Download or read book Pharmacogenomics in Psychiatry written by M. Schwab and published by Karger Medical and Scientific Publishers. This book was released on 2010-06-25 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years, there have been major developments in the fields of pharmacogenetics and pharmacogenomics, with the potential to make drug treatments in psychiatric medicine more effective. However, improvements in drug efficacy and tolerability, as well as finding the optimal dosage, can only be realized if in vivo mechanisms of drug action and ADME (absorption, distribution, metabolism, excretion) processes (pharmacokinetics) of psychopharmacological agents are better understood. In this volume, current progress and perspectives in pharmacogenetic testing of drug-metabolizing enzymes, drug transporters and other drug targets involved in the response to psychotropic agents are described extensively. This provides a timely overview of what has been achieved in the area of psychiatric pharmacogenomics alongside some promising directions and perspectives for future research.Psychiatrists, general medical doctors as well as pharmacologists and clinical pharmacologists will find new insights into the development and applications of pharmacogenomics in psychiatry.

Download or read book Pharmacological Treatment of Mental Disorders in Primary Health Care written by World Health Organization and published by World Health Organization. This book was released on 2009 with total page 80 pages. Available in PDF, EPUB and Kindle. Book excerpt: This manual attempts to provide simple, adequate and evidence-based information to health care professionals in primary health care especially in low- and middle-income countries to be able to provide pharmacological treatment to persons with mental disorders. The manual contains basic principles of prescribing followed by chapters on medicines used in psychotic disorders; depressive disorders; bipolar disorders; generalized anxiety and sleep disorders; obsessive compulsive disorders and panic attacks; and alcohol and opioid dependence. The annexes provide information on evidence retrieval, assessment and synthesis and the peer view process.

Download or read book The Pill That Steals Lives One Woman s Terrifying Journey to Discover the Truth About Antidepressants written by Katinka Newman and published by Kings Road Publishing. This book was released on 2016-07-07 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: While going through a divorce, documentary filmmaker Katinka Blackford Newman took an antidepressant. Not unusual – except that things didn't turn out quite as she expected. She went into a four-day toxic psychosis with violent hallucinations, imagining she had killed her children, and in fact attacking herself with a knife. Caught up in a real-life nightmare when doctors didn't realise she was suffering side effects of more pills, she went into a year-long decline. Soon she was wandering around in an old dressing gown, unable to care for herself, and dribbling. She nearly lost everything, but luck stepped in; treated at another hospital, she was taken off all the medication and made a miraculous recovery within weeks. By publicising her story, Katinka went on to make some startling discoveries. Could there really be thousands around the world who kill themselves and others from these drugs? What of the billions of dollars in settlements paid out by drug companies? Could they really be the cause of world mass killings, such as the Germanwings pilot who took an airliner down, killing 150, while on exactly the same medication as the author when she became psychotic? And how come so many people are taking these drugs when experts say they are no more effective than a sugarcoated pill for people like her, who are distressed rather than depressed? Moving, frightening and at times funny, this is the story of how a single mum in Harlesden, North-West London, juggles life and her quest for love in order to investigate Big Pharma. For more information visit www.thepillthatsteals.com

Download or read book Discontinuing Antidepressant Medications written by Giovanni A. Fava and published by Oxford University Press. This book was released on 2021-10-21 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: One in six people in the US are currently taking psychotropic drugs. In 80% of cases, the medication is taken for long-term use and predominantly involves new-generation antidepressants, such as SSRIs (e.g. paroxetine) and SNRIs (e.g. venlafaxine). When patients want to stop taking these drugs and/or their physicians decide it is time for them to stop, substantial problems often can ensue. About 50% of patients experience withdrawal symptoms that do not necessarily subside after a few days or weeks and may be severe and debilitating. Physicians often do not know what to do in these situations. As a result, patients experiencing the anguish and mental pain of withdrawal syndromes are unlikely to receive appropriate medical attention. Discontinuing antidepressants is a highly technical challenge that requires specific strategies. This handbook guides clinicians through each clinical step (assessment; what the counter-indications would be for stopping or continuing; and how discontinuation can best be achieved). It provides a detailed account of the assessment and management strategies, with many case illustrations and clinical examples, drawing from the literature that is available and the extensive personal experience of the author.

