Download or read book Development and Application of Polarization Sensitive Optical Coherence Tomography written by Peijun Tang and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT), a three-dimensional optical imaging technique based on low coherence interferometry, can be extended to measure the functional property of the biological sample. As a functional extension of OCT, polarization sensitive optical coherence tomography (PSOCT) enables 3D imaging of the anisotropic biological samples, such as scar, tendon, muscle, collagen, and nerve fiber bundles. This thesis focuses on the development and application of PSOCT. This goal includes four specific aims. The first aim is to develop a single input PSOCT imaging system with an improved image contrast. To achieve this aim, the polarization state is utilized as the imaging parameter and visualized using the Stokes parameters-based color-encoded algorithm. The second aim is to develop an algorithm that can derive depth-resolved polarization parameters with the single input PSOCT system. Towards this aim, a PSOCT-based polarization state transmission model is proposed. Based on this model, a novel method that utilizes discrete differential geometry (DDG) combined with a series of 3D rotations is developed to derive the local axis orientation and phase retardation. The third aim is to use the developed DDG-based PST method to extract the collagen organization embedded within the soft biological tissues. To achieve this aim, the proposed method is utilized to image the local axis orientation of the collagen fibers of the rodent heart and human facial skin. The fourth aim is to use the multiparameter provided by the PSOCT to detect and characterize the white spot lesions in the enamel of the tooth. Towards this aim, multiple parameters in the PSOCT: scattering, attenuation, degree of polarization (DOP), local axis orientation, and local phase retardation of the sample are provided simultaneously for the comprehensive investigation of the location, depth, and severity of the white spot lesions.
Download or read book Polarization sensitive Optical Coherence Tomography written by James J Pasquesi (Jr.) and published by . This book was released on 2005 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development and Application of Optical Coherence Tomography OCT written by Michael Pircher and published by MDPI. This book was released on 2018-03-23 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Development and Application of Optical Coherence Tomography (OCT)" that was published in Applied Sciences
Download or read book Optical Coherence Tomography written by Wolfgang Drexler and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.
Download or read book Developments of Magnetomotive Optical Coherence Tomography and Polarization sensitive Optical Coherence Tomography for Clinical Applications written by Wei Li and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Development and Application of Optical Coherence Tomography Oct written by and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Optical Polarization in Biomedical Applications written by Valery V. Tuchin and published by Springer Science & Business Media. This book was released on 2006-10-12 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Polarization in Biomedical Applications introduces key developments in optical polarization methods for quantitative studies of tissues, while presenting the theory of polarization transfer in a random medium as a basis for the quantitative description of polarized light interaction with tissues. This theory uses the modified transfer equation for Stokes parameters and predicts the polarization structure of multiple scattered optical fields. The backscattering polarization matrices (Jones matrix and Mueller matrix) important for noninvasive medical diagnostic are introduced. The text also describes a number of diagnostic techniques such as CW polarization imaging and spectroscopy, polarization microscopy and cytometry. As a new tool for medical diagnosis, optical coherent polarization tomography is analyzed. The monograph also covers a range of biomedical applications, among them cataract and glaucoma diagnostics, glucose sensing, and the detection of bacteria.
Download or read book Polarized Light in Biomedical Imaging and Sensing written by Jessica C. Ramella-Roman and published by Springer Nature. This book was released on 2022-11-14 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on biomedical applications of polarized light, covering instrumentation and modeling specific to the field. This will be the first book, written by leading researchers in the field, to tackle this important topic. Readers will learn the fundamentals of polarized light transport and how to develop instrumentation for clinical and preclinical studies. They will also become familiar with the latest advancement in data analysis and image processing for a variety of medical applications. The book is dedicated specifically to the biomedical community, including scientists, engineers, and physicians working on the development of instrumentation for clinical and preclinical use. Emphasizes biomedical imaging and sensing; Describes new computational approaches with examples; Provides detailed descriptions of novel instrumentation.
Download or read book Optical Coherence Tomography written by Rui Bernardes and published by Springer Science & Business Media. This book was released on 2012-05-08 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography represents the ultimate noninvasive ocular imaging technique although being in the field for over two-decades. This book encompasses both medical and technical developments and recent achievements. Here, the authors cover the field of application from the anterior to the posterior ocular segments (Part I) and present a comprehensive review on the development of OCT. Important developments towards clinical applications are covered in Part II, ranging from the adaptive optics to the integration on a slit-lamp, and passing through new structural and functional information extraction from OCT data. The book is intended to be informative, coherent and comprehensive for both the medical and technical communities and aims at easing the communication between the two fields and bridging the gap between the two scientific communities.
