Download or read book Development of Carbon based Nanomaterials and Their Use as New Therapeutic Carriers written by Cédric Klumpp and published by . This book was released on 2006 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fullerenes and carbon nanotubes are new allotropes of carbon discovered in 1985 and 1991 respectively. Fullerenes are spheres of few angströms theoretically constituted of at least 20 carbon atoms. The most stable and abundant isomer is the C60 which is formed of 12 pentagons and 20 hexagons. Carbon nanotubes are basically a rolled sheet of graphite terminated by two end caps similar to a half C60. Two main types of nanotubes exist: i) the single-walled carbon nanotubes which are composed by a rolled monolayered graphene sheet, and ii) the multi-walled carbon nanotubes which possess several graphitic concentric layers. The different chemical and physical properties of fullerenes and carbon nanotubes allowed finding already applications in the field of material sciences. Nevertheless, the search on their potential applications in the biological or medical field is still little explored. The different laboratories where I conducted my thesis are specialized in the development of fullerene and carbon nanotubes derivatives for therapeutics purposes. During my PhD thesis, I focused my interests on the functionalization and the characterization of fullerenes and carbon nanotubes and their potential biological applications. Nowadays, the characterization of functionalized nanotubes remains very complicate because the current techniques does not allow establishing simultaneously the presence of the carbon nanotubes, the presence of functional groups and the presence of covalent bonding between the tube and the functional moiety. Several techniques were therefore used like the nuclear magnetic resonance, the transmission electron microscopy, the atomic force microscopy and the thermogravimetry analysis to gather a maximum of data on the functionalized nanotubes. We studied then the biodistribution and elimination of functionalized carbon nanotubes in vivo. For this purpose, single or multiwalled carbon nanotubes were functionalized with the radiotracer indium 111. The conjugates were then injected in mice and the radioactivity was measured in the different organs after 30 minutes, 3 hours and 24 hours. Radioactivity was detected in every organ after 30 minutes and almost disappeared after 24 hours. These results indicated that the nanotube elimination process was fast. Moreover, transmission electron microscopy analysis of the urine revealed that the carbon nanotubes were eliminated via the renal excretion. No signs of toxicity were detected on the mice, meaning that functionalized nanotubes are biocompatible. Thus, we envisaged to use the carbon nanotubes as new vectors for therapeutic molecules. Amphotericin B was linked onto the surface of the carbon nanotubes and the conjugates were tested on several strains of fungi and on mammalian cells as well. It appeared that the carbon nanotube conjugates were more potent than the drug alone against the fungi and allowed also reducing the toxicity of the amphotericin B on mammalian cells. Alternatively, we explored the use of fullerene as potential vector systems. We described the synthesis and characterization of multi-functionalized fullerene derivatives. In this context, the 1,3-dipolar cycloaddition reaction of azomethine ylides was applied to obtain functionalized fullerene bearing a distribution of organic moieties around the spherical cage. Their characterization was realized by several techniques such as high pressure liquid chromatography, mass spectrometry and nuclear magnetic resonance. Moreover, the introduction of ammonium groups on the surface of C60 greatly increased the solubility in aqueous media. The linkage of a fluorescent probe on the fullerene derivatives permitted to evaluate by flow cytometry and confocal microscopy their biological compatibility and their potential to cross the plasma membrane. Secondly, warfarin, an anticoagulant molecule, was attached in order to use the fullerene derivatives as a drug delivery system and to determine if a multi-presentation of the biomolecule could enhance its effect. Previously, we reported the capacity of nanotubes to act as gene vectors. Thus, polycationic fullerenes were prepared to evaluate their ability to complex DNA. The complexes were characterized by gel electrophoresis and transmission electron microscopy. In addition, surface plasmon resonance allowed measuring the affinity constant. The fullerene derivatives are potentially able to deliver DNA inside the cells. In order to verify this hypothesis, gene transfer studies have already started.In conclusion, the preparation of functionalized carbon nanotubes and fullerenes for biological applications was reported. Notably, carbon nanotubes derivatives are non-toxic and can deliver antifungal molecules and modulate their cytotoxic effects. In the same way, fullerene derivatives were able to penetrate the plasma membrane without provoking cytotoxicity and to strongly complex plasmid DNA. Therefore, they could be used as a potential vector for gene and drug delivery. Finally, functionalized carbon-based nanomaterials can be considered an efficient alternative system for the delivery of therapeutics and may find interesting future biomedical applications.

