Download or read book Chromatographic Determination of Molecular Interactions Applications in Biochemistry Chemistry and Biophysics written by Tibor Cserhati and published by CRC Press. This book was released on 1993-10-13 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chromatographic Determination of Molecular Interactions describes the theory and practice of the measurement of molecular interactions by thin-layer, high performance liquid, and gas chromatography. Methods and various procedures used for the calculation of complex stability constants are compiled, and the stability constants of a wide variety of interactions determined by the various chromatographic techniques are included. New results of molecular interactions are covered, including those for protein-peptide and amino acid-nucleic acid bases. The book will appeal to biochemists, analytical chemists, molecular biologists, biotechnologists, biophysicists, and medicinal chemists.

Download or read book Journal of Chromatography written by and published by . This book was released on 2001 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Encyclopedia of Chromatography written by Jack Cazes and published by CRC Press. This book was released on 2005 with total page 996 pages. Available in PDF, EPUB and Kindle. Book excerpt: A convenient source of information for workers in analytical chemistry, experimental biology, physics, and engineering, this Second Edition stands as a quick reference source and clear guide to specific chromatographic techniques and principles-providing a basic introduction to the science and technology of the method, as well as additional references on the theory and methodology for analysis of specific chemicals and applications in a range of industries.

Download or read book Analytical Chemistry for Technicians written by John Kenkel and published by CRC Press. This book was released on 2002-10-29 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surpassing its bestselling predecessors, this thoroughly updated third edition is designed to be a powerful training tool for entry-level chemistry technicians. Analytical Chemistry for Technicians, Third Edition explains analytical chemistry and instrumental analysis principles and how to apply them in the real world. A unique feature of this edition is that it brings the workplace of the chemical technician into the classroom. With over 50 workplace scene sidebars, it offers stories and photographs of technicians and chemists working with the equipment or performing the techniques discussed in the text. It includes a supplemental CD that enhances training activities. The author incorporates knowledge gained from a number of American Chemical Society and PITTCON short courses and from personal visits to several laboratories at major chemical plants, where he determined firsthand what is important in the modern analytical laboratory. The book includes more than sixty experiments specifically relevant to the laboratory technician, along with a Questions and Problems section in each chapter. Analytical Chemistry for Technicians, Third Edition continues to offer the nuts and bolts of analytical chemistry while focusing on the practical aspects of training.

Download or read book Chromatographic Analysis of Alkaloids written by Milan Popl and published by Routledge. This book was released on 2018-10-08 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beginning with classification, nomenclature, and structures, this reference discussesphysicochemical properties of alkaloids relevant to the chromatographic process.Chromatographic Analysis of Alkaloids explores the main experimental factors affectingthe separation and detection of alkaloids in gas (GC), liquid (LC), and thinlayer(1LC) chromatography ... illustrates separation conditions described in recentliterature ... provides, for a given compound, the GC, LC, and 1LC techniquesavailable within the same paragraph ... surveys, in tabular form, the methods forsample preparation for chromatographic analysis ... contains over 1,200 up-to-datereferences covering the majority of papers on the chromatography of alkaloids... and more.Serving as a rich resource of practical information, Chromatographic Analysis ofAlkaloids is essential reading for analytical, organic, natural products, and forensicchemists and biochemists, pharmacologists, and graduate-level students in thesedisciplines.

