Furthermore, it contains appendices of relevant mathematical material.

Download or read book Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases written by Goutam Brahmachari and published by Elsevier. This book was released on 2019-04-15 with total page 461 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more. In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases. - Includes chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery - Draws together cutting-edge research advances in natural product chemistry that are targeted at neglected tropical diseases - Highlights the future potential of natural products as sources of novel medicinal compounds against neglected tropical diseases

Download or read book Report written by Indiana State Library and published by . This book was released on 1900 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Star Trek Discovery Aftermath written by Kirsten Beyer and published by IDW Publishing. This book was released on 2020-04-08 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Witness the Aftermath of the stunning second season of Star Trek: Discovery! An all-new graphic novel that ties directly into Season Two of the hit CBS All Access series! After the disappearance of the U.S.S. Discovery, Captain Pike and Chancellor L'Rell seek to forge a peace treaty between the Federation and the Klingons. But when a new enemy threatens to sabotage the negotiations, Spock must reclaim his place in Starfleet to save his friends and prevent the outbreak of a new war!

Download or read book Improving Almost Anything written by George E. P. Box and published by Wiley-Interscience. This book was released on 2006-04-21 with total page 638 pages. Available in PDF, EPUB and Kindle. Book excerpt: Masterworks in process improvement and quality technology— by George Box and friends George Box has a unique ability to explain complex ideas simply and eloquently. This revised edition of his masterworks since 1982 clearly demonstrates the range of his wit and intellect. These fascinating readings represent the cornerstones in the theory and application of process improvement, product design, and process control. Readers will gain valuable insights into the fundamentals and philosophy of scientific method using statistics and how it can drive creativity and discovery. The book is divided into five key parts: Part A, Some Thoughts on Quality Improvement, concerns the democratization of the scientific method and, in such papers as "When Murphy Speaks—Listen," advises managers to view operation of their processes as ongoing opportunities for improvement. Part B, Design of Experiments for Process Improvement, illustrates the enormous advantages offered by experimental design in the pursuit of better products and processes. Part C, Sequential Investigation and Discovery, shows how sequential assembly of designs allows the experimenter to match the difficulty of the problem with the effort needed to solve it. Part D, Control, describes application of feedback control in the Statistical Process Control (SPC) environment. A simple graphical technique using Box-Jenkins charts is set forth to appropriately adjust processes to target. Part E, Variance Reduction and Robustness, demonstrates how the existence of more than one source of variation may be used to achieve products robust to the environment in which they must function and emphasizes the importance of error transmission and data transformation in producing robust assemblies. A Foreword by Dr. J. Stuart Hunter allows readers to gain insight into the workings of a remarkable mind and explains how these ideas can greatly catalyze their efforts in process improvement.

Download or read book A Voyage of Discovery to the North Pacific Ocean written by George Vancouver and published by . This book was released on 1801 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Journals of Captain James Cook on his Voyages of Discovery written by J.C. Beaglehole and published by Routledge. This book was released on 2017-07-05 with total page 1039 pages. Available in PDF, EPUB and Kindle. Book excerpt: Captain James Cook’s first two voyages of exploration, in 1768-71 and 1772-75, had drawn the modern map of the South Pacific Ocean and had opened the door on the discovery of Antarctica. These expeditions were the subject of Volumes I and II of this edition of Cook’s Journals. The third voyage, on which Cook sailed in 1776, was directed to the Northern Hemisphere. Sailing north from Tahiti in 1778, Cook made the first recorded discovery of the Hawaiian Islands. On March 7 he sighted the Oregon coast in 44° N. The remarkable voyage which he made northward along the Canadian and Alaskan coasts and through Bering Strait to his farthest north in 70° nearly disproved the existence of a navigable passage towards the Atlantic and produced charts of impressive accuracy. Returning to Hawaii to refit, Cook met his death in a clash with the natives as tragic as it seems unnecessary. The volume and vitality of the records, both textual and graphic, for this voyage surpass those even for Cook’s second voyage. Dr Beaglehole prints the full text of Cook’s own holograph journals, followed by those of Captains Clerke and King for the course of the voyage after Cook’s death. This is a facsimile reprint of the edition published in 1967. For the print-on-demand edition, the illustrations originally in colour are reproduced in black-and-white, the fold-outs divided to fit on separate pages, and the volume itself split into two parts.

Download or read book Cosmic Discovery written by Martin Harwit and published by Cambridge University Press. This book was released on 2019-03-21 with total page 375 pages. Available in PDF, EPUB and Kindle. Book excerpt: The search -- Discoveries -- Observation -- Detection, recognition, and classification of cosmic phenomena -- The fringes of legitimacy : the need for enlightened planning.

Download or read book Historical Dictionary of the Discovery and Exploration of the Northwest Passage written by Alan Day and published by Scarecrow Press. This book was released on 2006-01-03 with total page 475 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Northwest Passage was repeatedly sought for over four centuries. From the first attempt in the late 15th century to Roald Amundsen's famous voyage of 1903-1906 where the feat was first accomplished to expeditions in the late 1940s by the Mounties to discover an even more northern route, author Alan Day covers all aspects of the ongoing quest that excited the imagination of the world. This compendium of explorers, navigators, and expeditions tackles this broad topic with a convenient, but extensive cross-referenced dictionary. A chronology traces the long succession of treks to find the passage, the introduction helps explain what motivated them, and the bibliography provides a means for those wishing to discover more information on this exciting subject.

Download or read book Burger s Medicinal Chemistry Drug Discovery and Development 8 Volume Set written by and published by John Wiley & Sons. This book was released on 2021-04-20 with total page 6057 pages. Available in PDF, EPUB and Kindle. Book excerpt: Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures. Along with the incorporation of practical material on drug hunting, the set features sections on drug discovery, drug development, cardiovascular diseases, metabolic diseases, immunology, cancer, anti-Infectives, and CNS disorders. The text continues the legacy of previous volumes in the series by providing recognized, renowned, authoritative, and comprehensive information in the area of drug discovery and development while adding cutting-edge new material on issues like the use of artificial intelligence in medicinal chemistry. Included: Volume 1: Methods in Drug Discovery, edited by Kent D. Stewart Volume 2: Discovering Lead Molecules, edited by Kent D. Stewart Volume 3: Drug Development, edited by Ramnarayan S. Randad and Michael Myers Volume 4: Cardiovascular, Endocrine, and Metabolic Diseases, edited by Scott D. Edmondson Volume 5: Pulmonary, Bone, Immunology, Vitamins, and Autocoid Therapeutic Agents, edited by Bryan H. Norman Volume 6: Cancer, edited by Barry Gold and Donna M. Huryn Volume 7: Anti-Infectives, edited by Roland E. Dolle Volume 8: CNS Disorders, edited by Richard A. Glennon Perfect for research departments in the pharmaceutical and biotechnology industries, Burger’s Medicinal Chemistry, Drug Discovery and Development can be used by graduate students seeking a one-stop reference for drug development and discovery and deserves its place in the libraries of biomedical research institutes, medical, pharmaceutical, and veterinary schools.