Download or read book Design Fabrication and Characterization of Biodegradable Scaffolds for Tissue Engineering and Regenerative Medicine Applications written by Muhammad Anwaar Nazeer and published by . This book was released on 2018 with total page 280 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Scaffolds for Tissue Engineering written by Claudio Migliaresi and published by CRC Press. This book was released on 2014-06-10 with total page 671 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scaffolds for tissue engineering are devices that exploit specific and complex physical and biological functions, in vitro or in vivo, and communicate through biochemical and physical signals with cells and, when implanted, with the body environment. Scaffolds are produced mainly with synthetic materials, and their fabrication technologies are deri
Download or read book Characterisation and Design of Tissue Scaffolds written by Paul Tomlins and published by Elsevier. This book was released on 2015-10-30 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Characterisation and Design of Tissue Scaffolds offers scientists a useful guide on the characterization of tissue scaffolds, detailing what needs to be measured and why, how such measurements can be made, and addressing industrially important issues. Part one provides readers with information on the fundamental considerations in the characterization of tissue scaffolds, while other sections detail how to prepare tissue scaffolds, discuss techniques in characterization, and present practical considerations for manufacturers. Summarizes concepts and current practice in the characterization and design of tissue scaffolds Discusses design and preparation of scaffolds Details how to prepare tissue scaffolds, discusses techniques in characterization, and presents practical considerations for manufacturers
Download or read book Development of 3D printed biodegradable composite scaffolds for tissue engineering applications written by Tiziano Serra and published by . This book was released on 2014 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt: The design of smart biodegradable scaffolds plays a crucial role in the regeneration of tissues and restoration of their functionality. Advances in material science and manufacturing and in the understanding on the effects of bio-chemical and bio-physical signals on cell behavior, are leading to a new generation of 3D scaffolds. Recent developments in additive manufacturing, also known as 3D-printing, open new exciting challenges in tissue/organ regeneration by means of the fabrication of complex and geometrically precise 3D structures. This thesis aimed the development and characterization of 3D scaffolds for tissue regeneration. For this, a nozzle-based rapid prototyping system was used to combine polylactic acid and a bioactive CaP glass (coded G5) to fabricate 3-D biodegradable scaffolds. Firstly, optimization of the printing conditions represents a key challenge for achieving high quality 3D-printed structures. Thus, we stress the importance of studying the outcome of the plasticizing effect of PEG on PLA-based blends used for the fabrication of 3D-printed scaffolds. Results indicated that the presence of PEG not only improves PLA processing but also leads to relevant surface, geometrical and structural changes including modulation of the degradation rate of PLA-based 3D printed scaffolds. Secondly, the obtained scaffolds were fully characterized from the physic-chemical point of view. Morphological and structural examinations showed that 3D scaffolds had completely interconnected porosity, uniform distribution of the glass particles, and a controlled and repetitive architecture. In addition, incorporation of G5 particles increased both roughness and hydrophilicity of the scaffolds. Compressive modulus was dependent on the scaffold geometry and the presence of glass. Cell study revealed that G5 glass improved mesenchymal stem cell adhesion after 4 h. Additional biological characterization in terms of the inflammatory response were also carried out. Novel studies have pointed towards a decisive role of inflammation in triggering tissue repair and regeneration, while at the same time it is accepted that an exacerbated inflammatory response may lead to rejection of an implant. Thus, understanding and having the capacity to regulate the inflammatory response elicited by 3D scaffolds aimed for tissue regeneration is crucial. In this context, cytokine secretion and cell morphology of human monocytes/macrophages in contact with biodegradable 3D-printed scaffolds (PLA, PLA/G5 and chitosan ones) with different surface properties, architecture and controlled pore geometry was reported. Results revealed that even though the material itself induced the biggest differences, scaffold geometry also affected on the secretion of cytokines. These findings strengthen the appropriateness of these 3D platforms to study modulation of macrophage responses by specific parameters (chemistry, topography, scaffold architecture). Finally, novel scaffolds composed by two phases (PLA and PLA/G5), for use in guided bone regeneration (GBR) were evaluated. Structural, morphological changes were observed during the in vitro degradation of both PLA and PLA/G5 structures. Although mechanical properties decreased, PLA/G5 scaffolds still showed higher compressive modulus than PLA ones, confirming the reinforcing effect of glass particles after immersion time. In vivo implantation was carried out subcutaneously in mice up to 30 days. Results showed that PLA scaffolds induced mononuclear cell without activating any relevant angiogenic process, while PLA/G5 induced higher presence of multinucleated giant cells and consequently stimulated the vascularization process and further tissue regeneration. The technique/materials combination used in this PhD thesis led to the fabrication of promising fully degradable, mechanically stable, bioactive and biocompatible composite scaffolds with well-defined architectures valuable for TE applications.
