Download or read book Cytotoxicity Mutagenicity and Genotoxicity of Emerging Drinking Water Disinfection Byproducts written by Claire Frances McGuigan and published by . This book was released on 2014 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drinking water disinfection byproducts (DBPs) are formed unintentionally when organic matter in raw water reacts with disinfectants used to kill pathogens. Epidemiological studies have shown that an increased risk of bladder cancer is associated with consumption of chlorinated water, but little is known of the toxicity of many DBPs. This thesis examined the cytotoxic, mutagenic, and genotoxic properties of phenazine and halobenzoquinone (HBQ) DBPs in human cells. Cytotoxicity was examined with an impedance-based real-time cell analysis (RTCA) instrument, mutagenicity was examined with the Ames test (bacterial reverse mutation assay), and genotoxicity was examined with the alkaline comet assay. Phenazine showed differential toxicity in human cell lines, producing an antiproliferative cytotoxic effect in HepG2 cells but a genotoxic effect in T24 cells. The BJ/XPA RTCA in vitro assay was developed and validated to provide high-throughput screening of cytotoxicity and nucleotide excision repair (NER)-mediated DNA damage simultaneously. Selected HBQs were examined with the BJ/XPA assay; the position, type, and number of substitutions on the benzoquinone ring affected cytotoxicity. All tested HBQs caused substitution mutations in the Ames test under at least some of the experimental conditions. 2,6-dichloro-3-methyl-1,4-benzoquinone (DCMBQ) was the most potent HBQ compound tested, demonstrating cytotoxicity, mutagenicity, and genotoxicity. Follow-up experiments indicated that N-acetylcysteine, a ROS scavenger, reduced cytotoxicity and genotoxicity when added concomitantly with DCMBQ. Both the cytotoxic and genotoxic effects of DCMBQ appeared to be mediated, at least in part, by the formation of reactive oxygen species. DCMBQ-induced genotoxicity appeared to be refractory to repair and may involve formation of complex oxidatively generated clustered lesions. Additional in vitro and in vivo studies are required for HBQ DBPs, particularly DCMBQ, to further determine their toxic effects. In summary, the original contributions of this research are: 1) the development of a novel in vitro method to simultaneously assess cytotoxicity and NER-mediated genotoxicity; 2) new information on the cytotoxic, mutagenic, and genotoxic properties of halobenzoquinone DBPs; 3) discovery of cytotoxic and genotoxic properties of phenazine; and 4) evidence of potential toxic mechanisms of action of DCMBQ.
Download or read book Comparative Cytotoxicity and Genotoxicity of Drinking Water Disinfection By products written by Yahya Kargalioglu and published by . This book was released on 2001 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Disinfection By products in Drinking Water written by M.N.V. Prasad and published by Butterworth-Heinemann. This book was released on 2020-02-18 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt: Disinfection Byproducts in Drinking Water: Detection and Treatment presents cutting-edge research on how to understand the procedures, processes and considerations for detecting and treating disinfection by-products from drinking water, swimming pool water, and wastewater. The book begins with an overview of the different groups of Disinfection Byproducts (DBPs), such as: Trihalomethanes (THM), Halo acetic acids, and Haloacetonitrile (HAN). This coverage is quickly followed by a clear and rigorous exposition of the latest methods and technologies for the characterization, occurrence, formation, transformation and removal of DBPs in drinking water. Other chapters focus on ultraviolet-visible spectroscopy, electron spin resonance, and gas chromatography-mass spectrometry. Researchers will find a valuable resource to a breath of topics for DBP detection and treatment, including various recent techniques, such as microfiltration, nanofiltration membrane and nanotechnology. - Explains the latest research in detection, treatment processes and remediation technologies - Includes sampling, analytical and characterization methods and approaches - Covers cutting-edge research, including membrane based technologies, nanotechnology treatment technologies and bioremediation treatment technologies - Provides background information regarding contamination sources
Download or read book Drinking Water Disinfection By products Toxicological Impacts and Biological Mechanisms Induced by Individual Compounds Or as Complex Mixtures written by and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comparative Cytotoxicity Genotoxicity and DNA Repair Kinetics of Drinking Water Disinfection By products written by Justin A. Pals and published by . This book was released on 2009 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Disinfection By products in Drinking Water written by Tanju Karanfil and published by Academic. This book was released on 2008 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a collection of chapters on the latest international research findings, including emerging issues and state-of-the-art studies, related to disinfection by-product formation and control in drinking waters and treated wastewaters.
