Download or read book Dna Deamination And The Immune System Aid In Health And Disease written by Nina Papavasiliou and published by World Scientific. This book was released on 2010-10-27 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the current understanding of the role of activation-induced cytidine deaminase (AID) in the generation of antibody response to antigenic challenge. Since the discovery of AID, and the genetic demonstration of its role in somatic hypermutation and class-switch recombination of antibody genes, much has been learned about the biochemistry of this enzyme. However, some key questions remain hotly contested, such as: how does this enzyme get to the antibody locus leaving the rest of the genome intact, and why are DNA repair pathways which normally repair deamination events co-opted into actually fixing mutations into the genome? These questions, among others, will be addressed in this monograph from various perspectives. Being leading experts in their respective fields, the contributors of this highly valued title summarize current research in the field of AID and put forth hypotheses in order to provide a platform for future experiments./a

Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book The Deamination and Rearrangement of Erythro 1 amino 1 phenyl 2 o tolyl 2 propanol written by M. M. Staum and published by . This book was released on 1961 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Comprehensive Biochemistry for Dentistry written by Anil Gupta and published by Springer. This book was released on 2018-12-30 with total page 617 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book combines fundamental concepts of biochemistry and the dental sciences to provide an authentic, coherent and comprehensive text for dental students. It describes in simple language the intricate pathophysiology of biomolecules in health and in diseases of dental and oral tissues. This book also describes the evolution of biochemistry in a chronological order, provides information about the fundamental chemical structure, classification and biological significance of biomolecules, vitamins and hormones, enriched with flow charts and diagrams for easy understanding and quick reference. It includes chapters on nucleic acids, nutrition and serum enzymes and organ function tests, and offers an innovative approach to familiarize dental students with the biochemical composition of enamel, dentine, cementum and saliva, explaining the biochemical basis of dental caries, periodontal diseases, role of fluorides in caries prophylaxis, fluoride toxicity, and the role of amino acids as anti-hypersensitive agents.

Download or read book DNA Methylation written by J. Jost and published by Birkhäuser. This book was released on 2013-11-11 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: The occurrence of 5-methylcytosine in DNA was first described in 1948 by Hotchkiss (see first chapter). Recognition of its possible physiologi cal role in eucaryotes was first suggested in 1964 by Srinivasan and Borek (see first chapter). Since then work in a great many laboratories has established both the ubiquity of 5-methylcytosine and the catholicity of its possible regulatory function. The explosive increase in the number of publications dealing with DNA methylation attests to its importance and makes it impossible to write a comprehensive coverage of the literature within the scope of a general review. Since the publication of the 3 most recent books dealing with the subject (DNA methylation by Razin A. , Cedar H. and Riggs A. D. , 1984 Springer Verlag; Molecular Biology of DNA methylation by Adams R. L. P. and Burdon R. H. , 1985 Springer Verlag; Nucleic Acids Methylation, UCLA Symposium suppl. 128, 1989) considerable progress both in the techniques and results has been made in the field of DNA methylation. Thus we asked several authors to write chapters dealing with aspects of DNA methyla tion in which they are experts. This book should be most useful for students, teachers as well as researchers in the field of differentiation and gene regulation. We are most grateful to all our colleagues who were willing to spend much time and effort on the publication of this book. We also want to express our gratitude to Yan Chim Jost for her help in preparing this book.

Download or read book Organic Syntheses Based on Name Reactions and Unnamed Reactions written by Alfred Hassner and published by Elsevier. This book was released on 2013-10-22 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetically useful organic reactions or reagents are often referred to by the name of the discoverer(s) or developer(s). Older name reactions are described in text books, but more recently developed synthetically useful reactions that may have been associated occasionally with a name are not always well known. For neither of the above are experimental procedures or references easy to find. In this monograph approximately 500 name reactions are included, of which over 200 represent newer name reactions and modern reagents. Each of these reactions are extremely useful for the contemporary organic chemistry researcher in industry or academic institutions. This book provides the information in an easily accessible form. In addition to seminal references and reviews, one or more examples for each name reaction are provided and a complete typical experimental procedure is included, to enable the student or researcher to immediately evaluate reaction conditions. Besides an alphabetical listing of reactions and reagents, cross references permit the organic practitioner to find those name reactions or reagents that enable specific transformations, such as, conversion of amines to nitriles, stereoselective reduction, fluoroalkylation, phenol alkynylation, asymmetric syntheses, allylic alkylation, nucleoside synthesis, cyclopentanation, hydrozirconation, to name a few. Emphasis has been placed on stereoselective and regioselective transformations as well as on enantioselective processes. The listing of reactions and reagents is supported by four indexes.

Download or read book Metabolic Control of Brain Homeostasis written by Detlev Boison and published by Frontiers Media SA. This book was released on 2017-10-03 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain function is under metabolic control, which in turn determines the equilibrium of homeostatic systems that affect neuronal and glial networks on the molecular, cellular, and systems levels. The collection of articles ranges from molecules and mechanisms involved in regulating homeostasis and neuronal excitability to therapeutic mechanisms tailored to restore homeostatic function. It also features neurological diseases and novel treatment approaches that are based on metabolic and homeostatic interventions. Together, the collection of articles outlines novel strategies to restore brain function in neurology and highlights limitations of conventional pharmacological approaches. We suggest that restoration of molecular and biochemical networks could lead to a new era of therapeutic opportunities.