Download or read book Extrusion Bioprinting of Scaffolds for Tissue Engineering Applications written by Daniel X. B. Chen and published by Springer. This book was released on 2018-12-13 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book introduces readers to the theory and practice of extrusion bio-printing of scaffolds for tissue engineering applications. The author emphasizes the fundamentals and practical applications of extrusion bio-printing to scaffold fabrication, in a manner particularly suitable for those who wish to master the subject matter and apply it to real tissue engineering applications. Readers will learn to design, fabricate, and characterize tissue scaffolds to be created by means of extrusion bio-printing technology.
Download or read book Design Characterization and Fabrication of Polymer Scaffolds for Tissue Engineering written by Dipankar Chattopadhyay and published by Elsevier. This book was released on 2024-06-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design, Characterization and Fabrication of Polymer Scaffolds for Tissue Engineering covers core elements of scaffold design, from properties and characterization of polymeric scaffolds to fabrication techniques and the structure-property relationship. Particular attention is given to the cell-scaffold interaction at the molecular level, helping the reader understand and adapt scaffold design to improve biocompatibility and function. The book goes on to discuss a range of tissue engineering applications for polymeric scaffolds, including bone, nerve, cardiac and fibroblast tissue engineering. Design, Characterization and Fabrication of Polymer Scaffolds for Tissue Engineering is an important, interdisciplinary work of relevance to materials scientists, polymer scientists, biomedical engineers and those working regenerative medicine. Helps the reader determine the most appropriate polymer for scaffold design by characterization, properties and structure-property relationship Discusses material-cell interactions at the molecular level, aiding in determining suitability Covers core elements of scaffold design, including fabrication techniques
Download or read book Composite Synthetic Scaffolds for Tissue Engineering and Regenerative Medicine written by Naznin Sultana and published by Springer. This book was released on 2014-10-16 with total page 69 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses important biomaterials which are commonly used to fabricate scaffolds and it describes two major protocols employed in scaffold fabrication. Tissue engineering or regenerative medicine aims at restoring ex-novo tissues and organs whose functionality has been compromised as a consequence of diseases or traumatic events. The innovative concept underlying tissue engineering is the use of autologous cells, obtained from a biopsy of the patient. Cells are seeded on a porous scaffold which has the role of supporting and guiding cells towards the development of tissue-like structures as well as providing a platform for the delivery under controlled condition of growth factor release, etc. The successful manufacture of scaffolds for tissue engineering applications is crucial. In this book, these biomaterials are discussed. The book also covers illustrated examples, structure and properties of scaffolds, cellular interactions and drug delivery.
Download or read book Biodegradable Systems in Tissue Engineering and Regenerative Medicine written by Rui L. Reis and published by CRC Press. This book was released on 2004-11-29 with total page 590 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conventional materials technology has yielded clear improvements in regenerative medicine. Ideally, however, a replacement material should mimic the living tissue mechanically, chemically, biologically and functionally. The use of tissue-engineered products based on novel biodegradable polymeric systems will lead to dramatic improvements in health
Download or read book Fabrication and Characterization of Novel Reinforced Biodegradable Polymeric water Dispersible Carbon Nanotubes Composite Scaffolds for Bone Tissue Regeneration written by Paiyz Esmat Mikael and published by . This book was released on 2010 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Biodegradable Polymer Based Scaffolds for Bone Tissue Engineering written by Naznin Sultana and published by Springer. This book was released on 2012-12-16 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses the principles, methods and applications of biodegradable polymer based scaffolds for bone tissue engineering. The general principle of bone tissue engineering is reviewed and the traditional and novel scaffolding materials, their properties and scaffold fabrication techniques are explored. By acting as temporary synthetic extracellular matrices for cell accommodation, proliferation, and differentiation, scaffolds play a pivotal role in tissue engineering. This book does not only provide the comprehensive summary of the current trends in scaffolding design but also presents the new trends and directions for scaffold development for the ever expanding tissue engineering applications.
Download or read book Bone Tissue Engineering written by Jeffrey O. Hollinger and published by CRC Press. This book was released on 2004-10-14 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t
Download or read book Natural Product Inspired Scaffolds written by Mohit Kumar and published by Springer Nature. This book was released on with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Micro and Nanotechnologies in Engineering Stem Cells and Tissues written by Murugan Ramalingam and published by John Wiley & Sons. This book was released on 2013-05-10 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: A cutting-edge look at the application of micro and nanotechnologies in regenerative medicine The area at the interface of micro/nanotechnology and stem cells/tissue engineering has seen an explosion of activity in recent years. This book provides a much-needed overview of these exciting developments, covering all aspects of micro and nanotechnologies, from the fundamental principles to the latest research to applications in regenerative medicine. Written and edited by the top researchers in the field, Micro and Nanotechnologies in Engineering Stem Cells and Tissues describes advances in material systems along with current techniques available for cell, tissue, and organ studies. Readers will gain tremendous insight into the state of the art of stem cells and tissue engineering, and learn how to use the technology in their own research or clinical trials. Coverage includes: Technologies for controlling or regulating stem cell and tissue growth Various engineering approaches for stem cell, vascular tissue, and bone regeneration The design and processing of biocompatible polymers and other biomaterials Characterization of the interactions between cells and biomaterials Unrivaled among books of this kind, Micro and Nanotechnologies in Engineering Stem Cells and Tissues is the ultimate forward-looking reference for researchers in numerous disciplines, from engineering and materials science to biomedicine, and for anyone wishing to understand the trends in this transformative field.
