Download or read book Ap4a and Other Dinucleoside Polyphosphates written by Alexander G. McLennan and published by CRC Press. This book was released on 2020-11-25 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ap4A and Other Dinucleoside Polyphosphates is the first compilation of contributions from major investigators involved in studying the chemistry and biology of dinucleoside polyphosphates. The book features reviews and original research (including unpublished and anecdotal material) covering the whole area of dinucleoside polyphosphate research from its inception to the present day. Ap4A and Other Dinucleoside Polyphosphates will be a useful reference for biological scientists studying nucleotide metabolism, cell signalling, DNA replication and repair, and cellular response to stress.
Download or read book Ap4a and Other Dinucleoside Polyphosphates written by Alexander G. McLennan and published by CRC Press. This book was released on 2020-11-25 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ap4A and Other Dinucleoside Polyphosphates is the first compilation of contributions from major investigators involved in studying the chemistry and biology of dinucleoside polyphosphates. The book features reviews and original research (including unpublished and anecdotal material) covering the whole area of dinucleoside polyphosphate research from its inception to the present day. Ap4A and Other Dinucleoside Polyphosphates will be a useful reference for biological scientists studying nucleotide metabolism, cell signalling, DNA replication and repair, and cellular response to stress.
Download or read book Uremic Toxins written by Toshimitsu Niwa and published by John Wiley & Sons. This book was released on 2012-09-04 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews all the latest basic and clinical research findings With contributions from leading international experts in the field, this book is dedicated to all facets of uremic toxins research, including low molecular weight solutes, protein-bound solutes, and middle molecules. Moreover, it covers everything from basic mass spectrometry research to the latest clinical findings and practices. Uremic Toxins is divided into three sections: Section One, Uremic Toxins, explores the definition, classification, listing, and mass spectrometric analysis of uremic toxins Section Two, Selected Uremic Toxins, describes key uremic toxins, explaining chemical structures, metabolism, analytical methods, plasma levels, toxicity, clinical implications, and removal methods. Among the uremic toxins covered are indoxyl sulfate, asymmetric dimethylarginine, PTH, ß2-microglobulin, and AGEs Section Three, Therapeutic Removal of Uremic Toxins, describes how uremic toxins can be removed by hemodialysis, peritoneal dialysis, and oral sorbent All chapters are based on the authors' thorough review of the literature as well as their own personal laboratory and clinical experience. References at the end of each chapter provide a gateway to the literature in the field. Reviewing all the latest basic and clinical research findings, Uremic Toxins will help bench scientists in nephrology advance their own investigations. It will also help clinicians take advantage of the latest tested and proven treatments for the management of chronic kidney disease.
Download or read book Cardiovascular Hormone Systems written by Michael Bader and published by John Wiley & Sons. This book was released on 2008-12-17 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by a renowned scientist in the field with more than 200 high profile scientific publications to his name, this is the first book to provide a comprehensive overview of all cardiovascular hormone systems. Clearly structured, the text covers steroid and peptide hormones, amines, and arachidonic acid metabolites, as well as such others as nucleotides, nitric oxide, and acetylcholine. An essential reference for researchers working on the cardiovascular system and related diseases.
