Download or read book Cyclic Nucleotides Cyclic Nucleotide Phosphodiesterase Protein Kinase and Phosphoprotein Phosphatase in the Central Nervous System of Manduca Sexta written by Edward Elmo Albin and published by . This book was released on 1973 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adenosine 3', 5' -cyclic monophosphate (cyclic AMP, cAMP) and guanosine 3', 5' -cyclic monophosphate (cyclic GMP, cGMP) were quantitated in the central nervous system (CNS) of the insect Manduca sexta by competitive protein binding techniques. The M. sexta CNS was found to contain a strikingly high level of cGMP, about 100-fold greater than that of mammalian brain. The level of cAMP, however, was estimated to be about one-sixth that of mammalian brain. The basal ratio of cGMP/cAMP in the insect CNS was approximately ten, whereas this ratio has been reported to be less than one in a variety of vertebrate and invertebrate tissues. Acetylcholine caused a great elevation of cGMP, but not cAMP, in the M. sexta CNS. Short-term incubation with ecdysterone (insect metamorphosis hormone) promoted the accumulation of both cyclic nucleotides. The existence of cyclic nucleotide- stimulable protein kinases (ATP: protein phosphotransferase, EC 2. 7. 1. 37), a system of enzymes postulated to be instrumental in the biochemical expression of cAMP and cGMP, was demonstrated in the CNS of both larval and adult M. sexta. At low concentrations, cAMP was a much more effective activator of kinase activity than cGMP, Cyclic AMP lowered the Km of the CNS kinase for ATP, a phenomenon which has been reported to be unique to nervous tissue in mammals. A number of the enzymological properties of the insect kinase were similar to those reported in the literature for this enzyme in mammalian tissues. This insect CNS was also shown to possess a potent enzyme system, viz. phosphoprotein phosphatase, for the dephosphorylation of the phosphorylated products of kinase. Phosphatase activity was gauged using phosphoprotamine as substrate. Both kinase and phosphatase activities were found to be enriched in particulate fractions of the CNS. An enzyme system for the destruction of cAMP and cGMP, cyclic nucleotide phosphodiesterase (nucleoside 3', 5' -cyclic phosphate nucleoside 5' -phosphate 31 -phosphohydrolase, EC 3.1. 4
Download or read book Cyclic Nucleotide Phosphodiesterases in the Central Nervous System written by Nicholas J. Brandon and published by John Wiley & Sons. This book was released on 2014-03-07 with total page 429 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews advances in understanding phosphodiesterases within the central nervous system and their therapeutic applications. A range of expert authors from both academia and industry describe these, then focus on the areas of greatest scientific and medical interest to provide more detailed coverage. Therapeutic and drug discovery applications are covered for diseases including Alzheimer's, Parkinson's, schizophrenia, erectile dysfunction, and spinal cord injuries. There is also a chapter on drug discovery tools such as in vitro assays and X-ray structures for medicinal chemistry studies.
Download or read book Cyclic Nucleotides in the Nervous System written by John Daly and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The elucidation of the cellular and molecular bases underlying the inte grated function of the central nervous system, both in disease and in health, must ultimately come from the combined efforts of scientists from many disciplines, including biology, chemistry, histology, pathology, physiology, pharmacology, and psychology. Communication between scientists from these various disciplines-vital to the advancement of our understanding of the function of the nervous system-has become more and more difficult in recent years. Both increasing specialization and the incredible increases in publications pertinent to brain research in a wide spectrum of journals, in symposium volumes, in monographs, in abstracts, and in reviews contrib ute to the problems of cross-communication and even of communication within a scientific discipline. Research on the significance of cyclic nucleo tides to the function of nervous systems is particularly illustrative of the communication problem. Since the initial publications by Sutherland, Rall, and Butcher in the late fifties and early sixties on high levels of adenylate cyclase, phosphodiesterases, and cyclic AMP in brain, the ensuing litera ture of this field has expanded exponentially. At the present time, from five to ten publications relevant to cyclic nucleotides and the nervous system appear each week. Indeed, these are minimal numbers based mainly on examination of literature titles and key index words. Many articles concerned with some aspect of central function contain, buried within their text, experiments with or related to cyclic nucleotides.
Download or read book Cyclic Nucleotides in the Nervous System written by George I. Drummond and published by New York : Raven Press. This book was released on 1984 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cyclic Nucleotide Phosphodiesterases in Health and Disease written by Joseph A. Beavo and published by CRC Press. This book was released on 2006-12-05 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the last major compendium dedicated to cyclic nucleotide phosphodiesterases (PDEs) was published over 15 years ago, an enormous amount of progress has occurred in the field. There is great need for a centralized source for key information in this burgeoning and therapeutically important area of medical research. Cyclic Nucleotide Phosph
Download or read book Cyclic Nucleotide Phosphodiesterases written by Joe Beavo and published by . This book was released on 1990-11-30 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Second volume in a series addressing topical areas important to the understanding of the control of biological processes. This volume focuses on the structure and molecular biology of isoenzymes and their role in signal transduction processes necessary for co-ordinating cellular functioning.
Download or read book Neurotransmitters Cyclic Nucleotides and Adenyl Cyclase in the Central Nervous System of Manduca Sexta written by Duncan Paul Taylor and published by . This book was released on 1977 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Dissertation Index written by University Microfilms International and published by Ann Arbor, Mich. : University Microfilms International. This book was released on 1984 with total page 712 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Dissertation Index written by and published by . This book was released on 1984 with total page 818 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1973- include the following subject areas: Biological sciences, Agriculture, Chemistry, Environmental sciences, Health sciences, Engineering, Mathematics and statistics, Earth sciences, Physics, Education, Psychology, Sociology, Anthropology, History, Law & political science, Business & economics, Geography & regional planning, Language & literature, Fine arts, Library & information science, Mass communications, Music, Philosophy and Religion.
Download or read book Comprehensive Dissertation Index Chemistry P Z written by and published by . This book was released on 1984 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book CSA Neurosciences Abstracts written by and published by . This book was released on 1989 with total page 880 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Dissertation Index Chemistry E O written by and published by . This book was released on 1984 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book National Agricultural Library Catalog written by National Agricultural Library (U.S.) and published by . This book was released on 1980 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book O S U Theses and Dissertations 1970 1977 written by Oregon State University and published by . This book was released on 1980 with total page 138 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book American Doctoral Dissertations written by and published by . This book was released on 1973 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Bibliography of Agriculture written by and published by . This book was released on 1975 with total page 1354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