Download or read book Handbook of LC MS Bioanalysis written by Wenkui Li and published by John Wiley & Sons. This book was released on 2013-10-21 with total page 709 pages. Available in PDF, EPUB and Kindle. Book excerpt: Consolidates the information LC-MS bioanalytical scientists need to analyze small molecules and macromolecules The field of bioanalysis has advanced rapidly, propelled by new approaches for developing bioanalytical methods, new liquid chromatographic (LC) techniques, and new mass spectrometric (MS) instruments. Moreover, there are a host of guidelines and regulations designed to ensure the quality of bioanalytical results. Presenting the best practices, experimental protocols, and the latest understanding of regulations, this book offers a comprehensive review of LC-MS bioanalysis of small molecules and macromolecules. It not only addresses the needs of bioanalytical scientists working on routine projects, but also explores advanced and emerging technologies such as high-resolution mass spectrometry and dried blood spot microsampling. Handbook of LC-MS Bioanalysis features contributions from an international team of leading bioanalytical scientists. Their contributions reflect a review of the latest findings, practices, and regulations as well as their own firsthand analytical laboratory experience. The book thoroughly examines: Fundamentals of LC-MS bioanalysis in drug discovery, drug development, and therapeutic drug monitoring The current understanding of regulations governing LC-MS bioanalysis Best practices and detailed technical instructions for LC-MS bioanalysis method development, validation, and stability assessment of analyte(s) of interest Experimental guidelines and protocols for quantitative LC-MS bioanalysis of challenging molecules, including pro-drugs, acyl glucuronides, N-oxides, reactive compounds, and photosensitive and autooxidative compounds With its focus on current bioanalytical practice, Handbook of LC-MS Bioanalysis enables bioanalytical scientists to develop and validate robust LC-MS assay methods, all in compliance with current regulations and standards.

Download or read book Chromatography and Capillary Electrophoresis in Food Analysis written by Hilmer Sorensen and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 489 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the rapidly developing field of analysis it is important to be aware of the newest methods within available techniques. Chromatography and Capillary Electrophoresis in Food Analysis describes chromatographic and electrophoretic principles and procedures for analyses of various amphiphilic and hydrophilic biomolecules, particularly for food analysis. Providing basic information, including general sample preparation, the book then goes on to describe individual analytical methods and exemplify the strategy and methodologies employed for the analyses. The theory necessary to understand the methods and interpretation of results is also included, as are numerous detailed instructions on experiments. Tables, figures and references are included to give a complete picture. Chromatography and Capillary Electrophoresis in Food Analysis will be especially valuable for students and more experienced researchers interested in analysis of natural products, both inside and outside the field of food chemistry.

Download or read book Drug Bioavailability written by Han van de Waterbeemd and published by John Wiley & Sons. This book was released on 2006-03-06 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: The peroral application (swallowing) of a medicine means that the body must first resorb the active substance before it can begin to take effect. The efficacy of drug uptake depends on the one hand on the chemical characteristics of the active substance, above all on its solubility and membrane permeability. On the other hand, it is determined by the organism's ability to absorb pharmaceuticals by way of specific transport proteins or to excrete them. Since many pharmacologically active substances are poorly suited for oral intake, a decisive criterion for the efficacy of a medicine is its so-called bioavailability. Written by an international team from academia and the pharmaceutical industry, this book covers all aspects of the oral bioavailability of medicines. The focus is placed on methods for determining the parameters relevant to bioavailability. These range from modern physicochemical techniques via biological studies in vitro and in vivo right up to computer-aided predictions. The authors specifically address possibilities for optimizing bioavailability during the early screening stage for the active substance. Its clear structure and comprehensive coverage make this book equally suitable for researchers and lecturers in industry and teaching.

Download or read book Encyclopedia of Chromatography 2004 Update Supplement written by Jack Cazes and published by CRC Press. This book was released on 2004-08-11 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: In step with novel technologies and methodologies that have reshaped chromatography in recent years, this supplement reviews developments in HPLC, TLC, SFC, CCC, and other areas-presenting 50 authoritative entries filled with practical information vital to applications from biotechnology to environmental science to clinical pathology.

