Download or read book Development of Thin Film Polymer Flexible Microelectrode Arrays for Neural Interface Applications written by Jiwan Kim and published by . This book was released on 2008 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Thin film Neural Interfaces for Brain computer Interface and Electroretinography Applications written by and published by . This book was released on 2012 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: THIN-FILM NEURAL INTERFACES FOR BRAIN-COMPUTER INTERFACE AND ELECTRORETINOGRAPHY APPLICATIONS Sanitta Thongpang Under the supervision of Associate Professor Justin C. Williams At the University of Wisconsin-Madison The brain, and more precisely the central nervous system (CNS), is an extremely complex organ responsible for controlling essential sensorimotor functions of the human body. These functions rely on nerves running all-throughout the organism, transporting the sensory information from the body towards the CNS and the motor information from the CNS to the muscles. However, when severed, these functions can be durably lost, provoking paralysis and significant loss of quality of life. Neuroprosthesis is a promising approach to allow the patient to regain some of the quality of life lost through the control of a computer directly from measuring brain activity. Unfortunately, current methods are either too invasive, risk a decrease of performance over time and require extreme precision to place (i.e. single-unit electrode) or non-invasive but imprecise and limited (e.g. electroencephalogram). Electrocorticogram interfaces (ECoG and micro-ECoG) have been developed to measure brain activity as close as possible to the neurons while minimizing invasivity and long-term effects. These are placed on between the cortex and the cranium and allow good improvements in signal quality and spatial resolution. Here, I present the improved electrode designs and fabrication methods for reliable micro-ECoG electrode arrays using flexible insulating materials such as polyimide and parylene C. Furthermore, we characterize the long-term effect of chronic implantation of the device both on the electrical and material properties as well as the biological response of the brain of the micro-ECoG arrays. In addition, leveraging recent developments in optogenetics, two-way neural interface devices were developed. By integrating these methods with cranial window imaging techniques, I demonstrated that very powerful tools for optimizing micro-ECoG electrode arrays, as well as answering fundamental biological question on the function of the brain, can be developed. Finally, the flexible thin-film bio-MEMS fabrication methods demonstrated were readily expanded to many other applications such as electroretinogram (ERG) recording.

Download or read book Development and Evaluation of Micro electrocorticography Arrays for Neural Interfacing Applications written by and published by . This book was released on 2016 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural interfaces have great promise for both electrophysiological research and therapeutic applications. Whether for the study of neural circuitry or for neural prosthetic or other therapeutic applications, micro-electrocorticography (micro-ECoG) arrays have proven extremely useful as neural interfacing devices. These devices strike a balance between invasiveness and signal resolution, an important step towards eventual human application. The objective of this research was to make design improvements to micro-ECoG devices to enhance both biocompatibility and device functionality. To best evaluate the effectiveness of these improvements, a cranial window imaging method for in vivo monitoring of the longitudinal tissue response post device implant was developed. Employment of this method provided valuable insight into the way tissue grows around micro-ECoG arrays after epidural implantation, spurring a study of the effects of substrate geometry on the meningeal tissue response. The results of the substrate footprint comparison suggest that a more open substrate geometry provides an easy path for the tissue to grow around to the top side of the device, whereas a solid device substrate encourages the tissue to thicken beneath the device, between the electrode sites and the brain. The formation of thick scar tissue between the recording electrode sites and the neural tissue is disadvantageous for long-term recorded signal quality, and thus future micro-ECoG device designs should incorporate open-architecture substrates for enhanced longitudinal in vivo function. In addition to investigating improvements for long-term device reliability, it was also desired to enhance the functionality of micro-ECoG devices for neural electrophysiology research applications. To achieve this goal, a completely transparent graphene-based device was fabricated for use with the cranial window imaging method and optogenetic techniques. The use of graphene as the conductive material provided the transparency necessary to image tissues directly below the micro-ECoG electrode sites, and to transmit light through the electrode sites to underlying neural tissue, for optical stimulation of neural cells. The flexibility and broad-spectrum transparency of graphene make it an ideal choice for thin-film, flexible electronic devices.

