Download or read book Cytochromes c written by Graham W. Pettigrew and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochrome c fulfills a central role in biological electron transport. This book draws together information from diverse disciplines in order to provide a common base for further research. The comprehensive treatment of this subject does not neglect to show the diversity of biological respirations and photosyntheses. But it also defines their unifying principles. This overview presents the evolutionary relatedness in bioenergetic systems. Such systems are discussed at the experimental level with emphasis on the interpretation of results and the methodological approaches used. No other text provides a broad survey of this central area of biology. Researchers on cytochrome c are presented with information on the impact and importance of other disciplines on their area of investigation. Advanced students gain a balanced account of biological electron transport and will be encouraged to seek new directions of research.
Download or read book Cytochromes c written by Geoffrey R. Moore and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochromes c are haemoproteins which carry out electron transfer in a wide variety of biological systems, necessitating different kinds of cytochrome c to fulfill different biological roles. The evolutionary relationship between cytochromes c and their host organisms are described, as well as their structural, spectroscopic and redox properties, including both electron-transfer rates and redox potentials. The treatment is aimed at the non-specialist so that both the techniques described and their application to cytochromes c can be understood. All classes of cytochrome c are dealt with to provide a comprehensive account of the field. No other text provides such a broad survey. Similar to the earlier volume "Cytochromes c: Biological Aspects" which deals with the classification, biosynthesis and biological role of cytochromes c, the present book is aimed at research workers and advanced students.
Download or read book Cytochrome P 450 written by Paul Ortiz De Monetllano and published by Springer Science & Business Media. This book was released on 1986-03 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major advances have been made in recent years in clarifying the molecular properties of the cytochrome P-450 system. These advances stem, in practical terms, from the generally recognized importance of cytochrome P-450 in the metabolism of drugs and in the bioactivation of xenobiotics to toxic products. The fascinating multiplicity and differential regulation of cytochrome P-450 isozymes, and their ability to catalyze extraordinarily difficult chemical transformations, have independently drawn many chemists and biochemists into the P-450 circle. Progress in the field, from a technical point of view, has been propelled by the de velopment of reliable procedures for the purification of membrane-bound enzymes, by the growing repertoire of molecular biological techniques, and by the development of chemical models that mimic the catalytic action of P-450. As a result, our understanding of the P-450 system is moving from the descriptive, pharmacological level into the tangible realm of atomic detail. The rapid progress and multidisciplinary character of the cytochrome P-450 field, which cuts across the lines that traditionally divide disciplines as diverse as inorganic chemistry and genetics, have created a need for an up-to-date evaluation of the advances that have been made. It is hoped that this book, with its molecular focus on the cytochrome P-450 system, will alleviate this need. The authors of the individual chapters have strived to emphasize recent results without sacrificing the background required to make their chapters comprehensible to informed nonspecialists.
Download or read book Cytochromes written by David F.V. Lewis and published by Taylor & Francis. This book was released on 2003-09 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Multiheme Cytochromes written by Carlos A. Salgueiro and published by Springer. This book was released on 2016-10-08 with total page 39 pages. Available in PDF, EPUB and Kindle. Book excerpt: This brief introduces the structural and functional characterization of this important group of proteins. The content of each chapter is aimed at the non-specialist so that key concepts, methodologies and applications can be presented in a "snapshot" style volume. Multiheme cytochromes are ever more important now that it is possible to obtain genome sequences of microorganisms which have major biotechnological and environmental implications. There is a tremendous profusion of multiheme cytochromes which have great potential as targets for bioremediation and bioenergy applications. This brief gives a glimpse of an intriguing and fast-moving field.
