Download or read book Development and Specification of Cortical Areas in the Non Human Primate written by Clarisse Pace and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The primate cerebral cortex has undergone evolutionary expansion and complexification, which is reflected by an increase in the number of cortical areas and an enlargement of the supragranular neuron layers. The developmental mechanisms involved in cortical expansion and aerial specification in primates are considered to be key factors underlying functional dynamics of the primate cortex as well as the highly developed computational abilities of the human brain. This PhD thesis seeks to refine our understanding of non human primate (NHP) cortical specification through two parallel approaches. The first part focuses on the analysis of the development of a cortical area rarely studied, the frontal cortex. Using long term live imaging with two-photon time lapse video microscopy on organotypic slices of embryonic NHP cortex as well as immunostainings experiments, we have characterized the morphology and proliferative behavior of frontal cortex progenitors. While our results point to conserved characteristics of cortical development between caudal and rostral regions of the cortex, it also reveals a differential temporal regulation of the balance between proliferative and differentiative divisions between the visual and the frontal cortex. In the second part of this work, we aimed to assess the role of thalamocortical afferents (TCA) on areal identity, focusing on their influence on cortical progenitor proliferation in the visual cortex of the embryonic NHP. A first aim was to determine the relationship between the thalamocortical pathway and the germinal zones in the visual cortex, before assessing the influence of TCA on cell cycle kinetics. Tracing experiments show that the spatiotemporal features of embryonic TCA development provide the necessary circumstances for TCA to interact with and have an influence on progenitors during corticogenesis. We provide evidence of a temporally regulated and area-specific mitogenic effect by TCA on progenitors in the embryonic visual NHP cortex. Together, the results of this PhD thesis provide new insights on area specific features of NHP corticogenesis and on the mechanisms involved in areal specification.
Download or read book Cortical Organization in Humans and Nonhuman Primates written by Chad J. Donahue and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Similarities in organization of cerebral cortex in humans and nonhuman primates offer the promise of leveraging data from invasive animal studies to better understand the complexities of the human brain, particularly those related to higher cognitive function (e.g. attention, working memory, language). Such comparisons necessitate the identification of convincing cortical homologues (areas or regions presumed to have derived from a common ancestor), requiring an accurate interspecies mapping of cortical areas and features. To this end, I describe (i) a survey of connectivity and its measures across primate species, particularly retrograde tracing and diffusion tractography, (ii) a morphometric analysis of cognitive regions, namely prefrontal cortex , and (iii) the development of a cortical surface registration driven by multimodal data types to directly compare cortical connectivity measures across species. This novel interspecies registration reveals expansion of primarily cognitive regions from macaque to human (e.g. the default mode network) not described by previous efforts and suggests non-uniform expansion across functional networks and their constituent areas.
Download or read book The Marmoset Brain in Stereotaxic Coordinates written by George Paxinos and published by Academic Press. This book was released on 2011-10-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Marmoset Brain in Stereotaxic Coordinates is the most comprehensive atlas of the brain of this animal available. The atlas is constructed in the style of The Rat Brain in Stereotaxic Coordinates, the most-cited book in neuroscience. It represents a collaboration between world leaders in neuroanatomy of the primate cortex and subcortex. It will be an indispensible tool for neuroanatomists, behavioral neuroscientists, and molecular biologists trying to understand the primate brain. ENDORSED BY SOCIETY FOR BRAIN MAPPING AND THERAPEUTICS (SBMT) - SBMT is a non-profit society organized for the purpose of encouraging basic and clinical scientists who are interested in areas of Brain Mapping, engineering, stem cell, nanotechnology, imaging and medical device to improve the diagnosis, treatment and rehabilitation of patients afflicted with neurological disorders. This society promotes the public welfare and improves patient care through the translation of new technologies/therapies into life saving diagnostic and therapeutic procedures. The Society is focused in breaking boundaries of science, technology, medicine, art and healthcare policy. For more information about how to become a member or participate in SBMT programs please visit: www.WorldBrainMapping.org
Download or read book Jasper s Basic Mechanisms of the Epilepsies written by Jeffrey Noebels and published by OUP USA. This book was released on 2012-06-29 with total page 1258 pages. Available in PDF, EPUB and Kindle. Book excerpt: Jasper's Basic Mechanisms, Fourth Edition, is the newest most ambitious and now clinically relevant publishing project to build on the four-decade legacy of the Jasper's series. In keeping with the original goal of searching for "a better understanding of the epilepsies and rational methods of prevention and treatment.", the book represents an encyclopedic compendium neurobiological mechanisms of seizures, epileptogenesis, epilepsy genetics and comordid conditions. Of practical importance to the clinician, and new to this edition are disease mechanisms of genetic epilepsies and therapeutic approaches, ranging from novel antiepileptic drug targets to cell and gene therapies.
