Download or read book De l apport de la PCR digitale dans le diagnostic pr natal non invasif des maladies monog niques written by Mathilde Pacault and published by . This book was released on 2017 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: La découverte de l'ADN fœtal libre circulant dans la circulation maternelle a permis le développement du diagnostic prénatal non invasif (DPNI). Celui-ci représente une très faible proportion de l'ADN présent dans le plasma maternel. Avec l'arrivée de nouvelles techniques très sensibles, il est maintenant envisageable de détecter des allèles fœtaux transmis par le père ou des biais de représentation des allèles maternels, et d'en déduire le génotype fœtal. A ce jour, les applications de l'étude de l'ADN fœtal libre circulant en routine se limitent à la recherche de séquences fœtales absentes du génome maternel et à la quantification de séquences du chromosome 21 dans le dépistage non invasif de la trisomie 21. Cette étude a pour objectif la mise au point d'une technique rapide, fiable et économiquement viable, permettant le DPNI des maladies monogéniques. Par PCR digitale, nous avons mis au point un protocole standardisé permettant la recherche en routine du variant paternel sur sang maternel, avec une sensibilité et une spécificité de 100%. Nous proposons également un algorithme permettant d'évaluer, avec un contrôle strict des risques statistiques, le déséquilibre allélique afin de déterminer le statut du fœtus vis-à-vis du variant maternel.
Download or read book Clinical Tuberculosis written by John Crofton and published by MacMillan. This book was released on 1999 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a guide to the diagnosis of all forms of tuberculosis (TB). The second edition of the text includes a rewritten and enlarged section on HIV infection in relation to TB as well as the recommendations from experts from the World Health Organization and the International Union against Tuberculosis and Lung Disease. An outline of the WHO DOTS (Directly Observed Treatment Shortcourse) programme is included and the whole text reviewed and updated. Case studies are used to demonstrate points raised.
Download or read book Strengthening Forensic Science in the United States written by National Research Council and published by National Academies Press. This book was released on 2009-07-29 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scores of talented and dedicated people serve the forensic science community, performing vitally important work. However, they are often constrained by lack of adequate resources, sound policies, and national support. It is clear that change and advancements, both systematic and scientific, are needed in a number of forensic science disciplines to ensure the reliability of work, establish enforceable standards, and promote best practices with consistent application. Strengthening Forensic Science in the United States: A Path Forward provides a detailed plan for addressing these needs and suggests the creation of a new government entity, the National Institute of Forensic Science, to establish and enforce standards within the forensic science community. The benefits of improving and regulating the forensic science disciplines are clear: assisting law enforcement officials, enhancing homeland security, and reducing the risk of wrongful conviction and exoneration. Strengthening Forensic Science in the United States gives a full account of what is needed to advance the forensic science disciplines, including upgrading of systems and organizational structures, better training, widespread adoption of uniform and enforceable best practices, and mandatory certification and accreditation programs. While this book provides an essential call-to-action for congress and policy makers, it also serves as a vital tool for law enforcement agencies, criminal prosecutors and attorneys, and forensic science educators.
Download or read book Trichier written by Alessandra Ceretto and published by Lulu.com. This book was released on with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Edible Caterpillars and Their Food Plants in Bas Congo written by Paul Latham and published by . This book was released on 2003 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lessons from Amazonia written by Richard O. Bierregaard and published by Yale University Press. This book was released on 2001-12-11 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: Deforestation is occurring at an alarming rate in many parts of the world, causing destruction of natural habitat and fragmentation of what remains. Nowhere is this problem more pressing than in the Amazon rainforest, which is rapidly vanishing in the face of enormous pressure from humans to exploit it. This book presents the results of the longest-running and most comprehensive study of forest fragmentation ever undertaken, the Biological Dynamics of Forest Fragments Project (BDFFP) in central Amazonia, the only experimental study of tropical forest fragmentation in which baseline data are available before isolation from continuous forest took place.A joint project of Brazil’s National Institute for Research in Amazonia and the U.S. Smithsonian Institution, the BDFFP has investigated the many effects that habitat fragmentation has on plants, invertebrates, and vertebrates. The book provides an overview of the BDFFP, reports on its case studies, looks at forest ecology and tree genetics, and considers what issues are involved in establishing conservation and management guidelines.
