Download or read book Development and Evaluation of Surface Enhanced Resonance Raman Scattering SERRS Spectroscopy for Quantitative Analysis written by Clare McLaughlin and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Surface Enhanced Raman Spectroscopy written by Marek Prochazka and published by Springer. This book was released on 2015-12-12 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an overview of recent developments in RS and SERS for sensing and biosensing considering also limitations, possibilities and prospects of this technique. Raman scattering (RS) is a widely used vibrational technique providing highly specific molecular spectral patterns. A severe limitation for the application of this spectroscopic technique lies in the low cross section of RS. Surface-enhanced Raman scattering (SERS) spectroscopy overcomes this problem by 6-11 orders of magnitude enhancement compared with the standard RS for molecules in the close vicinity of certain rough metal surfaces. Thus, SERS combines molecular fingerprint specificity with potential single-molecule sensitivity. Due to the recent development of new SERS-active substrates, labeling and derivatization chemistry as well as new instrumentations, SERS became a very promising tool for many varied applications, including bioanalytical studies and sensing. Both intrinsic and extrinsic SERS biosensing schemes have been employed to detect and identify small molecules, nucleic acids and proteins, and also for cellular and in vivo sensing.
Download or read book The Development of Surface Enhanced Resonance Raman Spectroscopy SERRS as a Quantitative and Qualitative Analytical Technique written by Caroline Rodger and published by . This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Principles and Clinical Diagnostic Applications of Surface Enhanced Raman Spectroscopy written by Yuling Wang and published by Elsevier. This book was released on 2021-09-17 with total page 465 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles and Clinical Diagnostic Applications of Surface-Enhanced Raman Spectroscopy summarizes the principles of surface-enhanced Raman scattering/spectroscopy (SERS) and plasmonic nanomaterials for SERS, with a focus on SERS applications in clinical diagnostics. This book covers the key concepts from the fundamentals, materials, experimental aspects, and applications of SERS in clinical diagnostics with discussions on label-free/direct SERS assay, design and synthesis of SERS nanotags, SERS nanotags for point-of-care diagnostics, microfluidic SERS assay, and in vitro and in vivo sensing and imaging. Written by experts from around the world, this comprehensive volume showcases the recent progress of SERS applications in clinical diagnostics and helps readers understand when and how to use SERS in a clinical setting. Introduces the basics of SERS and suitable nanomaterials for SERS application Gives an overview of the cutting-edge research on SERS applications for clinical diagnosis, including the latest advances in our understanding of underlying principles to enable material design and clinical applications Gradually builds from the fundamental concepts to the applications of SERS for clinical diagnostics
Download or read book Surface Enhanced Vibrational Spectroscopy written by Ricardo Aroca and published by John Wiley & Sons. This book was released on 2006-05-01 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface Enhanced Vibrational Spectroscopy (SEVS) has reached maturity as an analytical technique, but until now there has been no single work that describes the theory and experiments of SEVS. This book combines the two important techniques of surface-enhanced Raman scattering (SERS) and surface-enhanced infrared (SEIR) into one text that serves as the definitive resource on SEVS. Discusses both the theory and the applications of SEVS and provides an up-to-date study of the state of the art Offers interpretations of SEVS spectra for practicing analysts Discusses interpretation of SEVS spectra, which can often be very different to the non-enhanced spectrum - aids the practicing analyst
Download or read book The Use of Fourier Transform FT Surface enhanced Raman Scattering for Biochemical Analysis written by Robert Butler Jeffers and published by . This book was released on 2009 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Surface Enhanced Raman Scattering written by Zhong-Qun Tian and published by John Wiley & Sons Incorporated. This book was released on 2010-06-14 with total page 400 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface-Enhanced Raman Spectroscopy: Principles, Experiments, and Applications is a comprehensive, up to date, and balanced treatment of the theoretical and practical aspects of Surface-Enhanced Raman Scattering (SERS), a useful branch of spectroscopy for several areas of science. This book describes the basic principles of SERS, including SERS mechanisms, performing SERS measurements, and interpreting data. Also emphasized are applications in electrochemistry; catalysis; surface processing and corrosion; Self-Assemble-Layer and L-B Films; polymer science; biology; medicine and drug analysis; sensors; fuel cells; forensics; and archaeology. It is an essential guide for student and professional analytical chemists.
