Download or read book The Diels Alder Reaction written by Francesco Fringuelli and published by John Wiley & Sons. This book was released on 2002-01-21 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: 70 Jahre Forschung an der Diels-Alder-Reaktion: Dieses Buch fasst die wichtigsten und beeindruckendsten Ergebnisse in einzigartiger Weise zusammen! Zunächst werden die Grundprinzipien der Reaktion klar und verständlich anhand übersichtlicher Graphiken erläutert. Spezielle Vorschriften und gegebenenfalls ihre industrielle Umsetzung werden anschließend erklärt. Einen Schwerpunkt bilden auch physikalische und katalytische Verfahren zur Steigerung der Selektivität der Reaktion. Cycloadditionen in konventionellen und unkonventionellen Medien werden vorgestellt. Mit über 1.000 Literaturverweisen!
Download or read book Name Reactions written by Jie Jack Li and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 435 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book differs from others on name reactions in organic chemistry by focusing on their mechanisms. It covers over 300 classical as well as contemporary name reactions. Biographical sketches for the chemists who discovered or developed those name reactions have been included. Each reaction is delineated by its detailed step-by-step, electron-pushing mechanism, supplemented with the original and the latest references, especially review articles. This book contains major improvements over the previous edition and the subject index is significantly expanded.
Download or read book Intramolecular Diels Alder and Alder Ene Reactions written by Douglass F. Taber and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 106 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Diels-Alder reaction has long been a powerful tool in organic synthesis. In recent years, the Alder ene reaction has also achieved some prominence. From the beginning, it was apparent that the intramolecular variants of these reactions would be feasible. Many such have been reported, but the results are widely scattered in the chemical literature. This volume is an attempt to synthesize results observed to date, and to suggest directions for future development. One of the limiting factors in the application of the intramolecular Diels Alder reaction has been the development of methods for the preparation of the requisite trienes. The fIrst chapter of this volume summarizes methods for the preparation of dienes and dienophiles. Examples representative of every general approach to 1,3-dienes and to dienophilic functional group combinations have been included. There are two questions one might ask in considering the prospective cyclization of a given triene: what are the factors that govern the rate of cyclization? and, for cyclizations that lead to the creation of one or more new chiral centers, what are the factors that govern diastereoselectivity? These questions are addressed in Chapter Two. The third chapter is devoted to the all-carbon intramolecular Alder ene reaction. The tables in that chapter summarize all examples that could be found in the literature through 1981, with several additional examples from 1982. Leading references to heterocyclic ene reactions are also included in this chapter.
Download or read book The Conservation of Orbital Symmetry written by R. B. Woodward and published by Elsevier. This book was released on 2013-10-22 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Conservation of Orbital Symmetry examines the principle of conservation of orbital symmetry and its use. The central content of the principle was that reactions occur readily when there is congruence between orbital symmetry characteristics of reactants and products, and only with difficulty when that congruence does not obtain—or to put it more succinctly, orbital symmetry is conserved in concerted reaction. This principle is expected to endure, whatever the language in which it may be couched, or whatever greater precision may be developed in its application and extension. The book opens with a review of the elementary aspects of the molecular orbital theory of bonding. This is followed by separate chapters on correlation diagrams, the conservation of orbital symmetry, theory of electrocyclic reactions, theory of cycloadditions and cycloreversions, and theory of sigmatropic reactions. Subsequent chapters deal with group transfers and eliminations; secondary conformational effects in concerted cycloaddition reactions; and generalized selection rules for pericyclic reactions.