Download or read book Neural Microelectrodes Design and Applications written by Stuart Cogan and published by . This book was released on 2019 with total page 1 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural electrodes enable the recording and stimulation of bioelectrical activity in the nervous system. This technology provides neuroscientists with the means to probe the functionality of neural circuitry in both health and disease. In addition, neural electrodes can deliver therapeutic stimulation for the relief of debilitating symptoms associated with neurological disorders such as Parkinson's disease and may serve as the basis for the restoration of sensory perception through peripheral nerve and brain regions after disease or injury. Lastly, microscale neural electrodes recording signals associated with volitional movement in paralyzed individuals can be decoded for controlling external devices and prosthetic limbs or driving the stimulation of paralyzed muscles for functional movements. In spite of the promise of neural electrodes for a range of applications, chronic performance remains a goal for long-term basic science studies, as well as clinical applications. New perspectives and opportunities from fields including tissue biomechanics, materials science, and biological mechanisms of inflammation and neurodegeneration are critical to advances in neural electrode technology. This Special Issue will address the state-of-the-art knowledge and emerging opportunities for the development and demonstration of advanced neural electrodes.

Download or read book Brain Computer Interfaces written by Jonathan Wolpaw and published by Oxford University Press. This book was released on 2012-01-24 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: A recognizable surge in the field of Brain Computer Interface (BCI) research and development has emerged in the past two decades. This book is intended to provide an introduction to and summary of essentially all major aspects of BCI research and development. Its goal is to be a comprehensive, balanced, and coordinated presentation of the field's key principles, current practice, and future prospects.

Download or read book Integration of Process Incompatible Materials for Microfabricated Polymer Based Neural Interfaces written by Allison Elizabeth Hess and published by . This book was released on 2011 with total page 269 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation presents the development of microfabrication processes for the integration of process-incompatible, dissimilar materials in MEMS devices with application to neural interfaces for long-term implantation. Micromachining techniques were developed for a novel, mechanically-dynamic, chemo-responsive polymer nanocomposite based on a poly(vinyl acetate) matrix with embedded cellulose nanofibers designed to address issues related to the mechanical mismatch between the neural probe and cortical tissue. Microtensile testing was performed to assess the mechanical properties of laser-patterned nanocomposite microstructures. Within 3-7 minutes of immersion in DI water, the nanocomposite displayed a reduction in Young's modulus by a factor of 140-200, from 1.2-3.4 GPa to 4.9-22 MPa, depending upon the cellulose nanofiber source and concentration. A comparable reduction in Young's modulus was measured for samples that had been implanted in a rat cortex, suggesting this material can penetrate through the pia without buckling, but then softens and better matches the mechanics of cortical tissue. A process utilizing a parylene moisture barrier was developed to fabricate nanocomposite-based intracortical probes with integrated thin-film metal electrodes and interconnects. The electrode impedance was found to be 95.0 + 4.8 k[omega] for an electrode 6000 [mu]m^2 in area. To develop a microfabricated neural array technology with on-board recording, stimulation and chemical sensing capabilities, a process was developed to integrate semi-metallic diamond microelectrodes into a flexible polymer substrate. Diamond-on-polymer microelectrode arrays were fabricated using a "diamond-first" fabrication process whereby the diamond electrodes were first grown on a Si/SiO2 substrate, followed by the deposition and patterning of a polynorbornene capping layer, thin-film metal interconnects, and a polynorbornene substrate layer. A chemical release process in 49% HF was used to transfer the diamond from the Si substrate to the polymer substrate. Ohmic contact was made to diamond microelectrodes using Cr/Au metallization, without requiring an annealing step. Current pulse testing demonstrated potential for neural stimulation with diamond microelectrodes. The electrode impedance at 1 kHz was found to range from 300 k[omega] to 8 M[omega], indicating that there are some electrodes suitable for neural recording. Finally, electrochemical detection of 100 [mu]M dopamine in saline was achieved with a diamond-on-polymer electrode.

