Download or read book Development and Application of Optical Coherence Tomography OCT written by Michael Pircher and published by MDPI. This book was released on 2018-03-23 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Development and Application of Optical Coherence Tomography (OCT)" that was published in Applied Sciences

Download or read book Development and Application of Multifunctional Optical Coherence Tomography written by Zhongwei Zhi and published by . This book was released on 2014 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microcirculation refers to the functions of capillaries and the neighboring lymphatic vessels. It plays a vital role in the pathophysiology of disorders in many clinical areas including cardiology, dermatology, neurology and ophthalmology, and so forth. It is crucial to develop imaging technologies that can provide both qualitative and quantitative information as to how microcirculation responds to certain injury and/or disease, and its treatment. Optical coherence tomography (OCT) is a non-invasive optical imaging technique for high-resolution cross-sectional imaging of specimens, with many applications in clinical medicine. Current state-of-the-art OCT systems operate in the Fourier domain, using either a broadband light source with a spectrometer, known as spectral domain OCT (SDOCT), or a rapidly tunable laser, known as swept source OCT (SSOCT). The current Fourier domain OCT systems have dramatically improvement in sensitivity, resolution and speed compared to time domain OCT. In addition to the improvement in the OCT system hardware, different methods for functional measurements of tissue beds have been developed and demonstrated. This includes but not limited to, i) Phase-resolved Doppler OCT for quantifying the blood flow, ii) OCT angiography for visualization of microvasculature, iii) Polarization sensitive OCT for measuring the intrinsic optical property/ birefringence of tissue, iv) spectroscopic OCT for measuring blood oxygenation, etc. Functional OCT can provide important clinical information that is not available in the typical intensity based structural OCT images. Among these functional OCT modalities, Doppler OCT and OCT angiography attract great interests as they show high capability for in vivo study of microvascular pathology. By analyzing the Doppler effect of a flowing particle on light frequency, Doppler OCT allows the quantification of the blood flow speed and blood flow rate. The most popular approach for Doppler OCT is achieved through analysis of the phase term in complex OCT signal which termed as Phase-resolved Doppler OCT. However, as limited by the phase noise and motion, Phase-resolved Doppler OCT can only be applied for relative large blood vessels, such as arterioles and venules. On the other hand, in order to visualize the microcirculation network, a number of strategies to enable better contrast of microvasculature components, which we termed OCT angiography, have been introduced during recent years. As a variation of Fourier domain OCT, optical microangiography (OMAG) is one of earliest proposed OCT angiography technique which is capable of generating 3D images of dynamic blood perfusion distribution within microcirculatory tissue beds. The OMAG algorithm works by separating the static and moving elements by high pass filtering on complex valued interferometric data after Fourier transform. Based on the conventional OMAG algorithm, we further developed ultra-high sensitive OMAG (UHS-OMAG) by switching the high-pass filtering from fast scan direction (adjacent A-lines within one B-frame) to slow scan direction (adjacent B-frames), which has a dramatically improved performance for capillary network imaging and analysis. Apart from the microvascular study with current available functional OCT for, visualization of the lymphatic system (lymph nodes and lymphatic vessels) plays a significant role in assessing patients with various malignancies and lymphedema. However, there is a lack of label-free and noninvasive method for lymphangiography. Hence, a cutting edge research to investigate the capability of OCT as a tool for non-invasive and label-free lymphangiography would be highly desired. The objective of my thesis is to develop a multiple-functional SDOCT system to image the microcirculation and quantify the several important parameters of microcirculation within microcirculatory tissue beds, and further apply it for pre-clinical research applications. The multifunctional OCT system provides modalities including structural OCT, OCT angiography, Doppler OCT and Optical lymphangiography, for multi-parametric study of tissue microstructure, blood vessel morphology, blood flow and lymphatic vessel all together. The thesis mainly focus on two parts: first, development of multi-functional OCT/optical microangiography (OMAG) system and methods for volumetric imaging of microvasculature and quantitative measurement of blood flow, and its application for pathological research in ophthalmology on rodent eye models; second, development of ultra-high resolution OCT system and algorithm for simultaneous label free imaging of blood and lymphatic vessel, and its application in wound healing study on mouse ear flap model. Objectives of my research are achieved through the following specific aims: Aim 1: Improve the sensitivity of OMAG for microvasculature imaging; perform volumetric and quantitative imaging of vasculature with combined OMAG and Phase-resolved Doppler OCT for in vivo study of vascular physiology. Aim 2: Develop high speed high resolution OCT system and method for rodent eye imaging. Apply the combined OMAG and Phase-resolved Doppler OCT approach to investigate the impact of elevated intraocular pressure on retinal, choroidal and optic nerve head blood flow in rat eye model, which aids to the better understanding of the mechanism and development of glaucoma. Aim 3: Apply the developed OCT system and ultra-high sensitive OMAG algorithm for noninvasive imaging of retinal morphology and microvasculature in obese mice, which may play an important role in early diagnosis of Diabetic retinopathy. Aim 4: Developing an ultra-high resolution SDOCT system using broadband Supercontinuum light source to achieve ultra-high resolution microvasculature imaging of biological tissue. Aim 5: Develop methods for simultaneous label free optical imaging of blood and lymphatic vessel and demonstrate its capability by monitoring the blood and lymph response to wound healing on mouse ear pinna model.