Download or read book Polarization Sensitive Optical Coherence Tomography written by and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Optical Coherence Tomography Instrumentation and Application written by Yueli Chen and published by . This book was released on 2006 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Imaging of Fiber Structures in the Posterior Eye written by and published by . This book was released on 2023 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging the human body is the most important diagnostic tool in healthcare. Therefore, there is an endless need for improvement of imaging techniques. In this thesis, an extension of a medical imaging technique is further developed to provide extra image contrast based on polarization-changing properties of the tissue. This technique, called polarization-sensitive optical coherence tomography (PS-OCT), is an extension of optical coherence tomography (OCT), which is often used in ophthalmology to create high resolution images of the retina of the human eye. Retinal imaging is the main application of PS-OCT chosen for this thesis. Extra image contrast in PS-OCT includes imaging of birefringence, depolarization, and optic axis of the tissue. An in-house built PS-OCT setup is presented and improved. This setup is then used throughout the thesis to create 3D in vivo retinal images of healthy volunteers and patients. Improvements of PS-OCT data analysis are presented and demonstrated in healthy volunteers. A new imaging metric, optic axis uniformity (OAxU), is introduced. OAxU is defined as the length of the spatially averaged optic axis and varies between 0 and 1. Differential Mueller matrix calculations have been implemented and improved to visualize birefringent structures and their optic axes locally. A deep-learning model is developed as a tool to segment the PS-OCT images. Improvement of PS-OCT analysis allows for orientation images of the collagen in the peripapillary sclera, revealing a radially oriented fiber layer preceding a circumferentially orientated fiber layer. Close to the optic nerve head (ONH), the circumferentially oriented layer displaces the radially oriented fiber layer. PS-OCT is used to image patients with high myopia, glaucoma, osteogenesis imperfecta (OI) or wet age-related macular degeneration (wAMD) to compare the visualization of these new findings in ocular fibrillar architecture to healthy volunteers. These diseases are relevant for PS-OCT imaging to detect changes in scleral collagen, damage to the RNFL, or subretinal fibrosis. Multiple parameters are investigated in this study, including birefringence of the sclera and its correlation with axial length, orientations of RNFL in glaucoma patients, dimensions of the circularly oriented sclera (COS) ring, and thickness of the radially oriented sclera (ROS) layer. The ROS is thinner in myopia patients and OI patients. Besides a thinner ROS layer, birefringence of the sclera was lower in OI patients. Fibrosis can be detected and its orientation can be determined in 3D in AMD patients. Fibrosis shows a higher organization than expected and was often observed in large patches of similar orientations which can vary in depth. The applicability of (PS-)OCT goes beyond ophthalmology. In this thesis, it is investigated whether PS-OCT would be valuable in the imaging of airway. Multiple diseased lungs and healthy lungs are imaged ex vivo to investigate differences in alveoli size/presence and ASM thickness. Optic axis orientation images proved very useful to discriminate different birefringent structures, which is not possible in standard OCT imaging. This allowed for automatic ASM segmentation which is relevant for diseases were this layer is thickened such as asthma, fibrotic sarcoidosis (FS), and fibrotic hypersensitivity pneumonitis (fHP).
Download or read book Optical Coherence Tomography for Retinal Diagnostics written by Biwei Yin and published by . This book was released on 2013 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography (OCT) is a non-invasive three-dimensional imaging technique. OCT synthesizes a cross-sectional image from a series of lateral adjacent depth scans, and with a two-dimensional scanning scheme, three-dimensional intensity image of sample can be constructed. Due to its non-invasive capability, OCT has been widely applied in ophthalmology, cardiology and dermatology; and in addition to three-dimensional intensity image construction, various functional OCT imaging techniques have been developed for clinical application. My research is focused on developing functional OCT systems for application in ophthalmology, including polarization-sensitive optical coherence tomography (PS-OCT) for retinal nerve fiber layer (RNFL) birefringence measurement and dual-wavelength photothermal optical coherence tomography (DWP-OCT) for microvasculature blood oxygen saturation (SO2) measurement. In the study, a single-mode-fiber based polarization-sensitive swept-source OCT (PS-SS-OCT) with polarization modulator, polarization-sensitive bulk-optics balanced detection module is constructed and polarization processing methods based on Stokes vectors are applied to determine birefringence. PS-OCT is able to provide human subject's RNFL thickness, phase retardation, and birefringence information. Degradation in the degree of polarization (DOP) along depth is investigated and its difference between four quadrants of RNFL (superior, temporal, inferior and nasal) indicates the structural property difference. DWP-OCT is a novel functional OCT system consisting of a phase-sensitive optical coherence tomography system (PhS-OCT) and two photothermal excitation lasers. PhS-OCT is based on a swept-source laser operating in the 1060 nm wavelength range; the two photothermal excitation lasers with wavelength 770 nm and 800 nm are intensity modulated at different frequencies. PhS-OCT probe beam and two photothermal excitation beams are combined and incident on the sample, optical pathlength (op) change on the sample introduced by two photothermal excitation beams are measured and used for blood SO2 estimation. A polarization microscope is proposed for future study. The polarization microscope is an imaging technique providing molecular structure and orientation based on probe light's polarization state information. The polarization microscope uses a wavelength tunable light source, and can achieve any incident polarization state by a retarder-rotator combination. Specimen's birefringence can be determined based on the changing of detected light amplitude.