Download or read book The Journal of Biological Chemistry written by and published by . This book was released on 1926 with total page 1624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. 3-140 include the society's Proceedings, 1907-41

Download or read book Advances in Carbohydrate Chemistry and Biochemistry written by and published by Academic Press. This book was released on 1975-11-05 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Volume 31, Williams (Swansea) surveys the deamination of carbohydrate amines and related compounds, updating earlier discussions by Peat (Vol. 2), Shafizadeh (Vol. 3), and Defaye (Vol. 25). Gelpi and Cadenas (Buenos Aires) provide a comprehensive treatment of the reaction of ammonia with acyl esters of carbohydrates; their article greatly extends that by Deulofeu (Vol. 4). A chapter by Watson (Jackson, Miss.) and Orenstein (Boston, Mass.) brings the article by Hudson (Vol. 4) on the chemistry and biochemistry of apiose up to date. Lindberg, Lonngren, and Svensson (Stockholm) discuss the specific, chemical degradation of polysaccharides in an article that updates that by Bouveng and Lindberg (Vol. 15) and complements that by Marshall on their enzymic degradation (Vol. 30). The extensive literature on the chemistry and interactions of seed galactomannans is surveyed by Dea and Morrison (Shambrook, England), thus adding to previous articles on the chemistry of a variety of polysaccharides. Glaudemans (Bethesda, Md.) provides an interesting discussion on the interaction of homogeneous, murine myeloma immunoglobulins with polysaccharide antigens, and also describes the career of the late H. G. Fletcher, Jr. In a continuation of our series of bibliographic articles on carbohydrate structures that have been ascertained by crystallographic methods, Jeffrey (Pittsburgh) and Sundaralingam (Madison, Wis.) treat those structures definitively established in 1973, and list all of those determined satisfactorily before 1970.

Download or read book Organic Chemistry of Drug Degradation written by Min Li and published by Royal Society of Chemistry. This book was released on 2012-11-30 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vast majority of drugs are organic molecular entities. A clear understanding of the organic chemistry of drug degradation is essential to maintaining the stability, efficacy, and safety of a drug product throughout its shelf-life. During analytical method development, stability testing, and pharmaceutical manufacturing troubleshooting activities, one of the frequently occurring and usually challenging events would be the identification of drug degradants and understanding of drug degradation mechanisms and pathways. This book is written by a veteran of the pharmaceutical industry who has first-hand experience in drug design and development, drug degradation mechanism studies, analytical development, and manufacturing process troubleshooting and improvement. The author discusses various degradation pathways with an emphasis on the mechanisms of the underlying organic chemistry, which should aid greatly in the efforts of degradant identification, formulation development, analytical development, and manufacturing process improvement. Organic reactions that are significant in drug degradation will first be reviewed and then illustrated by examples of drug degradation reported in the literature. The author brings the book to a close with a final chapter dedicated to the strategy for rapid elucidation of drug degradants with regard to the current regulatory requirements and guidelines. One chapter that should be given special attention is Chapter 3, Oxidative Degradation. Oxidative degradation is one of the most common degradation pathways but perhaps the most complex one. This chapter employs more than sixty drug degradation case studies with in-depth discussion in regard to their unique degradation pathways. With the increasing regulatory requirements on the quality and safety of pharmaceutical products, in particular with regard to drug impurities and degradants, the book will be an invaluable resource for pharmaceutical and analytical scientists who engage in formulation development, analytical development, stability studies, degradant identification, and support of manufacturing process improvement. In addition, it will also be helpful to scientists engaged in drug discovery and development as well as in drug metabolism studies.

Download or read book Biochemistry written by Pamela C. Champe and published by Lippincott Williams & Wilkins. This book was released on 2005 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lippincott’s Illustrated Reviews: Biochemistry has been the best-selling medical-level biochemistry review book on the market for the past ten years. The book is beautifully designed and executed, and renders the study of biochemistry enormously appealing to medical students and various allied health students. It has over 125 USMLE-style questions with answers and explanations, as well as over 500 carefully-crafted illustrations. The Third Edition includes end-of-chapter summaries, illustrated case studies, and summaries of key diseases.

Download or read book Progress in Nucleic Acid Research and Molecular Biology written by and published by Academic Press. This book was released on 1966-01-01 with total page 471 pages. Available in PDF, EPUB and Kindle. Book excerpt: Progress in Nucleic Acid Research and Molecular Biology

Download or read book Cancer Chemotherapy Reports written by and published by . This book was released on 1975 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Textbook of Biochemistry for Medical Students written by DM Vasudevan and published by Jaypee Brothers Medical Publishers. This book was released on 2019-09-30 with total page 849 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biocatalysis in the Pharmaceutical and Biotechnology Industries written by Ramesh N. Patel and published by CRC Press. This book was released on 2006-09-26 with total page 878 pages. Available in PDF, EPUB and Kindle. Book excerpt: Because enzyme-catalyzed reactions exhibit higher enantioselectivity, regioselectivity, substrate specificity, and stability, they require mild conditions to react while prompting higher reaction efficiency and product yields. Biocatalysis in the Pharmaceutical and Biotechnology Industries examines the use of catalysts to produce fine chemic

Download or read book Advances in Protein Chemistry written by and published by Academic Press. This book was released on 1954-01-01 with total page 552 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Protein Chemistry

Download or read book Chromatin and Disease written by Tapas K. Kundu and published by Springer Science & Business Media. This book was released on 2007-05-04 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book includes a collection of articles with the broad theme of disease connection to chromatin structure and function. It elaborates on the molecular pharmacology of the drugs targeting chromatin structure and its components. The book contains up-to-date information about the chromatin structure and chromatin related diseases and drug functions. This work is the first endeavor to present different aspects encompassing the above theme.