Download or read book Developing Insights in Cartilage Repair written by Pieter J. Emans and published by Springer Science & Business Media. This book was released on 2013-10-16 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive book discusses cartilage repair and all its aspects. These aspects vary from basic insights in cartilage biology and regeneration via MRI, to results of existing cartilage repair techniques and upcoming novel approaches. Fundamental cartilage biology is the topic covered within the first chapters of the book. These chapters not only provide an insight in healthy, damaged and regenerative cartilage but also describe developments in gene therapy and methods to enhance chondrogenesis of stemcells and prevent hypertophic differentiation. There is a huge progress in the possibilities of MR imaging of both healthy, damaged and regenerative cartilage. These developments not only enable better monitoring of cartilage repair but may also unravel the pathophysiology of the development of cartilage defects. Different cartilage repair techniques (e.g. allografts, autologous chondrocytes transplantation [ACT], microfracture), there technical aspects (e.g. developments towards an total arthroscopic approach), pitfalls, and outcomes are reported in the following chapters. In these chapters factors important for the results of cartilage repair such as meniscal repair, patient factors are described. Finally, an overview of novel cartilage repair techniques such as minced cartilage, denovo cartilage and more areas are discussed in this comprehensive addition to the literature.
Download or read book Developing Insights in Cartilage Repair written by Pieter J. Emans and published by . This book was released on 2013-11-30 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cartilage written by Susanne Grässel and published by Springer. This book was released on 2017-05-09 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: In three Volumes this mini book series presents current knowledge and new perspectives on cartilage as a specialized yet versatile tissue. This third volume provides insight into current and future treatment strategies for repair of cartilage lesions. This book addresses Professors, researchers and PhD students who are interested in musculoskeletal and cartilage pathobiology and tissue-engineering.
Download or read book A Tissue Regeneration Approach to Bone and Cartilage Repair written by Hala Zreiqat and published by Springer. This book was released on 2014-12-05 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviewing exhaustively the current state of the art of tissue engineering strategies for regenerating bones and joints through the use of biomaterials, growth factors and stem cells, along with an investigation of the interactions between biomaterials, bone cells, growth factors and added stem cells and how together skeletal tissues can be optimised, this book serves to highlight the importance of biomaterials composition, surface topography, architectural and mechanical properties in providing support for tissue regeneration. Maximizing reader insights into the importance of the interplay of these attributes with bone cells (osteoblasts, osteocytes and osteoclasts) and cartilage cells (chondrocytes), this book also provides a detailed reference as to how key signalling pathways are activated. The contribution of growth factors to drive tissue regeneration and stem cell recruitment is discussed along with a review the potential and challenges of adult or embryonic mesenchymal stem cells to further enhance the formation of new bone and cartilage tissues. This book serves to demonstrate the interconnectedness of biomaterials, bone/cartilage cells, growth factors and stem cells in determining the regenerative process and thus the clinical outcome.
Download or read book Cartilage and Bone Development and Its Disorders written by C. Camacho-Hübner and published by Karger Medical and Scientific Publishers. This book was released on 2011-08-23 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: In systemic childhood diseases, including cancer, gastrointestinal, pulmonary and cardiac disorders, childhood growth is severely impaired. In addition, almost 400 known genetic diseases inhibit the ability of the growth plate to form new bone, leaving affected children with growth failure and bony deformities which can severely impact their quality of life and may lead to morbidity and early mortality.This book provides a comprehensive review of bone and cartilage development, growth and disease. Focusing on novel treatment strategies, regulatory signals and molecular mechanisms are discussed in relation to the diseases affecting them. Furthermore, novel methodologies in bone and cartilage research based on recent advances in skeletal stem cell biology, cartilage tissue engineering and allele-specific gene silencing is covered.Providing insight into the basic mechanisms of bone growth, structure and metabolism, research methodology, as well as discussing the clinical management of related diseases, this book is of particular value to physicians with a special interest in bone and cartilage biology; in particular endocrinologists and pediatric endocrinologists that see patients with growth disorders, osteoporosis, osteogenesis imperfecta, and skeletal dysplasias.
