Download or read book Mechanism of Action of Antimicrobial and Antitumor Agents written by J. F. Snell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 752 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is the third in the series devoted to Antibiotics initiated by Springer Verlag in 1967. The first two volumes were devoted to the Mode of Action of Antibiotics and Biogenesis, respectively and were received graciously. During the intervening years these two works have been used often by research workers and students alike and have been quoted extensively. Although a number of other excellent treatises on antibiotics have appeared, the Springer series has set a standard for thoroughness and quality that meets the need of the scientific community. It is against this background that the present Editors set about the preparation of a third volume in the Series on Antibiotics. Since the appearance of Volume I, also dealing with Mechanism of Action, tremendous strides have been made in the depth and breadth of our knowledge of molecular biology, microbial chemistry and molecular pharmacology and of their direct application to studies on the mode of action of drugs. The field of molecular biology itself was in its relative infancy during the preceding decade and the unique role played by many anti biotics in the development of our understanding of nucleic acid synthesis and function and its relationship to protein synthesis and cell physiology has led rapidly to a very precise, understanding of how many of these same antibiotics inhibit susceptible cells.
Download or read book Antineoplastic and Immunosuppressive Agents written by Alan C. Sartorelli and published by Springer Science & Business Media. This book was released on 2013-11-27 with total page 1100 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over the past two decades a number of attempts have been made, with varying degrees of success, to collect in a single treatise available information on the basic and applied pharmacology and biochemical mechanism of action of antineoplastic and immunosuppressive agents. The logarithmic growth of knowledge in this field has made it progressively more difficult to do justice to all aspects of this topic, and it is possible that the present handbook, more than four years in preparation, may be the last attempt to survey in a single volume the entire field of drugs employed in cancer chemotherapy and immunosuppression. Even in the present instance, it has proved necessary for practical reasons to publish the material in two parts, although the plan of the work constitutes, at least in the editors' view, a single integrated treatment of this research area. A number of factors have contributed to the continuous expansion of research in the areas of cancer chemotherapy and immunosuppression. Active compounds have been emerging at ever-increasing rates from experimental tumor screening systems maintained by a variety of private and governmental laboratories through out the world. At the molecular level, knowledge of the modes of action of established agents has continued to expand, and has permitted rational drug design to play a significantly greater role in a process which, in its early years, depended almost completely upon empirical and fortuitous observations.
Download or read book Toxicity Bibliography written by and published by . This book was released on 1977 with total page 836 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Pharmacology and Chemotherapy written by and published by Academic Press. This book was released on 1978-10-04 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Pharmacology and Chemotherapy
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1974 with total page 1348 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cancer Chemotherapy Reports written by and published by . This book was released on 1968 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Progress in Molecular and Subcellular Biology written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Anthracycline Chemistry and Biology II written by Karsten Krohn and published by Springer. This book was released on 2009-11-04 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This series presents critical reviews of the present position and future trends in modern chemical research. It contains short and concise reports on chemistry, each written by the world renowned experts. The series is still valid and useful after five or ten years. More information as well as the electronic version of the whole content is available at: springerlink.com.
Download or read book Molecular Basis of Specificity in Nucleic Acid Drug Interactions written by A. Pullman and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the central problems in the study of the mechanism of DNA-ligand interactions is the existence and nature of sequence specificity with respect to the base pairs of DNA. The presence of such a specificity could be of particular significance because it might possibly mean the involvement of specific genes in the effectiveness of the different drugs. The elucidation of the factors responsible for the specificity could then be important for the development of compounds susceptible to contribute to the control of gene expression and also to the development of rationally conceived, improved new generations of effective and specific chemotherapeutic agents. Important recent achievements, experimental and theoretical, in the analysis of such sequence specificities open prospects for possible rapid progress in this field. The 23rd Jerusalem symposium was devoted to the exploration of these recent achievements in relation to many types of ligand, with special emphasis on antitumor drugs. All major types of interaction, intercalation, groove binding, covalent linking, coordination, have been considered. So was also the effect of the interaction on the structure and properties of the nucleic acids and the relationship between the interaction and biological or pharmacological activities. We feel that this Volume presents a relatively complete up-to-date account of the state of the art in this important field of research.
Download or read book Biotechnological Applications of Proteins and Enzymes written by Zvi Bohak and published by Elsevier. This book was released on 2012-12-02 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biotechnological Applications of Proteins and Enzymes contains the proceedings of a conference honoring the 60th birthday of Israeli scientist Ephraim Katchalski-Katzir, held at Kiryat Anavim, Israel, on May 23-27, 1976. The papers focus on the applications of proteins and enzymes in biotechnology, medicine, and nutrition. It provides an extensive biography of Ephraim Katchalski-Katzir and a discussion of his pioneering efforts in biotechnological applications of proteins and enzymes. Organized into four sections comprised of 20 chapters, this compilation begins with an overview of applied research in non-industrial laboratories. Then, it discusses the enzymes and their production, exploitation of soluble and insolubilized enzymes, medical applications of enzymes and proteins, and use of proteins as food. Individual chapters look at protein immobilization and affinity chromatography, cells and enzymes as industrial catalysts, exploitation of multienzyme systems for synthesis, biotransformation of steroid hormones and antibiotics, and the role of zinc in normal and abnormal growth processes. It explains the applications of antibodies, use of immobilized enzymes in analysis, some medical applications of immobilized proteins and enzymes, and interaction of food proteins with water and lipids. The book concludes with a chapter on muscle and connective tissue proteins as food. This book will be of interest to biochemists, biologists and microbiologists, biotechnologists, food technologists, and others involved in research on the biotechnological applications of proteins and enzymes.