Download or read book Frontiers of Surface Enhanced Raman Scattering written by Yukihiro Ozaki and published by John Wiley & Sons. This book was released on 2014-02-19 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive presentation of Surface-Enhanced Raman Scattering (SERS) theory, substrate fabrication, applications of SERS to biosystems, chemical analysis, sensing and fundamental innovation through experimentation. Written by internationally recognized editors and contributors. Relevant to all those within the scientific community dealing with Raman Spectroscopy, i.e. physicists, chemists, biologists, material scientists, physicians and biomedical scientists. SERS applications are widely expanding and the technology is now used in the field of nanotechnologies, applications to biosystems, nonosensors, nanoimaging and nanoscience.
Download or read book Development of a Surface Enhanced Resonance Raman Scattering SERRS Method for the Determination of 2 4 6 trinitrotoluene written by Mairi Campbell and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Surface Enhanced Raman Scattering written by Richard Chang and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 424 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the course of the development of surface science, advances have been identified with the introduction of new diagnostic probes for analytical characterization of the adsorbates and microscopic structure of surfaces and interfaces. Among the most recently de veloped techniques, and one around which a storm of controversy has developed, is what has now been earmarked as surface enhanced Raman scattering (SERS). Within this phenomenon, molecules adsorbed onto metal surfaces under certain conditions exhibit an anomalously large interaction cross section for the Raman effect. This makes it possible to observe the detailed vibrational signature of the adsorbate in the ambient phase with an energy resolution much higher than that which is presently available in electron energy loss spectroscopy and when the surface is in contact with a much larger amount of material than that which can be tolerated in infrared absorption experiments. The ability to perform vibrational spectroscopy under these conditions would lead to a new understanding about the chemical identity, geome try, and bonding of adsorbed material at a level previously unacces sible. It is for these reasons that the last few years have brought an explosion of activity surrounding the exploitation of SERS. The search for the origines) of the anomalous enhancement has given rise to a research sub-activity of its own. Efforts to explain the en hancement have led to an increased understanding of the whole range of phenomena associated with the interaction of photons with adsor bates and metal surfaces.
Download or read book Surface Enhanced Raman Scattering written by Katrin Kneipp and published by Springer Science & Business Media. This book was released on 2006-06-21 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Almost 30 years after the first reports on surface-enhanced Raman signals, the phenomenon of surface-enhanced Raman scattering (SERS) is now well established. SERS gained particular interest after single-molecule Raman spectroscopy had been demonstrated. This book summarizes and discusses present theoretical approaches that explain the phenomenon of SERS and reports on new and exciting experiments and applications of the fascinating spectroscopic effect.