Download or read book Mechanobiology and Biomechanics of Articular Cartilage Repair written by Quynhhoa T. Nguyen and published by . This book was released on 2012 with total page 155 pages. Available in PDF, EPUB and Kindle. Book excerpt: Articular cartilage has limited capacity to self-repair once damaged. Contact stresses and strains in areas of cartilage near the edges of a focal defect are altered during compression and articulation. To prevent further damage to the surrounding cartilage, cartilage defects can be repaired with a biomaterial or tissue with properties similar to those of normal cartilage to provide mechanical support and restore normal mechanical environment. Understanding structural and functional changes of native cartilage during maturation in response to chemical and mechanical stimuli is useful to fabricate cartilage tissues with properties approaching those of normal adult cartilage. Characterization of the restoration of biomechanical properties of cartilage defect with a repair material will provide valuable insights into the development of appropriate constructs to repair and restore cartilage function. To facilitate a study of cartilage mechanobiology, a novel material and biomechanical testing system that can induce a range of shear stress and strain in cartilage was developed and fully characterized. Such biomechanical testing system can be used as a framework to study cartilage responses to a mechanical stimulus that mimics certain aspects of articulating cartilage. The mechano-biological responses of immature articular cartilage were investigated by examining the structural and functional changes of cartilage in response to chemical and mechanical stimuli. Biochemical treatments of immature articular cartilage increased GAG release, reduced tissue GAG content, and increased tensile properties of immature articular cartilage. Dynamic compression, superimposed on biochemical treatment induced organization of collagen network to variable extents. The results suggest that cartilage maturation is a complex process that may involve metabolic processes in addition to matrix consolidation at the surface. The extent to which biomechanical environment of cartilage defect was restored with a biomaterials was elucidated using poly(ethylene glycol)- (PEG) hydrogels. PEG hydrogels with cartilage-like mechanical properties were fabricated, characterized, and inserted into a focal defect. The overall and local strains elevated in cartilage near the edge of an empty defect was returned to levels similar to intact cartilage when the defect was filled with PEG hydrogels. This suggests that a biomaterial or tissue with mechanical properties comparable to surrounding cartilage could be used to treat cartilage focal defects and restore its function.
Download or read book Cartilage Imaging written by Thomas M. Link and published by Springer. This book was released on 2011-05-03 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative book provides state-of-the-art practices and new developments in the imaging of cartilage, associated pathologies, and repair procedures. With a main focus on MRI, major advances in cartilage imaging are put into clinical context relevant for radiologists, rheumatologists, and orthopedic surgeons. International experts provide their insights on cartilage pathologies associated with such conditions as osteoarthritis, osteochondral trauma, and cartilage repair. Morphological MRI techniques are outlined, including new sequences and high field imaging. Molecular imaging techniques able to characterize the biochemical composition of the cartilage matrix are discussed, such as T2 relaxation time, T1rho, and dGEMRIC methods. The first book of its kind, Cartilage Imaging: Significance, Techniques, and New Developments encompasses the full scope of knowledge in this rapidly evolving field. Identifying key techniques for characterizing disease processes as well as objectively and quantitatively evaluating the results of therapy, this outstanding resource is of benefit to all physicians interested in assessing cartilage disease and repair.
