Download or read book Microfluidic Reactors for Polymer Particles written by Eugenia Kumacheva and published by John Wiley & Sons. This book was released on 2011-02-14 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: The manipulation of fluids in channels with dimensions in the range from tens to hundreds of micrometers – microfluidics – has recently emerged as a new field of science and technology. Microfluidics has applications spanning analytical chemistry, organic and inorganic synthesis, cell biology, optics and information technology. One particularly promising application is the microfluidic synthesis of polymer particles with precisely controlled dimensions, and a variety of shapes, morphologies and compositions. Written as a comprehensive introduction for scientists and engineers working in microfabrication and microfluidics, Microfluidic Reactors for Polymer Particles covers topics such as: Applications and methods of generation of polymer particles Physics of microfluidic emulsification Formation of droplets in microfluidic systems High-throughput microfluidic systems for formation of droplets Microfluidic production of polymer particles and hydrogel particles Polymer capsules Synthesis of polymer particles with non-conventional shapes This book is intended for a broad audience, including students, researchers and engineers in industry, with interests in physics, chemistry, materials science, engineering or biotechnology.

Download or read book Microfluidics for Pharmaceutical Applications written by Hélder A. Santos and published by William Andrew. This book was released on 2018-10-12 with total page 498 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery is a concept-orientated reference that features case studies on utilizing microfluidics for drug delivery applications. It is a valuable learning reference on microfluidics for drug delivery applications and assists practitioners developing novel drug delivery platforms using microfluidics. It explores advances in microfluidics for drug delivery applications from different perspectives, covering device fabrication, fluid dynamics, cutting-edge microfluidic technology in the global drug delivery industry, lab-on-chip nano/micro fabrication and drug encapsulation, cell encapsulation and delivery, and cell- drug interaction screening. These microfluidic platforms have revolutionized the drug delivery field, but also show great potential for industrial applications. - Presents detailed coverage on the fabrication of novel drug delivery systems with desired characteristics, such as uniform size, Janus particles, and particular or combined responsiveness - Includes a variety of case studies that explain principles - Focuses on commercialization, cost, safety, society and educational issues of microfluidic applications, showing how microfluidics is used in the real world

Download or read book Droplet and Digital Microfluidics written by Sanket Goel and published by Elsevier. This book was released on 2024-03-11 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: Droplet and Digital Microfluidics: Ideation to Implementation is a detailed introduction to the dynamics of droplet and digital microfluidics, also featuring coverage of new methods and applications. The explosion of applications of microelectromechanical systems (MEMS) in recent years has driven demand for expertise and innovation in fluid flow in the microchannels they contain. In this book, detailed descriptions of methods for biological and chemical applications of microfluidics are provided, along with supporting foundational knowledge. In addition, the principles of droplet and digital microfluidics are explained, along with their different applications and governing physics. New additions to the technological knowledgebase that enable advances in droplet and digital microfluidics include machine learning and exciting future avenues for research. - Provides step-by-step fabrication, testing, and characterization instructions in each chapter to support implementation - Includes explanations of applications and methods in biological and chemical settings - Describes the path to automation of digital and droplet microfluidic platforms

Download or read book Nanotechnology for Microfluidics written by Xingyu Jiang and published by John Wiley & Sons. This book was released on 2020-09-08 with total page 444 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book focuses on microfluidics with applications in nanotechnology. The first part summarizes the recent advances and achievements in the field of microfluidic technology, with emphasize on the the influence of nanotechnology. The second part introduces various applications of microfluidics in nanotechnology, such as drug delivery, tissue engineering and biomedical diagnosis.

Download or read book Droplet Microfluidics written by Abraham Lee and published by Royal Society of Chemistry. This book was released on 2020-11-27 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by two leaders, this book has drawn together expertise from around the globe to form a unified, cohesive resource for the droplet microfluidics community. Starting with the basic theory of droplet microfluidics before introducing its use as a tool, the reader is treated to chapters on important techniques, including robust passive and active droplet manipulations and applications such as single cell analysis, which is key for drug discovery. This book is a go-to resource for the community yearning to adopt and promote droplet microfluidics into different applications.