Download or read book Official Gazette of the United States Patent and Trademark Office written by and published by . This book was released on 1981 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Targeting of Drugs written by Gregory Gregoriadis and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: Successful drug use in biology and medicine is often prejudiced by the failure of drugs that are otherwise active in vitro to act as efficiently in vivo. This is because in the living animal drugs must, as a rule, bypass or traverse organs, membranes, cells and molecules that stand between the site of administration and the site of action. In practice, however, drugs can be toxic to normal tissues, have limited or no access to the target and be prematurely excreted or inactivated. There is now growing optimism that such problems may be resolved by the use of carrier systems that will not only protect the non-target environment from the drugs they carry but also deliver them to where they are needed or facilitate their release there. Carrier systems presently under investigation include antibodies, glycoproteins, cells, reconstituted viruses and liposomes. Recent advances in the chemistry of cell receptor and receptor-recognising molecules, llnmunology, and natural and artificial membranes have revealed a multitude of ways in which such carrier systems can be modified or improved upon.
Download or read book Hazardous Chemicals written by Jaspal Singh and published by Elsevier. This book was released on 2024-09-19 with total page 864 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hazardous Chemicals: Overview, Toxicological Profile, Challenges, and Future Perspectives offers comprehensive coverage of hazardous chemicals and their routes of exposures, mechanism of toxicity, hazard control measures, handling and storage, emergency guidelines, and safety measures. The book is organized into specific classifications of chemical hazards: pesticides, fertilizers, insecticides, automotive, paint and paint solvents, chemical manufacturing solvents, dyes, cleaning agents, pharmaceuticals, and radioactive products. It discusses the health risk and environmental impact of these toxic substances. It also provides management strategies including risk assessment, risk management, and risk communication. Hazardous Chemicals is a practical resource for researchers, academics, industry professionals, graduate and postgraduate students in toxicology and environmental science engaged in the evaluation of toxic substances and human health concerns. - Covers exposure routes, health impacts, risk assessment and control measures of hazardous chemicals - Includes storage and handling information for personnel vulnerable to hazards and risks from the toxic substances - Provides case studies related to toxic substances that have resulted in a disastrous event - Examines recent research trends in the field of specific toxic substances
Download or read book Cancer Treatment Reports written by and published by . This book was released on 1981 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Urinary System written by Thomas C. Jones and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete update on the safety testing of foods, drugs, and chemicals in laboratory animals, featuring: - a thorough review of each subject area with extensive revision in line with new information and concepts - electron micrographs in exquisite detail to illustrate results of recent research - the effects of many carcinogens described succinctly and illustrated in detail - neoplasms described in detail and compared with natural and induced tumours in other species - standardised nomenclature. Of interest to those interested in the many applications to human patients, Urinary System: - facilitates uniform interpretation of bioassay results world-wide - provides a basis for understanding mechanisms involved in the functions and malfunctions of the most minute, but important structures of the kidneys - explains the functional significance of details by identifying the composition of structures at the molecular level. Forming a solid basis for understanding the causes and effects of disease of the urinary system, this is essential reading for pathologists, toxicologists, regulatory agencies, and all those involved in carcinogenicity and toxicity studies.
Download or read book The Guanine Nucleotide Binding Proteins written by L. Bosch and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains the proceedings of the EMBO-NATO-CEC Advanced Research Workshop on "Guanine-nucleotide binding proteins. Common structural and functional properties", which was held in Renesse, The Netherlands, August 6-11, 1988. The transmission of information is one of the most important processes in cellular life and involves the most diverse physiological functions. The cellular membrane, as the obligatory target for external signals, harbours complex pathways transducing the signals from the receptors of the external stimuli to the cytoplasmic effector. Heterotrimeric proteins are fundamental components of these pathways. Other proteins that are monomeric may be found associated with the membrane or in soluble form in the cytoplasm, and' can also function in signal transduction. Intracellular transmission of signals may proceed in an analogous fashion, protein synthesis being a well-known example. It is one of the most remarkable and puzzling observations of recent years that all of these proteins share common properties, both functionally and structurally. The ir primary structures show pronounced s imilari ties, in most cases concentrated in the NH2-terminal portion of the molecule. They all bind guanine nucleotides (hence the general name of G-proteins) and are GTPases, a crucial enzymatic activity, since it converts the active complex induced by GTP into the inactive one induced by GDP. Consensus sequences have been ident if ied as responsable for interact ing with the different parts of the guanine nucleotide.
Download or read book Proceedings of the National Academy of Sciences of the United States of America written by National Academy of Sciences (U.S.) and published by . This book was released on 1988 with total page 1294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