Download or read book Drug Induced Liver Injury written by and published by Academic Press. This book was released on 2019-07-13 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug-Induced Liver Injury, Volume 85, the newest volume in the Advances in Pharmacology series, presents a variety of chapters from the best authors in the field. Chapters in this new release include Cell death mechanisms in DILI, Mitochondria in DILI, Primary hepatocytes and their cultures for the testing of drug-induced liver injury, MetaHeps an alternate approach to identify IDILI, Autophagy and DILI, Biomarkers and DILI, Regeneration and DILI, Drug-induced liver injury in obesity and nonalcoholic fatty liver disease, Mechanisms of Idiosyncratic Drug-Induced Liver Injury, the Evaluation and Treatment of Acetaminophen Toxicity, and much more. - Includes the authority and expertise of leading contributors in pharmacology - Presents the latest release in the Advances in Pharmacology series

Download or read book Fluoxetine written by Graziano Pinna and published by . This book was released on 2015-04-01 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: Fluoxetine, best known by the trade name Prozac®, unlike other psychotropic drugs whose effects were serendipitously stumbled upon, was the first developed for a precise mechanism of action, that is, the ability to selectively inhibit serotonin reuptake, based upon the theory that increasing the availability of serotonin would treat major depression. Once approved by the FDA in 1987, fluoxetine quickly became the most prescribed psychotropic drug worldwide and its success in improving mood disorders has triggered the development of a large number of congener molecules, commonly known as SSRIs after their purported mechanism of action. However, a quarter of a century after its development, the idea that fluoxetine asserts its positive behavioral effect through inhibition of serotonergic reuptake is not firmly established. This book reviews several preclinical and clinical reports suggesting that the pharmacological effects of fluoxetine may be mediated by means other than the regulation of serotonin, including the regulation of gene expression, modifying epigenetic mechanisms as well as modifying microRNAs. One of the most prominent mechanisms for the therapeutic relevance of fluoxetine relates to influencing neuroplasticity by enhancing neurotropic factors, including BDNF signaling and altering adult neurogenesis. The ability of fluoxetine to rapidly increase neurosteroid levels accounts for the fast anxiolytic effects of this drug. Fluoxetine action at sigma-1 receptor or modulating glutamatergic neurotransmission as well as the combination of fluoxetine with other psychotropic drugs is discussed in relation to its therapeutic effects. While fluoxetine was primarily prescribed as an antidepressant, this drug currently represents a treatment of choice for a broad spectrum of psychiatric disorders, including post-traumatic stress disorder and a range of anxiety disorders. This drug even possesses analgesic actions and is a valuable therapy for stroke. This book also highlights emerging evidence on the gender-specific effects of fluoxetine, its potential adverse features, including its addiction liability in combination with psychostimulants, and the impact of perinatal fluoxetine exposure.

Download or read book Prozac Backlash written by Joseph Glenmullen and published by Simon and Schuster. This book was released on 2001-04-17 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: In a controversial look at the potent drugs millions of Americans consume each day--for everything from anxiety to sexual addiction--Dr. Glenmullen presents authoritative information on why they are risky and provides advice on choosing safer alternative treatments.

Download or read book Pediatric Anxiety Disorders written by Scott N. Compton and published by Academic Press. This book was released on 2019-03-28 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Pediatric Anxiety Disorders provides a critical, updated and comprehensive overview of anxiety disorders in children and adolescents based on the current state of empirical research. The book provides specific clinical recommendations which integrate new knowledge from neuroscience and innovative delivery formats for interventions. This is the first reference to examine anxiety diagnoses in accordance with the latest edition of the DSM-5, including childhood onset disorders, such as Separation Anxiety Disorder, Selective Mutism, Specific Phobia, Social Anxiety Disorder, Panic Disorder, Agoraphobia and Generalized Anxiety Disorder. The book assists clinicians in critically appraising the certainty of the evidence-base and the strength of clinical recommendations. - Uses the latest edition of the Diagnostic and Statistical Manual of Mental Disorders, the DSM-5 - Includes the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach in assessing guideline development - Focuses on advances in etiology, assessment and treatment - Presents new advances in our understanding of the brain behind fear and anxiety - Uses a stepped care approach to treatment