Download or read book Microfluidic Fabrication of Polymer Based Microparticles for Biomedical Applications written by Tiantian Kong and published by Open Dissertation Press. This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Microfluidic Fabrication of Polymer-based Microparticles for Biomedical Applications" by Tiantian, Kong, 孔湉湉, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Delivery vehicles that can encapsulate and release active ingredients of pre-determined volumes at the target site on-demand present a challenge in biomedical field. Due to their tunable physiochemical properties and degradation rate, polymeric particles are one of the most extensively employed delivery vehicles. Generally they are fabricated from emulsion templates. Conventional bulk emulsification technique provides little control over the characteristics of droplets generated. Thus the properties of the subsequent particles cannot be controlled. The advance of droplet microfluidics enables the generation and manipulation of designer single, double or higher-order emulsion droplets with customizable structure. These droplets are powerful and versatile templates for fabricating polymeric delivery vehicles with pre-determined properties. Due to the monodispersity of droplet templates by microfluidics, the relationship between size, size distribution, shape, architecture, elastic responses and release kinetics can be systematically studied. These understandings are of key importance for the design and fabrication of the next generation polymeric delivery vehicles with custom-made functions for specific applications. In the present work, we engineer the droplet templates generated from microfluidics to fabricate designer polymeric microparticles as delivery vehicles. We investigate and obtain the relationship between the particle size, size distribution, structure of microparticles and their release kinetics. Moreover, we also identify an innovative route to tune the particle shape that enables the investigation of the relationship between particle shape and release kinetics. We take advantage of the dewetting phenomena driving by interfacial tensions of different liquid phases to vary the droplet shape. We find that the phase-separation-induced shape variation of polymeric composite particles can be engineered by manipulating the kinetic barriers during droplet shape evolution. To predict the performance of our advanced polymer particles in practical applications, for instance, in narrow blood vessels in vivo, we also develop a novel capillary micromechanics technique to characterize the linear and non-linear elastic response of our polymer particles on single particle level. The knowledge of the mechanical properties enables the prediction as well as the design of the mechanical aspects of polymer particles in different applications. The ability to control and design the physical, chemical, mechanical properties of the delivery vehicles, and the understanding between these properties and the biological functionalities of delivery vehicles, such as the release kinetics, lead towards tailor-designed delivery vehicles with finely-designed functionalities for various biomedical applications. Our proposed electro-microfluidic platform potentially enables generation of submicron droplet templates with a narrow size distribution and nanoscaled delivery vehicles with well-controlled properties, leading to a next generation of intracellular delivery vehicles. Microfluidic-based technique has the potential to be scaled up by parallel operation. Therefore, we are well-equipped for the massive production of custom-made droplet templates of both micron-size and nanosized, and we can design the physiochemical properties and biological functionalities of the delivery vehicle

Download or read book Microfluidics for Biological Applications written by Wei-Cheng Tian and published by Springer Science & Business Media. This book was released on 2009-03-02 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microfluidics for Biological Applications provides researchers and scientists in the biotechnology, pharmaceutical, and life science industries with an introduction to the basics of microfluidics and also discusses how to link these technologies to various biological applications at the industrial and academic level. Readers will gain insight into a wide variety of biological applications for microfluidics. The material presented here is divided into four parts, Part I gives perspective on the history and development of microfluidic technologies, Part II presents overviews on how microfluidic systems have been used to study and manipulate specific classes of components, Part III focuses on specific biological applications of microfluidics: biodefense, diagnostics, high throughput screening, and tissue engineering and finally Part IV concludes with a discussion of emerging trends in the microfluidics field and the current challenges to the growth and continuing success of the field.

Download or read book Polymer Based Multifunctional Nanocomposites and Their Applications written by John Zhanhu Guo and published by Elsevier. This book was released on 2018-09-14 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymer-Based Multifunctional Nanocomposites and Their Applications provides an up-to-date review of the latest advances and developments in the field of polymer nanocomposites. It will serve as a one-stop reference resource on important research accomplishments in the area of multifunctional nanocomposites, with a particular emphasis placed on the use of nanofillers and different functionality combinations. Edited and written by an expert team of researchers in the field, the book provides a practical analysis of functional polymers, nanoscience, and nanotechnology in important and developing areas, such as transportation engineering, mechanical systems, aerospace manufacturing, construction materials, and more. The book covers both theory and experimental results regarding the relationships between the effective properties of polymer composites and those of polymer matrices and reinforcements. - Presents a thorough and up-to-date review of the latest advances and developments in the field of multifunctional polymer nanocomposites - Integrates coverage of fundamentals, research and development, and the range of applications for multifunctional polymers and their composites, such as in the automotive, aerospace, biomedical and electrical industries - Supports further technological developments by discussing both theory and real world experimental data from academia and industry