Download or read book Nanomaterials Evolution and Advancement towards Therapeutic Drug Delivery Part II written by Surendra Nimesh and published by Bentham Science Publishers. This book was released on 2021-06-02 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: The development of a vector for the delivery of therapeutic drugs in a controlled and targeted fashion is still a major challenge in the treatment of many diseases. The conventional application of drugs may lead to many limitations including poor distribution, limited effectiveness, lack of selectivity and dose dependent toxicity. An efficient drug delivery system can address these problems. Recent nanotechnology advancements in the biomedical field have the potential to meet these challenges in developing drug delivery systems. Nanomaterials are changing the biomedical platform in terms of disease diagnosis, treatment and prevention. Nanomaterials aided drug delivery provides an advantage by enhancing aqueous solubility that leads to improved bioavailability, increased resistance time in the body, decreased side effects by targeting drugs to the specific location, reduced dose dependent toxicity and protection of drugs from early release. In this two-part book, the contributors have compiled reports of recent studies illustrating the promising nanomaterials that can work as drug carriers which can navigate conventional physiological barriers. A detailed account of several types of nanomaterials including polymeric nanoparticles, liposomes, dendrimers, micelles, carbon nanomaterials, magnetic nanoparticles, solid lipid-based nanoparticles, silica nanomaterials and hydrogels for drug delivery is provided in separate chapters. The contributors also present a discussion on clinical aspects of ongoing research with insights towards future prospects of specific nanotechnologies. Part II covers the following topics: · Solid lipid nanoparticles and nanostructured lipid carriers · Silica based nanomaterials · Hydrogels · Metallic nanoparticles · Computational and experimental binding interactions of drug and β-cyclodextrin · Clinical milestones in nanotherapeutics · Drug delivery systems based on poly(lactide-co-glycolide) and its copolymers The book set is an informative resource for scholars who seek updates in nanomedicine with reference to nanomaterials used in drug delivery systems.

Download or read book Carbon based Nanomaterials in Analytical Chemistry written by Carlos D Garcia and published by Royal Society of Chemistry. This book was released on 2018-09-07 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presenting the most relevant advances for employing carbon-based nanostructured materials for analytical purposes, this book serves as a reference manual that guides readers through the possibilities and helps when selecting the most appropriate material for targeted analytical applications. It critically discusses the role these nanomaterials can play in sample preparation, separation procedures and detection limit improvements whilst also considering the future trends in this field. Useful to direct initiatives, this book fills a gap in the literature for graduate students and professional researchers discussing the advantages and limitations across analytical chemistry in industry and academia.

Download or read book Carbon Based Nanocarriers for Drug Delivery written by Mihir Kumar Purkait and published by CRC Press. This book was released on 2023-10-12 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon-Based Nanocarriers for Drug Delivery enlists the latitudes and advancements in the synthesis processes, functionalization, and applications of carbon-based nanomaterials (CBNs) in targeted drug delivery systems (DDSs). It covers the applicability and suitability of CBNs as nanocarriers for efficient drug delivery application via elucidating the recent advancements in CBNs, their functionalized and innovative derivatives, and the relevant case studies. The book explores the necessity, efficacy, toxicological aspects, and challenges for the application of CBN in targeted DDSs. Some of the features of this book are provided as follows: Provides elaborative description on significance and adaptability of carbon-based nanomaterial in targeted drug delivery for wide ranges of therapeutics Delivers a full-spectrum discussion on drug delivery through carbon-based nanocarriers Explores each carbon-based nanocarrier fundamentally for its drug and gene-delivery-related applications Describes critical discussion on various toxicological effects over the utilization of these nanocarriers Embraces existing as well as novel technologies/methodologies related to the synthesis and functionalization of CBNs, including graphene, graphene oxide, carbon quantum dots, carbon nanotube, fullerene, and smart carbon-based nanocarriers This book is aimed at researchers and graduate students in materials and pharmaceutical engineering, including drug delivery systems.

