Download or read book Design Synthesis and Application of Novel Light Activated Molecular Probes written by Megan N. Stanton-Humphreys and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Application of Novel Conjugated Materials Part II written by Haichang Zhang and published by Frontiers Media SA. This book was released on 2021-11-09 with total page 70 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Application of Novel Conjugated Materials written by Haichang Zhang and published by Frontiers Media SA. This book was released on 2021-02-11 with total page 126 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Design Synthesis and Application of a Range of Novel Fluorescent Thiol specific Probes written by and published by . This book was released on 1980 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Design and Synthesis of Novel Reductively Activated Molecular Sensors written by Carl Andrew Roeschlaub and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Evaluation of Chemical Probes for Biochemical Applications written by and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Biological Evaluation of Cell permeable Small Molecule Probes written by and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Evaluation of Fluorescent Probes for Biological Applications written by Andrea Fin and published by . This book was released on 2012 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Applications of Novel Multi functional Imaging Agents written by Myra Sae-Heng and published by . This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Design Synthesis and Evaluation of Fluorescent Small Molecule Probes of Biological Systems written by Michael James DeGrazia and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis and Evaluation of Novel Imaging Probes for the Study of Glycosylation and Fatty Acid Uptake In Vivo written by Allison Stacey Cohen and published by . This book was released on 2011 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Imaging represents a powerful method for advancing our understanding of biology. In particular, it has been used as a tool for the diagnosis and monitoring of diseases in vivo. Bioluminescence imaging (BLI) represents one of the molecular imaging modalities and has been applied to the study of numerous processes in cells and in animals. However, there is a need for the design of new bioluminescence imaging probes for the study of several key metabolic processes. Activatable bioluminescence imaging probes represent an attractive approach to this problem and are the subject of this dissertation. Activatable bioluminescence imaging probes have several desirable characteristics, including high sensitivity and the ability to be triggered in response to various stimuli. In particular, we describe the design, synthesis and biological evaluation of activatable bioluminescence imaging probes for the study of two metabolic processes: glycosylation and fatty acid uptake. Specific emphasis is placed on the development of probes that have optimal properties for imaging of these processes in mice. Chapter 1 introduces the basics of bioluminescence imaging with an overview of the different luciferins and luciferases. The advantages of bioluminescence imaging are discussed. Additionally, the uses of bioluminescence imaging are reviewed. An emphasis is placed on activatable bioluminescence imaging probes, with two main types of stimuli discussed: enzymatic and small molecule. The potential of bioluminescence imaging for the study of two new biological processes, glycosylation and fatty acid uptake, is presented along with an overview of these two fields. In Chapter 2, the synthesis and evaluation of a bioluminescence imaging probe for the study of glycosylation is discussed. A phosphine-luciferin probe was designed to undergo Staudinger ligation with metabolically incorporated azidosugars. The probe was synthesized and evaluated for its ability to label cell-surface glycans in a luciferase-expressing prostate cancer cell line. The probe was able to successfully image these glycans and demonstrated higher sensitivity than other previously published fluorescent phosphine probes. Chapter 3 describes the design, synthesis, and evaluation of a bioluminescence imaging probe for the study of fatty acid uptake. The probe is activated inside of cells after uptake by fatty acid transport proteins (FATPs). The fatty-acid luciferin probe was synthesized and evaluated for physiological uptake in vitro using luciferase-expressing adipocytes. The probe was next tested in vivo using several modes of administration. Imaging of intestinal fatty acid uptake and uptake by brown adipose tissue (BAT) was demonstrated. In the next two chapters, we switch our focus and describe a different project involving the synthesis and use of peptoids. In Chapter 4, the design of novel architectures of peptoids is discussed. The synthesis of dendritic and cyclic peptoid architectures is presented using various diamine monomers. Several synthetic parameters were changed in order to gain an understanding and control of which architecture is ultimately obtained. Optimized conditions were found for synthesis of dendritic and cyclic architectures. Dendrimers composed of aromatic diamines were subsequently used in the synthesis of two classes of amphiphilic molecules. Chapter 5 discusses the synthesis and sequencing of combinatorial peptoid libraries. A number of amines were optimized for incorporation in peptoid libraries and three combinatorial libraries were synthesized. In addition, we report a rapid, high-throughput, sensitive, and inexpensive sequencing method for the identification of peptoids on a single bead. This method is based on partial Edman degradation/mass spectrometry (PED/MS) and should help facilitate the screening of large libraries of peptoids.
