Download or read book Development and Assessment of an Oral Biphasic Lipophilic Drug Delivery System with Greatly Enhanced Bioavailability Characteristics written by Stephen John Burns and published by . This book was released on 1997 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oral Lipid Based Formulations written by David J. Hauss and published by CRC Press. This book was released on 2007-06-08 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem
Download or read book Self Emulsifying Systems for Oral Bioavailability Enhancement of Drugs written by Suryakanta Swain and published by LAP Lambert Academic Publishing. This book was released on 2014-10-22 with total page 84 pages. Available in PDF, EPUB and Kindle. Book excerpt: Self-nanoemulsifying drug delivery systems (SNEDDS) have been proved as technologically worthwhile, effortlessly scalable and economically sound delivery systems for enhancing the oral bioavailability of highly lipophilic drugs. Distinct merits of smaller globule size, higher solubilization tendency and robust formulation advantages have made them as one of the most promising alternatives among the diverse lipid-based nanostructured systems. In the last two decades, the phenomenal success of SNEDDS as a potential delivery platform for oral delivery of drugs has gained phenomenal interest in academia and industry with utility of them in non-oral drug delivery too. The current book manuscript provides an overview account on the recent advances in the development of self-nanoemulsifying formulations along with their characterization and applications in enhancing biopharmaceutical performance of the drugs. Besides, the book highlights two research case studies as instances to the pharmaceutical formulation scientists for development of solid self-nanoemulsifying systems of two poorly water soluble drugs, ondansetron and valsartan, for enhancing their oral bioavailability.
Download or read book An Investigation of the Impact of Intestinal Lymphatic Transport on Bioavailability Systemic Clearance and Disposition of Lipophilic Drugs written by Suzanne Mary Caliph and published by . This book was released on 2013 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highly lipophilic and poorly water soluble drug candidates are common outcomes ofdrug discovery programs in recent years, presenting drug development challenges throughpoor gastrointestinal absorption and insufficient systemic exposure after oral administration.Co-administration with lipidic excipients presents an apparent strategy to improve the oralbioavailability of these compounds by stimulating enhanced solubilisation in the gut andrecruitment of intestinal lymphatic drug transport. The impact of stimulating intestinallymphatic transport to improve oral bioavailability on systemic drug exposure, clearance anddeposition has been poorly understood. The interpretation of lymphatic drug transport data isfurther complicated by variations in dosing excipients and dispersed states, study models,prandial (fed/fasted) states, intravenous dosing conditions and formulations used for theassessment of absolute bioavailability. The studies described in this thesis investigatedvarious factors affecting the intestinal lymphatic transport and oral bioavailability assessmentof highly lipophilic compounds using lymph-cannulated and non lymph-cannulated animals.These factors examined included subtle differences in lipophilicity and lipid solubility ofchemically similar drug analogues, lipid and non-lipid based oral formulations, intravenousdosing states and dosing conditions. The impact of lymphatic drug delivery on systemicexposure, clearance and drug deposition was also examined in comparison with portal routeof drug absorption in this thesis. Oral bioavailability of highly lipophilic analogues wassignificantly enhanced after administration in long chain lipid-based formulations viastimulation of intestinal lymphatic transport and significantly influenced by subtle differencesin lipid solubility, however, not lipophilicity as indicated by log P. After delivery in lymph orthe lipid-based emulsion, systemic clearance (Cl) and volume of distribution (Vd) of a highlylipophilic, lymphatically transported model drug, halofantrine (Hf) were significantly lowerthan when delivered in plasma or lipid-free co-solvent formulation. However, where drug andlipid entered the systemic circulation coincidentally, Cl and Vd were unaffected by the routeof entry, but significantly altered by total plasma lipid levels. These findings suggest that amismatch in plasma lipid levels after intravenous and oral administration may lead todifferences in drug clearance and errors in bioavailability assessment. This thesis alsoinvestigated the influence of absorption route (lymphatics vs. blood) on drugpharmacokinetics and tissue distribution. Brain to blood ratios were found to be significantlylower after stimulation of intestinal lymphatic delivery suggesting that drug association withintestinal lymph lipoproteins might limit brain drug access. Lipophilic model compounds(DDT, Hf) and lipids were assessed following delivery to the systemic circulation inassociation with lymph lipoproteins or plasma, and were found to differ significantly. ForDDT, Cl and Vd were higher whereas for Hf, these parameters were lower due, in particular,to differences in adipose tissue uptake and liver uptake. For compounds like DDT, changes tothe route of absorption may thus directly impact on pharmacokinetics and tissue distribution,whereas for Hf, factors which influence lymphatic transport may, by altering systemiclipoprotein concentrations, indirectly impact pharmacokinetics and tissue distribution.Ultimately, careful control of dosing conditions and thus the extent of lymphatic transportmay be important in assuring reproducible efficacy and toxicity for lymphatically transporteddrugs.