Download or read book Carbon Based Nanomaterials written by Archana (Joshi) Bachheti and published by Springer Nature. This book was released on with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Carbon Based Nanomaterials in Biosystems written by Kunal Biswas and published by Elsevier. This book was released on 2024-04-29 with total page 656 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon-Based Nanomaterials in Biosystems: Biophysical interface at Lower Dimensions provides a thoroughly comprehensive overview of all major aspects of carbon-based nanomaterials, their biophysical response, and biotechnological application. The book articulates the underlying physics, chemistry, and the basic phenomenon of the broad-range carbon-based nanomaterials (CNMs) with the biological systems particularly the interface analysis. Organized in six sections, it discusses state-of art technological interventions of carbon-based nanomaterials and their application in biomedical sectors in healthcare, food sciences, and technology. The book also highlights the carrying capacity of different CNMs in payload efficiency mechanisms in various biomedical fields. The theranostic efficiency and the safety of various forms of CNMs is assessed. Carbon-Based Nanomaterials in Biosystems is a helpful resource to those specializing in the areas of nanomedicine, bionanomaterials and nanotechnology applications. Covers major breakthroughs in carbon nanomaterials (CNMs) Distinguishes between the advantages and disadvantages of carbon-based and non-carbon-based nanomaterials Discusses the significance of different forms of carbon nanomaterials and their unique physico-chemical and electrochemical properties at the lower dimension Examines the appropriate methodologies for tackling safety and health-related matters while using carbon-based nanomaterials Discusses recent developments of various forms of carbon-based nanomaterials such as graphene, carbon nanotubes, fullerenes, and carbon nano-onions

Download or read book Carbon Based Nanomaterials for Environmental Applications written by Muhammad Ikram and published by Springer Nature. This book was released on with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Carbon Based Nanomaterials and Nanocomposites for Gas Sensing written by Navinchandra Gopal Shimpi and published by Elsevier. This book was released on 2022-10-12 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon-Based Nanomaterials and Nanocomposites for Gas Sensing discusses the state of the art, emerging challenges, properties, and opportunities of various carbon-based nanomaterials and nanocomposites, for their application in smart gas sensors. The book focuses on various carbon-based nanomaterials and their nanocomposites, sensing mechanism, device fabrication, and their application for the sensing of various hazardous gases. This is important for several industries, environmental monitoring, and human healthcare, due to increased industrialization. Carbon-Based Nanomaterials and Nanocomposites for Gas Sensing provides systematic and effective guidelines for researchers who want to gain a fundamental understanding of how this class of materials is being used for gas sensing. Since these sensors can be applied for the automation of numerous industrial processes, as well as for everyday monitoring of various activities, such as public safety, engine performance, medical therapeutics, and in many other situations, this book will catch the attention of readers and motivate them for advanced research in the development of smart and efficient gas sensors. Offers a one-stop resource, bringing together information currently scattered over journal papers and project reports Presents a focused concept reflecting the properties, synthesis, and sensing capabilities of carbon-based nanomaterials and their composites Combines fundamental experimental and theoretical information with industrial needs and engineering design methods