Download or read book Surface Enhanced Raman Scattering New Theoretical Approaches Materials and Strategies written by Ivano Alessandri and published by Frontiers Media SA. This book was released on 2020-03-25 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Quantitative Analysis of Surface Enchanced Raman Spectra written by Shuo Li and published by . This book was released on 2013 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative analysis of Raman spectra using surface-enhanced Raman scattering (SERS) nanoparticles has shown the potential and promising trend of development in vivo molecular imaging. One of the key job is from the intensities of Raman signals to predict the quantities of analytes. Direct classical least squares (DCLS) and multivariate calibration (MC) are commonly used methods. DCLS relies on source Raman signals as the references. But the inherent Instability of Raman signals make the DCLS model not robust enough. MC model relies on a batch of training mixture Raman signals together with the ground truth mixing concentrations to build the multivariate multiple linear regression models, so as to reduce the bias from the instability of source Raman signals. But it also brings in the more variables than observations problem. Latent variable regression (LVR) model avoids that problem by extracting low dimensional latent variables (LVs) (or extracted features) to do regression with concentrations. Among several LVR methods, partial least squares regression (PLSR) algorithms are more robust, since their LVs both represent original Raman signals and predict concentrations. In this thesis, quantitative analysis models and methods are compared to show why PLSR algorithms are more robust for the purpose of quantitative analysis of Raman spectra. Only PLSR cannot handle the instable background of Raman signals. Baseline correction methods are commonly used as the preprocessing to find a slowly changed baseline under the signal as the estimated background. Raman peaks are extracted then by subtracting the baseline from the Raman signal. But baseline correction methods are usually time consuming iterative processes, and normally they cannot deal with the multi-scale property of Raman peaks. We designed a simple algorithm, called continuous wavelet transform (CWT) based partial least squares regression (CWT-PLSR) that uses the average CWT coefficients of mixture Raman signals to do PLSR with mixing concentrations. It extracts the multi-scale information of Raman peaks and so is more robust than traditional baseline correction methods.The features extracted by PLSR give more weights to those Raman peaks that both representing Raman signals and predicting concentrations well. But the portion of each purpose is fixed in the objective function of PLSR. To improve the flexibility of PLSR, we designed a new continuum regression (CR) method that use a tuning parameter to control the portion of each purpose in the objective function and it gives more reasonable weights to Raman peaks. It beats other two CR methods by embracing PCR, RRR and PLS as three special cases, and is simply achieved by NIPALS algorithm.Tuning parameters of PLSR and CR methods are normally decided by time-consuming cross-validation methods. And some parameters have infinite numbers of possible values in continuous ranges. There is no way to test every value by cross-validation methods. Nonparametric Bayesian models of these methods are needed to decide the parameters automatically from the training data. As a foundation work, we design a probabilistic PLS regression model to give a probabilistic view of the PLSR methods. Future Bayesian models can be achieved by adding reasonable priors of the parameters.
Download or read book Towards a Quantitative Understanding of Surface Enhanced Raman Phenomena by Using Internal References written by Fathima Suraiya Ameer and published by . This book was released on 2015 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: Accurate determination of the surface enhanced Raman scattering (SERS) enhancement factor (EF) is critically important for a fundamental understanding of the SERS phenomenon. Experimental quantification of SERS EFs is challenging. A series of instrument-, analyte-, and SERS-substrate related issues can affect the SERS intensity and thus compromise the reliability of the measured SERS EFs. This dissertation presents a series of computational and experimental studies that enhance the quantitative understanding of the SERS signal variation and identify ways to enhance the reliability of the SERS EF determination. Chapter I presents an overview of works described in this dissertation. The gold nanoparticle (AuNP) inner filter effect on SERS measurements is demonstrated in Chapter II. Using dithiopurine and ethanol as model analytes, we demonstrate that the nanoparticle will modify the analytes’ Raman signal through two competitive mechanisms: enhancing the Raman signal of the analyte on the nanoparticle surface through electromagnetic enhancement, and attenuating the analyte Raman signal through photon extinction. The significance of the AuNP inner filter effect is quantitatively evaluated using ethanol as the internal reference. A solvent internal reference method is presented in Chapter III for quantifying the SERS EFs of analytes adsorbed onto AuNPs and AgNPs. One of the key findings is that while an analyte’s SERS EF varies significantly as a function of nanoparticle aggregation, its peak SERS EF depends only on the types and sizes of nanoparticles, but not on experimental conditions including concentrations of analyte, nanoparticle, and aggregation reagent. Chapter IV presents a SERS internal reference method for the determination of the resonance Raman EFs in the SERS study of rhodamine 6G (R6G) adsorbed onto AuNPs and AgNPs. The most striking finding is that the AgNP binding reduces, instead of enhancing, the R6G resonance enhancement. Finally, the wavelength-dependent correlation between UV-vis intensities and SERS EFs of aggregated AuNPs and AgNPs were investigated under three fixed excitation wavelengths (532, 632, and 785 nm). The nanoparticle UV-vis intensity is an excellent indicator for identifying the optimal aggregation state for AgNP-based SERS acquisitions under each of the three excitation wavelengths and for the AuNP-based SERS under a 632 nm excitation.