Download or read book Microfluidic assisted Synthesis and Release Properties of Multi domain Polymer Microparticles Drug Carriers written by Ikram Ullah Khan and published by . This book was released on 2014 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Characteristics and release properties of drug loaded microparticles depend upon material used and choice of production method. Conversely to most of the conventional ones, microfluidic methods give an edge by improving the control over droplet generation, size and size distribution. Capillary-based microfluidic devices were successfully used to obtain monodisperse drug(s) loaded microbeads, janus, core-shell and trojan particles using UV initiated free radical polymerization while keeping activity of active loaded molecules. These devices can be assembled in a short period of time and a slight change in design gives completely different microparticles morphologies. These particles were developed with the aim to address different issues experienced in oral drug delivery. For instance microbeads can be used to deliver NASIDs in a sustained release manner while janus particles can release two APIs with completely different properties (solubility, compatibility) also in a sustained release manner. Core-shell particles were designed to target colonic region of human intestine for dual drug delivery. Trojan particles were synthesized in a new semi-continuous microfluidic process, thus improving nanoparticles safety handling and release in simulated gastric fluid. Each system was fully characterized to insure batch to batch consistency and reproducibility. In general, the release of active ingredients was controlled by tuning the operating and material parameters like phases flow rates, nature and concentration of drug, (co)monomers, surfactant and crosslinker, pH of release media with the result of different particle morphologies, sizes and shapes or matrix crosslinking density.

Download or read book Microfluidics written by Fouad Sabry and published by One Billion Knowledgeable. This book was released on 2022-01-16 with total page 477 pages. Available in PDF, EPUB and Kindle. Book excerpt: What Is Microfluidics Microfluidics refers to the behavior, precise control, and manipulation of fluids that are geometrically constrained to a small scale at which surface forces dominate volumetric forces. It is a multidisciplinary field that involves engineering, physics, chemistry, biochemistry, nanotechnology, and biotechnology. It has practical applications in the design of systems that process low volumes of fluids to achieve multiplexing, automation, and high-throughput screening. Microfluidics emerged in the beginning of the 1980s and is used in the development of inkjet printheads, DNA chips, lab-on-a-chip technology, micro-propulsion, and micro-thermal technologies. How You Will Benefit (I) Insights, and validations about the following topics: Chapter 1: Microfluidics Chapter 2: Droplet-based microfluidics Chapter 3: Digital microfluidics Chapter 4: Paper-based microfluidics Chapter 5: Microfluidic cell culture Chapter 6: Electroosmotic pump Chapter 7: Materials science (II) Answering the public top questions about microfluidics. (III) Real world examples for the usage of microfluidics in many fields. (IV) 17 appendices to explain, briefly, 266 emerging technologies in each industry to have 360-degree full understanding of microfluidics' technologies. Who This Book Is For Professionals, undergraduate and graduate students, enthusiasts, hobbyists, and those who want to go beyond basic knowledge or information for any kind of microfluidics.

Download or read book Microfluidics in Pharmaceutical Sciences written by Dimitrios A. Lamprou and published by Springer Nature. This book was released on with total page 494 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Handbook of Nanoparticles written by Mahmood Aliofkhazraei and published by Springer. This book was released on 2015-08-07 with total page 2000 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Handbook covers all aspects of Nanoparticles, from their preparation to their practical application. The chapters present different ways to synthesize nanometer particles, as well as their functionalization and other surface treatments to allow them to a practical use. Several industrial applications of such nanometer particles are also covered in this Handbook. It is a complete reference for those working with Nanotechnology at the lab level, from students to professionals.

