Download or read book Directory of Agents Being Tested for Carcinogenicity Number 15 written by and published by . This book was released on 1992 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Some Antiviral and Antineoplastic Drugs and Other Pharmaceutical Agents written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 2000 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evaluates the carcinogenic risks to humans posed by the use of four antiretroviral agents four DNA topoisomerase II inhibitors used in the treatment of cancer and an additional three pharmaceutical agents (hydroxyures phenolphthalein and vitamin K substances). The volume marks the first IARC evaluation of nucleoside analogs that act as antiviral agents. The evaluation responds in part to recent findings that zidovudine (AZT) an effective antiretroviral agent now being given to pregnant HIV-infected women to prevent maternal-to-fetal transmission of the virus is a transplacental carcinogen in mice. The opening monograph evaluates the carcinogenicity to humans of the antiretroviral nucleoside analogs zidovudine (AZT) zalcitabine (ddC) and didanosine (ddI) and the antiherpesvirus drug aciclovir. Of these aciclovir and didanosine could not be classified on the basis of available data. For zidovudine transplacental administration to mice resulted in an increased incidence and multiplicity of lung and liver tumours and in an increased incidence of female reproductive tract tumours in one study but not in another involving treatment at a lower dose. Despite observation of toxic effects in some studies of humans human carcinogenicity data were judged to provide inadequate evidence of carcinogenicity in humans. Zidovudine was classified as possibly carcinogenic to humans. Similar weaknesses in human carcinogenicity data for zalcitabine which consistently induces thymic lymphomas in mice resulted in its classification as possibly carcinogenic to humans. The second monograph evaluates four DNA topoisomerase II inhibitors: etoposide teniposide mitoxantrone and amsacrine. Of these etoposide - one of the most widely used and effective cytotoxic drugs in combination therapy - was classified as probably carcinogenic to humans and etoposide in combination with cisplatin and bleomycin was judged to be carcinogenic to humans. Teniposide was classified as probably carcinogenic to humans and mitoxantrone and amsacrine were classified as possibly carcinogenic to humans. Of the three pharmaceutical agents evaluated in the final monograph hydroxyurea which is widely used in cancer treatment and increasingly in combination with didanosine in HIV infection could not be classified. Phenolphthalein a widely used laxative now being withdrawn from the market in many countries because of toxicological concerns was classified as possibly carcinogenic. Vitamin K substances could not be classified on the basis of available evidence.
Download or read book A Review of Human Carcinogens written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Conference and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Annual Report on Carcinogens written by and published by . This book was released on 1998 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Dictionary of Substances and Their Effects written by and published by Royal Society of Chemistry. This book was released on 1999 with total page 978 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Some Naturally Occurring Substances written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by World Health Organization. This book was released on 1993 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: Evaluates the carcinogenic risk to humans posed by the ingestion of several naturally occurring substances. Separate monographs are presented for two food items (salted fish and pickled vegetables), two naturally occurring plant substances (caffeic acid and d-limonene), four heterocyclic aromatic amines found in cooked meat and fish, and selected mycotoxins, including aflatoxins. The monograph on salted fish concentrates on fish as traditionally prepared in southern China, where very high rates of nasopharyngeal carcinoma have been linked to the consumption of salted fish prepared in a manner which involves putrefaction. The monograph concludes that Chinese-style salted fish is carcinogenic to humans. The second monograph concludes that pickled vegetables prepared according to traditional Asian methods are possibly carcinogenic to humans. Caffeic acid was judged to be possibly carcinogenic to humans. The report was unable to classify the carcinogenicity of d-limonene. For the heterocyclic aromatic amines present in cooked meat and fish, IQ was classified as probably carcinogenic to humans; MeIQ MeIQx and PhIP were classified as possibly carcinogenic. The most extensive monograph on aflatoxins concludes that naturally occurring mixtures of aflatoxins are carcinogenic to humans and that aflatoxin M1 occurring in milk is possibly carcinogenic. Toxins derived from Fusarium moniliforme and ochratoxin A, which has been linked to Balkan endemic nephropathy, were classified as possibly carcinogenic to humans. The remaining mycotoxins could not be classified.
Download or read book Red Meat and Processed Meat written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by International Agency for Research on Cancer. This book was released on 2018-07-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the IARC Monographs provides evaluations of the consumption of red meat and the consumption of processed meat. Red meat refers to unprocessed mammalian muscle meat (e.g. beef, veal, pork, lamb) including that which may be minced or frozen. Processed meat refers to meat that has been transformed through salting, curing, fermentation, smoking or other processes to enhance flavor or improve preservation. Most processed meats contain pork or beef, but may also contain other meats including poultry and offal (e.g. liver) or meat by-products such as blood. Red meat contains proteins of high biological value, and important micronutrients such as B vitamins, iron (both free iron and haem iron), and zinc. Carcinogens, including heterocyclic aromatic amines and polycyclic aromatic hydrocarbons, can be produced by cooking of meat, with greatest amounts generated at high temperatures by pan-frying, grilling, or barbecuing. Meat processing such as curing and smoking can result in formation of carcinogenic chemicals including N-nitroso compounds and polycyclic aromatic hydrocarbons. An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of the consumption of red meat and processed meat. The Working Group assessed more than 800 epidemiological studies that investigated the association of cancer (more than 15 types) with consumption of red meat or processed meat, including large cohorts in many countries, from several continents, with diverse ethnicities and diets.