Download or read book Development and Application of Optical Coherence Tomography Oct written by and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Development and Applications of 4D Real time Multi functional Spectral domain Optical Coherence Tomography written by Yan Wang and published by . This book was released on 2013 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chapter 1 describes the construction and characterization of a multi-functional SD-OCT system at 1300nm. The axial resolution, lateral resolution, imaging depth, signal sensitivity drop-off, spectrometer efficiency, phase noise, system noise, polarization noise, computation of phase retardation, optic axis and diattenuation were characterized. Multiple samples were imaged to demonstrate each imaging facet (intensity, polarization and flow) of the system.

Download or read book Optical Coherence Tomography written by Wolfgang Drexler and published by Springer Science & Business Media. This book was released on 2008-12-10 with total page 1346 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is the optical analog of ultrasound imaging and is emerging as a powerful imaging technique that enables non-invasive, in vivo, high resolution, cross-sectional imaging in biological tissue. This book introduces OCT technology and applications not only from an optical and technological viewpoint, but also from biomedical and clinical perspectives. The chapters are written by leading research groups, in a style comprehensible to a broad audience.

Download or read book Multi scale Optical Coherence Tomography Imaging written by Michael Christopher Oliveira and published by . This book was released on 2014 with total page 103 pages. Available in PDF, EPUB and Kindle. Book excerpt: An optical modality capable of quantitative, label-free, high-speed and high-resolution imaging across spatiotemporal scales coupled with sophisticated software for image reconstruction and quantitative analyses would be of great utility to scientists and engineers in the medical and life sciences fields. Currently, a combination of optical imaging techniques and software packages are needed to address the list of capabilities described previously. Optical coherence tomography is an optical imaging technique based on low coherence interferometry capable of measuring light backscattered from the sample at micrometer-level resolutions over millimeter-level penetration depths in biological tissue. Phase-sensitive extensions of OCT enable the functional assessment of biological tissue samples as well as the structural examination of samples down to the single-cell level. This dissertation describes the development and application of high-speed real-time multi-functional spectral-domain OCT (MF-SD-OCT) for structural and functional examination of biological samples across spatiotemporal scales. A discussion of the development of a GPU-accelerated high-speed MF-SD-OCT imaging system accompanied by demonstrations of the performance enhancements due to the GPU are presented initially. Next, the development of MF-SD-OCT-based quantitative methods for the structural and functional assessment and characterization and classification of biological tissue samples is discussed. The utility of these methods is demonstrated through structural, functional and optical characterization and classification of peripheral nerve and muscle tissue. The dissertation concludes with a discussion of the improvements made to spectral-domain optical coherence phase microscopy (SD-OCPM) to enable dynamic live cell imaging and the application of dynamic live cell SD-OCPM for morphological visualization of cheek epithelial cells and examination of functionally stimulated morphological changes in neurons. The work described in this dissertation demonstrates the versatility of OCT imaging technology to perform quantitative, label-free, high-speed and high-resolution imaging across spatiotemporal scales, enabling the examination of native dynamic tissue and cellular physiology.

