Download or read book Design and Development of Redox responsive Nanocarriers for Therapeutic Delivery written by Priyaa Prasad and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Biologically active agents like drugs, proteins and nucleic acids have been widely explored as therapeutics for numerous diseases and particularly for anti-cancer therapy. Delivering drugs, proteins and nucleic acids efficiently and safely is however the looming challenge in the field of chemical biology. A significant percentage of drugs are poorly water-soluble which affects its pharmacological properties for instance bioavailability, stability and dose dependent toxicity. Drug development and discovery is a time consuming and expensive process which typically takes more than a decade and costs more than 10 million dollars. Nucleic acids are also known to degrade rapidly by nucleases. Therapeutic delivery using a delivery vehicle is realized to be advantageous in many fronts. Delivery vehicles, specifically nanocarriers improve the physiochemical properties of conventional drugs like water solubility, biodistribution, reduce dose dependent toxicity, bioavailability and help in targeting. For nucleic acids, they essentially protect it from degradation and aid in intracellular transfection. Polymeric nanocarrier systems show superior characteristics as therapeutic delivery vehicles. Polymers are extremely versatile in terms of synthesis, incorporating reactive functional groups for stimuli responsive behavior and facile tunability of hydrophobic and/or hydrophilic segments for structure property relationship. Self-crosslinked polymeric nanocarriers developed in our group have shown important properties for therapeutic delivery like redox responsive release mechanism, size tunability, encapsulation stability etc. We have utilized this system as the blueprint and developed it to improve and address some crucial properties of drug delivery vehicles. We designed a crosslinked polymeric nanogel system composed of molecules that are approved by the FDA as safe and non-toxic. The nanogels were found to be highly non-toxic when evaluated by in vitro cell viability assay and a more rigorous mouse pre-implantation embryo toxicity assay. We were also interested to tackle the issue of poor drug loading capacity of nanocarriers and designed a core crosslinked polymer and designed methods to quantify drug loading in crosslinked polymeric systems where we were also curious in studying the structure property relationship of different drugs with varying LogP values. Lastly, we designed a safe delivery system for nucleic acids which utilizes the cationic charge in the polymer for complexation with nucleic acid but through convenient crosslinking strategy we could eliminate the charged moieties making it a promising strategy for nucleic acid delivery.

Download or read book Stimuli Responsive Nanocarriers written by Virendra Gajbhiye and published by Academic Press. This book was released on 2022-01-04 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stimuli-Responsive Nanocarriers: Recent Advances in Tailor-Made Therapeutics compiles dispersed knowledge into a complete and comprehensive source to help researchers understand and progress stimuli-responsive nanocarriers. The book contains recent advancements made in the field of stimuli-responsive nanocarriers with their application in controlled drug delivery against various diseases. It focuses on the design, mechanism, construction, therapeutic application and future challenges of stimuli-responsive nanocarriers which will help new researchers in designing next generation tailor-made advanced therapeutics. Finally, the book covers future aspects and challenges present in the route of development of stimuli responsive nanocarriers for disease therapeutics. Various recent advances and biomedical applications assembled in this book will guide scientists on how to design and develop novel controlled drug release systems. Provides comprehensive knowledge of basic design, mechanism and construction of nanocarrier based stimuli-responsive drug releases Explores various nanocarriers characteristically used in the development of stimuli-responsive drug release systems Envisages future opportunities, challenges and implementation of nanocarrier based stimuli-responsive drug release systems in disease therapeutics

Download or read book Design and Synthesis of Redox Responsive and Enzyme Responsive Nanocarriers Based on Mesoporous Silica Nanoparticles for Targeted Drug Delivery Applications written by and published by . This book was released on 2016 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Smart Internal Stimulus Responsive Nanocarriers for Drug and Gene Delivery written by Mahdi Karimi and published by Morgan & Claypool Publishers. This book was released on 2015-12-01 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo. This can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to internal stimuli that are intrinsic to the target site. These stimuli are specific to the cell type, tissue or organ type, or to the disease state (cancer, infection, inflammation etc). pH-responsive nanostructures can be used for cargo release in acidic endosomal compartments, in the lower pH of tumors, and for specific oral delivery either to the stomach or intestine. Nanocarriers can be designed to be substrates of a wide-range of enzymes that are over-expressed at disease sites. Oxidation and reduction reactions can be taken advantage of in smart nanocarriers by judicious molecular design. Likewise, nanocarriers can be designed to respond to a range of specific biomolecules that may occur at the target site. In this volume we also cover dual and multi-responsive systems that combine stimuli that could be either internal or external.