Download or read book Cytochromes P450 written by Costas Ioannides and published by Royal Society of Chemistry. This book was released on 2008-06-27 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: During half a century, cytochrome P450 in its original uniqueness as an optically "wrong" cytochrome has attracted many investigators, who have contributed to the unveiling of a bewildering multiplicity of biologically important functions of the, by now very large, superfamily of cytochrome P 450 enzymes. With its discovery in 1958 and with the advent of more refined spectroscopic methodologies, through the double wavelength spectrophotometry, the mysterious enzyme system began to reveal its secrets in a swift stream of investigative successes. As one of the most extensively studied enzyme systems worldwide the interest in cytochromes P450 very much reflects its importance in the elimination of drugs and other chemicals from the body and its role in chemical toxicity and in the aetiology of diseases such as cancer. There has been significant progress in research in this area in recent years and current books on this subject are now out of date. This much needed, new, fully up-to-date publication fills this gap and emphasises the new relevant topics that have emerged during the last decade in an easily accessible manner. The enzyme system, cytochromes P450, comprises a number of families/subfamilies, and the focus of the book is to deal with each individually, furnishing information directly relevant to scientists involved in the development of chemicals, in particular in the evaluation of their safety. The book has contributions from internationally respected scientists who are research-active in the relevant areas. The authors have made extensive use of figures and tables so that the reader can access the necessary information without always having to read the text. In addition, a very extensive, user-friendly index is a unique hallmark of the book. Part A of this monograph introduces the reader to the current knowledge of the evolutionary development of cytochrome P450 structure and function. Furthermore, it deals with the role of this enzyme in the formation of reactive intermediates. The shrewd and extensive utilisation of the molecular biology methodology very rapidly led to a vast body of enzymes calling for a classification of the plethora of different cytochromes P450 (the superfamily) into families and subfamilies. This is aptly exemplified by the ten chapters in Part B of this book, dealing with ten subfamilies and two families of cytochrome P450. Part C offers an insight into another aspect of cytochrome P450 research, namely its regulation through receptor-mediated stimuli - as opposed to enzyme induction or inhibition. The final chapter translates the current data on one of several drug metabolising systems into clinical application and highlights the role of cytochromes P450 in the treatment of neoplastic growth. The book deals extensively with each family/subfamily of the cytochromes P450 that contribute to the metabolism of xenobiotics. Essential and invaluable information is provided for the industrial research scientist working with fine chemicals, and especially those in the pharmaceutical industry, dealing with the safety evaluation of chemicals or being involved in the study of their metabolism, pharmacokinetics and toxicological properties. It should also prove of interest to Regulators concerned with the safety evaluation of chemicals, research pharmacologists and toxicologists, and postgraduate students studying drug metabolism and toxicology at an advanced level.
Download or read book Cytochromes Current Research II written by Richard A. Morton and published by Ardent Media. This book was released on 1972 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book From Cyclotrons To Cytochromes written by Nathan Kaplan and published by Elsevier. This book was released on 2012-12-02 with total page 903 pages. Available in PDF, EPUB and Kindle. Book excerpt: From Cyclotrons to Cytochromes: Essays in Molecular Biology and Chemistry focuses on the uses of the cyclotron and radioactive isotopes in molecular biology and chemistry. The book includes a tribute to Martin Kamen, who played an important role in the development of biochemical sciences in the United States, particularly through his research on the cyclotron. The text also documents research on isotopes carried out at the Radiation Laboratory of the University of California at Berkeley during the 1930s, as well as the role of radioactive carbon in bacterial metabolism and experimental work on cytochromes. This volume is organized into six sections encompassing 54 chapters and begins with an overview of science and technology, and then discusses carbon-14 and its half-life. The next chapters discuss the chemistry and structure of cytochromes; the role of cytochromes and redox systems in photosynthesis; the biological aspects of phosphorylation and oxidation; and protein structure. The book also methodically explains the regulatory mechanisms and miscellaneous metabolic processes such as the metabolism of cyclic nucleotides and related compounds; biological functions of lactate dehydrogenase; and nucleotide excision repair of damaged DNA. The final chapter discusses the deamidation of asparagine and glutamine side chains when incorporated into polypeptide chains, with reference to the role of cryptic amidase active sites in catalyzing the process. This book is a valuable resource for biochemists and molecular biologists.