Download or read book Mechanics and Development of Tarsal Cartilage Anlagen written by Roza Mahmoodian and published by . This book was released on 2010 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bioprocessing for Cell Based Therapies written by Che J. Connon and published by John Wiley & Sons. This book was released on 2017-03-01 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions from leading, international academics and industrial practitioners, Bioprocessing for Cell-Based Therapies explores the very latest techniques and guidelines in bioprocess production to meet safety, regulatory and ethical requirements, for the production of therapeutic cells, including stem cells. An authoritative, cutting-edge handbook on bioprocessing for the production of therapeutic cells with extensive illustrations in full colour throughout An authoritative, cutting-edge handbook on bioprocessing for the production of therapeutic cells with extensive illustrations in full colour throughout In depth discussion of the application of cell therapy including methods used in the delivery of cells to the patient Includes contributions from experts in both academia and industry, combining a practical approach with cutting edge research The only handbook currently available to provide a state of the art guide to Bioprocessing covering the complete range of cell-based therapies, from experts in academia and industry
Download or read book Articular Cartilage Tissue Engineering written by Kyriacos A. Athanasiou and published by Morgan & Claypool Publishers. This book was released on 2010 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cartilage injuries in children and adolescents are increasingly observed, with roughly 20% of knee injuries in adolescents requiring surgery. In the US alone, costs of osteoarthritis (OA) are in excess of $65 billion per year (both medical costs and lost wages). Comorbidities are common with OA and are also costly to manage. Articular cartilage's low friction and high capacity to bear load makes it critical in the movement of one bone against another, and its lack of a sustained natural healing response has necessitated a plethora of therapies. Tissue engineering is an emerging technology at the threshold of translation to clinical use. Replacement cartilage can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical and biochemical characteristics of articular cartilage in both normal and pathological states, through development and aging. It also provides a historical perspective of past and current cartilage treatments and previous tissue engineering efforts. Methods and standards for evaluating the function of engineered tissues are discussed, and current cartilage products are presented with an analysis on the United States Food and Drug Administration regulatory pathways that products must follow to market. This book was written to serve as a reference for researchers seeking to learn about articular cartilage, for undergraduate and graduate level courses, and as a compendium of articular cartilage tissue engineering design criteria. Table of Contents: Hyaline Articular Cartilage / Cartilage Aging and Pathology / In Vitro / Bioreactors / Future Directions
Download or read book Cell Based Approaches for Modulating Cartilage and Bone Phenotype written by Roberto Narcisi and published by Frontiers Media SA. This book was released on 2021-12-22 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Engineering and Regeneration written by Heinz Redl and published by Springer. This book was released on 2017-02-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This reference work presents the origins of cells for tissue engineering and regeneration, including primary cells, tissue-specific stem cells, pluripotent stem cells and trans-differentiated or reprogrammed cells. There is particular emphasis on current understanding of tissue regeneration based on embryology and evolution studies, including mechanisms of amphibian regeneration. The book covers the use of autologous versus allogeneic cell sources, as well as various procedures used for cell isolation and cell pre-conditioning , such as cell sorting, biochemical and biophysical pre-conditioning, transfection and aggregation. It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. The volume concludes with an in-depth discussion of the tracking of cells in vivo and their various regenerative activities inside the body, including differentiation, new tissue formation and actions on other cells by direct cell-to-cell communication and by secretion of biomolecules.
Download or read book The Illustrative Book of Cartilage Repair written by Deepak Rajkumar Goyal and published by Springer Nature. This book was released on 2020-10-26 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book employs a wealth of high-quality illustrations to provide the reader with a detailed understanding of the anatomy and the histology of the cartilage, the etiology and the classification of the cartilage lesions, and the numerous techniques employed for cartilage repair. Detailed attention is devoted to healthy cartilage, to each stage in the degenerative process, and to the response of the cartilage to the treatment. Imaging of the damaged and the repaired cartilage, as well as the information on the biomechanics are provided in great detail. The chapters on the techniques cover a wide range of approaches: marrow stimulation techniques, osteochondral cylinder transfer techniques, first, second and third generation autologous chondrocyte implantation techniques, allografts, cell-based therapies, orthobiologic approaches, and the role of 3D printing. The chapters closes with a consideration of the success of rehabilitation devices and the long-term results of cartilage repair.The book will be invaluable for all general orthopaedic and arthroscopic surgeons seeking a deeper knowledge of cartilage science and will help to dispel the confusion that still surrounds the reparative treatment. The authors are recognized experts in the fields of cartilage histology, assessment, classification, and repair.
Download or read book Advancements in Synovial Joint Science Structure Function and Beyond written by Alessandro Rozim Zorzi and published by BoD – Books on Demand. This book was released on 2024-03-27 with total page 122 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advancements in Synovial Joint Science - Structure, Function, and Beyond is a groundbreaking exploration into the fascinating world of synovial joints, offering a comprehensive look at the latest research, innovations, and therapeutic strategies shaping the field. Expertly edited and written by leading figures in orthopedics and biomedical research, this volume dives deep into the biomechanics, pathology, and cutting-edge treatments associated with joint health. It seamlessly blends detailed scientific insights with practical clinical applications, making it an invaluable resource for professionals and students alike. With its holistic approach, readers gain not only a thorough understanding of current knowledge but also insights into future research directions.