Download or read book Gas Chromatography in Air Pollution Analysis written by V.G. Berezkin and published by Elsevier. This book was released on 1991-04-25 with total page 225 pages. Available in PDF, EPUB and Kindle. Book excerpt: Air pollution determination is one of the most important fields of gas chromatography application in practice. This book provides a systematic description of the main stages of air pollution determination, ranging from sampling problems to the quantitative estimation of the acquired data. Special attention is paid to the problem of gas, vapor, spray and solid particles extraction from air. The main methods of sampling procedure, namely, container utilization, cryogenic concentration, absorption, adsorption, chemisorption and filter usage, and successive impurities extraction are also handled. Sorption theory and the problems of sorption and desorption efficiency for hazardous impurities being extracted from traps with sorbents are discussed in detail. The practical utilization of different sorbents (silica, activated carbon, polymers etc.) to carry out sampling procedures for 200 main pollutants with known TLV (USSR and USA) is also considered. This highly informative book, reflecting several insufficiently known techniques as well as the experience of both western and Soviet researchers, should be of interest to both beginners and skilled researchers.

Download or read book Bentley s Textbook of Pharmaceutics E Book written by Sanjay Kumar Jain and published by Elsevier Health Sciences. This book was released on 2011-08-23 with total page 778 pages. Available in PDF, EPUB and Kindle. Book excerpt: This adaptation of Bentley's Textbook of Pharmaceutics follows the same goals as those of the previous edition, albeit in a new look. The content of the old edition has been updated and expanded and several new chapters, viz. Complexations, Stability Testing as per ICH Guidelines, Parenteral Formulations, New Drug Delivery Systems and Pilot Plant Manufacturing, have been included, with an intention to make the book more informative for the modern pharmacists. The book has six sections: - Section I deals with the physicochemical principles. Two new chapters: Complexations and ICH Guidelines for Stability Testing, have been added to make it more informative. - Section II conveys the information regarding pharmaceutical unit operations and processes. - Section III describes the area of pharmaceutical practice. Extensive recent updates have been included in many chapters of this section. Two new chapters: Parenteral Formulations and New Drug Delivery Systems, have been added. - Section IV contains radioactivity principles and applications. - Section V deals with microbiology and animal products. - Section VI contains the formulation and packaging aspects of pharmaceuticals. Pilot Plant Manufacturing concepts are added as a new chapter, which may be beneficial to readers to understand the art of designing of a plant from the pilot plant model.

Download or read book Fundamentals of Analytical Toxicology written by Robert J. Flanagan and published by John Wiley & Sons. This book was released on 2008-03-03 with total page 605 pages. Available in PDF, EPUB and Kindle. Book excerpt: The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book gives principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens. After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques - colour tests and spectrophotometry, chromatography and electro­phoresis, mass spectrometry, and immunoassay – are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results. A clearly written, practical, integrated approach to the basics of analytical toxicology. Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications. Assumes only a basic knowledge of analytical chemistry. An accompanying website provides additional material and links to related sites. Written by an experienced team of authors,Fundamentals of Analytical Toxicology is an invaluable resource for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development. Praise from the reviews: “This is an ambitious effort to describe in detail the many and varied aspects of the science of toxicological analysis. The 17 chapters cover every foreseeable aspect, from specimen collection through analytical techniques and quality control to pharmacological principles and interpretation of results. The authors bring together a great deal of experience in the field and have succeeded admirably in achieving their goal: "to give principles and practical information on the analysis of drugs, poisons and other relevant analytes in biological specimens...". The book is very readable and quite up-to-date, and contains many illustrative figures, charts and tables. Both the student and the practicing professional would do well to study this material carefully, as there is something here for every conceivable level of interest.” Review from Randall Baselt "This text comes highly recommended for any analytical toxicology trainee." The Bulletin of the Royal College of Pathologists “Overall, this book provides a comprehensive, thorough, clear, up to date and practical treatment of analytical toxicology at a high standard. Understanding of the text is enhanced by the use of many illustrations. Specifications, guidelines, and methods are highlighted in grey background “Boxes”. The many and up to date literature references in each chapter demonstrate the authors’ thorough work and permit easy access to deeper information. Therefore this book can be highly recommended as a valuable source of knowledge in analytical toxicology both as an introduction and for the advanced reader.” GTFCh Bulletin “Toxichem + Krimtech”, May 2008 (translated, original review in German) “Many toxicologists will add this important reference to their libraries because it competently fills a need ...” International Journal of Toxicology “The book is very well illustrated, easy to understand and pleasant to read, and contains a wealth of dedicated information.” International Journal of Environmental Analytical Chemistry