Download or read book Some Drinking water Disinfectants and Contaminants Including Arsenic written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by IARC. This book was released on 2004 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt: A working group of 23 experts from 13 countries met in Lyon to evaluate the evidence for carcinogenicity of arsenic (mostly naturally occurring) as a contaminant of drinking-water, and of the water-disinfectant chloramine. The working group also evaluated or re-evaluated four chlorination by-products found in drinking-water, namely chloral hydrate, di- and trichloroacetic acids, and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (also known as MX). High-level exposure to arsenic in drinking-water occurs in some regions such as China, Latin America, Bangladesh and West Bengal. The Working Group reviewed epidemiological studies of human cancer (mainly ecological studies in Taiwan and Chile, and several case-control and cohort studies) in relation to arsenic in drinking-water. Arsenic in drinking-water (primarily inorganic, as arsenate and to a lesser extent arsenite) was evaluated as carcinogenic to humans (Group 1) on the basis of sufficient evidence for an increased risk for cancer of the urinary bladder, lung and skin. Studies on inorganic arsenic in experimental animals provided limited evidence for its carcinogenicity, but sufficient evidence was found in experimental animals for the carcinogenicity of dimethylarsinic acid (an organic form of arsenic), which produced urinary bladder tumours in rats and lung tumours in mice after oral administration.
Download or read book Some Chemicals Present in Industrial and Consumer Products Food and Drinking water written by IARC Working Group on the Evaluation of Carcinogenic Risks to Humans and published by IARC Monographs on the Evaluat. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of the IARC Monographs provides an assessment of the carcinogenicity of 18 chemicals present in industrial and consumer products or food (natural constituents, contaminants, or flavorings) or occurring as water-chlorination by-products. The compounds evaluated include the widely used plasticizer di(2-ethylhexyl) phthalate and the food contaminant 4-methylimidazole. In view of the limited agent-specific information available from epidemiological studies, the IARC Monographs Working Group relied mainly on carcinogenicity bioassays, and mechanistic and other relevant data to evaluate the carcinogenic hazards to humans exposed to these agents.
Download or read book Mammalian Cell Cytotoxicity and Genotoxicity of Disinfection By products written by and published by American Water Works Association. This book was released on 2009 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt: This project represents basic research to generate quantitative, comparative in vitro mammalian cell toxicity data of emerging DBPs and related compounds. It is the first systematic cytotoxicity and genotoxicity analysis of its kind --
Download or read book Handbook of Solid Phase Microextraction written by Janusz Pawliszyn and published by Elsevier. This book was released on 2011-12-01 with total page 497 pages. Available in PDF, EPUB and Kindle. Book excerpt: The relatively new technique of solid phase microextraction (SPME) is an important tool to prepare samples both in the lab and on-site. SPME is a "green" technology because it eliminates organic solvents from analytical laboratory and can be used in environmental, food and fragrance, and forensic and drug analysis. This handbook offers a thorough background of the theory and practical implementation of SPME. SPME protocols are presented outlining each stage of the method and providing useful tips and potential pitfalls. In addition, devices and fiber coatings, automated SPME systems, SPME method development, and In Vivo applications are discussed. This handbook is essential for its discussion of the latest SPME developments as well as its in depth information on the history, theory, and practical application of the method. - Practical application of Solid Phase Microextraction methods including detailed steps - Provides history of extraction methods to better understand the process - Suitable for all levels, from beginning student to experienced practitioner
Download or read book Advanced Oxidation Processes for Water Treatment written by Mihaela I. Stefan and published by IWA Publishing. This book was released on 2017-09-15 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advanced Oxidation Processes (AOPs) rely on the efficient generation of reactive radical species and are increasingly attractive options for water remediation from a wide variety of organic micropollutants of human health and/or environmental concern. Advanced Oxidation Processes for Water Treatment covers the key advanced oxidation processes developed for chemical contaminant destruction in polluted water sources, some of which have been implemented successfully at water treatment plants around the world. The book is structured in two sections; the first part is dedicated to the most relevant AOPs, whereas the topics covered in the second section include the photochemistry of chemical contaminants in the aquatic environment, advanced water treatment for water reuse, implementation of advanced treatment processes for drinking water production at a state-of-the art water treatment plant in Europe, advanced treatment of municipal and industrial wastewater, and green technologies for water remediation. The advanced oxidation processes discussed in the book cover the following aspects: - Process principles including the most recent scientific findings and interpretation. - Classes of compounds suitable to AOP treatment and examples of reaction