Download or read book Polarization sensitive optical coherence tomography of the eye written by Jason David Marsack and published by . This book was released on 2001 with total page 234 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Polarization sensitive Mueller matrix Optical Coherence Tomography written by Shuliang Jiao and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Measuring the Mueller matrix with optical coherence tomography (OCT) makes it possible to acquire the complete polarization properties of scattering media with three-dimensional spatial resolution. We first proved that the measured degree-of-polarization (DOP) of the backscattered light by OCT remains unity--a conclusion that validated the use of Jones calculus in OCT. A multi-channel Mueller-matrix OCT system was then built to measure the Jones-matrix, which can be transformed into a Mueller matrix, images of scattering biological tissues accurately with single depth scan. We showed that when diattenuation is negligible, the round-trip Jones matrix represents a linear retarder, which is the foundation of conventional PS-OCT, and can be calculated with a single incident polarization state although the one-way Jones matrix generally represents an elliptical retarder; otherwise, two incident polarization states are needed. We discovered the transpose symmetry in the roundtrip Jones matrix, which is critical for eliminating the arbitrary phase difference between the two measured Jones vectors corresponding to the two incident polarization states to yield the correct Jones matrix. We investigated the various contrast mechanisms provided by Mueller-matrix OCT. Our OCT system for the first time offers simultaneously comprehensive polarization contrast mechanisms including the amplitude of birefringence, the orientation of birefringence, and the diattenuation in addition to the polarization-independent intensity contrast, all of which can be extracted from the measured Jones or the equivalent Mueller matrix. The experimental results obtained from rat skin samples, show that Mueller OCT provides complementary structural and functional information on biological samples and reveal that polarization contrast is more sensitive to thermal degeneration of biological tissues than amplitude-based contrast. Finally, an optical-fiber-based multi-channel Mueller-matrix OCT was built and a new rigorous algorithm was developed to retrieve the calibrated polarization properties of a sample. For the first time to our knowledge, fiber-based polarization-sensitive OCT was dynamically calibrated to eliminate the polarization distortion caused by the single-mode optical fiber in the sample arm, thereby overcoming a key technical impediment to the application of optical fibers in this technology.
Download or read book Polarization sensitive Optical Coherence Tomography written by Simon Christopher Schlachter and published by . This book was released on 2006 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book High Resolution Imaging in Microscopy and Ophthalmology written by Josef F. Bille and published by Springer. This book was released on 2019-08-13 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book provides a comprehensive overview of the application of the newest laser and microscope/ophthalmoscope technology in the field of high resolution imaging in microscopy and ophthalmology. Starting by describing High-Resolution 3D Light Microscopy with STED and RESOLFT, the book goes on to cover retinal and anterior segment imaging and image-guided treatment and also discusses the development of adaptive optics in vision science and ophthalmology. Using an interdisciplinary approach, the reader will learn about the latest developments and most up to date technology in the field and how these translate to a medical setting. High Resolution Imaging in Microscopy and Ophthalmology – New Frontiers in Biomedical Optics has been written by leading experts in the field and offers insights on engineering, biology, and medicine, thus being a valuable addition for scientists, engineers, and clinicians with technical and medical interest who would like to understand the equipment, the applications and the medical/biological background. Lastly, this book is dedicated to the memory of Dr. Gerhard Zinser, co-founder of Heidelberg Engineering GmbH, a scientist, a husband, a brother, a colleague, and a friend.