Download or read book Advances in Personalized Nanotherapeutics written by Ajeet Kaushik and published by Springer. This book was released on 2017-12-08 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personalized health care to manage diseases and optimized treatment is crucial for everyone to maintain health quality. Significant efforts have been made to design and develop novel nano-enabling therapeutic strategies to cure and monitor diseases for personalized health care. As state-of-the-art, various strategies have been reported to develop personalized nanomedicine to combat against target diseases with no side effects. In this book proposal, we are trying to describe fundamentals of personalized nanomedicine, novel nanomaterials for drug delivery, role of nanotechnology for efficient therapeutics approach, nano-pharmacology, targeted CNS drug delivery, stimuli responsive drug release and nanotechnology for diseases management. This book would serve as a platform for new scholars to understand state-of-the-art of nanotechnology for therapeutics and designing their future research to develop effective personalized nanomedicine against targeted diseases. As of now, various studies have been reported to design and develop nanomedicines of higher efficacy but unfortunately, such products are up to laboratory research only and need to be well-tested using pre-clinical or human models. Our book would be a call for experts to explore multidisciplinary research for developing novel and efficient approaches to explore smart efficient nanocarriers for site-specific on-demand controlled drug delivery to combat against targeted diseases to personalized health care.

Download or read book Advanced Nanocarbon Materials written by Sarika Verma and published by CRC Press. This book was released on 2022-05-05 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a well-focused and comprehensive overview of the history and background of nanocarbon based materials like carbon nanotubes, graphene, and fullerenes. It discusses their structure, synthesis, properties and modifications for making various advanced materials. The authors focus on their use in the health care sector as therapeutic agents in pharmacy and medicine, in diagnosis and analysis in pharmacy and medicine, as biosensors, gene and drug delivery, cancer therapy, biosensing and bioimaging, go-based antibacterial materials, and as a promising antioxidant and GO-based scaffold for cell culture. The authors also showcase the application potential of advanced nanocarbon based materials by examining the biomedical applications developed via novel advanced designing, in which the technologies will be adopted and the end users can be benefited. Finally the authors discuss the increasing research on carbon based materials, along with the challenges they are currently facing along with possible solutions that may result in the availability of the accessible, reliable and cost-efficient technology. The potential user for this book may be medical practitioners, biologists, pharmacists, and chemists.This book covers in-depth knowledge of processing parameters for making nanocarbon based material for high end applications in the biomedical and pharmaceutical fields.

Download or read book Nanostructured Carbon for Energy Generation Storage and Conversion written by V. I. Kodolov and published by CRC Press. This book was released on 2023-05-12 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Carbon materials play a significant role in the development of alternative clean and sustainable energy technologies. This new volume focuses on the new applications of different carbon nanomaterials and graphene-carbon-nanotube hybrids for energy generation, energy storage, and energy conversion. It presents a comprehensive overview of recent developments on carbon-based nanomaterials with a focus on sustainable and clean energy applications. With chapters written by the leading academicians and researchers working in the field, the volume explores state-of-the-art developments using both commercially available and emerging materials and their potential applications for energy storage and energy harvesting.

Download or read book Functionalized Carbon Nanomaterials for Theranostic Applications written by Shadpour Mallakpour and published by Elsevier. This book was released on 2022-09-17 with total page 588 pages. Available in PDF, EPUB and Kindle. Book excerpt: Functionalized Carbon Nanomaterials for Theranostic Applications offers insights into the developments and trends that are progressing fast in the field of functionalized carbon nanomaterials-based devices as diagnostic tools for early stage detection of human diseases. The book provides information on how functionalized carbon nanomaterials are being used as the basis for products, such as early disease diagnostic kits, quantum dots for medical imaging and a growing list of other applications. Sections cover different mechanical, absorption, optical and electrical properties than those found in original nanomaterials. This is an important reference source that will be valuable to materials scientists, biomedical engineers and pharmaceutical scientists who are looking to increase their understanding on how functionalized carbon nanomaterials are being used for a variety of theranostic applications. Provides readers with information on how to develop functionalized carbon nanomaterials based diagnostic devices and tools Identifies fabrication and characterization methods for integrated devices for use in theranostic applications Assesses major challenges for manufacturing functionalized carbon nanomaterial materials for theranostic devices on an industrial scale