Download or read book Alphaherpesviruses written by Sandra Knowles Weller and published by Caister Academic Press Limited. This book was released on 2011 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Alphaherpesviruses are a fascinating group of DNA viruses that includes important human pathogens such as herpes simplex virus type 1 (HSV-1), HSV-2, and varicella-zoster virus (VZV): the causative agents of cold sores, genital ulcerous disease, and chickenpox/shingles, respectively. A key attribute of these viruses is their ability to establish lifelong latent infection in the peripheral nervous system of the host. Such persistence requires subversion of the host's immune system and intrinsic antiviral defense mechanisms. Understanding the mechanisms of the immune evasion and what triggers viral reactivation is a major challenge for today's researchers. This has prompted enormous research efforts into understanding the molecular and cellular biology of these viruses. This up-to-date and comprehensive volume aims to distill the most important research in this area providing a timely overview of the field. Topics covered include: transcriptional regulation, DNA replication, translational control, virus entry and capsid assembly, the role of microRNAs in infection and oncolytic vectors for cancer therapy. In addition there is coverage of virus-host interactions, including apoptosis, subversion of host protein quality control and DNA damage response pathways, autophagy, establishment and reactivation from latency, interferon responses, immunity and vaccine development. Essential reading for everyone working with alphaherpesviruses and of interest to all virologists working on latent infections.
Download or read book Quantitative Qualitative Friction Ridge Analysis written by David R. Ashbaugh and published by CRC Press. This book was released on 1999-10-27 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thumb print left at the scene of a grisly murder. Fingerprints taken from a getaway car used in a bank robbery. A palm print recovered from the shattered glass door of a burglarized home. Indeed, where crimes are committed, careless perpetrators will invariably leave behind the critical pieces of evidence most likely in the form of fingerprints n
Download or read book Statistics and the Evaluation of Evidence for Forensic Scientists written by Colin Aitken and published by John Wiley & Sons. This book was released on 2004-11-19 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first edition of Statistics and the Evaluation of Evidence for Forensic Scientists established itself as a highly regarded authority on this area. Fully revised and updated, the second edition provides significant new material on areas of current interest including: Glass Interpretation Fibres Interpretation Bayes’ Nets The title presents comprehensive coverage of the statistical evaluation of forensic evidence. It is written with the assumption of a modest mathematical background and is illustrated throughout with up-to-date examples from a forensic science background. The clarity of exposition makes this book ideal for all forensic scientists, lawyers and other professionals in related fields interested in the quantitative assessment and evaluation of evidence. 'There can be no doubt that the appreciation of some evidence in a court of law has been greatly enhanced by the sound use of statistical ideas and one can be confident that the next decade will see further developments, during which time this book will admirably serve those who have cause to use statistics in forensic science.' D.V. Lindley
Download or read book Biocompatibility of Co Cr Ni Alloys written by H. Hildebrand and published by Springer. This book was released on 1988 with total page 404 pages. Available in PDF, EPUB and Kindle. Book excerpt: For several years now scientific and medical sLaff have recognised the risks of toxicity of certain metals contained in alloys used in Lhe manufacture of biomaterials protheses, implants, and artificial organs. A number or scientific and industrial research centres have focussed their investigations in this direction and international societies and commissions have organised meetings with specialists from complementary disciplines in attendance in attempts to guage the importance of biological risks and to determine the toxicity of certain metals, with the aim of establishing preventive measures and guidelines. In the last century great efforts have been made to reduce unwanted biological effects caused by orthopaedic implants. The problems of pain and infection were overcome and the development of modern technology has resulted in a convincing decrease in corrosion problems and mechanical failure, such that ostosynthesis and endoprosthesis have rapidly progressed beyond the level of tentative investingation.llowever, a number of problems still remain to be solved, such as the influence of the material type on the healing process and its relative speed. The increasing use of cobalt-,chromium-and nickel-containing alloys in surgical and dental implants has raised various questions concerning the biological consequences of chronic internal release of these elements in the human body. A total of 55 delegates representing 16 countries heard presentations of fundamental aspects, local and remote tissue response, immunopathology, clinical aspects, and manufacturing qual ity control issues.