Download or read book Microfluidic Processes to Create Structured Microparticle Arrangements and Their Applications written by Jae Jung Kim (Ph. D.) and published by . This book was released on 2017 with total page 145 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multifunctional polymeric microparticles have shown the great potentials in a variety of fields. While the advance in particle synthesis allows for fine tuning of their physical properties and chemical functionality, particle manipulation is still appealing, but challenging issue in colloidal science. In order to expand the utility of microparticles, many particle manipulation techniques have been developed to arrange large-scale of particles at precise locations. However, current approaches cannot simultaneously fulfill desired capabilities of arrangement: scalability, precision, specificity, and versatility. This thesis explores the ability to synthesize particles with a controllability of characteristics, and development of a new microfluidic platform, porous microwell arrays, to create structured large-scale microparticle arrays using a scaling theory, which is a function of particles' characteristics. Lastly, we demonstrate the potential of generated particle arrays in various bioengineering application and material sciences. First, we synthesize anisotropic, cell-adhesive microparticles using stop flow lithography (SFL) and carbodimide coupling. Synthesized microparticles are functionalized with collagen or poly-L-lysine using streptavidin-biotin interaction, resulting in cell-adhesiveness. After functionalization, target cells are spread on the particles and spatially patterned only on the functionalized region. Thus, cells are not exposed to potentially harmful components of particle synthesis processes, photoinitiators and ultraviolet light, ensuring no physiological changes. Second, we synthesize multi-striped, upconverting nanocrystal (UCN)-laden microparticles using SFL. Distinct upconversion emission colors are combined with the ability to spatial pattern them, providing superior encoding capacities. We can fine-tune upconversion emission by controlling the dopant composition in nanocrystal, and synthesize microparticles in a highly reproducible manner by SFL, allowing for the development of predictable decoding system. Two types of particles are synthesized with this appealing encoding strategy for two distinct applications: thermally stable particles for anti-counterfeiting application; and porous hydrogels for multiplexed microRNA detection. Third, we develop a microfluidic platform, porous microwell arrays, to manipulate microparticles while fulfilling all four desired capabilities (i.e. scalability, precision, specificity, and versatility). Microwells are fabricated on top of porous membrane by a vacuum-assisted molding method. Particles are guided and assembled into wells by hydrodynamic force associated with fluid flow through pores in microwell. Iteration of assembly and washing steps ensures high-throughput, large-scale particle arrangement with high yields on filling and capturing. Scaling theory allows for the rational design of platform to specifically position microparticles depending on their physical characteristics (i.e. size, shape, and modulus), enabling to generate complex patterns. We utilize this platform in three practical applications: high-throughput, large-scale single-cell arrays; microenvironment fabrication for neutrophil chemotaxis; and UCN-laden covert 2D tags for anti-counterfeiting. Lastly, we modified the porous microwell platform to a closed system, microfluidic channels, to park and isolate particles in monodisperse droplets surrounded by fluorinated oil. Rational modification retains the platform's desired capabilities, resulting in a single particle in a droplet with high yields on both parking and isolation. Particle-in-droplet arrays enables the observation of reaction in confined volume over the time. Such arrays can be utilized to accumulate the desired product from enzymatic reaction, amplifying the signal and improving the sensitivity of bioassays. We demonstrate the highly sensitive, multiplexed miRNA detections with these particle-in-droplet arrays.

Download or read book Microfluidics written by Sagnik Basuray and published by Springer Science & Business Media. This book was released on 2011-10-05 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Flow Control Methods and Devices in Micrometer Scale Channels, by Shuichi Shoji and Kentaro Kawai. Micromixing Within Microfluidic Devices, by Lorenzo Capretto, Wei Cheng, Martyn Hill and Xunli Zhang. Basic Technologies for Droplet Microfluidics, by Shaojiang Zeng, Xin Liu, Hua Xie and Bingcheng Lin. Electrorheological Fluid and Its Applications in Microfluidics, by Limu Wang, Xiuqing Gong and Weijia Wen. Biosensors in Microfluidic Chips, by Jongmin Noh, Hee Chan Kim and Taek Dong Chung. A Nanomembrane-Based Nucleic Acid Sensing Platform for Portable Diagnostics, by Satyajyoti Senapati, Sagnik Basuray, Zdenek Slouka, Li-Jing Cheng and Hsueh-Chia Chang. Optical Detection Systems on Microfluidic Chips, by Hongwei Gai, Yongjun Li and Edward S. Yeung. Integrated Microfluidic Systems for DNA Analysis, by Samuel K. Njoroge, Hui-Wen Chen, Małgorzata A. Witek and Steven A. Soper. Integrated Multifunctional Microfluidics for Automated Proteome Analyses, by John K. Osiri, Hamed Shadpour, Małgorzata A. Witek and Steven A. Soper. Cells in Microfluidics, by Chi Zhang and Danny van Noort. Microfluidic Platform for the Study of Caenorhabditis elegans,by Weiwei Shi, Hui Wen, Bingcheng Lin and Jianhua Qin.