Download or read book Optical Coherence Tomography written by Rui Bernardes and published by Springer Science & Business Media. This book was released on 2012-05-08 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography represents the ultimate noninvasive ocular imaging technique although being in the field for over two-decades. This book encompasses both medical and technical developments and recent achievements. Here, the authors cover the field of application from the anterior to the posterior ocular segments (Part I) and present a comprehensive review on the development of OCT. Important developments towards clinical applications are covered in Part II, ranging from the adaptive optics to the integration on a slit-lamp, and passing through new structural and functional information extraction from OCT data. The book is intended to be informative, coherent and comprehensive for both the medical and technical communities and aims at easing the communication between the two fields and bridging the gap between the two scientific communities.

Download or read book Development and Application of Polarization Sensitive Optical Coherence Tomography written by Peijun Tang and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT), a three-dimensional optical imaging technique based on low coherence interferometry, can be extended to measure the functional property of the biological sample. As a functional extension of OCT, polarization sensitive optical coherence tomography (PSOCT) enables 3D imaging of the anisotropic biological samples, such as scar, tendon, muscle, collagen, and nerve fiber bundles. This thesis focuses on the development and application of PSOCT. This goal includes four specific aims. The first aim is to develop a single input PSOCT imaging system with an improved image contrast. To achieve this aim, the polarization state is utilized as the imaging parameter and visualized using the Stokes parameters-based color-encoded algorithm. The second aim is to develop an algorithm that can derive depth-resolved polarization parameters with the single input PSOCT system. Towards this aim, a PSOCT-based polarization state transmission model is proposed. Based on this model, a novel method that utilizes discrete differential geometry (DDG) combined with a series of 3D rotations is developed to derive the local axis orientation and phase retardation. The third aim is to use the developed DDG-based PST method to extract the collagen organization embedded within the soft biological tissues. To achieve this aim, the proposed method is utilized to image the local axis orientation of the collagen fibers of the rodent heart and human facial skin. The fourth aim is to use the multiparameter provided by the PSOCT to detect and characterize the white spot lesions in the enamel of the tooth. Towards this aim, multiple parameters in the PSOCT: scattering, attenuation, degree of polarization (DOP), local axis orientation, and local phase retardation of the sample are provided simultaneously for the comprehensive investigation of the location, depth, and severity of the white spot lesions.