Download or read book The Neocortex written by Wolf Singer and published by MIT Press. This book was released on 2019-10-29 with total page 449 pages. Available in PDF, EPUB and Kindle. Book excerpt: Experts review the latest research on the neocortex and consider potential directions for future research. Over the past decade, technological advances have dramatically increased information on the structural and functional organization of the brain, especially the cerebral cortex. This explosion of data has radically expanded our ability to characterize neural circuits and intervene at increasingly higher resolutions, but it is unclear how this has informed our understanding of underlying mechanisms and processes. In search of a conceptual framework to guide future research, leading researchers address in this volume the evolution and ontogenetic development of cortical structures, the cortical connectome, and functional properties of neuronal circuits and populations. They explore what constitutes “uniquely human” mental capacities and whether neural solutions and computations can be shared across species or repurposed for potentially uniquely human capacities. Contributors Danielle S. Bassett, Randy M. Bruno, Elizabeth A. Buffalo, Michael E. Coulter, Hermann Cuntz, Stanislas Dehaene, James J. DiCarlo, Pascal Fries, Karl J. Friston, Asif A. Ghazanfar, Anne-Lise Giraud, Joshua I. Gold, Scott T. Grafton, Jennifer M. Groh, Elizabeth A. Grove, Saskia Haegens, Kenneth D. Harris, Kristen M. Harris, Nicholas G. Hatsopoulos, Tarik F. Haydar, Takao K. Hensch, Wieland B. Huttner, Matthias Kaschube, Gilles Laurent, David A. Leopold, Johannes Leugering, Belen Lorente-Galdos, Jason N. MacLean, David A. McCormick, Lucia Melloni, Anish Mitra, Zoltán Molnár, Sydney K. Muchnik, Pascal Nieters, Marcel Oberlaender, Bijan Pesaran, Christopher I. Petkov, Gordon Pipa, David Poeppel, Marcus E. Raichle, Pasko Rakic, John H. Reynolds, Ryan V. Raut, John L. Rubenstein, Andrew B. Schwartz, Terrence J. Sejnowski, Nenad Sestan, Debra L. Silver, Wolf Singer, Peter L. Strick, Michael P. Stryker, Mriganka Sur, Mary Elizabeth Sutherland, Maria Antonietta Tosches, William A. Tyler, Martin Vinck, Christopher A. Walsh, Perry Zurn
Download or read book Mouse Brain Development written by Andre M. Goffinet and published by Springer Science & Business Media. This book was released on 2012-08-10 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our understanding of the molecular mechanisms involved in mammalian brain development remains limited. However, the last few years have wit nessed a quantum leap in our knowledge, due to technological improve ments, particularly in molecular genetics. Despite this progress, the available body of data remains mostly phenomenological and reveals very little about the grammar that organizes the molecular dictionary to articulate a pheno type. Nevertheless, the recent progress in genetics will allow us to contem plate, for the first time, the integration of observation into a coherent view of brain development. Clearly, this may be a major challenge for the next century, and arguably is the most important task of contemporary develop mental biology. The purpose of the present book is to provide an overview that syn thesizes up-to-date information on selected aspects of mouse brain devel opment. Given the format, it was not possible to cover all aspects of brain development, and many important subjects are missing. The selected themes are, to a certain extent, subjective and reflect the interests of the contributing authors. Examples of major themes that are not covered are peripheral nervous system development, including myelination, the development of the hippocampus and several other CNS structures, as well as the developmental function of some important morphoregulatory molecules.