Download or read book Oxford Textbook of Critical Care written by Webb and published by Oxford University Press. This book was released on 2020-01-10 with total page 1961 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in paperback, the second edition of the Oxford Textbook of Critical Care is a comprehensive multi-disciplinary text covering all aspects of adult intensive care management. Uniquely this text takes a problem-orientated approach providing a key resource for daily clinical issues in the intensive care unit. The text is organized into short topics allowing readers to rapidly access authoritative information on specific clinical problems. Each topic refers to basic physiological principles and provides up-to-date treatment advice supported by references to the most vital literature. Where international differences exist in clinical practice, authors cover alternative views. Key messages summarise each topic in order to aid quick review and decision making. Edited and written by an international group of recognized experts from many disciplines, the second edition of the Oxford Textbook of Critical Careprovides an up-to-date reference that is relevant for intensive care units and emergency departments globally. This volume is the definitive text for all health care providers, including physicians, nurses, respiratory therapists, and other allied health professionals who take care of critically ill patients.

Download or read book Lost Connections written by Johann Hari and published by Bloomsbury Publishing. This book was released on 2020-11-12 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: THE INTERNATIONAL BESTSELLER: A radically new way of thinking about depression and anxiety 'A book that could actually make us happy' SIMON AMSTELL 'This amazing book will change your life' ELTON JOHN 'One of the most important texts of recent years' BRITISH JOURNAL OF GENERAL PRACTICE 'Brilliant, stimulating, radical' MATT HAIG 'The more people read this book, the better off the world will be' NAOMI KLEIN 'Wonderful' HILLARY CLINTON 'Eye-opening' GUARDIAN 'Brilliant for anyone wanting a better understanding of mental health' ZOE BALL 'A game-changer' DAVINA MCCALL 'Extraordinary' DR MAX PEMBERTON Depression and anxiety are now at epidemic levels. Why? Across the world, scientists have uncovered evidence for nine different causes. Some are in our biology, but most are in the way we are living today. Lost Connections offers a radical new way of thinking about this crisis. It shows that once we understand the real causes, we can begin to turn to pioneering new solutions – ones that offer real hope.

Download or read book The Antidepressant Solution written by Joseph Glenmullen and published by Simon and Schuster. This book was released on 2006-01-20 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the FDA's warning that antidepressants may cause agitation, anxiety, hostility, and even violent or suicidal tendencies, these medications are at the forefront of national legal news. Harvard physician Joseph Glenmullen has led the charge to warn the public that antidepressants are overprescribed, underregulated, and, especially, misunderstood in their side and withdrawal effects. Now he offers a solution! More than twenty million Americans -- including over one million teens and children -- take one of today's popular antidepressants, such as Paxil, Zoloft, or Effexor. Dr. Glenmullen recognizes the many benefits of antidepressants and prescribes them to his patients, but he is also committed to warning the public of the dangers associated with overprescription. Dr. Glenmullen's last book, Prozac Backlash, sounded the alarm about possible dangers. The Antidepressant Solution provides the remedy. It is the first book to call attention to the drugs' catch-22: Although many people are ready to go off these drugs, they continue to take them because either the patient or the doctor mistakes antidepressant withdrawal for depressive relapse. The Antidepressant Solution offers an easy, step-by-step guide for patients and their doctors. Written by the premier authority in the field, The Antidepressant Solution is an invaluable book for all those concerned with going through the process -- from friends and family members to doctors and patients themselves.