Download or read book Continuous Microfluidic Reactors for Polymer Particles written by Minseok Seo and published by . This book was released on 2008 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this thesis, we present a versatile new method for preparing highly monodisperse droplets, polymer particles, double emulsions, and self-assemblies of droplets in continuous microfluidic reactors. Recently, microfluidic systems are significantly being used in many areas of chemistry and biotechnology to achieve improved performance. Microfluidics provides the ability to automate highly repetitive laboratory tasks by replacing huge cumbersome equipment with miniaturized and integrated systems, and it enables the handling of small amounts, e.g., from microliters to femtoliters of fluids, reactants and products. These methods have the following useful features: (1) the generation of extremely monodisperse droplets, (2) the generation and control of both the shape and the size of the droplets, (3) the use of a wide variety of materials, including: gels, monomers, polymers, copolymers, and polymers doped with functional additives, (4) a possibility of in situ solidification of the droplets by means of photopolymerization and/or thermopolymerization, and (5) the ability to scale up the production of large quantities of particles. We focus on the effect of the properties of the disperse and continuous phases on the emulsification process, the effect of the polymerization rate on the production of high-quality particles, the role of the material and geometry of the microfluidic device in droplet formation, and the synthesis of particles with different shapes and compositions.

Download or read book The Principles of Life written by Tibor Ganti and published by Oxford University Press. This book was released on 2003-09-18 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beginning with a new essay, "Levels of Life and Death," Tibor Gánti develops three general arguments about the nature of life. In "The Nature of the Living State," Professor Gánti answers Francis Crick's puzzles about "life itself," offering a set of reflections on the parameters of the problems to be solved in origins of life research and, more broadly, in the search for principles governing the living state in general. "The Principle of Life" describes in accessible language Gánti's chief insight about the organization of living systems-his theory of the "chemoton," or chemical automaton. The simplest chemoton model of the living state consists of three chemically coupled subsystems: an autocatalytic metabolism, a genetic molecule and a membrane. Gánti offers a fresh approach to the ancient problem of "life criteria," articulating a basic philosophy of the units of life applicable to the deepest theoretical considerations of genetics, chemical synthesis, evolutionary biology and the requirements of an "exact theoretical biology." New essays by Eörs Szathmáry and James Griesemer on the biological and philosophical significance of Gánti's work of thirty years indicate not only the enduring theoretical significance, but also the continuing relevance and heuristic power of Gánti's insights. New endnotes by Szathmáry and Griesemer bring this legacy into dialogue with current thought in biology and philosophy. Gánti's chemoton model reveals the fundamental importance of chemistry for biology and philosophy. Gánti's technical innovation - cycle stoichiometry - at once captures the fundamental fact that biological systems are organized in cycles and at the same time offers a way to understand what it is to think chemically. Perhaps most fundamentally, Gánti's chemoton model avoids dualistic thinking enforced by the dichotomies of modern biology: germ and soma, gene and character, genotype and phenotype.

Download or read book Developing Droplet Microfluidic Technologies for Single cell and Single molecule Assays written by Soroush Kahkeshani and published by . This book was released on 2017 with total page 115 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the past decade, growing number of commercialized "lab on a chip" systems have been addressing needs in biology for patients and researchers. The ability to miniaturize conventional systems used in lab while increasing sensitivity in addition to newly developed platforms, have enabled new applications such as point-of-care diagnostics and single-cell sequencing. This dissertation focuses on new droplet microfluidic platforms developed for addressing the current challenges (controlling encapsulation beyond Poisson distribution, removing bulky and expensive pumps,...) in commercialization of single-cell and single-molecule assays. In chapter 1, current state of the art, recent commercialized products and their limitations are discussed. In chapter 2, new findings about particle interactions in single-phase microfluidics leading to "preferred interparticle spacings" and trajectory attractors in inertial microflow regimes are presented. Furthermore, these findings have been combined with new modifications made to conventional flow focusing droplet generators in order to avoid jetting regime in inertial regimes, thus allowing making use of preferred spacing between cells/particles in inertial flows for controlling number of cells/particles encapsulated in droplets (one cell/particle per drop). Our findings could be used for many applications such as drug discovery. The other application could be for droplet sequencing (drop-seq) where for example RNA of individual cells are sequenced and it is important that only one cell is present in each droplet to generate unbiased data. In chapter 3 and 4 of the dissertation, new patented technology for generation of droplets, replacing bulky and expensive pumps, with body force exerted on the ferrofluid by magnetic field acting on magnetic nanoparticles mixed with the fluid. Thus the cost and footprint of the device is reduced significantly, allowing for use in limited-resource settings (global health) for quantification of biomolecules by controlled magnetic dosing of nanoliter droplets.