Download or read book Lawesson s Reagent in Heterocycle Synthesis written by Navjeet Kaur and published by Springer Nature. This book was released on 2021-09-10 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the new and old methods for the synthesis of various heterocycles using Lawesson’s reagent. The book covers an important and rapidly growing branch of heterocyclic chemistry and can serve as a guide to those who are completing their education and are about to enter the job market. Students will be able to find all Lawesson’s reagent-assisted protocols for the synthesis of heterocycles in one place. This feature of the book provides an important benefit, because sometimes users want to see all the possibilities and relevant information for making a particular compound using one particular reagent. The purpose of this valuable resource is to provide the knowledge not only to students but also to pharmacologists, biochemists, organic and medicinal chemists, researchers, and academic professionals for easy access to synthetic protocols for different heterocycles using Lawesson’s reagent. The book will be greatly helpful for everyone involved in the field and can pave the way for better understanding and quantification of heterocycle synthesis.

Download or read book Vicinal Diaryl Substituted Heterocycles written by M. R. Yadav and published by Elsevier. This book was released on 2018-03-14 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vicinal Diaryl-Substituted Heterocycles: A Gold Mine for the Discovery of Novel Therapeutic Agents draws together all of the key information about these compounds in one place for the first time. Following an informative overview of the importance of these structures to the discovery of potential therapeutic agents, the text goes on to outline the main compound types, with each chapter focusing on the activities of a different structure. Designed to support researchers by consolidating this important information in a single, practical guide, the authors hope to encourage further advancement and development in the discovery of novel therapeutic agents. As flexible building blocks for the production of novel compounds, vicinal diaryl-substituted heterocycles are a rich source of leads for the development of new drugs. Their adaptability means that they can be used to produce structures with a broad range of attractive characteristics, and a large number of vicinal diaryl-substituted heterocyclic compounds have already been synthesized and investigated by medicinal chemists as promising lead molecules. - Collects together details of the key vicinal diaryl-substituted heterocyclic compounds in one place for the first time - Highlights biological activities and SAR of derivatives - Structured practically for ease of navigation between different derivatives

Download or read book Privileged Scaffolds in Medicinal Chemistry written by Stefan Bräse and published by Royal Society of Chemistry. This book was released on 2015-11-20 with total page 486 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the various classes of privileged scaffolds and covers the history of their discovery and use.

Download or read book Thiazole and Its Derivatives written by Jacques V. Metzger and published by . This book was released on 1979 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Textbook of Organic Medicinal and Pharmaceutical Chemistry written by T. C. Daniels and published by . This book was released on 1971 with total page 1078 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Drug Resistance in Bacteria Fungi Malaria and Cancer written by Gunjan Arora and published by Springer. This book was released on 2018-07-20 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a compilation of past and recent knowledge in the field of emerging drug resistance. The book covers major aspects of drug resistance in bacteria, fungi, malaria, and cancer.Human survival on earth is constantly threatened by disease and syndrome. From the early days, the aim of research in medicine was to find therapeutic agents that can improve the quality of human life. Although humans are dependent on natural compounds from early days their dependence of drugs increased excessively in last century. The advances in chemistry and biology have helped researchers to identify the drugs that have improved treatment of many diseases. The primary factor for treatment of these diseases is dependent on the efficacy of drugs available. The development of resistance to these drugs is one of the major hindrances. Although there are number of books available on this topic, “drug resistance” biology across kingdoms has never been discussed in a coherent way.

Download or read book Approaches to Design and Synthesis of Antiparasitic Drugs written by N. Anand and published by Elsevier. This book was released on 1997-07-10 with total page 525 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a comprehensive and up to date account of the chemotherapy of parasitic diseases, both human and veterinary. The book starts with an overview of parasitic diseases. The body of the book is divided into two parts: antihelminthic drugs, and antiprotozoal drugs. Both parts start with chapters highlighting the 'biochemical targets' available for chemotherapeutic interference. Individual chapters deal with one chemical class of compounds and describe their origin, structure-activity relationship, mode of action, and methods of synthesis and their status both in clinical and veterinary practice. The book will be useful to a wide spectrum of readers: students embarking on a research career in parasitic chemotherapy, clinicians (and veterinarians) and clinical pharmacologists desiring detailed information about the drugs currently in use, and pharmaceutical technologists wanting to update their knowledge of the methods of manufacture.

