Download or read book Development and Assessment of Advanced Quantitative Body Diffusion Weighted MRI written by Yuxin Zhang and published by . This book was released on 2021 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffusion-Weighted MRI (DW-MRI) has a unique ability to non-invasively probe tissue microstructure without the need for ionizing radiation or contrast agent administration. This ability makes DW-MRI a powerful tool for the detection, staging, and treatment monitoring of cancer. However, DWI remains limited by multiple imaging challenges, especially in extracranial organs such as liver and prostate. The major challenges include: 1) relatively long acquisition time in multi-parametric mapping, 2), T2-shinethrough effect 3) artifacts caused by tissue motion and 4) image distortions arising from local magnetic field heterogeneities. In this thesis, technical developments are introduced to address these challenges in prostate and liver DWI. A STimulated-Echo based mapping (STEM) approach is developed and optimized to achieve simultaneous T1, T2 and ADC mapping within five minutes. The STE-DWI sequence is also evaluated in patients with prostate cancer, in order to achieve high contrast-to-noise ratio (CNR) with moderate b-values. To address the motion artifacts in liver DWI caused by cardiac motion, a M1-Optimized Diffusion Imaging (MODI) method is proposed to compensate the motion sensitivity while maintaining the blood-suppression effect using optimized diffusion encoding gradient waveforms. Additionally, reduced Field-of-View and multi-shot EPI acquisitions are assessed in prostate DWI to reduce the geometric distortion artifacts. Finally, a synergistic combination of MODI and multi-shot EPI acquisitions are proposed for motion-robust, reduced-distortion liver DWI. In this work, the feasibility, quantitative accuracy and reproducibility of the proposed techniques are evaluated in simulations, quantitative diffusion phantoms, healthy volunteers and a small number of patients with known or suspected cancer.
Download or read book Quantitative Magnetic Resonance Imaging written by Nicole Seiberlich and published by Academic Press. This book was released on 2020-11-18 with total page 1094 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative Magnetic Resonance Imaging is a ‘go-to’ reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: The basic physics behind tissue property mapping How to implement basic pulse sequences for the quantitative measurement of tissue properties The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* The pros and cons for different approaches to mapping perfusion The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor maps and more complex representations of diffusion How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance Fingerprinting can be used to accelerate or improve tissue property mapping schemes How tissue property mapping is used clinically in different organs Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches
Download or read book Diffusion Weighted MR Imaging written by Dow-Mu Koh and published by Springer Science & Business Media. This book was released on 2010-01-13 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is a great privilege to introduce this book devoted to the current and future roles in research and clinical practice of another exciting new development in MRI: Diffusi- weighted MR imaging. This new, quick and non-invasive technique, which requires no contrast media or i- izing radiation, offers great potential for the detection and characterization of disease in the body as well as for the assessment of tumour response to therapy. Indeed, whereas DW-MRI is already ? rmly established for the study of the brain, progress in MR techn- ogy has only recently enabled its successful application in the body. Although the main focus of this book is on the role of DW-MRI in patients with malignant tumours, n- oncological emerging applications in other conditions are also discussed. The editors of this volume, Dr. D. M. Koh and Prof. H. Thoeny, are internationally well known for their pioneering work in the ? eld and their original contributions to the l- erature on DW-MRI of the body. I am very much indebted to them for the enthusiasm and engagement with which they prepared and edited this splendid volume in a record short time for our series Medical Radiology – Diagnostic section.
Download or read book Development and Assessment of Advanced R 2 Relaxometry and Susceptibility Based Quantitative Body MRI written by Ante Zhu and published by . This book was released on 2019 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Quantitative magnetic resonance imaging (qMRI) techniques have the potential to enable accurate and reproducible characterization of tissue biophysical properties, with broad research and clinical applications. The development of quantitative imaging biomarkers enables reproducible exams across sites, reduces the subjectivity and variability of qualitative evaluation, leading to standardized, evidence-based clinical diagnosis and treatment decisions. In quantitative body MRI, R[2]* relaxometry and tissue magnetic susceptibility have become important biomarkers in assessing diseases including fibrosis, liver iron overload, inflammation, and hyperoxia-related organ dysfunction. In the liver, however, additional factors have recently emerged that limit the accuracy of R[2]* relaxometry and quantitative susceptibility mapping (QSM) based techniques, including the presence of short T[2]* (=1/R[2]*) signals in the liver, and the presence of resolution dependent bias in QSM. In this thesis, an advanced relaxometry technique is developed to characterize the short T[2]* component in the liver and assess its correlation with liver fibrosis. Furthermore, the effect of resolution dependent bias on body QSM is characterized in order to develop accurate and reproducible QSM for the assessment of liver iron overload. Additionally, R[2]* relaxometry and susceptibility based qMRI techniques are highly promising for evaluating the health of the placenta, the organ that mediates the maternal-fetal exchange of nutrients, metabolites, oxygen, and waste. In this thesis, the feasibility and safety of volumetric tracking of super-paramagnetic iron oxide (SPIO) deposition using R[2]* mapping and QSM in ferumoxytol-enhanced MRI for detection of placental inflammation are evaluated in a pregnant rhesus macaque model. Finally, the feasibility of R[2]*-based placental oxygenation mapping is evaluated in both animal and human studies.
