Download or read book Current Directions in Radiopharmaceutical Research and Development written by Steven J. Mather and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 248 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiophannaceutical research has recently undergone a major change in direction. In past years it has been concerned mainly with the development of perfusion tracers, the biodistribution of which reflect the regional blood flow to areas of major organs such as the heart and brain. However, a major new direction of interest now lies in the development of receptor-binding radio-tracers which can be used to perform in-vivo characterisation of diseased tissues and it is likely that much of the future research in this field will follow this direction. The difficulties in developing such tracers are considerable. The researcher must first identify a promising target for radiopharmaceutical development. High specific activity radioactive molecules must be designed and synthesised which will both bind to the target receptor with high affinity, and also have the physicochemical characteristics which will allow them to reach the target site in sufficient quantity while at the same time showing minimal uptake in non-target tissues. Thus the knowledge base required for radiophannaceutical development has now expanded beyond the limits of radiopharmaceutical chemistry to include aspects of biochemistry, molecular biology and conventional drug design. The portfolio of basic knowledge required to support current radiopharmaceutical development is changing and scientists working in this arena need to be trained in this regard. At the same time, the very latest developments in the field need to be communicated to the scientific community in order to stimulate the advancement of this exciting new direction of research.
Download or read book Advancing Nuclear Medicine Through Innovation written by National Research Council and published by National Academies Press. This book was released on 2007-09-11 with total page 173 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nearly 20 million nuclear medicine procedures are carried out each year in the United States alone to diagnose and treat cancers, cardiovascular disease, and certain neurological disorders. Many of the advancements in nuclear medicine have been the result of research investments made during the past 50 years where these procedures are now a routine part of clinical care. Although nuclear medicine plays an important role in biomedical research and disease management, its promise is only beginning to be realized. Advancing Nuclear Medicine Through Innovation highlights the exciting emerging opportunities in nuclear medicine, which include assessing the efficacy of new drugs in development, individualizing treatment to the patient, and understanding the biology of human diseases. Health care and pharmaceutical professionals will be most interested in this book's examination of the challenges the field faces and its recommendations for ways to reduce these impediments.
Download or read book Radiopharmaceuticals written by Farid A. Badria and published by BoD – Books on Demand. This book was released on 2022-06-15 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Radiopharmaceuticals - Current Research for Better Diagnosis and Therapy discusses the importance of radiopharmaceuticals and their environmental, pharmaceutical, diagnostic, therapeutic, and research applications. Chapters address such topics as the fundamentals of radiopharmaceutical chemistry and preparation, fabrication, materials manipulation, and characterization of radiopharmaceuticals, applications of radiopharmaceuticals in preclinical studies, radiopharmaceuticals in modern cancer therapy, and new trends in preparation, biodistribution, and pharmacokinetics of radiopharmaceuticals in diagnosis and research.
Download or read book Radiopharmaceuticals for Therapy written by F. F. (Russ) Knapp and published by Springer. This book was released on 2016-01-20 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides detailed information on therapeutic radiopharmaceuticals and discusses emerging technologies which have potential for broad clinical implementation. Recent advances in molecular biology, radiopharmaceutical chemistry and radioisotope production have stimulated a new era for the use of radiopharmaceuticals for targeted radionuclide therapy (TRT). Emerging clinical trials include use of peptides and monoclonal antibodies radiolabeled with therapeutic radionuclides for cancer therapy. In addition, small molecules are used for the treatment of chronic diseases such as metastatic bone pain palliation and radiation synovectomy of inflammatory joints. In the interventional arena, therapy of primary and metastatic liver cancer and arterial restenosis following angioplasty of both the coronary and peripheral arteries are being explored. Reactor and accelerator production of therapeutic radioisotopes is also integrated into these discussions. The development and use of radiopharmaceutical targeting characteristics required for treatment of specific disease processes and how these are implemented for radiopharmaceutical design strategies are also described. Radiopharmaceuticals for Therapy will benefit audiences in nuclear medicine and radionuclide therapy and will thus prove an invaluable source of up-to-date information for students, radiopharmaceutical scientists and professionals working in the radiopharmacy and nuclear medicine specialties.
Download or read book Radionuclide Therapy written by Recep Bekiş and published by Springer Nature. This book was released on 2022-08-01 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main purpose of this book is to create a reference for the indications, contraindications, patient selection, treatment practice, treatment side effect management, and follow-up of radionuclide treatments. Besides standard methods such as surgery, chemotherapy, radiotherapy, and hormone therapy, newly developed biological treatments, targeted treatments, personalized treatments, external beam radiotherapy, and targeted radionuclide treatments have begun to take their place in professional practice. Nuclear medicine, in addition to its role as a tracer of cancer, also assumes the role of treating with radioactive molecules directed to the cancer it traces. These traceable next-generation radionuclide treatments, whose efficacy and reliability have been proven and where diagnosis, treatment, and follow-up are carried out together, are increasingly included in oncology practice together with the new developed radiopharmaceuticals, ensuring a high rate of damage to cancer cells while protecting the surrounding normal tissues. Molecular cancer treatment will become more effective with individualized next-generation traceable radionuclide treatments, which will be shaped by genetic studies in the future. Radionuclide treatments for many cancer types and benign diseases are presented by experienced nuclear medicine experts in the light of their own experience and case studies, while systemic treatments in common cancer types and side effect management of these treatments are summarized by medical oncologists. This book will be of interest to nuclear medicine physicians as well as oncologists.
Download or read book Small Animal Imaging written by Fabian Kiessling and published by Springer. This book was released on 2017-05-22 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook is a practical guide to the use of small animal imaging in preclinical research that will assist in the choice of imaging modality and contrast agent and in study design, experimental setup, and data evaluation. All established imaging modalities are discussed in detail, with the assistance of numerous informative illustrations. While the focus of the new edition remains on practical basics, it has been updated to encompass a variety of emerging imaging modalities, methods, and applications. Additional useful hints are also supplied on the installation of a small animal unit, study planning, animal handling, and cost-effective performance of small animal imaging. Cross-calibration methods and data postprocessing are considered in depth. This new edition of Small Animal Imaging will be an invaluable aid for researchers, students, and technicians involved in research into and applications of small animal imaging.
Download or read book SPECT Imaging of the Brain written by R. Duncan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 202 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the developed world, images of brain structure are available as an everyday diagnostic aid, and the characteristic appearances of most pathological conditions can be looked up in a textbook. Functional brain imaging is to this day less widely used, partly because most pressing diagnostic questions can be answered by refer ence to the patient's cerebral anatomy, partly for reasons of technical limitations of functional techniques. PET as a technique is sufficiently resource-demanding and complex to inhibit its use as an everyday diagnostic technique. SPECT lacked suitable tracers for many years, and early systems had poor spatial resolution. However, rotating gamma camera technology has advanced to the point where images of the brain of reasonable quality can be obtained at most large hospitals, and practical tracers, particularly of regional cerebral blood flow, are easily avail able. As research advances, clinical applications are emerging. A recent report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology! details a number of currently recognised clinical appli cations, some of which are dealt with in this book. Given this recognition, it is increasingly important that clinicians (particularly neuroclinicians, psychiatrists and specialists in cerebrovascular disease), nuclear medicine specialists and physicists acquire an idea of the major applications of the technique, and the research background on which these applications are based.
Download or read book Nuclear Medicine in Tropical and Infectious Diseases written by Francisco José H.N. Braga and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 282 pages. Available in PDF, EPUB and Kindle. Book excerpt: "More than half of the world's population is at risk of the tropical diseases malaria, leprosy, schistosomiasis, lymphatic filariasis, onchocerciasis, Chagas' disease, African trypanosomiasis and leishmaniasis and half a billion are infected with at least one of these diseases". J. H. F. Remme, World Health Organisation, 1993. "If it is true that science is not limited by frontiers and all research Institutions then belong to mankind, so it is natural for each Institution to be responsible for the problems of those who live in the geographic area under its influence. There are no specific aspects concerning physical, chemical or philosophical concepts and facts, but specificity does exist concerning geology, sociology and pathology. It is the duty of each Institution to study the particular aspects concerning its geographic region, as missing links of the chain of universal knowledge may be found there." H. L. de Oliveira, fonner Rector of the University ofSiio Paulo, 1967. "Nuclear Medicine is cost effective, especially in the developing countries. ( ... ).