Download or read book Cisplatin written by Bernhard Lippert and published by John Wiley & Sons. This book was released on 1999 with total page 630 pages. Available in PDF, EPUB and Kindle. Book excerpt: 30 years after its discovery as an antitumor agent, cisplatin represents today one of the most successful drugs in chemotherapy. This book is intended to reminisce this event, to take inventory, and to point out new lines of development in this field. Divided in 6 sections and 22 chapters, the book provides an up-to-date account on topics such as - the chemistry and biochemistry of cisplatin, - the clinical status of Pt anticancer drugs, - the impact of cisplatin on inorganic and coordination chemistry, - new developments in drug design, testing and delivery. It also includes a chapter describing the historical development of the discovery of cisplatin. The ultimate question - How does cisplatin kill a cell? - is yet to be answered, but there are now new links suggesting how Pt binding to DNA may trigger a cascade of cellular reactions that eventually result in apoptosis. p53 and a series of damage recognition proteins of the HMG-domain family appear to be involved. The book addresses the problem of mutagenicity of Pt drugs and raises the question of the possible relevance of the minor DNA adducts, e.g. of interstrand cross-links, and the possible use of trans-(NH3)2Pt(II)-modified oligonucleotides in antisense and antigene strategies. Our present understanding of reactions of cisplatin with DNA is based upon numerous model studies (from isolated model nucleobases to short DNA fragments) and application of a large body of spectroscopic and other physico-chemical techniques. Thanks to these efforts there is presently no other metal ion whose reactions with nucleic acids are better understood than Pt. In a series of chapters, basic studies on the interactions of Pt electrophiles with nucleobases, oligonucleotides, DNA, amino acids, peptides and proteins are reported, which use, among others, sophisticated NMR techniques or X-ray crystallography, to get remarkable understanding of details on such reactions. Reactivity of cisplatin, once bound to DNA and formerly believed to be inert enough to stay, is an emerging phenomenon. It has (not yet) widely been studied but is potentially extremely important. Medicinal bioinorganic chemistry - the role of metal compounds in medicine - has received an enormous boost from cisplatin, and so has bioinorganic chemistry as a whole. There is hardly a better example than cisplatin to demonstrate what bioinorganic chemistry is all about: The marriage between classic inorganic (coordination) chemistry and the other life sciences - medicine, pharmacy, biology, biochemistry. Cisplatin has left its mark also on areas that are generally considered largely inorganic. The subject of mixed-valance Pt compounds is an example: From the sleeping beauty it made its way to the headlines of scientific journals, thanks to a class of novel Pt antitumor agents, the so-called "platinum pyrimidine blues". In the aftermath diplatinum (III) compounds were recognized and studies in large numbers, and now an organometalic chemistry of these diplatinum (III) species is beginning to emerge. The final section of the book is concerned with new developments such as novel di- and trinuclear Pt(II) drugs with DNA binding properties different from those of cisplatin, with orally active Pt(IV) drugs which are presently in clinical studies, and with attempts to modify combinatorial chemistry in such a way that it may become applicable to fast screening of Pt antitumor drugs. The potential of including computational methods in solving questions of Pt-DNA interactions is critically dealt with in the concluding chapter.

Download or read book Modified Nucleosides written by Piet Herdewijn and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 684 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by one of the main driving forces behind the field's momentous rise in recent years, this one-stop reference is the first comprehensive resource to integrate recent advances. The first part addresses biochemical aspects and applications, the second and third parts are devoted to compounds with therapeutic potential, with the third part focusing on newly introduced anticancer nucleoside drugs. Essential reading for every scientist working in this area.

Download or read book Recent Highlights in the Discovery and Optimization of Crop Protection Products written by Peter Maienfisch and published by Academic Press. This book was released on 2021-03-24 with total page 647 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent Highlights in the Discovery and Optimization of Crop Protection Products highlights the most prominent, recent results in the search for safe and effective new crop protection products. With a focus on the design, synthesis, optimization and/or structure-activity relationships of new chemistries targeting insect, disease, weed, nematode, vector and animal parasite control, the book also includes recent developments in crop enhancement chemistries and new approaches to crop protection products. The inclusion of information on testing tools, green chemistry approaches, and the latest discovery tools, like modeling, structure-based design, and testing tools makes this volume complete. Based on key presentations given at the 14th International IUPAC conference on Crop Protection, May 19-24, 2019 in Ghent, Belgium, this book includes the many exciting new discoveries and findings reported. It is designed to inspire additional research and advancement in the field. - Based on science presented at the 2019 International Union of Pure and Applied Chemistry Conference on Crop Protection - Provides real-world perspectives on pesticide and disease control progress - Presents scientific developments from an international array of contributing authors

Download or read book Methods and Applications of Cycloaddition Reactions in Organic Syntheses written by Nagatoshi Nishiwaki and published by John Wiley & Sons. This book was released on 2013-12-17 with total page 996 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced tools for developing new functional materials and applications in chemical research, pharmaceuticals, and materials science Cycloadditions are among the most useful tools for organic chemists, enabling them to build carbocyclic and heterocyclic structures. These structures can then be used to develop a broad range of functional materials, including pharmaceuticals, agrochemicals, dyes, and optics. With contributions from an international team of leading experts and pioneers in cycloaddition chemistry, this book brings together and reviews recent advances, trends, and emerging research in the field. Methods and Applications of Cycloaddition Reactions in Organic Syntheses focuses on two component cycloadditions, with chapters covering such topics as: N1 unit transfer reaction to C–C double bonds [3+2] Cycloaddition of α, β-unsaturated metal-carbene complexes Formal [3+3] cycloaddition approach to natural product synthesis Development of new methods for the construction of heterocycles based on cycloaddition reaction of 1,3-dipoles Cycloreversion approach for preparation of large π-conjugated compounds Transition metal-catalyzed or mediated [5+1] cycloadditions Readers will learn methods for seamlessly executing important reactions such as Diels-Alder and stereoselective dipolar reactions in order to fabricate heterocyclic compounds, natural products, and functional molecules. The book not only features cutting-edge topics, but also important background information, such as the contributors’ process for developing new methodologies, to help novices become fully adept in the field. References at the end of each chapter lead to original research papers and reviews for facilitating further investigation of individual topics. Covering the state of the science and technology, Methods and Applications of Cycloaddition Reactions in Organic Syntheses enables synthetic organic chemists to advance their research and develop new functional materials and applications in chemical research, pharmaceuticals, and materials science.