Download or read book Guide to Cytochromes P450 written by David F. V. Lewis and published by CRC Press. This book was released on 2001-04-12 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochromes are coloured iron-containing proteins that transfer electrons during cellular respiration and photosynthesis. The Cytochrome P450 family of enzymes catalyze reactions whereby water-insoluble drugs or metabolites, that would otherwise reach toxic levels in cell membranes, are rendered suitably water-soluble to leave the cell and be excreted in the urine. Due to the extensive nature of this subject, which is an area of intense scientific interest, the field is rapidly advancing and there is a need for new textbooks to keep abreast of the latest developments. The book fulfils that role in providing a fast-track approach for those coming into the P450 field, either at postgraduate level or in particular within the pharmaceutical industry. A Guide to Cytochrome P450 Structure and Function acts as an adjunct to the previous book Cytochromes P450: Structure, Function and Mechanism. It reviews the current status of the P450 field in terms of our present knowledge and understanding of the enzymes structure and function, including their multiplicity of forms, diversity of substrates, and selectivity. This is brought together with the latest research topics, including pharmacogenetics, regulation, human DMEs, toxicity screening and molecule modeling, to provide a fast-track approach for those new to the field.
Download or read book Guide to Cytochromes written by David F.V. Lewis and published by CRC Press. This book was released on 1996-07-03 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide to the structure, function and mechanism of the cytochromes P450 focuses on the role of P450s in xenobiotic metabolism and toxicity. Colour illustrations show how modelling of P450s can rationalize their substrate specificity for the metabolism of both endogenous and exogenous chemicals.
Download or read book Cytochromes P450 Drug Metabolism Bioactivation and Biodiversity 2 0 written by Patrick M. Dansette and published by MDPI. This book was released on 2021-08-31 with total page 286 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book, "Cytochromes P450: Drug Metabolism, Bioactivation and Biodiversity", presents five papers on human cytochrome P450 (CYP) and P450 reductase, three reviews on the role of CYPs in humans and their use as biomarkers, six papers on CYPs in microorganisms, and one study on CYP in insects. The first paper reports the in silico modeling of human CYP3A4 access channels. The second uses structural methods to explain the mechanism-based inactivation of CYP3A4 by mibefradil, 6,7-dihydroxy-bergamottin, and azamulin. The third article compares electron transfer in CYP2C9 and CYP2C19 using structural and biochemical methods, and the fourth uses kinetic methods to study electron transfer to CYP2C8 allelic mutants. The fifth article characterizes electron transfer between the reductase and CYP using in silico and in vitro methods, focusing on the conformations of the reductase. Then, two reviews describe clinical implications in cardiology and oncology and the role of fatty acid metabolism in cardiology and skin diseases. The second review is on the potential use of circulating extracellular vesicles as biomarkers. Five papers analyze the CYPomes of diverse microorganisms: the Bacillus genus, Mycobacteria, the fungi Tremellomycetes, Cyanobacteria, and Streptomyces. The sixth focuses on a specific Mycobacterium CYP, CYP128, and its importance in M. tuberculosis. The subject of the last paper is CYP in Sogatella furcifera, a plant pest, and its resistance to the insecticide sulfoxaflor.
Download or read book Cytochromes P 450 and b5 written by David Cooper and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 550 pages. Available in PDF, EPUB and Kindle. Book excerpt: P-450 has in common with our nation that it can call Phila delphia its hometown. Yet there are differences, too. The U. S. A. was born and named in this city. P-450 was first recog nized here -- an odd CO-combining pigment without family or func tion. Japanese workers identified it as an unusual member of the cytochrome family. Finally, in Philadelphia, its biological func tion was established and its growth to a global power initiated. Since discovery of its function as terminal oxidase of the 21-steroid hydroxylase system of adrenocortical microsomes, P-450 has proved to play the same role in a wide variety of other mixed function oxidase systems involved in biosynthesis and catabolism of specific cell or body components as well as in the metabolism of foreign substances entering organisms. P-450-like oxygenating enzymes appear to be fundamental cellular constituents in most forms of aerobic organisms. Activation of molecular oxygen and incorporation of one of its atoms into organic compounds as cata lyzed by P-450 enzymes are reactions of vital importance not only for biosynthesis and degradation of steroid hormones necessary for sustaining life, but also for metabolic activation or inactivation of foreign agents such as drugs, food preservatives and additives, insecticides and carcinogens. Moreover, P-450 linked enzyme sys tems can either be induced or suppressed by these agents with significant biological consequences.