Download or read book Efficiency in Natural Product Total Synthesis written by Pei-Qiang Huang and published by John Wiley & Sons. This book was released on 2018-07-24 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: Uniting the key organic topics of total synthesis and efficient synthetic methodologies, this book clearly overviews synthetic strategies and tactics applied in total synthesis, demonstrating how the total synthesis of natural products enables scientific and drug discovery. • Focuses on efficiency, a fundamental and important issue in natural products synthesis that makes natural product synthesis a powerful tool in biological and pharmaceutical science • Describes new methods like organocatalysis, multicomponent and cascade reactions, and biomimetic synthesis • Appeals to graduate students with two sections at the end of each chapter illustrating key reactions, strategies, tactics, and concepts; and good but unfinished total synthesis (synthesis of core structure) before the last section • Compiles examples of solid phase synthesis and continuing flow chemistry-based total synthesis which are very relevant and attractive to industry R&D professionals
Download or read book Hetero Diels Alder Methodology in Organic Synthesis written by and published by Elsevier. This book was released on 2012-12-02 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organic Chemistry: A Series of Monographs, Volume 47: Hetero Diels-Alder Methodology in Organic Synthesis focuses on the use of hetero Diels-Alder reactions as pivotal steps in natural product total syntheses. The publication first offers information on N-sulfinyl compounds and sulfur diimides and imino dienophiles. Discussions focus on sulfur dioxide and related compounds, selenium dioxide, sulfur diimide cycloadditions, regiochemical, stereochemical, and mechanistic aspects, iminium salts and neutral imines, oximino compounds, and intramolecular cycloadditions. The text then takes a look at nitroso and thionitroso dienophiles and carbonyl dienophiles. The manuscript elaborates on thiocarbonyl and selenocarbonyl dienophiles and miscellaneous dienophiles. Topics include nitriles, azo compounds, selenoaldehydes, thioketones, thioesters, dithioesters, and related compounds, and thiophosgene and related compounds. The text also ponders on oxabutadienes, thiabutadienes, and azabutadienes. The publication is a valuable reference for chemists and readers interested in the Hetero Diels-Alder methodology.
Download or read book Chemoselective and Bioorthogonal Ligation Reactions written by W. Russ Algar and published by John Wiley & Sons. This book was released on 2017-06-19 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: This timely, one-stop reference is the first on an emerging and interdisciplinary topic. Covering both established and recently developed ligation chemistries, the book is divided into two didactic parts: a section that focuses on the details of bioorthogonal and chemoselective ligation reactions at the level of fundamental organic chemistry, and a section that focuses on applications, particularly in the areas of chemical biology, biomaterials, and bioanalysis, highlighting the capabilities and benefits of the ligation reactions. With chapters authored by outstanding scientists who range from trailblazers in the field to young and emerging leaders, this book on a highly interdisciplinary topic will be of great interest for biochemists, biologists, materials scientists, pharmaceutical chemists, organic chemists, and many others.
Download or read book Cycloaddition Reactions in Organic Synthesis written by W. Carruthers and published by Elsevier. This book was released on 2013-10-22 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Demonstrates the wide scope of cycloaddition reactions, including the Diels-Alder reaction, the ene reaction, 1,3-dipolar cycloadditions and [2+2] cycloadditions in organic synthesis. The author, a leading exponent of the subject, illustrates the ways in which they can be employed in the synthesis of a wide range of carbocyclic and heterocyclic compounds, including a variety of natural products of various types. Special attention is given to intramolecular reactions, which often provide a rapid and efficient route to polycyclic compounds, and to the stereochemistry of the reactions, including recent and developing work on enantioselective synthesis.
Download or read book Flow Chemistry written by Santiago V Luis and published by Royal Society of Chemistry. This book was released on 2019-10-18 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: In flow chemistry reactions are performed in a reactor with the reactants pumped through it. It has the benefit of being easily scaled up and it is straightforward to integrate synthesis, workup and analysis into one system. This volume provides an update on recent advances in the field of flow chemistry, with special emphasis on new, integrated approaches for green and efficient chemistry. This book is a valuable resource for researchers in green chemistry, chemical engineers and Industrial chemists working in the pharmaceutical and fine chemicals industries.