Download or read book Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications written by Abdel Salam Hamdy Makhlouf and published by Woodhead Publishing. This book was released on 2018-11-12 with total page 637 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stimuli Responsive Polymeric Nanocarriers for Drug Delivery Applications: Volume Two: Advanced Nanocarriers for Therapeutics discusses, in detail, the recent trends in designing dual and multi-responsive polymers and nanoparticles for safe drug delivery. Chapters cover dual-responsive polymeric nanocarriers for drug delivery and their different stimuli, multi-responsive polymeric nanocarriers, and the therapeutic applications of stimuli-responsive polymers. With an emphasis on advanced medical applications and synergistic operational and technological methodologies for the improvement of polymers systems for the production of stimuli-responsive polymers, this book is essential reading for materials scientists and researchers working in the drug delivery and pharmaceutical industries. As innovation and development in the area of stimuli responsive polymer-based nanomaterials for drug delivery is moving fast and there is an increased global demand for biodegradable and biocompatible responsive polymers and nanoparticles for safe drug delivery, users will find this to be a timely resource. Focusses on the most advanced technologies, recent evaluation methods, technical aspects, and advanced synthesis techniques stimuli-responsive polymers Examines advanced medical applications of stimuli responsive polymers Analyzes synergistic operational and technological methodologies for the improvement of polymer systems for the production of stimuli-responsive polymers in drug delivery

Download or read book Block Co polymeric Nanocarriers Design Concept and Therapeutic Applications written by Neeraj Mishra and published by Springer Nature. This book was released on 2023-11-29 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on current advancements in the field of block copolymers and covers design, concept, and various therapeutic applications in the drug delivery. It also reviews the use of block copolymers in drug delivery applications from the development of sustained release products to smart polymeric delivery systems such as stimuli-responsive polymeric systems, for example, thermosensitive, redox-sensitive, photo-sensitive, and enzyme-sensitive. The book further discusses the nano assemblies from amphiphilic block copolymers as nanomedicine platforms for diagnosis and therapy due to their relatively small size, high drug loading capacity, controlled drug release, in vivo stability, and prolonged blood circulation. The chapters also review the various patents and ongoing clinical trials on the applications, covering several important new concepts and findings in the field of block copolymers. The book is aimed at researchers, academicians, and industrial scientists involved in the development of drug-delivery systems based on polymers.

Download or read book Rational Design and Development of Dual Location Dual Stimuli Responsive Polymeric Nanocarriers for Drug Delivery written by Newsha Arezi and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design and development of smart nano-sized delivery devices for controlled drug release in response to endogenous stimuli (such as acidic pH and glutathione (GSH)) inherently found in tumor tissue is a promising platform in tumor-targeting nanomedicine. This platform allows for the maximization of therapeutic efficacy whilst reducing unwanted off-target side effects. Particularly, polymeric nanocarriers self-assembled from amphiphilic block copolymers (ABCP) have gained significant attention due of their size tunability and enhanced colloidal stability. Well-controlled ABCPs enable the formation of core-shell micelles in aqueous solutions having hydrophobic cores, enabling the physical entrapment of hydrophobic anticancer drugs, surrounded with hydrophilic coronas. Further, an incorporation of stimuli-responsive degradable (SRD) linkages in ABCPs allows for controlled micelle degradation and drug release at the site of action. In this research, a dual location dual stimuli-responsive degradation (DL-DSRD) strategy is explored as a versatile platform for intracellular tumor-targeting drug delivery. Two ABCPs exhibiting dual acidic pH/reduction-responsive degradation are studied. The self-assembled ABCPs form colloidally stable nanoassemblies showing synergistically rapid release of encapsulated doxorubicin (a clinically used anticancer drug) at pH = 5.4 in 10 mM GSH solution caused by the cleavage of acid-labile and disulfide linkages. In addition, a new approach utilizing carbonylimidazole-hydroxyl coupling chemistry is explored to synthesize reduction-degradable poly(carbonate-disulfides) labeled with disulfide linkage on the backbones. They possess multi-functionalities as well as tunable and rapid reductive-degradation through main-chain degradation mechanism. Further, the versatility of the approach is demonstrated with the synthesis of an amphiphilic triblock copolymer exhibiting DL-DSRD responses. Overall, the results obtained through this research contribute to the advancement of current understanding and helps guide the design of improved SRD-exhibiting ABCP-based drug delivery nanocarriers.