Download or read book The Rhesus Monkey Brain in Stereotaxic Coordinates written by George Paxinos and published by Academic Press. This book was released on 2023-12-22 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Rhesus Monkey Brain in Stereotaxic Coordinates is the most comprehensive and accurate atlas of the monkey brain. The fourth edition of this classic book is a complete revision featuring many improvements and upgrades. Constructed by the established leaders in neuroanatomical atlas development, the new edition will continue to be the indispensable resource for all scientists working on the primate nervous system. - 141 completely revised coronal diagrams and accompanying colour photographic plates spaced at approximately 120 μm intervals - 60 colour photographic coronal plates of SMI immunoreactivity with completely revised delineations - Includes MR images at approximately the same levels as the coronal diagrams - Follows the same nomenclature and abbreviations as the mouse, rat, chicken, marmoset and human brain atlases, with indications of correspondence to alternative macaque nomenclatures - This atlas was used for the delineation and nomenclature of MRI-based macaque brain atlases for neuroimaging analyses, including the SARM
Download or read book Cortical Development written by Gregory R. Bock and published by Wiley-Interscience. This book was released on 2007 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: To understand the brain and its devastating diseases, we need to reveal the mechanisms that produce it and the ways in which it can constantly change throughout a lifetime. This book features a timely and insightful discussion between developmental neurobiologists and clinicians who deal with disorders of the nervous system. Chapters in this book deal specifically with cell fate determination, cell migration and disorders of cell migration; current concepts and new ideas about cortical arealisation, and disorders which can arise from incorrect arealisation; genes implicated in the development of cortical connectivity and related pathologies such as schizophrenia and synaesthesia; and susceptibility genes for cognitive disorders such as schizophrenia, autism, dyslexia, and attention deficit disorder.
Download or read book Normal and Abnormal Development of the Cortex written by Albert M. Galaburda and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, the seventh in the series 'Research and Perspectives in Neuroscience', contains the procedings of a meeting that was held in Paris on October14, 1996. The conference consisted of invited papers and poster presentations. The invited papers, included in this volume, were on cell proliferation prior to neuronal migration, on cellular and molecular factors characteristic of neuronal migration, and on postmigrational neuronal and axonal plasticity. There was a section devoted to disorders of neuronal migration and plasticity and the genetics of some developmental disorders. Great strides have been made in this relatively young branch of modern neuroscience.
Download or read book Developmental Neuropathology written by Reinhard L. Friede and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: I was gratified by the most favorable reception and wide usage received by the first edition of this book. A decade seems to be a short period for a book on pathology, and yet it witnessed many important changes of concepts, along with a formidable growth of knowledge. The second edition required extensive reorganization. There are new chapters on mitochondriopathies, on peroxisomal diseases and on spongy myelino pathies. Major revisions and new additions were necessary in many chapters, for instance those on the dysplasias of the cerebral and of the cerebellar hemispheres, which were largely reorganized. The chapters on perinatal pathology were reordered and reorganized to give a more logical sequence of prenatal, perinatal and postnatal lesions. The entire text was worked over for brevity. A wealth of new references was added with the. aim of staying abreast with the literature up to summer 1988. All refer ences were double checked for errors. My gratitude goes to Mrs. Gisela Ropte and Mrs. Cynthia Bunker for their untiring, diligent help. As a result, this second edition is an essentially rewritten text. Advance in the prevention of human suffering is based on a thorough understand ing of the nature of disease. I hope that this text will continue to be of service in this behalf. Perhaps it may also reflect and foster the intellectual curiosity which makes the "reading of brains" so interesting an occupation. Gottingen, 1989 Reinhard L.
Download or read book Functional Organisation of the Human Visual Cortex written by Balázs Gulyás and published by Pergamon. This book was released on 1993 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: As vision is one of the most important sensory modalities present in almost all animal species, the systematic exploration of the visual system has been a major target of neurobiological research in recent years. This research activity has led to increased understanding of the functional, anatomical and biochemical organisation of the primate visual system. This book gives a comprehensive overview of key discoveries relating to the human visual cortex, made possible by new methodologies, such as brain imaging techniques, which have enabled scientists to map the human visual cortex with respect to its functional organisation. Providing a platform for discussion of developments, uncertainties and future exploration in this multidisciplinary field, the book summarises our state-of-the-art knowledge, and gives impetus to comparative studies on the visual systems of humans and other primates.