Download or read book Oral Delivery of Therapeutic Peptides and Proteins written by Puneet Tyagi and published by Elsevier. This book was released on 2022-08-15 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral Delivery of Therapeutic Peptides and Proteins provides a complete overview of the journey scientists pursue to attain protein and peptide oral delivery. The book highlights the physiological challenges that must be accounted for in addition to overcoming protease inhibition and acid stability issues that are commonly mentioned in this area of research. Primary topics include formulation technologies being adopted for oral delivery of proteins and peptides, modification of actives to make them more suited for oral delivery, animal models and their shortcomings in assessing oral bioavailability, and in vitro models to simulate drug absorption and transport. Academics and industry researchers working in formulation development and researchers and advanced students in biotechnology and pharmacy will find this a useful resource. Demonstrates how proteins and peptides transport throughout the gastrointestinal tract and how to evaluate their biological fate when encapsulated into certain delivery systems Examines developing technologies to improve future oral bioavailability Includes the in vitro and preclinical techniques needed for development
Download or read book Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards written by and published by . This book was released on 1998 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt: Theses on any subject submitted by the academic libraries in the UK and Ireland.
Download or read book Oral Controlled Release Formulation Design and Drug Delivery written by Hong Wen and published by John Wiley & Sons. This book was released on 2011-01-14 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.
Download or read book Lipid Nanocarriers for Drug Targeting written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2018-04-16 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid Nanocarriers for Drug Targeting presents recent advances in the area of lipid nanocarriers. The book focuses on cationic lipid nanocarriers, solid lipid nanocarriers, liposomes, thermosensitive vesicles, and cubosomes, with applications in phototherapy, cosmetic and others. As the first book related to lipid nanocarriers and their direct implication in pharmaceutical nanotechnology, this important reference resource is ideal for biomaterials scientists and those working in the medical and pharmaceutical industries that want to learn more on how lipids can be used to create more effective drug delivery systems. - Highlights the most commonly used types of lipid nanocarriers and explains how they are applied in pharmacy - Shows how lipid nanocarriers are used in different types of treatment, including oral medicine, skin repair and cancer treatment - Assesses the pros and cons of using different lipid nanocarriers for different therapies
Download or read book Drug Delivery Approaches written by Bret Berner and published by John Wiley & Sons. This book was released on 2021-08-31 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explore this comprehensive discussion of the application of physiologically- and physicochemical-based models to guide drug delivery edited by leading experts in the field Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics delivers a thorough discussion of drug delivery options to achieve target profiles and approaches as defined by physical and pharmacokinetic models. The book offers an overview of drug absorption and physiological models, chapters on oral delivery routes with a focus on both PBPK and multiple dosage form options. It also provides an explanation of the pharmacokinetics of the formulation of drugs delivered by systemic transdermal routes. The distinguished editors have included practical and accessible resources that address the biological and delivery approaches to pulmonary and mucosal delivery of drugs. Emergency care settings are also described, with explorations of the relationship between parenteral infusion profiles and PK/PD. The future of drug delivery is addressed via discussions of virtual experiments to elucidate mechanisms and approaches to drug delivery and personalized medicine. Readers will also benefit from the inclusion of: A thorough introduction to the utility of mathematical models in drug development and delivery An exploration of the techniques and applications of physiologically based models to drug delivery Discussions of oral delivery and pharmacokinetic models and oral site-directed delivery A review of integrated transdermal delivery and pharmacokinetics in development An examination of virtual experiment methods for integrating pharmacokinetic, pharmacodynamic, and drug delivery mechanisms Alternative endpoints to pharmacokinetics for topical delivery Perfect for researchers, industrial scientists, graduate students, and postdoctoral students in the area of pharmaceutical science and engineering, Drug Delivery Approaches: Perspectives from Pharmacokinetics and Pharmacodynamics will also earn a place in the libraries of formulators, pharmacokineticists, and clinical pharmacologists.
