Download or read book Application of Systematic Review Methods in an Overall Strategy for Evaluating Low Dose Toxicity from Endocrine Active Chemicals written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-08-14 with total page 423 pages. Available in PDF, EPUB and Kindle. Book excerpt: To safeguard public health, the US Environmental Protection Agency (EPA) must keep abreast of new scientific information and emerging technologies so that it can apply them to regulatory decision-making. For decades the agency has dealt with questions about what animal-testing data to use to make predictions about human health hazards, how to perform dose-response extrapolations, how to identify and protect susceptible subpopulations, and how to address uncertainties. As alternatives to traditional toxicity testing have emerged, the agency has been faced with additional questions about how to incorporate data from such tests into its chemical assessments and whether such tests can replace some traditional testing methods. Endocrine active chemicals (EACs) have raised concerns that traditional toxicity-testing protocols might be inadequate to identify all potential hazards to human health because they have the ability to modulate normal hormone function, and small alterations in hormone concentrations, particularly during sensitive life stages, can have lasting and significant effects. To address concerns about potential human health effects from EACs at low doses, this report develops a strategy to evaluate the evidence for such low-dose effects.
Download or read book Toxicological Profile for Polybrominated Biphenyls and Polybrominated Diphenyl Ethers written by and published by . This book was released on 2004 with total page 628 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Child specific Exposure Factors Handbook written by and published by . This book was released on 2002 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book New Types of Persistent Halogenated Compounds written by Jaakko Paasivirta and published by Springer. This book was released on 2008-01-26 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Chemistry is a relatively young science. Interest in this subject, however, is growing very rapidly and, although no agreement has been reached as yet about the exact content and limits of this interdisciplinary discipline, there appears to be increasing interest in seeing environmental topics which are based on chemistry embodied in this subject. One of the first objectives of Environ mental Chemistry must be the study of the environment and of natural chemical processes which occur in the environment. A major purpose of this series on Environmental Chemistry, therefore, is to present a reasonably uniform view of various aspects of the chemistry of the environment and chemical reactions occurring in the environment. The industrial activities of man have given a new dimension to Environ mental Chemistry. We have now synthesized and described over five million chemical compounds and chemical industry produces about hundred and fifty million tons of synthetic chemicals annually. We ship billions of tons of oil per year and through mining operations and other geophysical modifications, large quantities of inorganic and organic materials are released from their natural deposits. Cities and metropolitan areas of up to 15 million inhabitants produce large quantities of waste in relatively small and confined areas. Much of the chemical products and waste products of modern society are released into the environment either during production, storage, transport, use or ultimate disposal. These released materials participate in natural cycles and reactions and frequently lead to interference and disturbance of natural systems.
Download or read book Polybrominated diphenyl ethers food contamination and potential risks report from a NNT group written by and published by Nordic Council of Ministers. This book was released on 1998 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Determination of Polybrominated Diphenyl Ethers PBDEs in Sediment and Biota written by L. Webster and published by . This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fast Facts written by and published by . This book was released on 2010 with total page 3 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transport and Fate of Polybrominated Diphenyl Ethers in the Baltic and Arctic Regions written by Anna Palm and published by Nordic Council of Ministers. This book was released on 2004 with total page 81 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Persistent Organic Pollutants POPs Analytical Techniques Environmental Fate and Biological Effects written by and published by Elsevier. This book was released on 2015-03-02 with total page 685 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on those organic chemicals that are regulated by the Stockholm Convention on Persistent Organic Pollutants (POPs). as well as organic chemical with the attributes of being persistent, bioaccumulative, and toxic to ecosystem and human beings, criteria used by the Stockholm Convention for screening POP candidates. Because of the unfavourable properties of POPs, numerous research efforts have been directed toward investigating their input sources, fate, and effects, with the help of continuously improving analytical technologies. The contributors to this book provide an integrated assessment of existing data, which will benefit both the scientific and management communities in planning further research projects and/or pollution control measures. - Comprehensive overview of recent advances in analyzing persistent organic pollutants (POPs) - Covers input sources, fate and biological effects of POPs - Contains essential information for environmental management
Download or read book Polybrominated Diphenyl Ethers Disturb Neural Development in Mice and Men written by Sebastian Timm Schreiber and published by . This book was released on 2010 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polybrominated diphenyl ethers (PBDEs) are persistent and bioaccumulative flame retardants that are of concern as they are ubiquitous and potentially toxic; and they have been found at rapidly rising levels in humans during the past few decades. The greatest concern of PBDEs for potential adverse health effects relates to their developmental neurotoxicity (DNT). Various PBDE congeners caused behavioral alterations like hyperactivity and disrupted performance in learning and memory tests in perinatally exposed mice and rats. To facilitate hazard assessment for humans, the impact of PBDEs on human and murine neurodevelopment in vitro and the mechanisms underlying these changes were investigated.
Download or read book Environmental Epigenetics in Toxicology and Public Health written by Rebecca Fry and published by Academic Press. This book was released on 2020-11-04 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental Epigenetics in Toxicology and Public Health provides in-depth discussions of the suite of complex environmental factors shown to impact epigenetic components within the cell, as well as evidence that these epigenetic modifications are tied to early and later life health effects. This book offers a translational research perspective, highlighting both in vivo and human population-based evidence for ties between the environment, the epigenome, and health outcomes, with an emphasis on evidence for transgenerational effects of exposures, as well as developmental windows of susceptibility to environmentally-linked epigenetic effects. This volume in the Translational Epigenetics series aides in the development of new therapeutic options meant to reverse inappropriate epigenetic alterations, helping researchers in their efforts prevent and treat a variety of chronic diseases tied to environmental exposures. Offers a thorough discussion of the environmental factors influencing epigenetic mechanisms in early and late life, and in transgenerational inheritance Examines both animal model and human population-based research in environmental epigenetics, highlighting developmental windows of vulnerability to epigenetic modification Features contributions from international experts in the field
Download or read book Advanced Techniques in Gas Chromatography Mass Spectrometry GC MS MS and GC TOF MS for Environmental Chemistry written by and published by Newnes. This book was released on 2013-09-26 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gas chromatography mass spectrometry (GC-MS) has been the technique of choice of analytical scientists for many years. The latest developments in instrumentation, including tandem mass spectrometry (MS-MS) and time-of-flight (TOF) detectors, have opened up and broadened the scope of environmental analytical chemistry. This book summarizes the major advances and relevant applications of GC-MS techniques over the last 10 years, with chapters by leading authors in the field of environmental chemistry. The authors are drawn from academia, industry and government. The book is organized in three main parts. Part I covers applications of basic GC-MS to solve environmental-related problems. Part II focuses on GC-MS-MS instrumentation for the analyses of a broad range of analysis in environmental samples (pesticides, persistent organic pollutants, endocrine disruptors, etc.). Part III covers the use of more advanced GC-MS techniques using low- and high-resolution mass spectrometry for many applications related to the environment, food and industry. - Summarizes the major advances of GC-MS techniques in the last decade - Presents relevant applications of GC-MS techniques - Covers academic, industrial and governmental sectors
Download or read book Toxicological Profile for Polybrominated Diphenyl Ethers PBDEs written by and published by . This book was released on 2017 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Bioaccumulation of Polybrominated Diphenyl Ethers in a Lake Michigan Food Web written by Dana L. Barton and published by . This book was released on 2002 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Understanding the Long range Transport of Polybrominated Diphenyl Ethers written by Fiona Kin-Yao Lau and published by . This book was released on 2006 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Reviews of Environmental Contamination and Toxicology written by George W. Ware and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 165 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews of Environmental Contamination and Toxicology provides detailed review articles concerned with aspects of chemical contaminants, including pesticides, in the total environment with toxicological considerations and consequences.
Download or read book An Assessment of Polybrominated Diphenyl Ethers PBDEs in Sediments and Bivalves of the U S Coastal Zone written by K. L. Kimbrough and published by . This book was released on 2009 with total page 96 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report represents the first national assessment of PBDEs in the U.S. coastal zone. Results suggest that they are widely distributed nationally. Several regions, including the northern Mid-Atlantic, central Gulf of Mexico, Southern California, Pacific Northwest and the Great lakes have elevated PBDE concentrations compared with other coastal regions. Furthermore, PBDE concentrations are positively correlated with human population density along the U.S. coastline. The national and regional perspectives provided herein are intended to support research, local monitoring, and to assist resource managers and policy makers tasked with making regulatory decisions about these contaminants.