Download or read book Stimuli responsive Drug Delivery Systems written by Amit Singh and published by Royal Society of Chemistry. This book was released on 2018-07-09 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: The increased understanding of molecular aspects associated with chronic diseases, such as cancer and the role of tumor microenvironment, has led to the identification of endogenous and exogenous stimuli that can be exploited to devise “stimuli-responsive” materials for site-specific drug delivery applications. This book provides a comprehensive account on the design, materials chemistry, and application aspects behind these novel stimuli-responsive materials. Setting the scene, the editors open with a chapter addressing the need for smart materials in delivery applications for therapy, imaging and disease diagnosis. The following chapter describes the key physical and chemical aspects of smart materials, from lipids to polymers to hybrid materials, providing the reader with a springboard to delve into the more application oriented chapters that follow. With in-depth coverage of key drug delivery systems such as pH-responsive, temperature responsive, enzyme-responsive and light responsive systems, this book provides a rigorous foundation to the field. A perfect resource for graduate students and newcomers, the closing chapter on regulatory and commercialization challenges also makes the book ideal for those wanting to take the next step towards clinical translation.

Download or read book Design and Development of New Nanocarriers written by Alexandru Mihai Grumezescu and published by William Andrew. This book was released on 2017-11-30 with total page 769 pages. Available in PDF, EPUB and Kindle. Book excerpt: Design and Development of New Nanocarriers focuses on the design and development of new nanocarriers used in pharmaceutical applications that have emerged in recent years. In particular, the pharmaceutical uses of microfluidic techniques, supramolecular design of nanocapsules, smart hydrogels, polymeric micelles, exosomes and metal nanoparticles are discussed in detail. Written by a diverse group of international researchers, this book is a valuable reference resource for those working in both biomaterials science and the pharmaceutical industry. Shows how nanomanufacturing techniques can help to create more effective, cheaper pharmaceutical products Explores how nanofabrication techniques developed in the lab have been translated to commercial applications in recent years Explains safety and regulatory aspects of the use of nanomanufacturing processes in the pharmaceutical industry

Download or read book Advances in Personalized Nanotherapeutics written by Ajeet Kaushik and published by Springer. This book was released on 2017-12-08 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: Personalized health care to manage diseases and optimized treatment is crucial for everyone to maintain health quality. Significant efforts have been made to design and develop novel nano-enabling therapeutic strategies to cure and monitor diseases for personalized health care. As state-of-the-art, various strategies have been reported to develop personalized nanomedicine to combat against target diseases with no side effects. In this book proposal, we are trying to describe fundamentals of personalized nanomedicine, novel nanomaterials for drug delivery, role of nanotechnology for efficient therapeutics approach, nano-pharmacology, targeted CNS drug delivery, stimuli responsive drug release and nanotechnology for diseases management. This book would serve as a platform for new scholars to understand state-of-the-art of nanotechnology for therapeutics and designing their future research to develop effective personalized nanomedicine against targeted diseases. As of now, various studies have been reported to design and develop nanomedicines of higher efficacy but unfortunately, such products are up to laboratory research only and need to be well-tested using pre-clinical or human models. Our book would be a call for experts to explore multidisciplinary research for developing novel and efficient approaches to explore smart efficient nanocarriers for site-specific on-demand controlled drug delivery to combat against targeted diseases to personalized health care.