Download or read book Cytochromes P450 written by Costas Ioannides and published by CRC Press. This book was released on 1996-09-06 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochromes P450: Metabolic and Toxicological Aspects examines cytochrome P450 proteins and their role in toxicity/carcinogenicity and the metabolism of foreign chemicals. Studying the function of these proteins enables us to: Predict the pathways and outcome of chemical metabolism to rationalize species, sex, and age differences in toxicity Anticipate drug interactions Modify doses to fit the needs of patients Contributions from internationally acknowledged experts are organized into three sections. The first section provides an overview, the next profiles each of the cytochrome P450 families and subfamilies involved in chemical metabolism, and the last section discusses new issues and developments of current interest. This detailed and thorough examination of cytochrome P450 will be a useful source for research scientists, especially those working in the pharmaceutical industry, dealing with the safety evaluation of chemicals and the study of their metabolism, pharmacokinetics, and toxicological properties.
Download or read book Cytochrome P450 written by Paul R. Ortiz de Montellano and published by Springer Science & Business Media. This book was released on 2007-02-05 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cytochrome P450: Structure, Mechanism, and Biochemistry, third edition is a revision of a review that summarizes the current state of research in the field of drug metabolism. The emphasis is on structure, mechanism, biochemistry, and regulation. Coverage is interdisciplinary, ranging from bioinorganic chemistry of cytochrome P450 to its relevance in human medicine. Each chapter provides an in-depth review of a given topic, but concentrates on advances of the last 10 years.
Download or read book Encyclopedia of Biophysics written by Gordon Roberts and published by Springer. This book was released on 2012-10-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Biophysics is envisioned both as an easily accessible source of information and as an introductory guide to the scientific literature. It includes entries describing both Techniques and Systems. In the Techniques entries, each of the wide range of methods which fall under the heading of Biophysics are explained in detail, together with the value and the limitations of the information each provides. Techniques covered range from diffraction (X-ray, electron and neutron) through a wide range of spectroscopic methods (X-ray, optical, EPR, NMR) to imaging (from electron microscopy to live cell imaging and MRI), as well as computational and simulation approaches. In the Systems entries, biophysical approaches to specific biological systems or problems – from protein and nucleic acid structure to membranes, ion channels and receptors – are described. These sections, which place emphasis on the integration of the different techniques, therefore provide an inroad into Biophysics from a biological more than from a technique-oriented physical/chemical perspective. Thus the Encyclopedia is intended to provide a resource both for biophysicists interested in methods beyond those used in their immediate sub-discipline and for those readers who are approaching biophysics from either a physical or biological background.
Download or read book Cytochrome P450 written by Paul R. Ortiz de Montellano and published by Springer Science & Business Media. This book was released on 1995-10-31 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Second Edition reviews the impressive progress that has been made in the last ten years in cytochrome P450 research. Chapters emphasize structure, mechanism, biochemistry, and regulation. This edition offers expanded coverage of P450 crystal structures, site-specific mutagenesis as a probe of structure and function. New chapters explore the hormonal regulation of P450 enzymes, the cytochrome P450-catalyzed oxidation of eicosanoids, human P450 enzymes, and thiolate-ligated hemoproteins other than P450.
Download or read book Cytochromes P450 written by Costas Ioannides and published by Royal Society of Chemistry. This book was released on 2008 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by a team of internationally respected scientists, this book provides up-to-date information on the extensively studied cytochrome P450 enzyme in a very accessible manner.