Download or read book A Flexible Thin film Microelectrode Array as a Chronic Interface to Small Nerves written by Michael Vinent Carroll McConnell and published by . This book was released on 1983 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Bio Medical CMOS ICs written by Hoi-Jun Yoo and published by Springer Science & Business Media. This book was released on 2010-11-02 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is based on a graduate course entitled, Ubiquitous Healthcare Circuits and Systems, that was given by one of the editors at his university. It includes an introduction and overview to the field of biomedical ICs and provides information on the current trends in research. The material focuses on the design of biomedical ICs rather than focusing on how to use prepared ICs.

Download or read book Smart Sensors for Health and Environment Monitoring written by Chong-Min Kyung and published by Springer. This book was released on 2015-07-22 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers two most important applications of smart sensors, namely bio-health sensing and environmental monitoring. The approach taken is holistic and covers the complete scope of the subject matter from the principles of the sensing mechanism, through device physics, circuit and system implementation techniques, and energy issues to wireless connectivity solutions. It is written at a level suitable mainly for post-graduate level researchers interested in practical applications. The chapters are independent but complementary to each other, and the book works within the wider perspective of essential smart sensors for the Internet of Things (IoT). This is the second of three books based on the Integrated Smart Sensors research project, which describe the development of innovative devices, circuits, and system-level enabling technologies. The aim of the project was to develop common platforms on which various devices and sensors can be loaded, and to create systems offering significant improvements in information processing speed, energy usage, and size. This book contains substantial reference lists and over 150 figures, introducing the reader to the subject in a tutorial style whilst also addressing state-of-the-art research results, allowing it to be used as a guide for starting researchers.

Download or read book Handbook of Neuroengineering written by Nitish V. Thakor and published by Springer Nature. This book was released on 2023-02-02 with total page 3686 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook serves as an authoritative reference book in the field of Neuroengineering. Neuroengineering is a very exciting field that is rapidly getting established as core subject matter for research and education. The Neuroengineering field has also produced an impressive array of industry products and clinical applications. It also serves as a reference book for graduate students, research scholars and teachers. Selected sections or a compendium of chapters may be used as “reference book” for a one or two semester graduate course in Biomedical Engineering. Some academicians will construct a “textbook” out of selected sections or chapters. The Handbook is also meant as a state-of-the-art volume for researchers. Due to its comprehensive coverage, researchers in one field covered by a certain section of the Handbook would find other sections valuable sources of cross-reference for information and fertilization of interdisciplinary ideas. Industry researchers as well as clinicians using neurotechnologies will find the Handbook a single source for foundation and state-of-the-art applications in the field of Neuroengineering. Regulatory agencies, entrepreneurs, investors and legal experts can use the Handbook as a reference for their professional work as well.​

Download or read book Development of Flexible Electrode Arrays for Chronic Stable and Scalable Neural Recording written by Zhengtuo Zhao and published by . This book was released on 2019 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: The brain is a massively-interconnected and constantly-evolving network of specialized circuits; a systematic understanding of the circuits requires a probe-tissue interface that can record and modulate brain activities at diverse spatial and temporal scales. Implanted electrodes provide a unique approach to decipher brain circuitry by allowing for time-resolved electrical detection of individual neuron activity. However, conventional intracortical recordings are often sparse, and importantly, unstable over long term. These pose limitations on their scientific and clinical applications. Through the use of less-rigid polymer materials and the ten-to-a-hundred fold reduction on probe size, the flexibility of a neural probe can be improved by four orders of magnitude, which results in a friendly probe-tissue interfaces, long-term recording performance, and greater potential for scaling up in implantation density. Here we present our progress on the development of a novel neural recording platform including 1. A stable neural interface named nanoelectronic threads (NETs) which demonstrated long-term stable recording over four months, seamless chronic probe-tissue integration and easy compatibility with optical imaging. 2. A facile implantation method to apply the flexible NETs in scalable, reliable neural recording in rodent brain. 3. A dense and high-bandwidth NET platform towards volumetric mapping and large-scale distributed recordings in the neocortex and subcortical structures, and 4. A low-cost and versatile multifunctional neural probe platform to achieve optogenetic stimulation and controlled drug infusion with simultaneous, spatially resolved neural recording. These capabilities will drive new long-term studies of brain circuits across different spatiotemporal dimensions and modalities