Download or read book Phosphates Advances in Research and Application 2011 Edition written by and published by ScholarlyEditions. This book was released on 2012-01-09 with total page 127 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphates: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Phosphates. The editors have built Phosphates: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Phosphates in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Phosphates: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Download or read book Library of Congress Subject Headings written by Library of Congress and published by . This book was released on 1997 with total page 1500 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Library of Congress Subject Headings written by Library of Congress. Cataloging Policy and Support Office and published by . This book was released on 2009 with total page 1688 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Library of Congress Subject Headings written by Library of Congress. Office for Subject Cataloging Policy and published by . This book was released on 1992 with total page 1330 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Organophosphorus Chemistry 2018 written by György Keglevich and published by MDPI. This book was released on 2020-03-05 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organophosphorus chemistry is an important discipline within organic chemistry. Phosphorus compounds, such as phosphines, trialkyl phosphites, phosphine oxides (chalcogenides), phosphonates, phosphinates and >P(O)H species, etc., may be important starting materials or intermediates in syntheses. Let us mention the Wittig reaction and the related transformations, the Arbuzov- and the Pudovik reactions, the Kabachnik–Fields condensation, the Hirao reaction, the Mitsunobu reaction, etc. Other reactions, e.g., homogeneous catalytic transformations or C-C coupling reactions involve P-ligands in transition metal (Pt, Pd, etc.) complex catalysts. The synthesis of chiral organophosphorus compounds means a continuous challenge. Methods have been elaborated for the resolution of tertiary phosphine oxides and for stereoselective organophosphorus transformations. P-heterocyclic compounds, including aromatic and bridged derivatives, P-functionalized macrocycles, dendrimers and low coordinated P-fragments, are also of interest. An important segment of organophosphorus chemistry is the pool of biologically-active compounds that are searched and used as drugs, or as plant-protecting agents. The natural analogue of P-compounds may also be mentioned. Many new phosphine oxides, phosphinates, phosphonates and phosphoric esters have been described, which may find application on a broad scale. Phase transfer catalysis, ionic liquids and detergents also have connections to phosphorus chemistry. Green chemical aspects of organophosphorus chemistry (e.g., microwave-assisted syntheses, solvent-free accomplishments, optimizations, and atom-efficient syntheses) represent a dynamically developing field. Last, but not least, theoretical approaches and computational chemistry are also a strong sub-discipline within organophosphorus chemistry.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1828 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Heart Physiology and Pathophysiology written by Yoshihisa Kurachi and published by Elsevier. This book was released on 2000-10-09 with total page 1286 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students. Key Features* The most comprehensive book available on this topic* Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology* Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology* Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology
Download or read book Roles of Inositol Diphosphates and Dinucleoside Polyphosphates in Drosophila Melanogaster Development written by Lucinda J. Winward and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 1940 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Download or read book Acta Biochimica Polonica written by and published by . This book was released on 2003 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nucleic Acids and Related Compounds written by Ante M. Krstulović and published by . This book was released on 1987 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book CRC Handbook of Chromatography written by and published by . This book was released on 1984 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis of Dinucleoside Tetraphosphates and Their Analogs written by and published by . This book was released on 2007 with total page 152 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dinucleoside polyphosphates, NpnN' (n = 2 - 7), are observed in many biological processes and are recognized as playing important regulatory functions. Ap4A is a particularly important signaling molecule. AZTp4A is the product of excision of AZT by HIV-1 RT from a growing chain of viral DNA, and can be used to study details of the excision process. Its hydrolysis-resistant analogs can be used to study the inhibition of AZT excision. Current methods to prepare dinucleoside tetraphosphates, enzymatic or chemical, are not satisfactory. A convenient and high-yield method was developed to prepare dinucleoside tetra- and pentaphosphates. The method was based on a mixture of P(III) and P(V) chemistry and involved a trimetaphosphate intermediate. Six dinucleoside tetraphosphates and two pentaphosphates were prepared. In addition, the method was modified to prepare thio, seleno, borano, methylene and difluoromethylene analogs of Ap4A and AZTp4A. These analogs are good model compounds for their unmodified versions. Ap4A analogs can be used to study the mechanisms of its molecular signaling processes. The AZTp4A analogs are currently being used in HIV-1 RT drug resistance studies. The configurations of the diastereomers of the thio, seleno and borano analogs were assigned based on the elution order on reverse-phase HPLC. Enzymatic degradation of the Ap4A analogs was done with snake venom phosphodiesterase in order to confirm the configuration assignments. Furthermore, this method was extended to prepare multimodified hydrolysis-resistant AZTpSpCX2ppSA and AZTpSpCX2ppSAZT (X = H or F) as potential inhibitors of the AZT excision reaction by HIV-1 RT. The reactions were carried out by the coupling of adenosine or AZT H-phosphonate with trimetaphosphate analogs, taking advantage of the differential power of elemental sulfur to sulfurize H-phosphonate diesters but not monoesters. Enzymatic degradation was performed in order to assign configurations of the diastereomers and compare their enzymatic stabilities.
