Download or read book Detection of Drugs of Abuse by Surface Enhanced Raman Scattering SERS written by Karen Jade Faulds and published by . This book was released on 2004 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Study of SERS for the Detection of Drugs of Abuse written by Sarah Louise Lamping and published by . This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A study of the use of Surface Enhanced Raman Spectroscopy (SERS) for the detection of illicit drugs in oral fluid using metal enhancement mechanisms was undertaken. Initial work investigated ecstasy tablet composition using Raman to identify what drugs and excipients might be present in oral fluid samples obtained from users. Overall, it is possible to identify the presence of phenethylamines and excipients in the seized tablets but not categorically distinguish between the phenethylamine derivative(s) especially when in a mixture. Comparison of the overall batch average peak positions and peak responses of the phenethylamine derivatives and excipients shows variability across the batches and reveals trends within the sub-batches. The Raman spectra appear to reflect the findings of the GUMS analysis tentatively, implying this technique could be used for initial intelligence gathering applications whilst confirmatory analysis results are awaited. Initial SERS research focused on achieving enhancement of aqueous drug solutions with silver and gold colloid. Overall a lack of reproducibility was observed. Therefore, alternative SERS enhancement mechanisms were sought. Ag/Ti02 substrates demonstrated low limits of detection and the possibility of detecting SERS enhancement of aqueous amphetamine solution at levels below 8x10−2 M. The work also showed that cotton swabs for sample application onto the surface of the substrate are a viable practical option for both experimental and field analysis. Successful detection of methadone and buprenorphine, used to treat heroin addiction, was achieved with Ag/Ti02 substrates at concentrations associated with therapeutic use, representing lower concentration drugs. The detection of MDMA in oral fluid following ecstasy use, not only showed promise for the detection of illicit drugs, but did so at the analytical cut-off concentration detailed in the draft type approval specification for roadside drug screening devices. This work confirms that SERS has a role for drug detection in oral fluid samples.
Download or read book Surface enhanced Raman Scattering SERS Spectroscopy Techniques for Trace Identification of Drugs of Abuse written by Vinesh Rana and published by . This book was released on 2008 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Surface Enhanced Raman Spectroscopy written by Marek Prochazka and published by Springer. This book was released on 2015-12-12 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book gives an overview of recent developments in RS and SERS for sensing and biosensing considering also limitations, possibilities and prospects of this technique. Raman scattering (RS) is a widely used vibrational technique providing highly specific molecular spectral patterns. A severe limitation for the application of this spectroscopic technique lies in the low cross section of RS. Surface-enhanced Raman scattering (SERS) spectroscopy overcomes this problem by 6-11 orders of magnitude enhancement compared with the standard RS for molecules in the close vicinity of certain rough metal surfaces. Thus, SERS combines molecular fingerprint specificity with potential single-molecule sensitivity. Due to the recent development of new SERS-active substrates, labeling and derivatization chemistry as well as new instrumentations, SERS became a very promising tool for many varied applications, including bioanalytical studies and sensing. Both intrinsic and extrinsic SERS biosensing schemes have been employed to detect and identify small molecules, nucleic acids and proteins, and also for cellular and in vivo sensing.
Download or read book Sample Preparation with Nanomaterials written by Chaudhery Mustansar Hussain and published by John Wiley & Sons. This book was released on 2021-07-19 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover this timely, comprehensive, and up-to-date exploration of crucial aspects of the use of nanomaterials in analytical chemistry Sample Preparation with Nanomaterials: Next Generation Techniques for Sample Preparation delivers insightful and complete overview of recent progress in the use of nanomaterials in sample preparation. The book begins with an overview of special features of nanomaterials and their applications in analytical sciences. Important types of nanomaterials, like carbon nanotubes and magnetic particles, are reviewed and biological sample preparation and lab-on-a-chip systems are presented. The distinguished author places special emphasis on approaches that tend to green and reduce the cost of sample treatment processes. He also discusses the legal, economical, and toxicity aspects of nanomaterial samples. This book includes extensive reference material, like a complete list of manufacturers, that makes it invaluable for professionals in analytical chemistry. Sample Preparation with Nanomaterials offers considerations of the economic aspects of nanomaterials, as well as the assessment of their toxicity and risk. Readers will also benefit from the inclusion of: A thorough introduction to nanomaterials in the analytical sciences and special properties of nanomaterials for sample preparation An exploration of the mechanism of adsorption and desorption on nanomaterials, including carbon nanomaterials used as adsorbents Discussions of membrane applications of nanomaterials, surface enhanced raman spectroscopy, and the use of nanomaterials for biological sample preparation A treatment of magnetic nanomaterials, lab-on-a-chip nanomaterials, and toxicity and risk assessment of nanomaterials Perfect for analytical chemists, materials scientists, and process engineers, Sample Preparation with Nanomaterials: Next Generation Techniques for Sample Preparation will also earn a place in the libraries of analytical laboratories, universities, and companies who conduct research into nanomaterials and seek a one-stop resource for sample preparation.
Download or read book Application of Raman Spectroscopy Surface enhanced Raman Scattering SERS and Density Functional Theory for the Identification of Phenethylamine and Its Analogs written by Francis Taplin and published by . This book was released on 2011 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: This study evaluated normal Raman (NR) spectroscopy and the surface-enhanced Raman scattering (SERS) for the analysis of five sympathomimetic amines. Furthermore, quantum mechanical calculations -- geometry optimization and calculations of the harmonic vibrational frequencies -- were performed using the Density Functional Theory approach. Vibrational assignments were made by comparing the experimental and calculated spectra. Traditionally, drugs of abuse are analyzed by color test, GC-MS, and Infrared spectroscopy. However, there has been continuing and growing interest in applying Raman spectroscopy and surface-enhanced Raman scattering techniques for the identification of street drugs as they offer some clear advantages over previously used methods. Five commonly seized phenethylamines and their precursors were chosen. Normal Raman and SERS spectra were successfully obtained for each of the drug molecules. The normal Raman and SERS spectra were determined with 514nm, 633nm, and 1064 nm laser wavelenghts. SERS spectra were obtained with addition of a silver (Ag) colloid and 0.5M NaCl aggregating agent. The study found that both NR and SERS provided excellent spectra for the drugs tested. Certain conditions, such as response to various laser wavelengths and background fluorescence of the analyte could be easily managed using SERS techniques. The DFT calculated spectra could be correlated with the experimental spectra without the aid of a scaling factor.
Download or read book Surface Enhanced Raman Scattering New Theoretical Approaches Materials and Strategies written by Ivano Alessandri and published by Frontiers Media SA. This book was released on 2020-03-25 with total page 175 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Improving SERS Detection of Illicit Drugs Using a Plasmonic Substrate Modified with Self Assembled Monolayers written by John Harms and published by . This book was released on 2021 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt: Due to the worsening national drug epidemic and increasing prevalence of exceptionally potent synthetic opioids, there is a need to improve the forensic detection of illicit drugs, including sample analyses conducted on-site. In this thesis, the analysis of several illicit drugs spotted onto plasmonic surfaces was investigated using surface-enhanced Raman spectroscopy (SERS) with the goal of improving detection limits. Plasmonic surfaces (gold nanoparticle-loaded filter papers) were prepared and characterized prior to their SERS applications. Plasmonic surfaces were then further modified for improved SERS detection of each illicit drug with the treatment of self-assembled monolayer (SAM) forming compounds; in addition to the implementation of paper-spray ionization (PSI). Each of these modifications were optimized both independently and simultaneously for each drug through the screening process of many SAMs, durations of PSI, and SERS scan location on the sample surface. Finally, each combination of drug with optimal SAM and/or PSI optimization was calibrated to assess limits of detection. Limits of detection were found to be in the single-nanograms of drug deposited and improvements were observed in samples modified with SAMs and PSI.
Download or read book Surface Enhanced Vibrational Spectroscopy written by Ricardo Aroca and published by John Wiley & Sons. This book was released on 2006-05-01 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface Enhanced Vibrational Spectroscopy (SEVS) has reached maturity as an analytical technique, but until now there has been no single work that describes the theory and experiments of SEVS. This book combines the two important techniques of surface-enhanced Raman scattering (SERS) and surface-enhanced infrared (SEIR) into one text that serves as the definitive resource on SEVS. Discusses both the theory and the applications of SEVS and provides an up-to-date study of the state of the art Offers interpretations of SEVS spectra for practicing analysts Discusses interpretation of SEVS spectra, which can often be very different to the non-enhanced spectrum - aids the practicing analyst
Download or read book Potential for On site Prosecutorial Evidence from Drug Residues Collected on Plasmonic Paper written by Daniel S. Burr and published by . This book was released on 2019 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given the potential impact of improvements to on-site drug testing, as well as recent, successful displays of paper spray ionization mass spectrometry (PSI-MS) in this regard, this thesis pilots the implementation of Raman spectroscopy as a compliment to MS for field-based confirmatory drug testing. Surface enhanced Raman scattering (SERS) is utilized for applications to trace detection. Two-tiered analysis of individual drug samples is enabled using triangularly-cut plasmonic papers, from which both SERS and PS-MS analysis may be performed. Several drug compounds, representative of traditional and emerging drug types, are examined by these techniques, both separately and as a fully integrated, SERS-PSI-MS testing platform. The unique benefits offered by Raman/SERS are demonstrated via discrimination of isomers that are indistinguishable by MS. Optimization of the coupled, analytical platform culminate in a standard operating procedure, which is implemented in an error-rate study (N = 500) performed for sub-microgram quantities of drugs deposited on plasmonic papers.
Download or read book Practical Guide To Chemometrics written by Paul Gemperline and published by CRC Press. This book was released on 2006-04-16 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: The limited coverage of data analysis and statistics offered in most undergraduate and graduate analytical chemistry courses is usually focused on practical aspects of univariate methods. Drawing in real-world examples, Practical Guide to Chemometrics, Second Edition offers an accessible introduction to application-oriented multivariate meth
Download or read book Infrared and Raman Spectroscopy in Forensic Science written by John M. Chalmers and published by John Wiley & Sons. This book was released on 2012-01-03 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will provide a survey of the major areas in which information derived from vibrational spectroscopy investigations and studies have contributed to the benefit of forensic science, either in a complementary or a unique way. This is highlighted by examples taken from real case studies and analyses of forensic relevance, which provide a focus for current and future applications and developments.
Download or read book The Analysis of Drugs in Biological Fluids written by Joseph Chamberlain and published by CRC Press. This book was released on 2018-02-06 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new edition focuses on a variety of techniques available for the analysis of drugs in biological fluids. Over 150 figures and tables help to describe the latest advances and give examples of their applications. Current chiral analysis methods as well as discussions on the impact of chirality are described. Practical aspects of bioanalytical work, including many examples of laboratory problems not often reported in the scientific literature, are examined in depth.
Download or read book Handbook of Enhanced Spectroscopy written by Marc Lamy de la Chapelle and published by CRC Press. This book was released on 2015-10-16 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: Techniques such as Raman, infrared, fluorescence, and even nonlinear spectroscopies have recently grown in resolution and possibilities thanks to the use of nanostructured surfaces. Excitation of localized surface plasmon (LSP) and/or the use of specific shapes of nanostructures have made it possible to gain an incredible sensitivity in these spect
Download or read book Forensic Chemistry Handbook written by Lawrence Kobilinsky and published by John Wiley & Sons. This book was released on 2011-11-17 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: A concise, robust introduction to the various topics covered by the discipline of forensic chemistry The Forensic Chemistry Handbook focuses on topics in each of the major chemistry-related areas of forensic science. With chapter authors that span the forensic chemistry field, this book exposes readers to the state of the art on subjects such as serology (including blood, semen, and saliva), DNA/molecular biology, explosives and ballistics, toxicology, pharmacology, instrumental analysis, arson investigation, and various other types of chemical residue analysis. In addition, the Forensic Chemistry Handbook: Covers forensic chemistry in a clear, concise, and authoritative way Brings together in one volume the key topics in forensics where chemistry plays an important role, such as blood analysis, drug analysis, urine analysis, and DNA analysis Explains how to use analytical instruments to analyze crime scene evidence Contains numerous charts, illustrations, graphs, and tables to give quick access to pertinent information Media focus on high-profile trials like those of Scott Peterson or Kobe Bryant have peaked a growing interest in the fascinating subject of forensic chemistry. For those readers who want to understand the mechanisms of reactions used in laboratories to piece together crime scenes—and to fully grasp the chemistry behind it—this book is a must-have.
Download or read book Quantitative and Sensitive Detection of Prohibited Fish Drugs by Surface enhanced Raman Scattering Project Supported by the National Basic Research Program of China Grant No 2014CB745100 the National Natural Science Foundation of China Grant Nos 21390202 and 21676015 and the Beijing Higher Education Young Elite Teacher Project written by and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Abstract : Rapid and simple detections of two kinds of prohibited fish drugs, crystal violet (CV) and malachite green (MG), were accomplished by surface-enhanced Raman scattering (SERS). Based on the optimized Au/cicada wing, the detectable concentration of CV/MG can reach 10 −7 M, and the linear logarithmic quantitative relationship curves between log I and log C allows for the determination of the unknown concentration of CV/MG solution. The detection of these two analytes in real environment was also achieved, demonstrating the application potential of SERS in the fast screening of the prohibited fish drugs, which is of great benefit for food safety and environmental monitoring.
Download or read book Analysis of Drugs in Thin Films Using Surface Enhanced Raman Spectroscopy to Evaluate Their Detection in Latent Fingerprint Residues written by Caitlin R. Izzo and published by . This book was released on 2015 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surface-enhanced Raman spectroscopy was used to analyze thin films containing low levels of four drugs in order to determine the limit of detection for this technique.