Download or read book Polymeric Gels written by Kunal Pal and published by Woodhead Publishing. This book was released on 2018-06-15 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymeric Gels: Characterization, Properties and Biomedical Applications covers the fundamentals and applications of polymeric gels. Particular emphasis is given to their synthesis, properties and characteristics, with topics such as natural, synthetic, and smart polymeric gels, medical applications, and advancements in conductive and magnetic gels presented. The book covers the basics and applications of hydrogels, providing readers with a comprehensive guide on the types of polymeric gels used in the field of biomedical engineering. - Provides guidance for decisions on the suitability and appropriateness of a synthetic route and characterization technique for particular polymeric networks - Analyzes and compares experimental data - Presents in-depth information on the physical properties of polymeric gels using mathematical models - Uses an interdisciplinary approach to discuss potential new applications for both established polymeric gels and recent advances
Download or read book Lipid Based Nanocarriers for Drug Delivery and Diagnosis written by Muhammad Raza Shah and published by William Andrew. This book was released on 2017-06-07 with total page 373 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid-Based Nanocarriers for Drug Delivery and Diagnosis explores the present state of widely used lipid-based nanoparticulate delivery systems, such as solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), nanoliposomes, micelles, nanoemulsions, nanosuspensions and lipid nanotubes. The various types of lipids that can be exploited for drug delivery and their chemical composition and physicochemical characteristics are reviewed in detail, along with their characterization aspects and effects of their dimensions on drug delivery systems behavior in-vitro and in-vivo. The book covers the effective utilization of these lipids based systems for controlled and targeted delivery of potential drugs/genes for enhanced clinical efficacy. - Provides the present state of widely used lipid-based nanoparticulate delivery systems - Explores how lipid-based nanocarriers improve drug delivery safety - Describes the nanoformulation design and the preparation methods of lipid-based nanocarriers
Download or read book Toxicological Profile for Polycyclic Aromatic Hydrocarbons written by and published by . This book was released on 1995 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Excipient Applications in Formulation Design and Drug Delivery written by Ajit S Narang and published by Springer. This book was released on 2015-10-07 with total page 700 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, emerging trends in the design and development of drug products have indicated ever greater need for integrated characterization of excipients and in-depth understanding of their roles in drug delivery applications. This book presents a concise summary of relevant scientific and mechanistic information that can aid the use of excipients in formulation design and drug delivery applications. Each chapter is contributed by chosen experts in their respective fields, which affords truly in-depth perspective into a spectrum of excipient-focused topics. This book captures current subjects of interest – with the most up to date research updates – in the field of pharmaceutical excipients. This includes areas of interest to the biopharmaceutical industry users, students, educators, excipient manufacturers, and regulatory bodies alike.
Download or read book Drug Delivery Systems written by Kewal K. Jain and published by Springer Science & Business Media. This book was released on 2008-03-07 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this concise and systematic book, a team of experts select the most important, cutting-edge technologies used in drug delivery systems. They take into account significant drugs, new technologies such as nanoparticles, and therapeutic applications. The chapters present step-by-step laboratory protocols following the highly successful Methods in Molecular BiologyTM series format, offering readily reproducible results vital for pharmaceutical physicians and scientists.
Download or read book Electrospun Nanofibers written by Mehdi Afshari and published by Woodhead Publishing. This book was released on 2016-09-13 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Electrospun Nanofibers covers advances in the electrospinning process including characterization, testing and modeling of electrospun nanofibers, and electrospinning for particular fiber types and applications. Electrospun Nanofibers offers systematic and comprehensive coverage for academic researchers, industry professionals, and postgraduate students working in the field of fiber science. Electrospinning is the most commercially successful process for the production of nanofibers and rising demand is driving research and development in this field. Rapid progress is being made both in terms of the electrospinning process and in the production of nanofibers with superior chemical and physical properties. Electrospinning is becoming more efficient and more specialized in order to produce particular fiber types such as bicomponent and composite fibers, patterned and 3D nanofibers, carbon nanofibers and nanotubes, and nanofibers derived from chitosan. - Provides systematic and comprehensive coverage of the manufacture, properties, and applications of nanofibers - Covers recent developments in nanofibers materials including electrospinning of bicomponent, chitosan, carbon, and conductive fibers - Brings together expertise from academia and industry to provide comprehensive, up-to-date information on nanofiber research and development - Offers systematic and comprehensive coverage for academic researchers, industry professionals, and postgraduate students working in the field of fiber science
Download or read book Biopharmaceutics Applications in Drug Development written by Rajesh Krishna and published by Springer Science & Business Media. This book was released on 2007-09-20 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: The highly experienced authors here present readers with step-wise, detail-conscious information to develop quality pharmaceuticals. The book is made up of carefully crafted sections introducing key concepts and advances in the areas of dissolution, BA/BE, BCS, IVIC, and product quality. It provides a specific focus on the integration of regulatory considerations and includes case histories highlighting the biopharmaceutics strategies adopted in development of successful drugs.
Download or read book Drug Bioavailability written by Han van de Waterbeemd and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so-called bioavailability. Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability. These range from modern physicochemical techniques via biological studies in vitro and in vivo right up to computer-aided predictions. The authors specifically address possibilities for optimizing bioavailability during the early screening stage for the active substance. Its clear structure and comprehensive coverage make this book equally suitable for researchers and lecturers in industry and teaching.