Download or read book Development of Flexible based Electrode Arrays as a Neural Interface written by Theodore Bo-Yi Ng and published by . This book was released on 2015 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: Flexible electrode arrays are a crucial technology for neural interfaces. In this thesis, the continued development of a flexible based electrode array is discussed. Two types of strain relief are introduced into the leads to allow the base to deform like the spinal cord in a repeatable manner. The resulting sandwich and embedded lead configurations were characterized using a tensile tester. In addition, the base material was characterized after exposure to physiological solutions and a sterilization protocol. Results show that the sandwich lead configuration had properties that were better matched to those of the spinal cord tissue. Parametric finite element modelling was also performed to identify the effect of the base modulus after varying several properties associated with the base. The results of the modelling would help in the long term manufacturing of these flexible based electrode arrays.

Download or read book Transparent and Flexible Microelectrode Arrays Based on Graphene for Multimodal Neural Interfaces written by Yichen Lu and published by . This book was released on 2021 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt: The advancement of neuroscience research often requires recording of complex neural activities at high spatiotemporal resolution. Electrophysiology, being the backbone of neuroscience for decades, has the advantage of high temporal resolution, yet lacks the high spatial resolution of fluorescent imaging at single cell level. On the other hand, fluorescent imaging suffers from low temporal resolution due to the slow kinetics of the indicators. Recently, optogenetics revolutionized the capacity to control selective neural populations and provides researchers with unprecedented opportunities to investigate the causal relationships among different brain circuits. However, the traditional neural electrode arrays based on silicon and noble metals are opaque and hence not suitable to integrate electrophysiology and optical modalities. This dissertation presents a novel transparent microelectrode array based on graphene that demonstrates crosstalk-free integration of electrophysiology, calcium imaging, and optogenetics in in vivo experiments on mice models. Chapter 1 reviews the recent progress in the field of graphene-based neurotechnology. Graphene is widely used for microelectrode, field effect transistor, chemical sensing, and cell culture owing to its flexibility, transparency, high conductivity, low noise, and biocompatibility. Chapter 2 presents a novel transparent graphene microelectrode array designed for multimodal neural interfaces. The fabrication process was designed to avoid crack formation and organic residue, which is essential to eliminate light-induced artifacts. In vivo experiments were conducted to demonstrate a crosstalk-free integration of electrophysiology, optical imaging, and optogenetics for the first time. Chapter 3 demonstrates that electrochemical impedance of graphene is fundamentally limited by the quantum capacitance. And to overcome such limit, we created an alternative conduction path with electrochemically deposited platinum nanoparticles and reduced the impedance by 100-fold while maintaining high transparency. Chapter 4 presents a flexible implantable transparent microelectrode array that enables simultaneous electrical recordings from hippocampus during optical imaging of neural activity across large areas. Our neural probe has three advantages, flexibility, transparency, and shuttle-free implantation. We demonstrated seamless integration of simultaneous wide-field fluorescence imaging of the cortex with electrical recordings from the hippocampus. Chapter 5 is the conclusion of this dissertation. The outlook and roadmap of graphene-based neurotechnology for both neuroscience research and medical applications are discussed.

Download or read book Micro Electro Mechanical Systems written by Qing-An Huang and published by Springer. This book was released on 2018-05-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook volume aims to provide a comprehensive, self-contained, and authoritative reference in MEMS. It covers the theoretical and practical aspects including but not limited to sensors, actuators, RF MEMS, micro fluids and bio MEMS systems. It is particularly recommended to undergraduates, postgraduates, researchers, scientists, and field experts. This comprehensive summary will provide a solid knowledge background and inspire innovations in this highly interdisciplinary field. The handbook series consists of 5 volumes: Micro/nano fabrication technology, MEMS, Nanomaterial, Nanomedicine and Applications of micro-/nanotechnologies in IT. Experienced researchers and experts are invited to contribute in each of these areas.The series is published under Springer Major Reference works, which allows continuous online update and publication. These features allow newcomers and other readers to keep in touch with the most up-to-date information in micro-/nanotechnologies.It presents an overview of the knowledge base, as well as selected topics and provides comprehensive and authoritative information on the field for researchers, engineers, scientists and graduate students who are involved in different aspects of micro-/nanotechnologies.This publication will provide inspiration for innovative research and application ideas for continued growth of the field.