Download or read book Advances in Cycloaddition written by Michael Harmata and published by Elsevier. This book was released on 2000-01-21 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents work from six different groups working on various aspects of cycloaddition chemistry. José Mascareñas gives us a very interesting account of the chemistry of &Bgr;-alkoxy-&ggr;-pyrones and related species. Al Padwa and Chris Staub discuss further advances in rhodium carbenoid chemistry and the unusual cycloaddition processes possible with these intermediates. Higher order cycloadditions mediated by transition metals highlight Jim Rigby's update on his group's efforts in this area. Lily Lee and John Snyder present us with a detailed account of the indole ring as a dienophile, challenging us to consider the untapped potential in this area. Brian Keay and Ian Hunt discuss the intramolecular Diels-Alder reactions of furan; a report that is both top-notch science, and what could be a great learning tool for students who need to see how fundamental chemical principles can and should be applied to synthetic problems. Finally, Kay Brummond introduces us to a new version of the Pauson-Khand reactions, one that will no doubt be further exploited in productive ways by her group well into the future.

Download or read book Toxicology and Human Environments written by Ernest Hodgson and published by Academic Press. This book was released on 2012-09-28 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments. The primary emphasis is on public health, including the potential health effects of toxicants found in different environments, the bioprocessing of such toxicants in humans and surrogate animals and the principles of risk analysis. Approaches the toxicology of human environments in a new and unique way, stressing the complex interrelationships of all human environments and the implication for human and environmental health Each chapter is written by an acknowledged expert and is addressed to those interested in the broader implications of the environmental modifications that are always associated with the activities of humans living and working in them

Download or read book Aminoff s Neurology and General Medicine written by Michael J. Aminoff and published by Elsevier. This book was released on 2014-02-18 with total page 1393 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aminoff's Neurology and General Medicine is the standard and classic reference providing comprehensive coverage of the relationship between neurologic practice and general medicine. As neurologists are asked to consult on general medical conditions, this reference provides an authoritative tool linking general medical conditions to specific neurologic issues and disorders. This is also a valuable tool for the general practitioner seeking to understand the neurologic aspects of their medical practice. Completely revised with new chapters covering metastatic disease, bladder disease, psychogenic disorders, dementia, and pre-operative and post-operative care of patients with neurologic disorders, this new edition will again be the go-to reference for both neurologists and general practitioners. - The standard authoritative reference detailing the relationship between neurology and general medicine - 100% revised and updated with several new chapters - Well illustrated, with most illustrations in full color

Download or read book Applied Pharmacology written by Stan K. Bardal and published by Elsevier Health Sciences. This book was released on 2011-01-01 with total page 482 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applied Pharmacology provides the essential details that are required for a solid understanding of pharmacology: how the drugs work, why side effects occur, and how the drugs are used clinically. Drs. Stan Bardal, Jason Waechter, and Doug Martin integrate the experience of the pharmacologist and the physician for a clinical focus that ensures a complete understanding of pharmacology.in print and online. Find information quickly and compare and contrast drugs easily thanks to a clear and consistent format without extraneous material. Apply basic pharmacology to clinical situations through integrated text. Enhance your learning with "For Your Information" sections detailing history and anecdotes for many agents within a given drug class. Access the fully searchable text online at studentconsult.com, along with 150 USMLE-style multiple choice questions, downloadable images, and online only references. Learn the essential details of pharmacology and enhance your understanding through an entirely new, fantastic art program. Gain a thorough understanding of key pharmacology components in a concise and efficient format

Download or read book Economic Poisons written by and published by . This book was released on 1923 with total page 1388 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Handbook of Toxicologic Pathology written by Wanda M. Haschek and published by San Diego : Academic Press. This book was released on 2002 with total page 1012 pages. Available in PDF, EPUB and Kindle. Book excerpt: In volume I, the book covers toxicologic pathology in its basic aspects, including its definition, the basic biochemical and morphologic mechanisms underlying the discipline, the basic practice of toxicologic pathology (including special techniques) and issues essential to the understanding of toxicologic pathology such as risk assessment, experimental design, and statistical analysis. Next, the book moves to specific issues affecting the "practice" toxicologic pathology, including issues such as knowledge management, regulatory affairs and writing pathology reports. Finally, Volume I closes with several chapters that deal with specific classes of environmental toxicants such as endocrine disruptors and heavy metals. Volume II addresses the toxicologic pathology in a thoroughly standardized systems manner, addressing the basic structure and function of a particular organ system, its response to toxic injury, mechanisms of injury and methods of evaluation of such injury.-