Download or read book SWEPT SOURCE OPTICAL COHERENCE written by Luoqin Yu and published by Open Dissertation Press. This book was released on 2017-01-26 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Swept Source Optical Coherence Tomography System Development for Bioimaging Applications" by Luoqin, Yu, 俞罗琴, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Optical coherence tomography (OCT) is an imaging modality with strengths in high-resolution, label-free, and noninvasive, which strategically fills the gap between ultrasound and microscopy and is superior for some biomedical applications. Swept source OCT (SS-OCT) improves system simplicity and sensitivity compared to previous versions of time domain OCT (TD-OCT) because of a static reference mirror and has faster imaging speed compared to spectral domain OCT (SD-OCT) because of a single photodetector and the availability of high-repetition-rate broadband lasers. Furthermore, functional spectroscopic OCT (SOCT) analyzes materials according to their specific optical properties at different wavelengths. Thus, by utilizing an ultra-wide band OCT and analyzing the sub-band images, it provides us a spectroscopic way to recognize materials. These kinds of newly developed OCT systems are quite promising in clinical bioimaging applications. One of the most commonly used swept sources in SS-OCT systems is the Fourier domain mode-locked (FDML) laser. It has a narrow instantaneous linewidth that improves imaging range, a broad sweeping range that renders high resolution, fast building up time that enables fast scanning, and a proper output power. However, traditional FDML lasers have limited sweeping range because of a limited amplification window of the gain medium that is usually unable to achieve an ultra-wide wavelength range. It hinders its way in spectroscopic imaging applications. Nevertheless, multi-band illumination can break through the bandwidth limitation of single-band SOCT. Consequently, developing swept sources with various output wavelength ranges is of high interest. The FDML lasers with output at 1.0 m range are most suitable in water-rich tissues where water dispersion and absorption are minimized. Thus, 1.0 m FDML laser cavities are firstly proposed with different amplification schemes to compare their performances. Dual-and tri-band SS-OCT systems for SOCT application are further investigated for contrast enhancement and differentiation of materials, such as lipid and porcine artery. Not only the output wavelength ranges of swept sources are of big concern, the swept speed is another bottleneck yet to be surpassed, especially for endoscopic applications. As the mechanical inertia of FDML lasers will limit the fundamental A-scan rate to hundreds of kilohertz, an ultrafast mode-locked laser together with inertia-free optical time-stretch mechanism is a promising alternative for SS-OCT endoscopic application. It has long imaging range and allows an A-scan rate up to more than ten megahertz. We further demonstrated this kind of amplified optical time-stretch (AOT) OCT with extensional application by endoscopic imaging. In summary, the goal of this thesis is to develop and extend SS-OCT systems in different aspects for various bioimaging applications. The SS-OCT systems with different advantages are proposed for spectroscopic and endoscopic imaging. Subjects: Imaging systems in medicine Optical coherence tomography

Download or read book Development of a Multi channel Visible light Optical Coherence Tomography Platform for Investigating Fibrotic Disease Using Optical Scattering written by Ryan Niemeier and published by . This book was released on 2020 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical imaging and microscopy provide multi-dimensional information in both the laboratory and clinical settings. Novel imaging methods have leveraged several contrast sources in order to provide both qualitative and quantitative metrics. Optical coherence tomography (OCT) is a volumetric, micro-scale imaging modality which draws intrinsic contrast from the optical scattering of tissue. Visible-light OCT (VIS-OCT) increases the scattering contrast and is ideal for imaging thin layers of tissue with subtle changes to the optical scattering. The work contained in this dissertation is a modification of VIS-OCT to utilize simultaneous acquisition of multiple channels. Multi-channel VIS-OCT is capable of noise reduction, polarization sensitivity, and quantifying tissue optical scattering. The multi-channel system was used in several imaging applications with relevance to translational medical care and bench-top research. The system was used to image the optical scattering changes in esophageal tissue before and after microwave ablation. Measurements of optical scattering helped to identify the boundaries of the ablation which can provide valuable information both during treatment and for microwave and radiofrequency ablation antenna design. By adding polarization channels, multi-channel VIS-OCT was capable of measuring birefringence in a mouse model of pulmonary fibrosis which is being used to test novel therapeutics for lung disease. Finally, a variation of this OCT system was developed to be used in a multi-modal system which combines and co-registers several other imaging modalities and is well-suited to study fibrosis in glaucoma and cancer. The sensitivity of this VIS-OCT system to optical scattering and polarization effects make it a valuable tool with which to study fibrosis. This dissertation describes the framework of this platform and several utilities which in future work will incorporate a lens-free probe for cost-effective in vivo imaging and other bench-top variations will enable higher resolution imaging capable of capturing dynamic processes in live cells.