Download or read book Carbon Nanomaterials for Biomedical Applications written by Mei Zhang and published by Springer. This book was released on 2015-11-06 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers a wide range of topics relating to carbon nanomaterials, from synthesis and functionalization to applications in advanced biomedical devices and systems. As they possess unique and attractive chemical, physical, optical, and even magnetic properties for various applications, considerable effort has been made to employ carbon nanomaterials (e.g., fullerenes, carbon nanotubes, graphene, nanodiamond) as new materials for the development of novel biomedical tools, such as diagnostic sensors, imaging agents, and drug/gene delivery systems for both diagnostics and clinical treatment. Tremendous progress has been made and the scattered literature continues to grow rapidly. With chapters by world-renowned experts providing an overview of the state of the science as well as an understanding of the challenges that lie ahead, Carbon Nanomaterials for Biomedical Applications is essential reading not only for experienced scientists and engineers in biomedical and nanomaterials areas, but also for graduate students and advanced undergraduates in materials science and engineering, chemistry, and biology.

Download or read book Handbook of Carbon Based Nanomaterials written by Sabu Thomas and published by Elsevier. This book was released on 2021-07-23 with total page 912 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Carbon-Based Nanomaterials provides a comprehensive overview of carbon-based nanomaterials and recent advances in these specialized materials. This book opens with a brief introduction to carbon, including the different forms of carbon and their range of uses. Each chapter systematically covers a different type of carbon-based nanomaterial, including its individual characteristics, synthesis techniques and applications in industry, biomedicine and research. This book offers a broad handbook on carbon-based nanomaterials, detailing the materials aspects, applications and recent advances of this expansive topic. With its global team of contributing authors, Handbook of Carbon-Based Nanomaterials collates specific technical expertise from around the world, for each type of carbon-based nanomaterial. Due to the broad nature of the coverage, this book will be useful to an interdisciplinary readership, including researchers in academia and industry in the fields of materials science, engineering, chemistry, energy and biomedical engineering. Covers a range of carbon-based nanomaterials, including graphene, fullerenes and much more Describes key properties, synthesis techniques and characterization of each carbon-based nanomaterial Discusses a range of applications of carbon-based nanomaterials, from biomedicine to energy applications