Download or read book Evaluation of Substrates for Surface enhanced Raman Scattering written by Muyang Zhong and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface-enhanced Raman scattering (SERS) has long been the interest of researchers in chemistry, physics and engineering, especially since the discovery that SERS can probe into the system down to the single molecule (SM) level. Despite the large number of publications regarding the fabrication of SERS substrates, it has been a challenge in the field to quantify the SERS signal and universally compare substrates. Traditionally, enhancement factor (EF) is used as an indicator of substrate quality, but the EF calculation is hugely dependent on the estimation of the surface coverage and other factors that are determined largely subjectively. Therefore, this thesis aims at discussing other parameters that can also be used to evaluate different substrates. Six different SERS substrates of Ag or Au nanoparticles of different sizes were fabricated by nanosphere lithography (NSL) and characterized by electron microscopy and UV-vis spectroscopy. SERS substrates were mapped for different concentrations of a probe molecule. Through subsequent baseline correction and principle component analysis (PCA), the "intensity" of individual spectrum was obtained and the shapes of intensity histograms of each substrate were acquired.Instead of calculating EF, five criteria (six quantification methods in total) were employed to comprehensively evaluate the six substrates. These were density of hot spots (characterized by the number of zero-intensity events), enhancement (represented by mean intensity), spatial variation (calculated by RSD of intensity), repeatability (realized by cross correlation) and histogram shape (quantified by skewness and kurtosis). These new methods provide insights to the understanding of the properties of SERS substrates in terms of hot spots. Different substrates may exhibit better performance in terms of one criterion but worse in terms of others. Those variations in performance can be explained by their surface morphology.These more elaborated methods are believed to provide a more comprehensive approach to evaluate and compare substrates than the traditional EF values. The thesis also paves the way for future study on SM-SERS and fabricating better SERS substrates.
Download or read book Raman Spectroscopy written by Dheeraj Kumar Singh and published by Springer. This book was released on 2024-06-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights recent advances of spectroscopic techniques based on Raman scattering. Different applications are introduced that serve as examples for the versatile use of Raman techniques. Raman spectroscopy is a marker free technique, which is capable of yielding detailed information about molecular systems in a non-destructive way. This makes it a valuable tool for, e.g., material science or medical research. The access to vibrational energy and dynamics yields fundamental insights into static and dynamical structural properties of molecules being influenced by and influencing their material science or medical research environment. The better understanding of the basic building blocks of materials helps to improve the functionality in various applications. Raman spectroscopy has become a truly interdisciplinary research tool, and the ongoing development of techniques makes it attractive for growing variety of scientific and industrial applications, which will be demonstrated in the book. While the “classical” linear spontaneous Raman spectroscopy is restricted in its applicability due to low signal intensities or the excitation of strong fluorescence background, new techniques have helped to overcome such problems. Examples, presented in the book, are surface-enhanced Raman scattering (SERS), and various associated techniques are used to drastically increase signal intensity, confocal, and tip-enhanced Raman scattering (TERS) allowing for high and even sub-diffraction limited spatial resolutions, coherent anti-Stokes Raman scattering (CARS) avoiding fluorescence background and allowing for time-resolved observations of vibrational dynamics, or hyper- and resonance Raman scattering influencing the scattering based on electronic resonances, etc.
Download or read book Surface Enhanced Raman Spectroscopy written by Sebastian Schlücker and published by John Wiley & Sons. This book was released on 2011-09-19 with total page 97 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering everything from the basic theoretical and practical knowledge to new exciting developments in the field with a focus on analytical and life science applications, this monograph shows how to apply surface-enhanced Raman scattering (SERS) for solving real world problems. From the contents: * Theory and practice of SERS * Analytical applications * SERS combined with other analytical techniques * Biophysical applications * Life science applications including various microscopies Aimed at analytical, surface and medicinal chemists, spectroscopists, biophysicists and materials scientists. Includes a Foreword by the renowned Raman spectroscopist Professor Wolfgang Kiefer, the former Editor-in-Chief of the Journal of Raman Spectroscopy.