Download or read book Redox responsive and Adhesive Core multishell Nanocarriers for Dermal and Mucosal Drug Delivery written by Keerthana Rajes and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Smart External Stimulus Responsive Nanocarriers for Drug and Gene Delivery written by Mahdi Karimi and published by Morgan & Claypool Publishers. This book was released on 2015-12-01 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo, this can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to externally applied stimuli that usually involve application of physical energy. This physical energy can be applied from outside the body and can either cause cargo release, or can activate the nanostructure to be cytotoxic, or both. The stimuli covered include light of various wavelengths (ultraviolet, visible or infrared), temperature (increased or decreased), magnetic fields (used to externally manipulate nanostructures and to activate them), ultrasound, and electrical and mechanical forces. Finally we discuss the issue of nanotoxicology and the future scope of the field.

Download or read book Stimuli Responsive Nanocarriers for Targeted Drug Delivery written by Muhammad Raza Shah and published by Woodhead Publishing. This book was released on 2024-10-01 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stimuli Responsive Nanocarriers for Targeted Drug Delivery presents a comprehensive overview of the most significant physical and chemical stimuli-responsive drug delivery systems. This book reviews targeted and controlled drug delivery systems and how nanocarriers can be used to improve the pharmacokinetics of drugs in biological systems, such as increasing utilization rate and reducing toxicity and side effects. After a key introduction to the topic, a range of nanocarrier types is assessed before exploring the clinical translation challenges and considerations involved. This book is a useful resource for researchers and postgraduate students in the fields of materials science, nanotechnology, pharmaceutical science, and medicinal chemistry.

Download or read book Drug Delivery Using Nanomaterials written by Yasser Shahzad and published by CRC Press. This book was released on 2022-01-18 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: After the drug discovery and development process, designing suitable formulations to safely deliver the optimum dose, while avoiding side effects, has been a constant challenge, especially when drugs are very toxic and have poor solubility and undesirable clearance profiles. With recent advances in synthetic technologies, nanoparticles can be custom-made from a variety of advanced materials to mimic the bioenvironment and can be equipped with various targeting and imaging moieties for site-specific delivery and real-time imaging. Drug Delivery Using Nanomaterials covers advancements in the field of nanoparticle-based drug-delivery systems, along with all the aspects needed for a successful and marketable nanoformulation. FEATURES Offers a general overview of the entire process involved in the synthesis and characterization of pharmaceutical nanoparticles Covers a broad range of synthetic materials for developing nanoformulations customized for specific disease states, target organs, and drugs Every chapter sequentially builds, providing a progressive pathway from classical nanoparticles to the more advanced to be used as a full drug product by consumers Provides information in a bottom-up manner in that definitions and explanations of relevant background information serve as a framework for understanding advanced concepts This user-friendly reference is aimed at materials engineers, chemical engineers, biomedical engineers, pharmaceutical scientists, chemists, and others working on advanced drug delivery, from academia as well as industry.

Download or read book Nanotechnology Based Targeted Drug Delivery Systems for Lung Cancer written by Prashant Kesharwani and published by Academic Press. This book was released on 2019-01-26 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanotechnology-based Targeted Drug Delivery Systems for Lung Cancer is an indispensable resource that will help pharmaceutical scientists and clinical researchers design and develop novel drug delivery systems and devices for the treatment of lung cancer. As recent breakthroughs in nanomedicine are now making it possible to deliver drugs, genes and therapeutic agents to localized areas of disease to maximize clinical benefit, while also limiting unwanted side effects, this book explores promising approaches for the diagnosis and treatment of lung cancer using cutting-edge nanomedical technologies. Topics discussed include polymeric nanoparticles, solid lipid nanoparticles, liposomes, dendrimers, micelles and nanoemulsions. Provides an overview of an array of nanotechnology-based drug delivery systems Examines the design, synthesis and application of different nanocarriers in drug and gene delivery Provides an in-depth understanding of the design of targeted nanotherapeutics and technologies and its implication in various site-specific cancers

