Download or read book Diabetes and Protein Glycosylation written by Margo Panush Cohen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the years since the initial discovery that blood from diabetic patients contains increased amounts of a posttranslationally gluco sylated form of hemoglobin (hemoglobin Ale)' an impressive number of studies have clarified and expanded the use of glycohemoglobin levels to assess disease status. Many other structural proteins have been shown to undergo similar changes, including proteins from tissues most commonly affected in diabetes (e.g., lens, aorta, peripheral nerve, basement membrane). Thus, the nonenzymatic glycosylation of hemoglobin emerges as an invaluable model for the pathogenesis of certain chronic diabetes complications. In addition to reviewing a wealth of investigative possibilities in the area of these chronic complications-including eye, kidney, nerve, and vascular disease-Dr. Cohen indicates how enhanced nonenzymatic glycosylation in uncontrolled diabetes underscores the pressing need for maintenance of long-term euglycemia. Dr. Cohen is an endocrinologist and diabetes specialist whose research activities have largely focused on the chemistry and metabo lism of the basement membrane in diabetes. This superb monograph on nonenzymatic glycosylation clearly shows the major trends of her past and present research and clinical activities. This book is beautifully written and a pleasure to read. It provides great insight into the mechanisms of the pathogenesis of the oom- vii viii Foreword cations of diabetes and should be of immense value not only to basic and clinical investigators, but also to internists, diabetologists, and endocrinologists in clinical practice.
Download or read book The Role of Glycosylation in Health and Disease written by Gordan Lauc and published by Springer Nature. This book was released on 2021-09-08 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Glycobiology is an emerging field of studying glycans (sugars) and glycoconjugates that are essentially involved in almost all biological processes, from fine-tuning glycoprotein function to protein-protein interactions, signaling, immune response, host-pathogen interactions, etc. However, due to structural complexity of glycans and analytical challenges this exciting field was lagging behind other areas of biology. With technological advancements growing number of glycans’ functions are being discovered and the study of glycans is becoming a cutting-edge discipline in basic and clinical research. Despite recent developments in glycobiology field, many aspects of glycosylation process still remain unknown, both in a healthy human organism and in pathological states. Human glycome is dynamic and changes with physiological triggers, immune challenges and disease. Atypical glycosylation is consequently a subject of disease biomarker research, and a target for therapeutic interventions. On the other hand, properties of glycosylated biotherapeutics are predominantly determined by their glycans. The Role of Glycosylation in Health and Disease provides a comprehensive overview of types and functions of glycans in a healthy human organism as well as their role in pathophysiology of different diseases and efficiency of glycosylated biotherapeutics. Written by the experts in the field, this book aims to bring glycobiology field closer to students, researchers in life sciences and professionals in biopharmaceutical industry.
Download or read book The Relevance of Protein Glycosylation to Diabetes and Ageing written by Christopher William Aston and published by . This book was released on 1991 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fundamentals of Glycosylation written by Alok Raghav and published by BoD – Books on Demand. This book was released on 2022-01-26 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt: The diverse phenomenon of post-translational modifications of biological macromolecules (proteins, lipids, and nucleic acids) includes phosphorylation, glycosylation, ubiquitination, nitrosylation, methylation, acetylation, lipidation, and proteolysis. The mechanism of protein glycosylation has an important role in the regulation of human health. This book identifies the fundamentals of glycosylation that help in understanding the concepts of protein glycosylation and its significance.
Download or read book Protein Glycosylation Advances in Identification Characterization and Biological Function Elucidation using Mass Spectrometry written by Ganglong Yang and published by Frontiers Media SA. This book was released on 2022-03-14 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Glycosylation Of Proteins In Diabetic Nephropathy written by Kinnari N. Mistry and published by LAP Lambert Academic Publishing. This book was released on 2012 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diabetic nephropathy is a leading cause of end stage renal failure, which could account for disabilities and high mortality rates in patients. Diabetic nephropathy seems to occur as a result of an interaction between metabolic and hemodynamic factors, which activate common pathways that lead to renal damage. Non enzymatic glycation has recently attracted increasing interest as a crucial pathophysiological process behind all these hyperglycemia-related alterations and in the pathophysiology of the development of diabetic complications. This book discusses conceptual, practical, statistical and logistical consideration for the use of glycosylated proteins as biochemical markers in diabetic nephropathy. This knowledge would facilitate new approach for molecular diagnosis and drug discovery.
Download or read book Essentials of Glycobiology written by Ajit Varki and published by CSHL Press. This book was released on 1999 with total page 694 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sugar chains (glycans) are often attached to proteins and lipids and have multiple roles in the organization and function of all organisms. "Essentials of Glycobiology" describes their biogenesis and function and offers a useful gateway to the understanding of glycans.
Download or read book Human Hemoglobins written by Howard Franklin Bunn and published by W.B. Saunders Company. This book was released on 1977 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the dawn of the era of molecular biology, hemoglobin has been subjected to more scrutiny than any other protein, and Bunn, Forget, and Ranney can each lay claim to major contributions to the saga of hemoglobin. Their well-organized, comprehensive, and superbly illustrated work is an excellent review of the abnormal hemoglobin field. Early chapters deal with the structure and function of human hemoglobin and the way in which this is modified in various disease states. Later sections deal with the various structural hemoglobin variants and their associated clinical manifestations, the thalassaemias, and the acquired disorders of hemoglobin. The sections that deal with the modification of hemoglobin function in various disease states are particularly good. The book contains an extensive and up-to-date bibliography and is remarkably free from errors of fact or type--the best standard of reference on the subject as of the year 1977.
Download or read book Transforming Glycoscience written by National Research Council and published by National Academies Press. This book was released on 2012-10-23 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: A new focus on glycoscience, a field that explores the structures and functions of sugars, promises great advances in areas as diverse as medicine, energy generation, and materials science, this report finds. Glycans-also known as carbohydrates, saccharides, or simply as sugars-play central roles in many biological processes and have properties useful in an array of applications. However, glycans have received little attention from the research community due to a lack of tools to probe their often complex structures and properties. Transforming Glycoscience: A Roadmap for the Future presents a roadmap for transforming glycoscience from a field dominated by specialists to a widely studied and integrated discipline, which could lead to a more complete understanding of glycans and help solve key challenges in diverse fields.
Download or read book Glycosylation of Plasma Proteins written by John D. Ayres and published by . This book was released on 1979 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Diabetes and Protein Glycation written by Margo P. Cohen and published by J. C. Press. This book was released on 1996 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Protein Glycosylation written by Roslyn M. Bill and published by Springer Science & Business Media. This book was released on 1998-11-30 with total page 536 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein Glycosylation provides clear, up-to-date, and integrated coverage of key topics in this field. Particular emphasis is placed on the biosynthetic pathways that result in a wide variety of identified protein-bound oligosaccharides. Protein Glycosylation begins with an overview of the chemical structures of mono- and oligosaccharides, to provide a scientific basis for the later chapters. The book includes discussions on the purification, function, and enzyme kinetics of selected glycosidases and glycotransferases, as well as a review of the roles of oligosaccharides in glycoprotein function and the in vivo role of glycoproteins themselves. Finally, the in vitro synthesis of glycoproteins is presented, together with future directions in glycobiology. Protein Glycosylation serves as an excellent text for upper-level undergraduate and graduate students as well as a reference for those scientists whose training is not in glycobiology but who are moving into this field.
Download or read book Glycated Proteins in Diabetes Mellitus written by and published by . This book was released on 1990 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Nonenzymatic Glycosylation of Platelet Membrane Proteins and Its Relevance to Diabetes written by Edouard Rene Martin and published by . This book was released on 1983 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Heterogeneity of Cancer Metabolism written by Anne Le and published by Springer. This book was released on 2018-06-26 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic alterations in cancer, in addition to being the fundamental drivers of tumorigenesis, can give rise to a variety of metabolic adaptations that allow cancer cells to survive and proliferate in diverse tumor microenvironments. This metabolic flexibility is different from normal cellular metabolic processes and leads to heterogeneity in cancer metabolism within the same cancer type or even within the same tumor. In this book, we delve into the complexity and diversity of cancer metabolism, and highlight how understanding the heterogeneity of cancer metabolism is fundamental to the development of effective metabolism-based therapeutic strategies. Deciphering how cancer cells utilize various nutrient resources will enable clinicians and researchers to pair specific chemotherapeutic agents with patients who are most likely to respond with positive outcomes, allowing for more cost-effective and personalized cancer therapeutic strategies.
Download or read book Medicinal Foods as Potential Therapies for Type 2 Diabetes and Associated Diseases written by Solomon Habtemariam and published by Academic Press. This book was released on 2019-06-08 with total page 1180 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Foods as Potential Therapies for Type-2 Diabetes and Associated Diseases: The Chemical and Pharmacological Basis of their Action focuses on active pharmacological principles that modulate diabetes, associated risk factors, complications and the mechanism of action of widely used anti-diabetic herbal plants—rather than just the nutritional composition of certain foods. The book provides up-to-date information on acclaimed antidiabetic super fruits, spices and other food ingredients. Sections cover diabetes and obesity at the global level, the physiological control of carbohydrate and lipid metabolism, the pathophysiology of type-2 diabetes, the chemistry and pharmacology of a variety of spices, and much more. This book will be invaluable for research scientists and students in the medical and pharmaceutical sciences, medicinal chemistry, herbal medicine, drug discovery/development, nutrition science, and for herbal practitioners and those from the nutraceutical and pharm industries. Provides background knowledge on type-2 diabetes and its pathophysiology and therapeutic targets down to the molecular level Explores, in detail, the chemistry or secondary metabolites of the indicated foods that potentially modify diabetes and/or associated diseases Examines the pharmacological findings on medicinal foods, including available clinical trials
Download or read book Lecture Notes Endocrinology and Diabetes written by Amir H. Sam and published by John Wiley & Sons. This book was released on 2013-05-30 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brand new title in the Lecture Notes series coversa core element of the medical school curriculum. It presents the basic science needed to understand mechanisms ofdisease and describes the clinical presentations of the disordersassociated with different glands, concluding with the relevantinvestigations and management. Focusing on conditions commonly encountered on the wards and inexams, with key points to aid revision and recall, this new titleis perfect as a course companion and is the ideal revision tool formedical students, specialist nurses, and doctors working onendocrinology rotations. Lecture Notes: Endocrinology andDiabetes is also essential for endocrinology traineesapproaching the new Knowledge Based Assessment (KBA).