Download or read book New Frontiers of Cancer Causation written by Iversen and published by CRC Press. This book was released on 1993-08-01 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: Proceedings of the Second International Conference on Theories of Carcinogenesis, held in Oslo, Norway, August 1992. The papers, which discuss principles and theories rather than experimental setups and results, cover a wide range of topics, including cell proliferation, metastasis, oncogenes, carcinogens, genetic alterations, viruses, immunology, and radiation. Also detailed are public attitudes toward cancer, as well as attitudes of professionals in cancer research. The volume concludes with some brief considerations from speakers and participants. Annotation copyright by Book News, Inc., Portland, OR
Download or read book The Dictionary of Substances and their Effects DOSE written by S D Gangolli and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 974 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition of The Dictionary and Substances and their Effects (DOSE) supersedes the renowned 1st edition. The 1st edition has been completely revised, updated and extended with all the latest significant data on the chemicals known to have adverse effects on lifeforms or the environment. The new edition is a must for all those who need easy access to a single source of the latest essential and fully referenced data on chemicals which are known to have significant toxic or environmental effects. The web database is ideal for targeted searches and customised data retrieval. The 2nd edition of DOSE includes new toxicity, environmental and regulatory data from the world's literature, presented in concise summaries. These new data are essential for the accurate assessment of the risks associated with the use and disposal of chemicals. Data on over 100 chemicals new to this edition have been added, including endocrine disruptors, food carcinogens, pesticides and compounds studied by IARC and NTP. All of the 4000 chemicals contained in the 1st edition have been reviewed. New and updated information for these chemicals includes: * occupational exposure limits for 6 countries * recent toxicity and ecotoxicity data * results of new carcinogenicity, mutagenicity and environmental fate studies * the latest regulatory requirements DOSE 2nd edition comprises 7 hardcover volumes covering over 4000 chemicals alphabetically, and includes indexes of substance names and synonyms, molecular formulae, and CAS Registry Numbers; glossaries of medical terms and Latin to English organism names; an abbreviations listing and a comprehensive guide to the types of data and their origin. DOSE is also available via Knovel's Engineering and Scientific Online Reference, located at www.knovel.com.
Download or read book Drinking Coffee Mate and Very Hot Beverages written by International Agency for Research on Cancer and published by . This book was released on 2019-05 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the IARC Monographs presents evaluations of the carcinogenic hazard to humans of drinking coffee and very hot beverages including, but not limited to, mate. An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays and co-carcinogenicity studies, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of drinking coffee, mate, and very hot beverages. The Working Group assessed more than 1000 observational and experimental studies that investigated the association between cancer at more than 20 sites with drinking coffee, mate, and very hot beverages.
Download or read book HMSO Agency Catalogue written by Great Britain. Her Majesty's Stationery Office and published by . This book was released on 1994 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book IARC Monographs on the Evaluation of Carcinogenic Risks to Humans written by and published by . This book was released on 1988 with total page 876 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Carcinogenesis written by Michael P Waalkes and published by CRC Press. This book was released on 1994-06-30 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carcinogens, like chemicals with other toxic hazards, often produce adverse effects only in specific organs or tissues. The factors determining whether a chemical induces cancer in an organ range from simple toxicokinetics to complex phenomena such as expression or lack of expression of specific genes.; This volume examines the site-specific factor
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1120 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Carcinogens and Anticarcinogens in the Human Diet written by National Research Council and published by National Academies Press. This book was released on 1996-03-12 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite increasing knowledge of human nutrition, the dietary contribution to cancer remains a troubling question. Carcinogens and Anticarcinogens assembles the best available information on the magnitude of potential cancer riskâ€"and potential anticarcinogenic effectâ€"from naturally occurring chemicals compared with risk from synthetic chemical constituents. The committee draws important conclusions about diet and cancer, including the carcinogenic role of excess calories and fat, the anticarcinogenic benefit of fiber and other substances, and the impact of food additive regulation. The book offers recommendations for epidemiological and diet research. Carcinogens and Anticarcinogens provides a readable overview of issues and addresses critical questions: Does diet contribute to an appreciable proportion of human cancer? Are there significant interactions between carcinogens and anticarcinogens in the diet? The volume discusses the mechanisms of carcinogenic and anticarcinogenic properties and considers whether techniques used to evaluate the carcinogenic potential of synthetics can be used with naturally occurring chemicals. The committee provides criteria for prioritizing the vast number of substances that need to be tested. Carcinogens and Anticarcinogens clarifies the issues and sets the direction for further investigations into diet and cancer. This volume will be of interest to anyone involved in food and health issues: policymakers, regulators, researchers, nutrition professionals, and health advocates.
Download or read book Some Chemicals Present in Industrial and Consumer Products Food and Drinking water written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by IARC Monographs on the Evaluat. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the IARC Monographs provides an assessment of the carcinogenicity of 18 chemicals present in industrial and consumer products or food (natural constituents, contaminants, or flavorings) or occurring as water-chlorination by-products. The compounds evaluated include the widely used plasticizer di(2-ethylhexyl) phthalate and the food contaminant 4-methylimidazole. In view of the limited agent-specific information available from epidemiological studies, the IARC Monographs Working Group relied mainly on carcinogenicity bioassays, and mechanistic and other relevant data to evaluate the carcinogenic hazards to humans exposed to these agents.
Download or read book Identifying and Regulating Carcinogens written by Lewis Publishers and published by CRC Press. This book was released on 2018-02-01 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: This excellent resource describes the various Federal agency programs, guidelines, laws, and requirements regarding potential exposure to carcinogens in the environment-ambient air, water, and soil-workplace environment-food and drugs and other consumer products. It covers 16 different programs, activities, and Federal agencies. The reader is provided insight into the background and rationale behind current Federal Policy and regulations relating to public health and potential carcinogenic hazards. Necessary differentiation among Hazard Identification, risk characterization, risk assessment, and risk management are clearly described. This guide should prove valuable to scientists, engineers, and managers-companies, governments, universities, and consultants.