Download or read book Essential Organic Chemistry Global Edition written by Paula Yurkanis Bruice and published by . This book was released on 2015-06-04 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt: NOTE You are purchasing a standalone product; MasteringChemistry does not come packaged with this content. If you would like to purchase both the physical text and MasteringChemistry search for 032196747X / 9780321967473 Essential Organic Chemistry 3/e Plus MasteringChemistry with eText -- Access Card Package: The access card package consists of: 0321937716 / 9780321937711 Essential Organic Chemistry 3/e0133857972 / 9780133857979 MasteringChemistry with PearsonKey Benefits: MasteringChemistry should only be purchased when required by an instructor." For one-term Courses in Organic Chemistry. " A comprehensive, problem-solving approach for the brief Organic Chemistry course. Modern and thorough revisions to the streamlined, " Essential Organic Chemistry f"ocus on developing students' problem solving and analytical reasoning skills throughout organic chemistry. Organized around reaction similarities and rich with contemporary biochemical connections, Bruice's Third Edition discourages memorization and encourages students to be mindful of the fundamental reasoning behind organic reactivity: electrophiles react with nucleophiles. Developed to support a diverse student audience studying organic chemistry for the first and only time, Essentials fosters an understanding of the principles of organic structure and reaction mechanisms, encourages skill development through new Tutorial Spreads and emphasizes bioorganic processes. Contemporary and rigorous, Essentials addresses the skills needed for the 2015 MCAT and serves both pre-med and biology majors. Also Available with MasteringChemistry(R) This title is also available with MasteringChemistry - the leading online homework, tutorial, and assessment system, designed to improve results by engaging students before, during, and after class with powerful content. Instructors ensure students arrive ready to learn by assigning educationally effective content before class, and encourage critical thinking and retention with in-class resources such as Learning Catalytics(TM). Students can further master concepts after class through traditional and adaptive homework assignments that provide hints and answer-specific feedback. The Mastering gradebook records scores for all automatically graded assignments in one place, while diagnostic tools give instructors access to rich data to assess student understanding and misconceptions. MasteringChemistry brings learning full circle by continuously adapting to each student and making learning more personal than ever--before, during, and after class.
Download or read book Biomedical Applications of Functionalized Nanomaterials written by Bruno Filipe Carmelino Cardoso Sarmento and published by Elsevier. This book was released on 2018-03-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomedical Applications of Functionalized Nanomaterials: Concepts, Development and Clinical Translation presents a concise overview of the most promising nanomaterials functionalized with ligands for biomedical applications. The first section focuses on current strategies for identifying biological targets and screening of ligand to optimize anchoring to nanomaterials, providing the foundation for the remaining parts. Section Two covers specific applications of functionalized nanomaterials in therapy and diagnostics, highlighting current practice and addressing major challenges, in particular, case studies of successfully developed and marketed functionalized nanomaterials. The final section focuses on regulatory issues and clinical translation, providing a legal framework for their use in biomedicine. This book is an important reference source for worldwide drug and medical devices policymakers, biomaterials scientists and regulatory bodies.
Download or read book Mechanochemical Organic Synthesis written by Davor Margetic and published by Elsevier. This book was released on 2016-04-23 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mechanochemical Organic Synthesis is a comprehensive reference that not only synthesizes the current literature but also offers practical protocols that industrial and academic scientists can immediately put to use in their daily work. Increasing interest in green chemistry has led to the development of numerous environmentally-friendly methodologies for the synthesis of organic molecules of interest. Amongst the green methodologies drawing attention, mechanochemistry is emerging as a promising method to circumvent the use of toxic solvents and reagents as well as to increase energy efficiency. The development of synthetic strategies that require less, or the minimal, amount of energy to carry out a specific reaction with optimum productivity is of vital importance for large-scale industrial production. Experimental procedures at room temperature are the mildest reaction conditions (essentially required for many temperature-sensitive organic substrates as a key step in multi-step sequence reactions) and are the core of mechanochemical organic synthesis. This green synthetic method is now emerging in a very progressive manner and until now, there is no book that reviews the recent developments in this area. Features cutting-edge research in the field of mechanochemical organic synthesis for more sustainable reactions Integrates advances in green chemistry research into industrial applications and process development Focuses on designing techniques in organic synthesis directed toward mild reaction conditions Includes global coverage of mechanochemical synthetic protocols for the generation of organic compounds