Download or read book Drug like Properties Concepts Structure Design and Methods written by Li Di and published by Elsevier. This book was released on 2010-07-26 with total page 549 pages. Available in PDF, EPUB and Kindle. Book excerpt: Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacological activity and impact in vitro assays. Individual drug-like properties are discussed from a practical point of view, such as solubility, permeability and metabolic stability, with regard to fundamental understanding, applications of property data in drug discovery and examples of structural modifications that have achieved improved property performance. The authors also review various methods for the screening (high throughput), diagnosis (medium throughput) and in-depth (low throughput) analysis of drug properties. - Serves as an essential working handbook aimed at scientists and students in medicinal chemistry - Provides practical, step-by-step guidance on property fundamentals, effects, structure-property relationships, and structure modification strategies - Discusses improvements in pharmacokinetics from a practical chemist's standpoint

Download or read book Absorption and Drug Development written by Alex Avdeef and published by John Wiley & Sons. This book was released on 2012-04-11 with total page 741 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explains how to perform and analyze the results of the latest physicochemical methods With this book as their guide, readers have access to all the current information needed to thoroughly investigate and accurately determine a compound's pharmaceutical properties and their effects on drug absorption. The book emphasizes oral absorption, explaining all the physicochemical methods used today to analyze drug candidates. Moreover, the author provides expert guidance to help readers analyze the results of their studies in order to select the most promising drug candidates. This Second Edition has been thoroughly updated and revised, incorporating all the latest research findings, methods, and resources, including: Descriptions and applications of new PAMPA models, drawing on more than thirty papers published by the author's research group Two new chapters examining permeability and Caco-2/MDCK and permeability and the blood-brain barrier Expanded information and methods to support pKa determination New examples explaining the treatment of practically insoluble test compounds Additional case studies demonstrating the use of the latest physicochemical techniques New, revised, and expanded database tables throughout the book Well over 200 drawings help readers better understand difficult concepts and provide a visual guide to complex procedures. In addition, over 800 references serve as a gateway to the primary literature in the field, facilitating further research into all the topics covered in the book. This Second Edition is recommended as a reference for researchers in pharmaceutical R&D as well as in agrochemical, environmental, and other related areas of research. It is also recommended as a supplemental text for graduate courses in pharmaceutics.

Download or read book Doklady written by and published by . This book was released on 1979 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Handbook of Biochemistry and Molecular Biology written by Roger L. Lundblad and published by CRC Press. This book was released on 2018-06-14 with total page 2045 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by renowned protein scientist and bestselling author Roger L. Lundblad, with the assistance of Fiona M. Macdonald of CRC Press, this fifth edition of the Handbook of Biochemistry and Molecular Biology gathers a wealth of information not easily obtained, including information not found on the web. Presented in an organized, concise, and simple-to-use format, this popular reference allows quick access to the most frequently used data. Covering a wide range of topics, from classical biochemistry to proteomics and genomics, it also details the properties of commonly used biochemicals, laboratory solvents, and reagents. An entirely new section on Chemical Biology and Drug Design gathers data on amino acid antagonists, click chemistry, plus glossaries for computational drug design and medicinal chemistry. Each table is exhaustively referenced, giving the user a quick entry point into the primary literature. New tables for this edition: Chromatographic methods and solvents Protein spectroscopy Partial volumes of amino acids Matrix Metalloproteinases Gene Editing Click Chemistry

Download or read book Fibrinolysis Thrombolysis and Blood Clotting a Bibliography written by and published by . This book was released on 1973 with total page 1226 pages. Available in PDF, EPUB and Kindle. Book excerpt: