Download or read book Designing Nanosensors Based on Ion Channel forming Derivatives of Gramicidin A written by Steven Blake and published by . This book was released on 2008 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation will focus on detecting analytes in aqueous solution that chemically react with or bind to functional groups near the opening of synthetic ion channels derived from gramicidin A (gA). Detection is achieved when a measurable change in the conductance of ions across the ion channel is produced after the analyte interacts with the channel. Ion channel sensors have great potential for achieving ultrasensitive detection since a single chemical modification near the lumen of the channel can lead to detectable changes in channel conductance. The dissertation will specifically focus on: (1) the development of design parameters to improve sensing with gA-based nanosensors; (2) the demonstration of sensing analytes in aqueous solution by manipulating the charge of a chemical group near the pore of gA (charge-based sensing); (3) the chemistry for producing reactive building blocks of gA for developing robust and diverse gA-based nanosensors; (4) the detection of enzyme activity using our charge-based sensing approach to achieve picomolar limits of detection; and (5) the small structural changes that can be introduced to the peptide near the lumen of the channel to control conductance.
Download or read book Handbook of Single Molecule Biophysics written by Peter Hinterdorfer and published by Springer Science & Business Media. This book was released on 2009-12-24 with total page 634 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook describes experimental techniques to monitor and manipulate individual biomolecules, including fluorescence detection, atomic force microscopy, and optical and magnetic trapping. It includes single-molecule studies of physical properties of biomolecules such as folding, polymer physics of protein and DNA, enzymology and biochemistry, single molecules in the membrane, and single-molecule techniques in living cells.
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2009 with total page 840 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Nanoscale Sensing Methodology Via Functional Control of an Ion Channel forming Peptide Gramicidin A written by Michael X. Macrae and published by . This book was released on 2011 with total page 325 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gramicidin ion channels are formed by the association of two [Beta]-helix pentadecapeptides, each spanning half the lipid bilayer. A single dimerization event enables the flux of millions of cations across the bilayer per second. This signal amplification allows for the detection and monitoring of events on the single molecule level - a feat seldomly accomplished. Gramicidin is also remarkably simple to use as it both spontaneously self-incorporates into the membrane and forms channels under a broad range of conditions. Lastly, work primarily done by our lab has developed facile synthetic techniques for functional modifications of the native channel structure. This thesis represents a two-fold effort, both in the improved fundamental understanding of gramicidin A, as well as the exploration of this platform's utility as a tool for more applied problems. Through a comprehensive understanding of the influences which a permanent charge affixed to the channel entrance exert on both channel conductance and open channel lifetime, the ability to utilize the functional response to a wide variety of external stimuli has been realized.
Download or read book Metals in Cells written by Valeria Culotta and published by John Wiley & Sons. This book was released on 2016-03-16 with total page 608 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the last three decades a lot of research on the role of metals in biochemistry and medicine has been done. As a result many structures of biomolecules with metals have been characterized and medicinal chemistry studied the effects of metal containing drugs. This new book (from the EIBC Book Series) covers recent advances made by top researchers in the field of metals in cells [the “metallome”] and include: regulated metal ion uptake and trafficking, sensing of metals within cells and across tissues, and identification of the vast cellular factors designed to orchestrate assembly of metal cofactor sites while minimizing toxic side reactions of metals. In addition, it features aspects of metals in disease, including the role of metals in neuro-degeneration, liver disease, and inflammation, as a way to highlight the detrimental effects of mishandling of metal trafficking and response to "foreign" metals. With the breadth of our recently acquired understanding of metals in cells, a book that features key aspects of cellular handling of inorganic elements is both timely and important. At this point in our understanding, it is worthwhile to step back and take an expansive view of how far our understanding has come, while also highlighting how much we still do not know. The content from this book will publish online, as part of EIBC in December 2013, find out more about the Encyclopedia of Inorganic and Bioinorganic Chemistry, the essential online resource for researchers and students working in all areas of inorganic and bioinorganic chemistry.
Download or read book Microbial Products for Health Environment and Agriculture written by Pankaj Kumar Arora and published by Springer Nature. This book was released on 2021-09-21 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: This edited volume discusses the role of various microbial products in healthcare, environment and agriculture. Several microbial products are directly involved in solving major health problems, agricultural and environmental issues. In healthcare sector, microbes are used as anti-tumor compounds, antibiotics, anti-parasitic agents, enzyme inhibitors and immunosuppressive agents. Microbial products are also used to degrade xenobiotic compounds and bio-surfactants, for biodegradation process. In agriculture, microbial products are used to enhance nutrient uptake, to promote plant growth, or to control plant diseases. The book presents several such applications of microbes in the ecosystems. The chapters are contributed from across the globe and contain up-to-date information. This book is of interest to teachers, researchers, microbiologists and ecologists. Also the book serves as additional reading material for undergraduate and graduate students of agriculture, forestry, ecology, soil science, and environmental sciences.
Download or read book Current Trends in Plant Disease Diagnostics and Management Practices written by Pradeep Kumar and published by Springer. This book was released on 2016-04-28 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant diseases play an important role on our daily lives. Most of plant diseases are visible and are caused by biotic and/or abiotic factors. Symptoms are usually the results of a morphological change, alteration or damage to plant tissue and/or cells due to an interference of the plant’s metabolism. All basic structures of vascular plants are subject to attack by pathogens. The failure in accurate disease diagnosis and management may lead to huge losses in plant production and related commodities, which causes nutritional food scarcity. Typically, the appearance of a biotic symptom will indicate the relatively late stage of an infection and/or colonization of a pathogen. Expert detection, accurate diagnosis, and timely management play a significant role in keeping plants free from pathogens. In this book expert scholars share their research knowledge and key literature which are vital toward the diagnosis of plant diseases across the globe, addressing traditional plant pathology techniques, as well as advanced molecular diagnostic approach.
Download or read book Environment and Sustainable Development written by M.H. Fulekar and published by Springer Science & Business Media. This book was released on 2013-10-04 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Global society in the 21st century is facing challenges of improving the quality of air, water, soil and the environment and maintaining the ecological balance. Environmental pollution, thus, has become a major global concern. The modern growth of industrialization, urbanization, modern agricultural development and energy generation has resulted in the indiscriminate exploitation of natural resources for fulfilling human desires and needs, which has contributed in disturbing the ecological balance on which the quality of our environment depends. Human beings, in the truest sense, are the product of their environment. The man-environment relationship indicates that pollution and deterioration of the environment have a social origin. The modern technological advancements in chemical processes/operations have generated new products, resulting in new pollutants in such abundant levels that they are above the self-cleaning capacity of the environment. One of the major issues in recent times is the threat tohuman lives due to the progressive deterioration of the environment from various sources. The impact of the pollutants on the environment will be significant when the accumulated pollutants load will exceed the carrying capacity of the receiving environment. Sustainable development envisages the use of natural resources, such as forests, land, water and fisheries, in a sustainable manner without causing changes in our natural world. The Rio de Janeiro-Earth Summit, held in Brazil in 1992, focused on sustainable development to encourage respect and concern for the use of natural resources in a sustainable manner for the protection of the environment. This book will be beneficial as a source of educational material to post-graduate research scholars, teachers and industrial personnel for maintaining the balance in the use of natural sources for sustainable development.
Download or read book Live Cell Imaging written by Dmitri Papkovsky and published by Humana Press. This book was released on 2009-12-17 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now a routine tool in biomedical and life science research, live cell imaging has made major progress enabling this core biochemical, cell, and molecular biology technique to become even more powerful, versatile, and affordable. In Live Cell Imaging: Methods and Protocols, a panel of expert contributors provide a comprehensive compendium of experimental approaches to live cell imaging in the form of several overview chapters followed by representative examples and case studies covering different aspects of the most current methodology. By examining a range of state-of-the-art protocols extensively validated in complex biological studies, this volume highlights new experimental and instrumental opportunities and helps researchers to select appropriate imaging methods for their specific biological questions and measurement tasks. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Live Cell Imaging: Methods and Protocols promises to contribute greatly to the further development and dissemination of this fundamentally important technology which spans across many disciplines including molecular and cell biology, chemistry, physics, optics, engineering, cell physiology, and medicine.
Download or read book Nanobiotechnology Applications in Plant Protection written by Kamel A. Abd-Elsalam and published by Springer Nature. This book was released on 2019-10-04 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanobiotechnology Applications in Plant Protection: Volume 2 continues the important and timely discussion of nanotechnology applications in plant protection and pathology, filling a gap in the literature for nano applications in crop protection. Nanobiopesticides and nanobioformulations are examined in detail and presented as powerful alternatives for eco-friendly management of plant pathogens and nematodes. Leading scholars discuss the applications of nanobiomaterials as antimicrobials, plant growth enhancers and plant nutrition management, as well as nanodiagnostic tools in phytopathology and magnetic and supramagnetic nanostructure applications for plant protection. This second volume includes exciting new content on the roles of biologically synthesized nanoparticles in seed germination and zinc-based nanostructures in protecting against toxigenic fungi. Also included is new research in phytotoxicity, nano-scale fertilizers and nanomaterial applications in nematology and discussions on Botyris grey mold and nanobiocontrol. This book also explores the potential effects on the environment, ecosystems and consumers and addresses the implications of intellectual property for nanobiopesticides. Further discussed are nanotoxicity effects on the plant ecosystem and nano-applications for the detection, degradation and removal of pesticides.
Download or read book Enzymes in Food Technology written by Mohammed Kuddus and published by Springer. This book was released on 2018-11-19 with total page 419 pages. Available in PDF, EPUB and Kindle. Book excerpt: The integration of enzymes in food processing is well known, and dedicated research is continually being pursued to address the global food crisis. This book provides a broad, up-to-date overview of the enzymes used in food technology. It discusses microbial, plant and animal enzymes in the context of their applications in the food sector; process of immobilization; thermal and operational stability; increased product specificity and specific activity; enzyme engineering; implementation of high-throughput techniques; screening of relatively unexplored environments; and development of more efficient enzymes. Offering a comprehensive reference resource on the most progressive field of food technology, this book is of interest to professionals, scientists and academics in the food and biotech industries.
Download or read book The Handbook of Nanomedicine written by Kewal K. Jain and published by Humana Press. This book was released on 2017-03-20 with total page 661 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanomedicine is defined as the application of nanobiotechnology in clinical medicine, which is currently being used to research the pathomechanism of disease, refine molecular diagnostics, and aid in the discovery, development, and delivery of drugs. In The Handbook of Nanomedicine, Third Edition, Prof. Kewal K. Jain updates, reorganizes, and replaces information in the comprehensive second edition in order to capture the most recent advances in this dynamic field. Important components of nanomedicine such as drug delivery via nanobiotechnology and nanopharmaceuticals as well as nanooncology, where the greatest number of advances are occurring, are covered extensively. As this text is aimed at nonmedical scientists, pharmaceutical personnel, as well as physicians, descriptions of the technology involved and other medical terminology are kept as clear and simple as possible. In depth and cutting-edge, The Handbook of Nanomedicine, Third Edition informs its readers of the ever-growing field of nanomedicine, destined to play a significant role in the future of healthcare.
Download or read book Nanomaterials and Their Biomedical Applications written by Tuhin Subhra Santra and published by Springer Nature. This book was released on 2021-04-16 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the evolution of, and novel challenges currently facing, nanomaterials science, nanoengineering, and nanotechnology, and their applications and development in the biological and biomedical fields. It details different nanoscale and nanostructured materials syntheses, processing, characterization, and applications, and considers improvements that can be made in nanostructured materials with their different biomedical applications. The book also briefly covers the state of the art of different nanomaterials design, synthesis, fabrication and their potential biomedical applications. It will be particularly useful for reading and research purposes, especially for science and engineering students, academics, and industrial researchers.
Download or read book Who s Who in Fluorescence 2009 written by Chris D. Geddes and published by Springer Science & Business Media. This book was released on 2009-04-02 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: th The Who’s Who in Fluorescence 2009 is the 7 volume of the Who’s who series. The previous six volumes (2003 – 2008) have been very well received by the fluorescence community, with 1000’s of copies being distributed around the world, through conferences and workshops, as well as through internet book sites. In addition, the Institute of Fluorescence (http://theinstituteoffluorescence.com/) mailed 100’s of copies of the 2008 volume to contributors around the world. This new 2009 volume features some 419 entries from no fewer than 41 countries worldwide, as compared to 418 entries (38 different countries) in 2008 and 405 entries in the 2007 volume, respectively. We have received 29 new entries this year, and deleted 25 entries that were not updated by contributors from past years. In 2008, 129 AIM numbers were submitted as compared to 106 in 2007. This year the number has risen again to 136 AIM numbers submitted. This year we also see the introduction of the h-index number listing, a publication statistic provided by the Thompson’s ISI Web of Science. Some 42 contributors provided their h-numbers. In 2009 we also see a continued and strong company support, in light of the current world economic climate, which will enable us to further disseminate the volume in 2009– 2010. In this regard we especially thank the instrumentation companies for their continued support, where without their financial contributions, it is likely that the volume would not be the success it is today.
Download or read book Food Biosensors written by Minhaz Uddin Ahmed and published by Royal Society of Chemistry. This book was released on 2016-10-12 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nothing provided
Download or read book Ion Channel Drug Discovery written by Brian Cox and published by Royal Society of Chemistry. This book was released on 2014-09-03 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channel drug discovery is a rapidly evolving field fuelled by recent, but significant, advances in our understanding of ion channel function combined with enabling technologies such as automated electrophysiology. The resurgent interest in this target class by both pharmaceutical and academic scientists was clearly highlighted by the over-subscribed RSC/BPS 'Ion Channels as Therapeutic Targets' symposium in February 2009. This book builds on the platform created by that meeting, covering themes including advances in screening technology, ion channel structure and modelling and up-to-date case histories of the discovery of modulators of a range of channels, both voltage-gated and non-voltage-gated channels. The editors have built an extensive network of contacts in the field through their first-hand scientific experience, collaborations and conference participation and the organisation of the meeting at Novartis, Horsham, increased the network enabling the editors to draw on the experience of eminent researchers in the field. Interest and investment in ion channel modulation in both industrial and academic settings continues to grow as new therapeutic opportunities are identified and realised for ion channel modulation. This book provides a reference text by covering a combination of recent advances in the field, from technological and medicinal chemistry perspectives, as well as providing an introduction to the new 'ion channel drug discoverer'. The book has contributions from highly respected academic researchers, industrial researchers at the cutting edge of drug discovery and experts in enabling technology. This combination provides a complete picture of the field of interest to a wide range of readers.
Download or read book Chemical Sensors written by Ghenadii Korotcenkov and published by Momentum Press. This book was released on 2012-07-15 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical sensors are integral to the automation of myriad industrial processes and everyday monitoring of such activities as public safety, engine performance, medical therapeutics, and many more. This 4 volume reference work covering simulation and modeling will serve as the perfect complement to Momentum Press's 6 volume reference works 'Chemical Sensors: Fundamentals of Sensing Materials' and 'Chemical Sensors: Comprehensive Sensor Technologies', which present detailed information related to materials, technologies, construction and application of various devices for chemical sensing. This 4 volume comprehensive reference work analyzes approaches used for computer simulation and modeling in various fields of chemical sensing and discusses various phenomena important for chemical sensing such as bulk and surface diffusion, adsorption, surface reactions, sintering, conductivity, mass transport, interphase interactions, etc. In this work it will be shown that theoretical modeling and simulation of the processes, being a basic for chemical sensors operation, could provide considerable progress in choosing both optimal materials and optimal configurations of sensing elements for using in chemical sensors. Each simulation and modeling volume in the present series reviews modeling principles and approaches peculiar to specific groups of materials and devices applied for chemical sensing. Volume 2: Conductometric-Type Sensors covers phenomenological modeling and computational design of conductometric chemical sensors based on nanostructured materials such as metal oxides, carbon nanotubes and graphene. This volume contains an overview of the approaches used to quantitatively evaluate characteristics of sensitive structures in which electric charge transport depends on the interaction between the surfaces of the structures and chemical compounds in the surrounding.