Download or read book Methods and Applications of Cycloaddition Reactions in Organic Syntheses written by Nagatoshi Nishiwaki and published by John Wiley & Sons. This book was released on 2013-12-17 with total page 996 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced tools for developing new functional materials and applications in chemical research, pharmaceuticals, and materials science Cycloadditions are among the most useful tools for organic chemists, enabling them to build carbocyclic and heterocyclic structures. These structures can then be used to develop a broad range of functional materials, including pharmaceuticals, agrochemicals, dyes, and optics. With contributions from an international team of leading experts and pioneers in cycloaddition chemistry, this book brings together and reviews recent advances, trends, and emerging research in the field. Methods and Applications of Cycloaddition Reactions in Organic Syntheses focuses on two component cycloadditions, with chapters covering such topics as: N1 unit transfer reaction to C–C double bonds [3+2] Cycloaddition of α, β-unsaturated metal-carbene complexes Formal [3+3] cycloaddition approach to natural product synthesis Development of new methods for the construction of heterocycles based on cycloaddition reaction of 1,3-dipoles Cycloreversion approach for preparation of large π-conjugated compounds Transition metal-catalyzed or mediated [5+1] cycloadditions Readers will learn methods for seamlessly executing important reactions such as Diels-Alder and stereoselective dipolar reactions in order to fabricate heterocyclic compounds, natural products, and functional molecules. The book not only features cutting-edge topics, but also important background information, such as the contributors’ process for developing new methodologies, to help novices become fully adept in the field. References at the end of each chapter lead to original research papers and reviews for facilitating further investigation of individual topics. Covering the state of the science and technology, Methods and Applications of Cycloaddition Reactions in Organic Syntheses enables synthetic organic chemists to advance their research and develop new functional materials and applications in chemical research, pharmaceuticals, and materials science.
Download or read book Natural Product Biosynthesis written by Christopher T. Walsh and published by Royal Society of Chemistry. This book was released on 2017-04-28 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook describes the types of natural products, the biosynthetic pathways that enable the production of these molecules, and an update on the discovery of novel products in the post-genomic era.
Download or read book Helicene Chemistry written by Chuan-Feng Chen and published by Springer. This book was released on 2016-11-04 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book systematically reviews recent advances in the synthetic methods and applications of helicenes. The first part of this book introduces the nomenclature and structural features of helicenes. The second part reviews several classic and useful methods as well as recently-developed approaches for the preparation and functionalization of helicenes, including photocyclization and Diels-Alder reactions, which are two important breakthroughs in the syntheses of helicenes. In the last part, the applications of helicenes in asymmetric syntheses, molecular machines, molecular recognition, self-assembly and other fields are discussed. This book provides a useful reference source for researchers and graduate students working not only in the area of helicene chemistry, but also in other research areas including materials science, supramolecular chemistry, coordination chemistry, and physical organic chemistry. Chuan-Feng Chen is a Professor at the Institute of Chemistry, Chinese Academy of Sciences, China.
Download or read book Handbook of Benzoxazine Resins written by Hatsuo Ishida and published by Elsevier. This book was released on 2011-07-13 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook provides a wide overview of the field, fundamental understanding of the synthetic methods and structure/property correlation, as well as studies related to applications in a wide range of subjects. The handbook also provides 1H and 13C NMR spectra, FTIR spectra, DSC and TGA thermograms to aid in research activities. Additional tables on key NMR and FTIR frequencies unique to benzoxazine, heat of polymerization, Tg, and char yield will greatly aid in the choice of proper benzoxazine for a specific application. Provides thorough coverage of the chemistry and applications of benzoxazine resins with an evidence-based approach to enable chemists, engineers and material scientists to evaluate effectiveness Features spectra, which allow researchers to compare results, avoid repetition and save time as well as tables on key NMR frequency, IR frequency, heat of polymerization, of many benzoxazine resins to aid them in selection of materials Written by the foremost experts in the field
Download or read book Cycloadditions in Bioorthogonal Chemistry written by Milan Vrabel and published by Springer. This book was released on 2016-06-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series Topics in Current Chemistry Collections presents critical reviews from the journal Topics in Current Chemistry organized in topical volumes. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.
