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Book Matrix assisted Laser Desorption Fourier Transform Mass Spectrometry for Biological Compounds

Download or read book Matrix assisted Laser Desorption Fourier Transform Mass Spectrometry for Biological Compounds written by and published by . This book was released on 1990 with total page 9 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent development of matrix-assisted UV laser desorption (LD) mass spectrometry has made possible the ionization and detection of extremely large molecules (with molecular weights exceeding 100,000 Daltons). This technique has generated enormous interest in the biological community for the direct examination of large peptides and oligonucleotides. Although this matrix-assisted ionization method has been developed and used almost exclusively with time-of-flight (TOF) mass spectrometers, research is currently in progress to demonstrate this technique with trapped ion mass spectrometers, such as Fourier transform ion cyclotron resonance mass spectrometry (FTMS). The potential capabilities of FTMS for wide mass range, high resolution measurement, and ion trapping experiments suggest that this instrumental technique should be useful for the detailed structural characterization of large ions generated by the matrix-assisted technique. We have recently demonstrated that matrix-assisted ultraviolet laser desorption can be successfully used with FTMS for the ionization of small peptides. The objective of this report is to summarize the application and current limitations of matrix-assisted laser desorption FTMS for the characterization of peptides and oligonucleotides at the isomeric level. 4 refs., 3 figs., 2 tabs.

Book Laser desorption ionization Fourier transform mass spectrometry

Download or read book Laser desorption ionization Fourier transform mass spectrometry written by Jeremiah Duffy Hogan and published by . This book was released on 1991 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Laser induced Thermal Desorption and Fourier Tranform i e Transform Mass Spectrometry for the Analysis of Molecular Desorption on Pd 111

Download or read book Laser induced Thermal Desorption and Fourier Tranform i e Transform Mass Spectrometry for the Analysis of Molecular Desorption on Pd 111 written by Nick Alan Thornburg and published by . This book was released on 1997 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book FT ICR MS

Download or read book FT ICR MS written by Bruce Asamoto and published by Wiley-VCH. This book was released on 1991 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Fundamentals and Applications of Fourier Transform Mass Spectrometry

Download or read book Fundamentals and Applications of Fourier Transform Mass Spectrometry written by Philippe Schmitt-Kopplin and published by Elsevier. This book was released on 2019-08-11 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fundamentals and Applications of Fourier Transform Mass Spectrometry is the first book to delve into the underlying principles on the topic and their linkage to industrial applications. Drs. Schmitt-Kopplin and Kanawati have brought together a team of leading experts in their respective fields to present this technique from many different perspectives, describing, at length, the pros and cons of FT-ICR and Orbitrap. Numerous examples help researchers decide which instruments to use for their particular scientific problem and which data analysis methods should be applied to get the most out of their data. Covers FT-ICR-MS and Orbitrap’s fundamentals, enhancing researcher knowledge Includes details on ion sources, data processing, chemical analysis and imaging Provides examples across the wide spectrum of applications, including omics, environmental, chemical, pharmaceutical and food analysis

Book Laser Desorption chemical Ionization of Peptides Using Fourier Transform Mass Spectrometry

Download or read book Laser Desorption chemical Ionization of Peptides Using Fourier Transform Mass Spectrometry written by Johnny Paul Speir and published by . This book was released on 1993 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Mechanisms and Applications of Laser Desorption Fourier Transform Mass Spectrometry

Download or read book Mechanisms and Applications of Laser Desorption Fourier Transform Mass Spectrometry written by M. Paul Chiarelli and published by . This book was released on 1988 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Development and Characterization of an Atmospheric Pressure Ionization Source Matrix Assisted Laser Desorption Electrospray Ionization Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Analysis of Biological Macromolecules

Download or read book Development and Characterization of an Atmospheric Pressure Ionization Source Matrix Assisted Laser Desorption Electrospray Ionization Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Analysis of Biological Macromolecules written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The field of mass spectrometry has grown tremendously over the past few decades due in large part to the continued application to new and interesting areas of exploration. The advent of soft ionization sources such as electrospray ionization and matrix-assisted laser desorption/ionization have dramatically increased the capabilities of mass spectrometry and increased the amount of information derived from biological samples. As a result, there has been tremendous growth in the development of new ionization source technology in recent years. One of the main driving forces behind the development of new ionization technology is for the reduction of sample preparation required prior to analysis, yielding high throughput sample analysis. Demonstrated herein is the development and characterization of an atmospheric pressure ionization source called matrix-assisted laser desorption electrospray ionization (MALDESI). MALDESI is a hybrid combination of MALDI and ESI which utilizes laser desorption with electrospray postionization for the generation of multiply-charged ions. Multiply-charged ions are of particular importance when using Fourier transform mass spectrometry, due to the increase in resolving power and mass accuracy with increasing charge on the molecule. Top-down characterization of intact polypeptides is demonstrated as well as high mass accuracy utilizing internal calibration. A newly designed highly robust and versatile atmospheric pressure ionization platform is developed and described in detail. Solid- and liquid state analysis of three out of the four classes of biological molecules is demonstrated utilizing the newly developed versatile ionization platform. MALDESI utilizing ultraviolet and infrared laser desorption is demonstrated at various wavelengths (UV, 337 nm and 349 nm and IR, 2.94 Ã'Âæm and 10.6 Ã'Âæm) with and without ESI postionization for the generation of multiply-charged ions. The characteristics of liquid-state samples are described as a mac.

Book Matrix assisted Laser Desorption ionization and Ion Activation by Fourier transform Mass Spectroscopy

Download or read book Matrix assisted Laser Desorption ionization and Ion Activation by Fourier transform Mass Spectroscopy written by John Anthony Castoro and published by . This book was released on 1993 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Laser Desorption Fourier Transform Ion Cyclotron Resonance Mass Spectrometry of Organic Compounds

Download or read book Laser Desorption Fourier Transform Ion Cyclotron Resonance Mass Spectrometry of Organic Compounds written by Ronald Edward Shomo and published by . This book was released on 1985 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Book Applications of Matrix Assisted Laser Desorption ionization Fourier Transform Mass Spectrometry for Phospholipid Analysis

Download or read book Applications of Matrix Assisted Laser Desorption ionization Fourier Transform Mass Spectrometry for Phospholipid Analysis written by S. Mariccor Andresa Banluta Batoy and published by . This book was released on 2010 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: