Download or read book Current Strategies for Promoting Regeneration After Spinal Cord Injury written by Seth Daniel Schirmer and published by . This book was released on 2012 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A Review of Strategies for Promoting Axonal Regeneration in Spinal Cord Injury written by Shan Huang and published by . This book was released on 2013 with total page 82 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Indwelling Neural Implants written by William M. Reichert and published by CRC Press. This book was released on 2007-12-17 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite enormous advances made in the development of external effector prosthetics over the last quarter century, significant questions remain, especially those concerning signal degradation that occurs with chronically implanted neuroelectrodes. Offering contributions from pioneering researchers in neuroprosthetics and tissue repair, Indwel
Download or read book Spinal Cord Injury SCI Repair Strategies written by Giuseppe Perale and published by Woodhead Publishing. This book was released on 2019-10-30 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. - Covers current and future repair strategies for spinal cord injury repair - Focuses on key research trends, clinics, biology and engineering - Provides fundamentals on regenerative engineering and tissue engineering
Download or read book Therapeutic Strategies to Spinal Cord Injury written by Pavla Jendelova and published by MDPI. This book was released on 2018-11-29 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Therapeutic Strategies to Spinal Cord Injury" that was published in IJMS
Download or read book Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma written by Michael Fehlings and published by Academic Press. This book was released on 2022-02-17 with total page 646 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout. These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma. Contains contributions by international authors Covers recent clinical trial advancements and findings and updates on ongoing trials Presents an overview of clinical practice guidelines for the management of traumatic spinal cord injury featured Provides the reader with insights regarding the translation of research from bench to bedside and the skills needed to understand the translational pathway using real-life examples
Download or read book ISCoS Textbook on Comprehensive management of Spinal Cord Injuries written by Harvinder Singh Chhabra and published by Wolters kluwer india Pvt Ltd. This book was released on 2015-01-01 with total page 1252 pages. Available in PDF, EPUB and Kindle. Book excerpt: SCI needs management by a team comprising of doctors, physiotherapists, occupational therapists, nurses, vocational counsellor, psychologist, assistive technologist, orthotist and social worker. Since the available textbooks did not address the requirements of all disciplines, the need for the proposed textbook was reinforced.
Download or read book Regenerative Strategies in the Spinal Cord written by Michelle Ariana Wedemeyer and published by . This book was released on 2012 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Populations of cells were obtained from a clinic offering "treatments" for chronic spinal cord injury. Immunostaining and flow cytometry confirmed the populations to be neural and mesenchymal stem cells, respectively (NSCs and MSCs). ELISAs performed on conditioned media detected several growth factors although neurotrophic factors known to promote regeneration in the spinal cord were not detected. Treatment of primary cortical neurons with media conditioned by MSCs and NSCs did not lead to a statistically significant increase in axon length or complexity. A statistically significant increase in cell number was detected in cultures treated with NSC-conditioned media. In vitro analysis does not support the clinic's claim that the cells exhibit properties which would promote axon growth. Two human embryonic stem cell lines (ES) and three induced pluripotent stem cell lines (iPS) were differentiated into high purity populations of neuronal progenitor cells (NPCs) and oligodendrocyte progenitor cells (OPCs). Both ES and two of three iPS lines produced high purity populations of the desired lineage. Transplantation of OPCs generated from ES and iPS lines into spinal cord injured rats resulted in engraftment of human oligodendrocytes without formation of tumors. We conclude that iPS cells may be adapted to protocols developed for generation of high purity NPCs and OPCs from ES cells. Immature astrocytes are known to promote recovery from spinal cord injury. In order to determine properties of immature astrocytes which promote recovery after spinal cord injury an in vitro model of aged astrocytes was developed. As compared to aged astrocytes, a greater proportion of immature astrocytes are proliferating, express more laminin, are motile, and promote greater regeneration of dorsal root ganglion (DRG) axons. Reprogramming mature astrocytes into immature astrocytes is a potential therapy for chronic spinal cord injury. Nine factors which are expressed at higher levels in immature versus mature astrocytes were overexpressed in aged astrocytes. At two weeks, treated cultures exhibited greater laminin immunofluorescence, increased capacity to promote growth of adult DRG axons, and foci of increased motility mixed with foci of cell death. Treatment of aged astrocytes with 9 factors leads to partial recovery of immature properties.
Download or read book Neuroprotection written by Matilde Otero-Losada and published by BoD – Books on Demand. This book was released on 2020-11-26 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.
Download or read book AOSpine Masters Series Volume 7 Spinal Cord Injury and Regeneration written by Michael G. Fehlings and published by Thieme. This book was released on 2016-09-15 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: World-renowned experts share the latest updates in translational research as well as surgical and nonsurgical strategies for treating spinal cord injury Spinal cord injury (SCI) is a devastating, clinically challenging injury, leading to varying degrees of neurological function impairment and paralysis. Underlying biological mechanisms either inhibit or promote new growth in the spinal cord. Researchers have been making important discoveries about how neurons and their axons grow in the central nervous system and why they fail to regenerate after SCI. Although progress has been steady, there remains an urgent need to address issues in acute management such as early decompression and the use of biologics, as well as potential solutions for regeneration. Written by renowned experts in the ever-evolving field of SCI research and clinical practice, the 7th volume in the AOSpine Masters series is a state-of-the-art compendium on the latest in SCI diagnosis, spine surgery interventions, and long-term management. Each chapter contains pearls from leading spine specialists gleaned from the research laboratory and years of hands-on experience treating SCI patients in the emergency setting and long term. Key Features: Pathobiology, assessment, and diagnostic considerations The use of biomarkers as predictors of functional recovery Surgical and nonsurgical interventions for traumatic SCI The role of neural stem cells and biologics in spinal cord repair Functional and epidural stimulation and brain-computer interfaces The AOSpine Masters series, a copublication of Thieme and the AOSpine Foundation, addresses current clinical issues featuring international masters sharing their expertise in the core areas in the field. The goal of the series is to contribute to an evolving, dynamic model of evidence-based approach to spine care. This essential textbook delivers invaluable insights to spine surgeons, spinal cord injury clinicians and researchers and trainees, from translational researchers to experienced researchers and clinicians experienced in the operative and non-operative management of spinal cord injury.
Download or read book Strategies for Promoting Neural Plasticity After Experimental Spinal Cord Injury written by Malllika Dipayan Fairchild and published by . This book was released on 2009 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Promoting bridging axonal regeneration after spinal cord injury written by Thomas Christian Peter Sardella and published by . This book was released on 2010 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Recovery of Motor Function Following Spinal Cord Injury written by Heidi Fuller and published by BoD – Books on Demand. This book was released on 2016-08-17 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Restoration of motor function following spinal cord injury is a complex and challenging task. By reviewing emerging cellular, pharmacological, rehabilitative, as well as surgical approaches, this book seeks to highlight promising therapeutic strategies for the repair and regeneration of motor circuitry. The multidisciplinary nature of these approaches illustrates various routes to bridging the gap between the bench and the bedside and to identify the challenges that must be overcome in order to bring about a viable therapeutic strategy for spinal cord injury patients.
Download or read book Neurorestoratology written by Hongyun Huang and published by Nova Science Publishers. This book was released on 2015 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neurorestoratology is one of the most important disciplines in modern medicine and is also the most important discipline in neuroscience. Its core aim is to restore, promote and maintain the integrity of impaired or lost neuronal functions and/or structures by using novel cell-based comprehensive neurorestorative strategies. This book is the first and a unique one that systematically expounds the main aspects of neurorestoratology, which includes three sections with 22 chapters in two volumes. It systematically elaborates CNS neurorestorable theory and neurorestorative mechanisms. It firstly comprehends the Neurorestorative Process as a whole and Neurorestorative law. It fully describes all neurorestorative strategies and their continuing clinical progresses and achievements, especially the cell-based comprehensive neurorestorative strategies.
Download or read book CNS Regeneration written by Mark H. Tuszynski and published by Academic Press. This book was released on 1999 with total page 720 pages. Available in PDF, EPUB and Kindle. Book excerpt: CNS Regeneration focuses on some of the leading current neurological disease models and methods for promoting central nervous system regeneration. Editors and authors are experts in the field, with experience in basic as well as applied neuroscience. In a comprehensive, logical manner, the book unites important basic science advances in neuroscience with novel medical strategies. The first comprehensive, authoritative volume on the topic of CNS regeneration Reviews current therapeutic approaches Editors and authors are experts in the field Appeals to those interested in basic science as well as those concerned with its medical application
Download or read book Activating Neuron Intrinsic Growth Pathways to Promote Spinal Cord Regeneration After Dorsal Root Injury written by Meredith Ann Manire and published by . This book was released on 2019 with total page 154 pages. Available in PDF, EPUB and Kindle. Book excerpt: Primary sensory axons fail to regenerate into the spinal cord following dorsal root injury leading to permanent sensory deficits. Re-entry is prevented at the dorsal root entry zone (DREZ), the CNS-PNS interface. Current approaches for promoting DR regeneration across the DREZ have had some success, but sustained, long-distance regeneration, particularly of large-diameter myelinated axons, still remains a formidable challenge. Our lab has previously shown that induced expression of constitutively active B-RAF (kaBRAF) enhanced the regenerative competence of injured DRG neurons in adult mice. In this study, I investigated whether robust intraspinal regeneration can be achieved by selective expression of kaBRAF alone or in combination with deletion of the myelin-associated inhibitors or neuron-intrinsic growth suppressors (PTEN or SOCS3). To this end, I used LSL-kaBRAF: brn3a-CreERT2 transgenic mice in which kaBRAF can be induced selectively in sensory neurons. I have also bred LSL-kaBRAF: brn3a-CreERT2 mice with triple knock-out mice lacking Nogo, Mag and OMgp or mouse lines carrying floxed alleles of PTEN or SOCS3. Single, double, and triple conditional mice were subjected to cervical DR crush and AAV2-eGFP vectors were used to selectively label regenerating axons of large-diameter neurons. I compared the extent of regeneration at 3 weeks or 2 months after DR injury using conventional anatomical and behavioral analyses. I found that kaBRAF alone promoted axon regeneration across the DREZ but did not produce significant functional recovery by two months. Supplementary deletion of Nogo, MAG, and OMgp did not improve kaBRAF-induced regeneration. Deletion of PTEN or SOCS3 individually or in combination failed to promote axon regeneration across the DREZ. In marked contrast, simultaneous deletion of PTEN, but not SOCS3, dramatically enhanced kaBRAF-mediated regeneration enabling many more axons to penetrate the DREZ and grow deep into the spinal cord. This study shows that dual activation of BRAF-MEK-ERK and PI3K-Akt signaling is an effective strategy to stimulate robust intraspinal DR regeneration and may lead to recovery of sensory function after DR injury.
Download or read book Neurobiology of Spinal Cord Injury written by Robert G. Kalb and published by Springer Science & Business Media. This book was released on 2000 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Distinguished researchers review the latest scientific understanding of spinal cord injury (SCI), focusing on the mechanisms causing paralysis after spinal cord trauma, the molecular determinants of neural regeneration, and methods for improving damaged function. The authors examine the role of intracellular Ca2+ in neuronal death, the possibility of spinal learning, growth-promoting molecules for regenerating neurons, and the biochemistry and cell biology of microtubules. Among the treatment possibilities discussed are cell transplantation strategies beyond the use of fetal spinal cord tissue, remyelination in spinal cord demyelination models, high steroid therapy immediately after SCI, and the mixed use of anti- and proinflammatories. Comprehensive and highly promising, Neurobiology of Spinal Cord Injury summarizes and integrates the great progress that has been made in understanding and combating the paralysis that follows spinal cord injury.