mechanisms. - Chemical and photochemical degradation kinetics and modelling. - Water quality impact on process performance and practical considerations on process parameter selection criteria. - Process limitations and byproduct formation and strategies to mitigate any potential adverse effects on the treated water quality. - AOP equipment design and economics considerations. - Research studies and outcomes. - Case studies relevant to process implementation to water treatment. - Commercial applications. - Future research needs. Advanced Oxidation Processes for Water Treatment presents the most recent scientific and technological achievements in process understanding and implementation, and addresses to anyone interested in water remediation, including water industry professionals, consulting engineers, regulators, academics, students. Editor: Mihaela I. Stefan - Trojan Technologies - Canada
Download or read book Toxicological Profile for Polycyclic Aromatic Hydrocarbons written by and published by . This book was released on 1995 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Download or read book Fate and Effects of Anticancer Drugs in the Environment written by Ester Heath and published by Springer Nature. This book was released on 2020-01-01 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book provides current knowledge and research on the presence and effects of anticancer drug residues in the aqueous environment and covers all relevant aspects of the presence of these residues in wastewaters and natural aquatic systems, where numerous analogies between their pharmacokinetics and pharmacodynamics in humans and their effects in the environment can be drawn. This book comprises of 18 chapters and represents the combined work of leading scientists from different research institutions from across the globe. We present the state of the art in the field of anticancer drug residues in the aquatic environment while being cognizant of the many challenges that remain.
Download or read book Toxicological Profile for N nitrosodimethylamine written by and published by . This book was released on 1989 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Ultraviolet Light in Human Health Diseases and Environment written by Shamim I. Ahmad and published by Springer. This book was released on 2017-11-08 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the roles and importance of Ultraviolet (UV) light from sun and from man-made UV lamps in our daily life, on health and diseases, also its application in sterilization and treatment. The key words are: reactive oxygen species, DNA damage, UV mutagenicity, skin cancers, polymorphous light eruption, Xeroderma pigmentosum, vitiligo, psoriasis, rheumatoid arthritis, diabetes mellitus, metabolic syndromes, cardiovascular diseases, dermatology, photobiology, photodermatosis, vitamin D synthesis, vitamin D efficiency, water sterilization, blood sterilization, phototherapies, skin tanning and UV dosimeter. The book starts with introduction to UV light and the history of development of UV lamps and its applications. It then moves to describing the interaction of this light with biological components and the production of reactive oxygen species, their roles in cell signaling, cellular defense from foreign invaders, in mutagenesis leading to skin diseases including vitiligo, polymorphous light eruption and various forms of skin cancer. Then it presents the synthesis and importance of UV light and diseases, induced due to the deficiency of vitamin D. Roles of UV light in sterilization, disinfection, phototherapies are depicted in the next part and finally use and abuse of UV light in tanning salon and the availability and importance of use of UV dosimeter are highlighted. The three main focuses of this book are: - Damage to biological systems by UV light leading to certain skin diseases; most importantly skin cancers. - Importance of UV light in the in vivo synthesis of vitamin D when human bodies are exposed to it. - Diseases caused due to the deficiency of vitamin D and the use of UV lamps in phototherapy and sterilization processes. The editor has considerable experience in publishing medical books and has used it critically selecting the matters which will attract the readers from many areas of medical and non-medical fields. It is hoped that the materials presented in this book will give great benefit and will stimulate both novice and expert researchers in the field. The book gives excellent overviews of the current status of research and pointers to the future research achievements. Clinicians, medical general practitioners, technicians and staff working in UV related industries and especially those working in tanning salon should benefit from the information presented in safe handling of this light.
Download or read book Organic Pollutants in the Water Cycle written by Thorsten Reemtsma and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first in-depth and comprehensive reference on the most pertinent polar contaminant classes and their behavior in the whole water cycle includes, among others, industrial chemicals, consumer products, polar herbicides and pharmaceuticals. All chapters are uniformly structured, covering properties, pollution sources, occurrence in wastewater, surface water, and groundwater as well as water treatment aspects, while ecotoxicological and assessment aspects are also covered. Among the authors are leading experts in their relevant fields, many of whom provide here groundbreaking research results. The result is an up-to-date information source for researchers and professionals working in water quality monitoring, water supply, or wastewater treatment, as well as environmental and water chemists, geochemists, ecologists, chemists and engineers.