Download or read book Biodiversity in the Brazilian Amazon written by João Paulo Ribeiro Capobianco and published by . This book was released on 2004 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: A situação socioambiental da Amazônia brasileira na virada do milênio. Resultado do esforço coletivo de cientistas, técnicos de órgãos públicos e de organizações não governamentais e lideranças do movimento social, esta obra traz 27 artigos de 47 autores, mais de uma centena de mapas temáticos, extensos bancos de dados e fotos de cinco renomados fotógrafos.
Download or read book Statistical Science in the Courtroom written by Joseph L. Gastwirth and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Expert testimony relying on scientific and other specialized evidence has come under increased scrutiny by the legal system. A trilogy of recent U.S. Supreme Court cases has assigned judges the task of assessing the relevance and reliability of proposed expert testimony. In conjunction with the Federal judiciary, the American Association for the Advancement of Science has initiated a project to provide judges indicating a need with their own expert. This concern with the proper interpretation of scientific evidence, especially that of a probabilistic nature, has also occurred in England, Australia and in several European countries. Statistical Science in the Courtroom is a collection of articles written by statisticians and legal scholars who have been concerned with problems arising in the use of statistical evidence. A number of articles describe DNA evidence and the difficulties of properly calculating the probability that a random individual's profile would "match" that of the evidence as well as the proper way to intrepret the result. In addition to the technical issues, several authors tell about their experiences in court. A few have become disenchanted with their involvement and describe the events that led them to devote less time to this application. Other articles describe the role of statistical evidence in cases concerning discrimination against minorities, product liability, environmental regulation, the appropriateness and fairness of sentences and how being involved in legal statistics has raised interesting statistical problems requiring further research.
Download or read book Biodiversity and Sustainable Development written by Rabindra Nath Pati and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Papers presented at the First Global Summit on Sustainable Development and Biodiversity, held at Raipur during 7-9 February 2009.
Download or read book Computational Learning and Probabilistic Reasoning written by Alexander Gammerman and published by John Wiley & Sons. This book was released on 1996-08-06 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a unified coverage of the latest research and applications methods and techniques, this book is devoted to two interrelated techniques for solving some important problems in machine intelligence and pattern recognition, namely probabilistic reasoning and computational learning. The contributions in this volume describe and explore the current developments in computer science and theoretical statistics which provide computational probabilistic models for manipulating knowledge found in industrial and business data. These methods are very efficient for handling complex problems in medicine, commerce and finance. Part I covers Generalisation Principles and Learning and describes several new inductive principles and techniques used in computational learning. Part II describes Causation and Model Selection including the graphical probabilistic models that exploit the independence relationships presented in the graphs, and applications of Bayesian networks to multivariate statistical analysis. Part III includes case studies and descriptions of Bayesian Belief Networks and Hybrid Systems. Finally, Part IV on Decision-Making, Optimization and Classification describes some related theoretical work in the field of probabilistic reasoning. Statisticians, IT strategy planners, professionals and researchers with interests in learning, intelligent databases and pattern recognition and data processing for expert systems will find this book to be an invaluable resource. Real-life problems are used to demonstrate the practical and effective implementation of the relevant algorithms and techniques.
Download or read book Biological Concepts and Techniques in Toxicology written by Jim E. Riviere and published by CRC Press. This book was released on 2006-03-06 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Highlighting the latest advances in molecular biology, mathematical modeling, quantitative risk assessment, and biopharmaceutical development, this reference presents how current scientific applications and methods impact and revolutionize mainstream toxicological research. Presenting findings from disciplines that will impact the future of toxicol
Download or read book Onychomycosis written by Robert Baran and published by CRC Press. This book was released on 1999-07-29 with total page 78 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid advances have been made in the development of therapies for onychomycosis, and there is therefore an increasing need for accurate diagnosis and selection of appropriate treatment. This text, written by a team of authors with expert knowledge in nail disease and fungal infection, discusses clinical presentation, diagnosis, laboratory procedures, the assessment of results and identification of possible infection, and concludes with an overview of available treatments.
Download or read book Otosclerosis and Stapes Surgery written by Wolfgang Arnold and published by Karger Medical and Scientific Publishers. This book was released on 2007 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Otosclerosis is a disorder causing a hardening of the middle ear bones which leads to a progressive hearing loss. Internationally renowned experts met in Saas Fee (Switzerland) in 2004 to discuss otosclerosis and stapes surgery, and they have subsequently