Download or read book Neural Interface Engineering written by Liang Guo and published by Springer Nature. This book was released on 2020-05-04 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive reference to major neural interfacing technologies used to transmit signals between the physical world and the nervous system for repairing, restoring and even augmenting body functions. The authors discuss the classic approaches for neural interfacing, the major challenges encountered, and recent, emerging techniques to mitigate these challenges for better chronic performances. Readers will benefit from this book’s unprecedented scope and depth of coverage on the technology of neural interfaces, the most critical component in any type of neural prostheses. Provides comprehensive coverage of major neural interfacing technologies; Reviews and discusses both classic and latest, emerging topics; Includes classification of technologies to provide an easy grasp of research and trends in the field.

Download or read book Intra cortical Microelectrode Arrays for Neuro interfacing written by Salam Ramy Gabran and published by . This book was released on 2012 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neuro-engineering is an emerging multi-disciplinary domain which investigates the electrophysiological activities of the nervous system. It provides procedures and techniques to explore, analyze and characterize the functions of the different components comprising the nervous system. Neuro-engineering is not limited to research applications; it is employed in developing unconventional therapeutic techniques for treating different neurological disorders and restoring lost sensory or motor functions. Microelectrodes are principal elements in functional electric stimulation (FES) systems used in electrophysiological procedures. They are used in establishing an interface with the individual neurons or in clusters to record activities and communications, as well as modulate neuron behaviour through stimulation. Microelectrode technologies progressed through several modifications and innovations to improve their functionality and usability. However, conventional electrode technologies are open to further development, and advancement in microelectrodes technology will progressively meliorate the neuro-interfacing and electrotherapeutic techniques. This research introduced design methodology and fabrication processes for intra-cortical microelectrodes capable of befitting a wide range of design requirements and applications. The design process was employed in developing and implementing an ensemble of intra-cortical microelectrodes customized for different neuro-interfacing applications. The proposed designs presented several innovations and novelties. The research addressed practical considerations including assembly and interconnection to external circuitry. The research was concluded by exhibiting the Waterloo Array which is a high channel count flexible 3-D neuro-interfacing array. Finally, the dissertation was concluded by demonstrating the characterization, in vitro and acute in vivo testing results of the Waterloo Array. The implemented electrodes were tested and benchmarked against commercial equivalents and the results manifested improvement in the electrode performance compared to conventional electrodes. Electrode testing and evaluation were conducted in the Krembil Neuroscience Centre Research Lab (Toronto Western Hospital), and the Neurosciences & Mental Health Research Institute (the Sick Kids hospital). The research results and outcomes are currently being employed in developing chronic intra-cortical and electrocorticography (ECoG) electrode arrays for the epilepsy research and rodents nervous system investigations. The introduced electrode technologies will be used to develop customized designs for the clinical research labs collaborating with CIRFE Lab.

Download or read book Implantable Neural Prostheses 1 written by David Zhou and published by Springer Science & Business Media. This book was released on 2009-06-10 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Significant progress has been made in the development of neural prostheses to restore human functions and improve the quality of human life. Biomedical engineers and neuroscientists around the world are working to improve design and performance of existing devices and to develop novel devices for artificial vision, artificial limbs, and brain–machine interfaces. This book, Implantable Neural Prostheses 1: Devices and Applications,ispart one of a two-book series and describes state-of-the-art advances in techniques associated with implantable neural prosthetic devices and their applications. Devices covered include sensory prosthetic devices, such as visual implants, cochlear implants, auditory midbrain implants, and spinal cord stimulators. Motor prosthetic devices, such as deep brain stimulators, Bion microstimu- tors, the brain control and sensing interface, and cardiac electro-stimulation devices are also included. Progress in magnetic stimulation that may offer a non-invasive approach to prosthetic devices is introduced. Regulatory approval of implantable medical devices in the United States and Europe is also discussed.