Download or read book Micro and Nanotechnologies Based Product Development written by Neelesh Kumar Mehra and published by CRC Press. This book was released on 2021-09-06 with total page 582 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides comprehensive information of the nanotechnology-based pharmaceutical product development including a diverse range of arenas such as liposomes, nanoparticles, fullerenes, hydrogels, thermally responsive externally activated theranostics (TREAT), hydrogels, microspheres, micro- and nanoemulsions and carbon nanomaterials. It covers the micro- and nanotechnological aspects for pharmaceutical product development with the product development point of view and also covers the industrial aspects, novel technologies, stability studies, validation, safety and toxicity profiles, regulatory perspectives, scale-up technologies and fundamental concept in the development of products. Salient Features: Covers micro- and nanotechnology approaches with current trends with safety and efficacy in product development. Presents an overview of the recent progress of stability testing, reverse engineering, validation and regulatory perspectives as per regulatory requirements. Provides a comprehensive overview of the latest research related to micro- and nanotechnologies including designing, optimisation, validation and scale-up of micro- and nanotechnologies. Is edited by two well-known researchers by contribution of vivid chapters from renowned scientists across the globe in the field of pharmaceutical sciences. Dr. Neelesh Kumar Mehra is working as an Assistant Professor of Pharmaceutics & Biopharmaceutics at the Department of Pharmaceutics, National Institute of Pharmaceutical Education & Research (NIPER), Hyderabad, India. He received ‘TEAM AWARD’ for successful commercialisation of an ophthalmic suspension product. He has authored more than 60 peer-reviewed publications in highly reputed international journals and more than 10 book chapter contributions. He has filed patents on manufacturing process and composition to improved therapeutic efficacy for topical delivery. He guided PhD and MS students for their dissertations/research projects. He has received numerous outstanding awards including Young Scientist Award and Team Award for his research output. He recently published one edited book, ‘Dendrimers in Nanomedicine: Concept, Theory and Regulatory Perspectives’, in CRC Press. Currently, he is editing books on nano drug delivery-based products with Elsevier Pvt Ltd. He has rich research and teaching experience in the formulation and development of complex, innovative ophthalmic and injectable biopharmaceutical products including micro- and nanotechnologies for regulated market. Dr. Arvind Gulbake is working as an Assistant Professor at the Faculty of Pharmacy, School of Pharmaceutical & Population Health Informatics, at DIT University, Dehradun, India. He has authored more than 40 peer-reviewed publications in highly reputed international journals, four book chapters and a patent contribution. He has received outstanding awards including Young Scientist Award and BRG Travel Award for his research. He is an assistant editor for IJAP. He guided PhD and MS students for their dissertations/research projects. He has successfully completed extramural project funded by SERB, New Delhi, Government of India. He has more than 12 years of research and teaching experience in the formulation and development of nanopharmaceuticals.

Download or read book Carbon Nanomaterials for Bioimaging Bioanalysis and Therapy written by Yuen Y. Hui and published by John Wiley & Sons. This book was released on 2019-01-29 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive reference on biochemistry, bioimaging, bioanalysis, and therapeutic applications of carbon nanomaterials Carbon nanomaterials have been widely applied for biomedical applications in the past few decades, because of their unique physical properties, versatile functionalization chemistry, and biological compatibility. This book provides background knowledge at the entry level into the biomedical applications of carbon nanomaterials, focusing on three applications: bioimaging, bioanalysis, and therapy. Carbon Nanomaterials for Bioimaging, Bioanalysis and Therapy begins with a general introduction to carbon nanomaterials for biomedical applications, including a discussion about the pros and cons of various carbon nanomaterials for the respective therapeutic applications. It then goes on to cover fluorescence imaging; deep tissue imaging; photoacoustic imaging; pre-clinical/clinical bioimaging applications; carbon nanomaterial sensors for cancer and disease diagnosis; targeted cancer therapy; and photothermal/photodynamic therapy. Each chapter briefly introduces the biomedical application and emphasizes the most appropriate carbon nanomaterial(s) for the application. Provides an introduction to the biomedical applications of carbon nanomaterials for early-career scientists, as well as background and context for mid-career scientists and researchers Contains four sections covering biochemistry, bioimaging, bioanalysis, and therapeutic applications of carbon nanomaterials Presented by experts who have strong background in the field of nanotechnology for biomedical applications Covers a hot area of research which has very unique physical properties, versatile functionalization chemistry, and biological compatibility Carbon Nanomaterials for Bioimaging, Bioanalysis and Therapy is an excellent resource for academic researchers and industrial scientists working on preparation and bio-application of carbon nanomaterials, biomedical engineering, and nanotechnology.

Download or read book Next Generation Graphene Nanomaterials for Cancer Theranostic Applications written by Rohit Srivastava and published by Springer Nature. This book was released on 2021-01-24 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the use of graphene and its derivatives for application in cancer diagnosis and therapy. Readers are introduced to graphene nanomaterial history, synthesis procedures, properties, modifications, and applications in cancer research and development. The wide-ranging properties of graphene nanomaterials can be utilized for various cancer therapeutic and diagnostic applications. The contents discuss these applications with simple graphical overviews and provide comprehensive detail for a better understanding of the state of the art. The book will be of interest to professionals and academic researchers alike.