Download or read book Polarization sensitive Optical Coherence Tomography written by James J Pasquesi (Jr.) and published by . This book was released on 2005 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Optical Coherence Tomography and Its Non medical Applications written by Michael Wang and published by BoD – Books on Demand. This book was released on 2020-05-27 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography (OCT) is a promising non-invasive non-contact 3D imaging technique that can be used to evaluate and inspect material surfaces, multilayer polymer films, fiber coils, and coatings. OCT can be used for the examination of cultural heritage objects and 3D imaging of microstructures. With subsurface 3D fingerprint imaging capability, OCT could be a valuable tool for enhancing security in biometric applications. OCT can also be used for the evaluation of fastener flushness for improving aerodynamic performance of high-speed aircraft. More and more OCT non-medical applications are emerging. In this book, we present some recent advancements in OCT technology and non-medical applications.

Download or read book Applications of Optical Coherence Tomography in Ophthalmology written by Harold Anderson and published by Murphy & Moore Publishing. This book was released on 2021-11-16 with total page 243 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical coherence tomography is an imaging test which is non-invasive in nature, and makes use of light waves in order to take cross-section pictures of the retina. The different layers of the retina are visible through this technique. There are numerous eye conditions which can be diagnosed through optical coherence tomography. A few of them are glaucoma, diabetic retinopathy, macular edema and macular hole. The disorders of the optic nerve are also examined using this technique. The conditions which interfere with the passage of light through the eye cannot be diagnosed through optical coherence tomography, since it depends on light waves. This book brings forth some of the most innovative concepts and elucidates the unexplored aspects of optical coherence tomography. It strives to provide a fair idea about its clinical applications and to help develop a better understanding of the latest advances within this field. This book is a vital tool for all researching or studying ophthalmology as it gives incredible insights into emerging trends and concepts.

Download or read book Optical Coherence Tomography written by Rui Bernardes and published by Springer. This book was released on 2012-05-16 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography represents the ultimate noninvasive ocular imaging technique although being in the field for over two-decades. This book encompasses both medical and technical developments and recent achievements. Here, the authors cover the field of application from the anterior to the posterior ocular segments (Part I) and present a comprehensive review on the development of OCT. Important developments towards clinical applications are covered in Part II, ranging from the adaptive optics to the integration on a slit-lamp, and passing through new structural and functional information extraction from OCT data. The book is intended to be informative, coherent and comprehensive for both the medical and technical communities and aims at easing the communication between the two fields and bridging the gap between the two scientific communities.

Download or read book Technology Development and Application of Optical Coherence Tomography written by 呂志偉 and published by . This book was released on 2008 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Selected Topics in Optical Coherence Tomography written by Gangjun Liu and published by BoD – Books on Demand. This book was released on 2012-02-08 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes different exciting topics in the OCT fields, written by experts from all over the world. Technological developments, as well as clinical and industrial applications are covered. Some interesting topics like the ultrahigh resolution OCT, the functional extension of OCT and the full field OCT are reviewed, and the applications of OCT in ophthalmology, cardiology and dentistry are also addressed. I believe that a broad range of readers, such as students, researchers and physicians will benefit from this book.

Download or read book Optical Coherence Tomography written by Mark E. Brezinski and published by Elsevier. This book was released on 2006-08-25 with total page 645 pages. Available in PDF, EPUB and Kindle. Book excerpt: Optical Coherence Tomography gives a broad treatment of the subject which will include 1)the optics, science, and physics needed to understand the technology 2) a description of applications with a critical look at how the technology will successfully address actual clinical need, and 3) a discussion of delivery of OCT to the patient, FDA approval and comparisons with available competing technologies. The required mathematical rigor will be present where needed but be presented in such a way that it will not prevent non-scientists and non-engineers from gaining a basic understanding of OCT and the applications as well as the issues of bringing the technology to the market. Optical Coherence Tomography is a new medical high-resolution imaging technology which offers distinct advantages over current medical imaging technologies and is attracting a large number of researchers. Provides non-scientists and non-engineers basic understanding of Optical Coherence Tomography applications and issues.