Download or read book Developmental Biology and Musculoskeletal Tissue Engineering written by Martin J. Stoddart and published by Academic Press. This book was released on 2018-04-24 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Developmental Biology and Musculoskeletal Tissue Engineering: Principles and Applications focuses on the regeneration of orthopedic tissue, drawing upon expertise from developmental biologists specializing in orthopedic tissues and tissue engineers who have used and applied developmental biology approaches. Musculoskeletal tissues have an inherently poor repair capacity, and thus biologically-based treatments that can recapitulate the native tissue properties are desirable. Cell- and tissue-based therapies are gaining ground, but basic principles still need to be addressed to ensure successful development of clinical treatments. Written as a source of information for practitioners and those with a nascent interest, it provides background information and state-of-the-art solutions and technologies. Recent developments in orthopedic tissue engineering have sought to recapitulate developmental processes for tissue repair and regeneration, and such developmental-biology based approaches are also likely to be extremely amenable for use with more primitive stem cells. Brings the fields of tissue engineering and developmental biology together to explore the potential for regenerative medicine-based research to contribute to enhanced clinical outcomes Initial chapters provide an outline of the development of the musculoskeletal system in general, and later chapters focus on specific tissues Addresses the effect of mechanical forces on the musculoskeletal system during development and the relevance of these processes to tissue engineering Discusses the role of genes in the development of musculoskeletal tissues and their potential use in tissue engineering Describes how developmental biology is being used to influence and guide tissue engineering approaches for cartilage, bone, disc, and tendon repair
Download or read book Selected Health Conditions and Likelihood of Improvement with Treatment written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-07-12 with total page 319 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Social Security Administration (SSA) administers two programs that provide disability benefits: the Social Security Disability Insurance (SSDI) program and the Supplemental Security Income (SSI) program. SSDI provides disability benefits to people (under the full retirement age) who are no longer able to work because of a disabling medical condition. SSI provides income assistance for disabled, blind, and aged people who have limited income and resources regardless of their prior participation in the labor force. Both programs share a common disability determination process administered by SSA and state agencies as well as a common definition of disability for adults: "the inability to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be expected to result in death or which has lasted or can be expected to last for a continuous period of not less than 12 months." Disabled workers might receive either SSDI benefits or SSI payments, or both, depending on their recent work history and current income and assets. Disabled workers might also receive benefits from other public programs such as workers' compensation, which insures against work-related illness or injuries occurring on the job, but those other programs have their own definitions and eligibility criteria. Selected Health Conditions and Likelihood of Improvement with Treatment identifies and defines the professionally accepted, standard measurements of outcomes improvement for medical conditions. This report also identifies specific, long-lasting medical conditions for adults in the categories of mental health disorders, cancers, and musculoskeletal disorders. Specifically, these conditions are disabling for a length of time, but typically don't result in permanently disabling limitations; are responsive to treatment; and after a specific length of time of treatment, improve to the point at which the conditions are no longer disabling.
Download or read book Mesenchymal Stem Cell Derived Exosomes written by Yaoliang Tang and published by Academic Press. This book was released on 2015-09-02 with total page 287 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal stem cell-derived exosomes are at the forefront of research in two of the most high profile and funded scientific areas – cardiovascular research and stem cells. Mesenchymal Stem Cell Derived Exosomes provides insight into the biofunction and molecular mechanisms, practical tools for research, and a look toward the clinical applications of this exciting phenomenon which is emerging as an effective diagnostic. Primarily focused on the cardiovascular applications where there have been the greatest advancements toward the clinic, this is the first compendium for clinical and biomedical researchers who are interested in integrating MSC-derived exosomes as a diagnostic and therapeutic tool. Introduces the MSC-exosome mediated cell-cell communication Covers the major functional benefits in current MSC-derived exosome studies Discusses strategies for the use of MSC-derived exosomes in cardiovascular therapies