Download or read book Biofabrication written by Joydip Kundu and published by Elsevier Inc. Chapters. This book was released on 2013-03-18 with total page 38 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biomaterials have advanced from merely interacting with the body to controlling biological processes toward the goal of tissue regeneration. In order to reconstitute a new tissue or repair a damaged/diseased tissue, three components are critical for regenerative medicine or tissue engineering: cells, biomaterials as scaffold substrates, and growth factors. Thus, the design and selection of materials and the methods used for scaffold fabrication play a very important role in tissue engineering and regenerative medicine. Recent developments in biofabrication strategies have created enormous possibilities for the construction of biomimetic 3D scaffolds, where well-defined architectures can be generated with suitable surface chemistry using appropriate materials. This chapter summarizes the materials used for the fabrication of scaffolds, the different types of scaffold manufacturing processes, and the basics of the various tissue-specific scaffolds used in regenerative medicine.
Download or read book Bionanocomposites in Tissue Engineering and Regenerative Medicine written by Shakeel Ahmed and published by Woodhead Publishing. This book was released on 2021-06-03 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bionanocomposites in Tissue Engineering and Regenerative Medicine explores novel uses of these in tissue engineering and regenerative medicine. This book offers an interdisplinary approach, combining chemical, biomedical engineering, materials science and pharmacological aspects of the characterization, synthesis and application of bionanocomposites. Chapters cover a broad selection of bionanocomposites including chitosan, alginate and more, which are utilized in tissue engineering, wound healing, bone repair, drug formulation, cancer therapy, drug delivery, cartilage regeneration and dental implants. Additional sections of Bionanocomposites in Tissue Engineering and Regenerative Medicine discuss, in detail, the safety aspects and circular economy of bionanocomposites – offering an insight into the commercial and industrial aspects of these important materials. Bionanocomposites in Tissue Engineering and Regenerative Medicine will prove a highly useful text for for those in the fields of biomedical engineering, chemistry, pharmaceutics and materials science, both in academia and industrial R&D groups. Each bionanocomposite type is covered individually, providing specific and detailed information for each material Covers a range of tissue engineering and regenerative medicine applications, from dental and bone engineering to cancer therapy Offers an integrated approach, with contributions from authors across a variety of related disciplines, including biomedical engineering, chemistry and materials science
Download or read book Materials for Biomedical Engineering Hydrogels and Polymer based Scaffolds written by Alina-Maria Holban and published by Elsevier. This book was released on 2019-03-20 with total page 562 pages. Available in PDF, EPUB and Kindle. Book excerpt: Materials for Biomedical Engineering: Hydrogels and Polymer-Based Scaffolds discusses the use of a wide variety of hydrogels as bioactive scaffolds in regenerative medicine, including updates on innovative materials and their properties. Various types of currently investigated scaffolding materials and hydrogels are discussed, as is their future roles and applications, the main techniques for scaffold fabrication, and their characterization procedures. Readers will be able to use this book as a guide for the selection of the best materials for a specific application. Provides a valuable resource of recent scientific progress, highlighting the most well-known applications of hydrogels as bioactive scaffolds in regenerative medicine Includes novel opportunities and ideas for developing or improving technologies in biomaterials, and in related biomedical industries Features at least 50% of references from the last 2-3 years
Download or read book Handbook of Intelligent Scaffold for Tissue Engineering and Regenerative Medicine written by and published by CRC Press. This book was released on 2012-02-17 with total page 1018 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing detailed knowledge about fullerene nanowhiskers and the related low-dimensional fullerene nanomaterials, this book introduces tubular nanofibers made of fullerenes, "fullerene nanotubes," as well as the single crystalline thin film made of C60, called "fullerene nanosheet." It is the first publication featuring the fullerene nanowhiskers made of C60, C70, and C60 derivatives and so forth. It demonstrates the synthetic method (liquid–liquid interfacial precipitation method) and the physical and chemical properties such as electrical, mechanical, optical, magnetic, thermodynamic, and surface properties for the fullerene nanowhiskers, including their electronic device application.