Download or read book A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates written by Kadharbatcha S. Saleem and published by Academic Press. This book was released on 2012-04-23 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Combined MRI and Histology Atlas of the Rhesus Monkey Brain in Stereotaxic Coordinates, Second Edition maps the detailed architectonic subdivisions of the cortical and subcortical areas in the macaque monkey brain using high-resolution magnetic resonance (MR) images and the corresponding histology sections in the same animal. This edition of the atlas is unlike anything else available as it includes the detailed cyto- and chemoarchitectonic delineations of the brain areas in all three planes of sections (horizontal, coronal, and sagittal) that are derived from the same animal. This is a significant progress because in functional imaging studies, such as fMRI, both the horizontal and sagittal planes of sections are often the preferred planes given that multiple functionally active regions can be visualized simultaneously in a single horizontal or sagittal section. This combined MRI and histology atlas is designed to provide an easy-to-use reference for anatomical and physiological studies in macaque monkeys, and in functional-imaging studies in human and non-human primates using fMRI and PET. The first rhesus monkey brain atlas with horizontal, coronal, and sagittal planes of sections, derived from the same animal Shows the first detailed delineations of the cortical and subcortical areas in horizontal, coronal, and sagittal plane of sections in the same animal using different staining methods Horizonal series illustrates the dorsoventral extent of the left hemisphere in 47 horizontal MRI and photomicrographic sections matched with 47 detailed diagrams (Chapter 3) Coronal series presents the full rostrocaudal extent of the right hemisphere in 76 coronal MRI and photomicrographic sections, with 76 corresponding drawings (Chapter 4) Sagittal series shows the complete mediolateral extent of the left hemisphere in 30 sagittal MRI sections, with 30 corresponding drawings (Chapter 5). The sagittal series also illustrates the location of different fiber tracts in the white matter Individual variability - provides selected cortical and subcortical areas in three-dimensional MRI (horizontal, coronal, and sagittal MRI planes). For comparison, it also provides similar areas in coronal MRI section in six other monkeys. (Chapter 6) Vasculature - indicates the corresponding location of all major blood vessels in horizontal, coronal, and sagittal series of sections Provides updated information on the cortical and subcortical areas, such as architectonic areas and nomenclature, with references, in chapter 2 Provides the sterotaxic grid derived from the in-vivo MR image
Download or read book The Auditory Cortex written by Jeffery A. Winer and published by Springer Science & Business Media. This book was released on 2010-12-02 with total page 711 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been substantial progress in understanding the contributions of the auditory forebrain to hearing, sound localization, communication, emotive behavior, and cognition. The Auditory Cortex covers the latest knowledge about the auditory forebrain, including the auditory cortex as well as the medial geniculate body in the thalamus. This book will cover all important aspects of the auditory forebrain organization and function, integrating the auditory thalamus and cortex into a smooth, coherent whole. Volume One covers basic auditory neuroscience. It complements The Auditory Cortex, Volume 2: Integrative Neuroscience, which takes a more applied/clinical perspective.
Download or read book Models of the Visual Cortex written by David Rose and published by John Wiley & Sons. This book was released on 1985 with total page 616 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive and stimulating study which presents the views of 71 leading theorists on the underlying mechanisms and functions of the primary visual cortex.
Download or read book Patterning and Cell Type Specification in the Developing CNS and PNS written by Bin Chen and published by Academic Press. This book was released on 2020-06-02 with total page 1124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Patterning and Cell Type Specification in the Developing CNS and PNS, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents recent advances in genetic, molecular and cellular methods that have generated a massive increase in new information. The book provides a much-needed update to underscore the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neural patterning and cell type specification in the developing central and peripheral nervous systems. - Features leading experts in various subfields as section editors and article authors - Contains articles that are peer reviewed to ensure accuracy, thoroughness and scholarship - Covers mechanisms which control regional specification, regulate proliferation of neuronal progenitors, control differentiation and survival of specific neuronal subtypes, and control the development of non-neural cells
Download or read book Brain Inspired Computing written by Katrin Amunts and published by Springer Nature. This book was released on 2021-07-20 with total page 159 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book constitutes revised selected papers from the 4th International Workshop on Brain-Inspired Computing, BrainComp 2019, held in Cetraro, Italy, in July 2019. The 11 papers presented in this volume were carefully reviewed and selected for inclusion in this book. They deal with research on brain atlasing, multi-scale models and simulation, HPC and data infra-structures for neuroscience as well as artificial and natural neural architectures.
Download or read book Perceptual Neuroscience written by Vernon B. Mountcastle and published by Harvard University Press. This book was released on 1998 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monumental work creates a new subdiscipline: perceptual neuroscience. Mountcastle gathers information from a vast number of sources reaching back through two centuries, from phylogenetic, comparative, and neuroanatomical studies of the neocortex to rhythmicity and synchronization in neocortical networks and inquiries into the binding problem.