Download or read book Design and Synthesis of Molecular Probes for Medical and Environmental Applications written by Payagala Udawattage Ashvin Iresh Fernando and published by . This book was released on 2019 with total page 1042 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Transparency in Biology written by Kohei Soga and published by Springer Nature. This book was released on 2020-12-21 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explains transparency in biology with emphasis on bending and absorption, which together are the essence of transparency. The reader is provided with an understanding of why the interior of the body can be made to appear transparent through the application of elementary physics. Based on the principle of transparency, emerging imaging techniques using near-infrared light to view the body transparently are explained with examples such as cancer detection and temperature imaging of deep tissues. This book is useful to many researchers, including biologists, physicists, chemists, materials scientists, and device engineers as well as developers—all who seek a deep understanding of transparency in bioimaging.
Download or read book Handbook of Fluorescent Dyes and Probes written by R. W. Sabnis and published by John Wiley & Sons. This book was released on 2015-06-02 with total page 468 pages. Available in PDF, EPUB and Kindle. Book excerpt: A COMPLETE, UP-TO-DATE RESOURCE OF INFORMATION ON MORE THAN 150 FLUORESCENT DYES AND PROBES Handbook of Fluorescent Dyes and Probes is the most comprehensive volume available on the subject, covering all the available dyes and probes known to date in the literature for uses in various fields. Top dye expert Dr. Ram Sabnis organizes the compounds alphabetically by the most commonly used chemical name. He presents an easy-to-use reference complete with novel ideas for breakthrough research in medical, biological, chemical, color, material, physical and related allied fields. The ease of use of the handbook is further enhanced by various appendixes provided at the end of the book to conveniently and easily locate the dye as per the reader's need. This is the first book to give the CAS registry numbers, chemical structure, Chemical Abstract (CA) index name, all other chemical names, Merck Index number, chemical/dye class, molecular formula, molecular weight, physical form, solubility, melting point, boiling point, pKa, absorption maxima, emission maxima, molar extinction coefficient, and quantum yield of fluorescent dyes and probes, as well as to provide access to synthetic procedures (lab scale and industrial scale) of dyes and probes in a single source. This user-friendly handbook also features references on safety, toxicity and adverse effects of dyes and probes on humans, animals and the environment, including: acute/chronic toxicity aquatic toxicity carcinogenicity cytotoxicity ecotoxicity genotoxocity hematotoxicity hepatotoxicity immunotoxicity marine toxicity microbial toxicity mutagenicity nephrotoxicity neurotoxicity nucleic acid damage oral toxicity phototoxicity phytotoxicity reproductive toxicity skin toxicity Containing imaging/labeling applications, biological/medical applications and industrial applications, Handbook of Fluorescent Dyes and Probes is a convenient, vital resource for industrial and academic researchers, and a valuable desktop reference for medical professionals, lab supervisors, scientists, chemists, biologists, engineers, physicists, intellectual property professionals, students, and professors. Includes all fluorescent dyes & probes known to date and provides a complete, up-to-date library of information in one reference/handbook Includes more than 300 fluorescent dyes & probes organized alphabetically by the commonly used Chemical Name Provides access to synthesis procedures (lab scale and industrial scale) of fluorescent dyes & probes First book to provide references on safety, toxicity and adverse effects of fluorescent dyes and probes on humans, animals, and the environment User-friendly and convenient resource guide for chemical, biological, medical, and intellectual property professionals in a broad range of disciplines
Download or read book Make Life Visible written by Yoshiaki Toyama and published by Springer Nature. This book was released on 2019-10-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.
Download or read book Fluorescent Analogs of Biomolecular Building Blocks written by Marcus Wilhelmsson and published by John Wiley & Sons. This book was released on 2016-04-04 with total page 474 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluorescent Analogs of Biomolecular Building Blocks focuses on the design of fluorescent probes for the four major families of macromolecular building blocks. Compiling the expertise of multiple authors, this book moves from introductory chapters to an exploration of the design, synthesis, and implementation of new fluorescent analogues of biomolecular building blocks, including examples of small-molecule fluorophores and sensors that are part of biomolecular assemblies.
Download or read book Chemical Solution Synthesis for Materials Design and Thin Film Device Applications written by Soumen Das and published by Elsevier. This book was released on 2021-01-29 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Solution Synthesis for Materials Design and Thin Film Device Applications presents current research on wet chemical techniques for thin-film based devices. Sections cover the quality of thin films, types of common films used in devices, various thermodynamic properties, thin film patterning, device configuration and applications. As a whole, these topics create a roadmap for developing new materials and incorporating the results in device fabrication. This book is suitable for graduate, undergraduate, doctoral students, and researchers looking for quick guidance on material synthesis and device fabrication through wet chemical routes. Provides the different wet chemical routes for materials synthesis, along with the most relevant thin film structured materials for device applications Discusses patterning and solution processing of inorganic thin films, along with solvent-based processing techniques Includes an overview of key processes and methods in thin film synthesis, processing and device fabrication, such as nucleation, lithography and solution processing