Download or read book Design and Development of Affordable Healthcare Technologies written by Bit, Arindam and published by IGI Global. This book was released on 2018-06-22 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Technological advancements in the last few decades have significantly revolutionized the healthcare industry, resulting in life expectancy improvement in human beings. The use of automated machines in healthcare has reduced human errors and has notably improved disease diagnosis efficiency. Design and Development of Affordable Healthcare Technologies provides emerging research on biomedical instrumentation, bio-signal processing, and device development within the healthcare industry. This book provides insight into various subjects including patient monitoring, medical imaging, and disease classification. This book is a vital reference source for medical professionals, biomedical engineers, scientists, researchers, and medical students interested in the comprehensive research on the advancements in healthcare technologies.

Download or read book Development of Dual Enzyme and Oxidation responsive Drug Delivery Systems written by Sung Hwa Hong and published by . This book was released on 2018 with total page 93 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conventional chemotherapy using small molecular weight anticancer drugs presents many side effects due to poor specificities and aqueous solubility. To overcome the limitations, polymer-based drug delivery systems (PDDS) have been emerged for targeted delivery of therapeutic agents. Upon introduction of stimuli-responsive platform, the drugs can be released in controlled manner at the targeted tumor site providing enhanced drug efficacy and reduced toxicity. Stimuli-responsive degradation platform involves incorporation of covalent linkages that can be cleaved in response to external stimuli. The external stimuli can be found in altered microenvironment in pathophysiological tissues. For example, elevated levels of esterase and reactive oxygen species (ROS) are found in cancer tumor cells. As esters can be cleaved by the esterase and sulfides can be oxidized by the ROS, esters and sulfides can be incorporated to polymer to exhibit esterase and oxidation-responsive properties. Size is an important consideration for the design of drug delivery systems. Ideally, the size should be ranged from 50 to 150 nm for optimal biodistributions and targeting ability. Microfluidic process provides high degree of control over the size of NPs. Chapter 2 examines size tunability of the dual enzyme- and oxidation-responsive polyester-based nanoparticulates (DPE-NPs) using a microfluidic instrument for cancer therapy. The DPE-NPs can be fabricated by using the polyester and polymeric stabilizer. The size of NPs can be influenced by changing the variables such as microfluidic parameters (total flow rate and organic/aqueous flow rate ratio) and formulation parameters (molecular weight of polyesters, concentration of nanoparticles, and nature and amount of stabilizers). In addition to size of NPs, it turns out that these parameters have an effect on colloidal stability. The results obtained from dual stimuli-responsive degradation and in vitro experiments with an enhanced cellular uptake demonstrate that the DPE-NPs can offer a versatile platform for the development of drug delivery systems. Chapter 3 describes biological assessment of DPE-NPs as effective tumor-targeting intracellular nanocarriers. Doxorubicin (Dox), a clinically used anticancer drug, was incorporated into DPE-NPs stabilized with PEG and Brij S20. They exhibited excellent colloidal stability and as well as in pseudo-physiological conditions without any aggregation. They were destabilized in response to esterase that cleaved ester linkages and to hydrogen peroxide that oxidized sulfides. Such disruption led to an enhanced release of encapsulated therapeutics. For biological perspectives, the DPE-NPs were assessed in vitro using HeLa cervical cancer cells as a model. The results from MTT assay, epifluorescence microscope, flow cytometry, and cellular entry assay suggest that the dual responses triggered the intracellular release of the Dox to prohibit the cell proliferation followed by a rapid internalization through caveolae-mediated endocytosis. Further evaluation on 3D HeLa multicellular tumor spheroid (MCTS) indicated that the penetration ability of Dox was significantly enhanced when encapsulated in DPE NPs, suggesting that such deep penetration could be effective in vivo.