Download or read book Advanced analysis of diffusion MRI data written by Xuan Gu and published by Linköping University Electronic Press. This book was released on 2019-11-19 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffusion magnetic resonance imaging (diffusion MRI) is a non-invasive imaging modality which can measure diffusion of water molecules, by making the MRI acquisition sensitive to diffusion. Diffusion MRI provides unique possibilities to study structural connectivity of the human brain, e.g. how the white matter connects different parts of the brain. Diffusion MRI enables a range of tools that permit qualitative and quantitative assessments of many neurological disorders, such as stroke and Parkinson. This thesis introduces novel methods for diffusion MRI data analysis. Prior to estimating a diffusion model in each location (voxel) of the brain, the diffusion data needs to be preprocessed to correct for geometric distortions and head motion. A deep learning approach to synthesize diffusion scalar maps from a T1-weighted MR image is proposed, and it is shown that the distortion-free synthesized images can be used for distortion correction. An evaluation, involving both simulated data and real data, of six methods for susceptibility distortion correction is also presented in this thesis. A common problem in diffusion MRI is to estimate the uncertainty of a diffusion model. An empirical evaluation of tractography, a technique that permits reconstruction of white matter pathways in the human brain, is presented in this thesis. The evaluation is based on analyzing 32 diffusion datasets from a single healthy subject, to study how reliable tractography is. In most cases only a single dataset is available for each subject. This thesis presents methods based on frequentistic (bootstrap) as well as Bayesian inference, which can provide uncertainty estimates when only a single dataset is available. These uncertainty measures can then, for example, be used in a group analysis to downweight subjects with a higher uncertainty.
Download or read book Diffusion MRI written by Heidi Johansen-Berg and published by Academic Press. This book was released on 2013-11-04 with total page 627 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffusion MRI remains the most comprehensive reference for understanding this rapidly evolving and powerful technology and is an essential handbook for designing, analyzing, and interpreting diffusion MR experiments. Diffusion imaging provides a unique window on human brain anatomy. This non-invasive technique continues to grow in popularity as a way to study brain pathways that could never before be investigated in vivo. This book covers the fundamental theory of diffusion imaging, discusses its most promising applications to basic and clinical neuroscience, and introduces cutting-edge methodological developments that will shape the field in coming years. Written by leading experts in the field, it places the exciting new results emerging from diffusion imaging in the context of classical anatomical techniques to show where diffusion studies might offer unique insights and where potential limitations lie. Fully revised and updated edition of the first comprehensive reference on a powerful technique in brain imaging Covers all aspects of a diffusion MRI study from acquisition through analysis to interpretation, and from fundamental theory to cutting-edge developments New chapters covering connectomics, advanced diffusion acquisition, artifact removal, and applications to the neonatal brain Provides practical advice on running an experiment Includes discussion of applications in psychiatry, neurology, neurosurgery, and basic neuroscience Full color throughout
Download or read book Development of Methods for the Acquisition and Analysis of Diffusion Weighted MRI Data written by Marta Morgado Correia and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Experimental Evaluation of Advanced Diffusion MRI Methods Towards Improved Assessment of Myelinated Neural Tissue written by Nathaniel D. Kelm and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Quantitative Analysis of Diffusion weighted Magnetic Resonance Imaging in the Spine written by Andreas Biffar and published by . This book was released on 2010 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Imaging in Oncology written by Michael A. Blake and published by Springer Science & Business Media. This book was released on 2008-03-23 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: This pertinently illustrated and well referenced text serves as an up-to-date, attractive book of oncologic imaging for radiologists, oncologists, radiation therapists and others involved in oncologic care. This volume, with chapter contributions from world-renowned experts, provides clinical and research information that underpins accurate interpretation and sensible use of cancer imaging. The book also highlights new developments and advances in oncologic imaging.
Download or read book Intravoxel Incoherent Motion IVIM MRI written by Denis Le Bihan and published by CRC Press. This book was released on 2018-11-05 with total page 563 pages. Available in PDF, EPUB and Kindle. Book excerpt: First book ever on the topic Discusses current concepts and methodological issues for the successful implementation of IVIM MRI to investigate tissue perfusion non-invasively Covers a wide range of clinical applications Contributions by leading experts in the field from USA, Europe, and Asia and written with a good balance of methodological and clinical chapters Includes an extensive bibliography for further reading
Download or read book Diffusion MRI written by Derek K Jones and published by Oxford University Press. This book was released on 2010-11-11 with total page 784 pages. Available in PDF, EPUB and Kindle. Book excerpt: Professor Derek Jones, a world authority on diffusion MRI, has assembled most of the world's leading scientists and clinicians developing and applying diffusion MRI to produce an authorship list that reads like a "Who's Who" of the field and an essential resource for those working with diffusion MRI. Destined to be a modern classic, this definitive and richly illustrated work covers all aspects of diffusion MRI from basic theory to clinical application. Oxford Clinical Neuroscience is a comprehensive, cross-searchable collection of resources offering quick and easy access to eleven of Oxford University Press's prestigious neuroscience texts. Joining Oxford Medicine Online these resources offer students, specialists and clinical researchers the best quality content in an easy-to-access format.