Download or read book Listening to Prozac written by Peter D. Kramer and published by Penguin. This book was released on 1997-09-01 with total page 481 pages. Available in PDF, EPUB and Kindle. Book excerpt: The New York Times bestselling examination of the revolutionary antidepressant, with a new introduction and afterword reflecting on Prozac’s legacy and the latest medical research “Peter Kramer is an analyst of exceptional sensitivity and insight. To read his prose on virtually any subject is to be provoked, enthralled, illuminated.” —Joyce Carol Oates When antidepressants like Prozac first became available, Peter D. Kramer prescribed them, only to hear patients say that on medication, they felt different—less ill at ease, more like the person they had always imagined themselves to be. Referencing disciplines from cellular biology to animal ethology, Dr. Kramer worked to explain these reports. The result was Listening to Prozac, a revolutionary book that offered new perspectives on antidepressants, mood disorders, and our understanding of the self—and that became an instant national and international bestseller. In this thirtieth anniversary edition, Dr. Kramer looks back at the influence of his groundbreaking book, traces progress in the relevant sciences, follows trends in the use and public understanding of antidepressants, and assesses potential breakthroughs in the treatment of depression. The new introduction and afterword reinforce and reinvigorate a book that the New York Times called “originally insightful” and “intelligent and informative,” a window on a medicine that is “telling us new things about the chemistry of human character.”

Download or read book Rang Dale s Pharmacology written by James M. Ritter and published by Elsevier Health Sciences. This book was released on 2018-11-04 with total page 809 pages. Available in PDF, EPUB and Kindle. Book excerpt: World-renowned coverage of today's pharmacology at your fingertips - Keeps you up-to-date with new information in this fast-changing field, including significantly revised coverage of CNS drugs, cognitive enhancers, anti-infectives, biologicals/biopharmaceuticals, lifestyle drugs, and more. - Includes access to unique features, including more than 100 brand new chapter-specific multiple-choice questions and 6 new cases for immediate self-assessment. - Features a color-coded layout for faster navigation and cross-referencing. - Clarifies complex concepts with Key Points boxes, Clinical Uses boxes and full-color illustrations throughout.

Download or read book Deadly Medicines and Organised Crime written by Peter Gotzsche and published by CRC Press. This book was released on 2019-08-21 with total page 251 pages. Available in PDF, EPUB and Kindle. Book excerpt: PRESCRIPTION DRUGS ARE THE THIRD LEADING CAUSE OF DEATH AFTER HEART DISEASE AND CANCER. In his latest ground-breaking book, Peter C Gotzsche exposes the pharmaceutical industries and their charade of fraudulent behaviour, both in research and marketing where the morally repugnant disregard for human lives is the norm. He convincingly draws close co

Download or read book Depression and Heart Disease written by Alexander Glassman and published by John Wiley & Sons. This book was released on 2011-06-20 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recently, there has been a growing awareness of the multiple interrelationships between depression and various physical diseases. Patients with psychiatric problems, particularly depression, may be more susceptible to cardiovascular disorders. Depression and Heart Disease synthesizes current evidence, including some previously unpublished data, in a concise, easy-to-read format. The authors succinctly describe the epidemiology, pathogenesis (including cytokines and genetics), and risk factors of the comorbidity between depression and heart disease. The book also reviews the best pharmacological and psychotherapeutic approaches for people with this comorbidity.

Download or read book The Emperor s New Drugs written by Irving Kirsch and published by Basic Books. This book was released on 2010-01-26 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Do antidepressants work? Of course -- everyone knows it. Like his colleagues, Irving Kirsch, a researcher and clinical psychologist, for years referred patients to psychiatrists to have their depression treated with drugs before deciding to investigate for himself just how effective the drugs actually were. Over the course of the past fifteen years, however, Kirsch's research -- a thorough analysis of decades of Food and Drug Administration data -- has demonstrated that what everyone knew about antidepressants was wrong. Instead of treating depression with drugs, we've been treating it with suggestion. The Emperor's New Drugs makes an overwhelming case that what had seemed a cornerstone of psychiatric treatment is little more than a faulty consensus. But Kirsch does more than just criticize: he offers a path society can follow so that we stop popping pills and start proper treatment for depression.

Download or read book Drugs in Pregnancy and Lactation written by Gerald G. Briggs and published by Lippincott Williams & Wilkins. This book was released on 2012-03-28 with total page 1728 pages. Available in PDF, EPUB and Kindle. Book excerpt: An A-Z listing of drugs by generic name. Each monograph summarizes the known and/or possible effects of the drug on the fetus. It also summarizes the known/possible passage of the drug into the human breast milk. A careful and exhaustive summarization of the world literature as it relates to drugs in pregnancy and lacation. Each monograph contains six parts: generic US name, Pharmacologic class, Risk factor, Fetal risk summary, Breast feeding summary, References