Download or read book Bone Marrow MRI written by Lia Angela Moulopoulos and published by Springer. This book was released on 2014-11-17 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: MRI provides the best means of imaging the bone marrow directly and of non-invasively assessing its composition. Normal age-related bone marrow changes, alterations related to red marrow reconversion, and pathological bone marrow processes generally conform to certain patterns that reflect the underlying marrow changes and can be clearly recognized on MR images. In addition to conventional pulse sequences, advanced MRI techniques such as Dynamic Contrast-Enhanced MRI and Diffusion-Weighted Imaging depict marrow changes at the microvascular and cellular level respectively. This book provides radiologists with in-depth information on the MRI appearances of normal, abnormal and treated marrow following a structured, pattern-based approach. MRI findings for various diseases that affect the bone marrow, particularly those of a malignant nature, are presented in detail. MRI pattern recognition not only offers a systematic approach to image interpretation and diagnosis but also has prognostic implications with regard to some disease entities. Each chapter includes a wealth of high-quality images, together with Key Points summarizing the most important information. In addition to radiologists, practitioners with an interest in hematology and oncology will find this textbook-atlas to be a valuable resource for the latest, clinically relevant advances in bone marrow imaging.
Download or read book Introduction to Diffusion Tensor Imaging written by Susumu Mori and published by Academic Press. This book was released on 2013-08-02 with total page 141 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concepts behind diffusion tensor imaging (DTI) are commonly difficult to grasp, even for magnetic resonance physicists. To make matters worse, a many more complex higher-order methods have been proposed over the last few years to overcome the now well-known deficiencies of DTI. In Introduction to Diffusion Tensor Imaging: And Higher Order Models, these concepts are explained through extensive use of illustrations rather than equations to help readers gain a more intuitive understanding of the inner workings of these techniques. Emphasis is placed on the interpretation of DTI images and tractography results, the design of experiments, and the types of application studies that can be undertaken. Diffusion MRI is a very active field of research, and theories and techniques are constantly evolving. To make sense of this constantly shifting landscape, there is a need for a textbook that explains the concepts behind how these techniques work in a way that is easy and intuitive to understand—Introduction to Diffusion Tensor Imaging fills this gap. Extensive use of illustrations to explain the concepts of diffusion tensor imaging and related methods Easy to understand, even without a background in physics Includes sections on image interpretation, experimental design, and applications Up-to-date information on more recent higher-order models, which are increasingly being used for clinical applications
Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme
Download or read book Handbook of MRI Pulse Sequences written by Matt A. Bernstein and published by Elsevier. This book was released on 2004-09-21 with total page 1041 pages. Available in PDF, EPUB and Kindle. Book excerpt: Magnetic Resonance Imaging (MRI) is among the most important medical imaging techniques available today. There is an installed base of approximately 15,000 MRI scanners worldwide. Each of these scanners is capable of running many different "pulse sequences", which are governed by physics and engineering principles, and implemented by software programs that control the MRI hardware. To utilize an MRI scanner to the fullest extent, a conceptual understanding of its pulse sequences is crucial. Handbook of MRI Pulse Sequences offers a complete guide that can help the scientists, engineers, clinicians, and technologists in the field of MRI understand and better employ their scanner. Explains pulse sequences, their components, and the associated image reconstruction methods commonly used in MRI Provides self-contained sections for individual techniques Can be used as a quick reference guide or as a resource for deeper study Includes both non-mathematical and mathematical descriptions Contains numerous figures, tables, references, and worked example problems
Download or read book Advanced Musculoskeletal MR Imaging An Issue of Magnetic Resonance Imaging Clinics of North America E Book written by Roberto Domingues and published by Elsevier Health Sciences. This book was released on 2018-10-16 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This issue of MRI Clinics of North America focuses on Advanced Musculoskeletal MR Imaging, and is edited by Drs. Roberto Domingues and Flávia Martins Costa. Articles will include: Quantitative Whole Body MRI; Multiparametric Bone Marrow Imaging; MET-RADS-P in Practice; Whole Body MRI Beyond Oncology; Whole Body Imaging in Multiple Myeloma; MRI Neurography in Musculoskeletal Disorders; MR Imaging in Rheumatology; Multiparametric MRI of Soft Tissue Tumors and Pseudotumors; Multiparametric MRI of Benign and Malignant Bone Tumors; MR Imaging of Fetal Musculoskeletal Disorders; MRI at Rio 2016 Olympic and Paralympic Games: Our Experience using State-of-the-art 3.0 T and 1.5 T Wide-bore MRI Scanners in High Performance Athletes; Ultrasound and Advanced MRI Fusion for Musculoskeletal Tumors Biopsy; and more!