Download or read book Textbook of in vivo Imaging in Vertebrates written by Vasilis Ntziachristos and published by John Wiley & Sons. This book was released on 2007-08-20 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the new imaging techniques being developed to monitor physiological, cellular and subcellular function within living animals. This exciting field of imaging science brings together physics, chemistry, engineering, biology and medicine to yield powerful and versatile imaging approaches. By combining advanced non-invasive imaging technologies with new mechanisms for visualizing biochemical events and protein and gene function, non-invasive vertebrate imaging enables the in vivo study of biology and offers rapid routes from basic discovery to drug development and clinical application. Combined with the availability of an increasing number of animal models of human disease, and the ability to perform longitudinal studies of disease evolution and of the long-term effects of therapeutic procedures, this new technology offers the next generation of tools for biomedical research. Well illustrated, largely in colour, the book reviews the most common and technologically advanced methods for vertebrate imaging, presented in a clear, comprehensive format. The basic principles are described, followed by several examples of the use of imaging in the study of living multicellular organisms, concentrating on small animal models of human diseases. The book illustrates: The types of information that can be obtained with modern in vivo imaging; The substitution of imaging methods for more destructive histological techniques; The advantages conferred by in vivo imaging in building a more accurate picture of the response of tissues to stimuli over time while significantly reducing the number of animals required for such studies. Part 1 describes current techniques in in vivo imaging, providing specialists and laboratory scientists from all disciplines with clear and helpful information regarding the tools available for their specific research field. Part 2 looks in more detail at imaging organ development and function, covering the brain, heart, lung and others. Part 3 describes the use of imaging to monitor various new types of therapy, following the reaction in an individual organism over time, e.g. after gene or cell therapy. Most chapters are written by teams of physicists and biologists, giving a balanced coherent description of each technique and its potential applications.
Download or read book Imaging of Hypoxia written by H.J. Machulla and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 195 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hypoxia, i.e. insufficient availability of oxygen within the tissue, is a more serious problem than realized in clinical routine work, although a large variety of theoretical and experimental data give clearly proven indications. During incidences and progress of many types of diseases hypoxia may enhance development and progress of the disease and, furthermore, decrease chances of efficient treatment of, e.g., tumors. Hypoxic tumor cells are up to three times more resistant towards radiation therapy than normoxic cells. With a diagnostic tool such as provided by hypoxia tracers suitable for PET and SPECT imaging, the particular tissue situation becomes detectable and, thus, treatable. Although the clinical importance of hypoxia imaging is obviously great, to date neither the clinical nor the scientific community at an international level has focused many research activities on the hypoxia problem. As the result of a workshop held by the Section for Radiopharmacy in Tübingen, this book collects observations and findings in order to stimulate the on-going research resulting in important clinical applications. Hypoxia imaging is needed in areas of cardiology, neurology and oncology. Additional applications are to be expected in the field of diabetes, infections and organ transplantation. Therefore, the book addresses those who are basically involved in research in radiochemistry and radiopharmacy as well as those dealing with all biological aspects and facing direct clinical applications.
Download or read book Cannabinoids and Their Receptors written by and published by Academic Press. This book was released on 2017-07-24 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cannabinoids and Their Receptors, Volume 593, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This updated volume includes comprehensive chapters on a variety of topics, including Real time cAMP signaling in response to CB1 activation, CB1 signaling in mitochondria, Lipidomics of cannabinoid systems, Studying endocannabinoid transport, Metabolic profiling of CB1 neutral antagonists, Approaches to assess biased signaling at the CB1 receptor, and the Development of CB1 allosteric modulators. Continues the legacy of this premier serial with a new and updated release Covers research cannabinoids and their receptors
Download or read book Contrast Agents for MRI written by Valérie C Pierre and published by Royal Society of Chemistry. This book was released on 2017-11-09 with total page 612 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a practical reference guide for designing and performing experiments, this book focuses on the five most common classes of contrast agents for MRI namely gadolinium complexes, chemical exchange saturation transfer agents, iron oxide nanoparticles, manganese complexes and fluorine contrast agents. It describes how to characterize and evaluate them and for each class, a description of the theory behind their mechanisms is discussed briefly to orient the new reader. Detailed subchapters discuss the different physical chemistry methods used to characterize them in terms of their efficacy, safety and in vivo behavior. Important consideration is also given to the different physical properties that affect the performance of the contrast agents. The editors and contributors are at the forefront of research in the field of MRI contrast agents and this unique, cutting edge book is a timely addition to the literature in this area.
Download or read book High Throughput Screening Methods written by Joshua A. Bittker and published by Royal Society of Chemistry. This book was released on 2016-12-08 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions. This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.
Download or read book Targets Tracers and Translation Novel Radiopharmaceuticals Boost Nuclear Medicine written by Gerald Reischl and published by MDPI. This book was released on 2019-09-20 with total page 214 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the fourth Special Issue in Pharmaceuticals within the last six years dealing with aspects of radiopharmaceutical sciences. It demonstrates the significant interest and increasing relevance to ameliorate nuclear medicine imaging with PET or SPECT, and also radiotherapeutical procedures.Numerous targets and mechanisms have been identified and have been under investigation over the previous years, covering many fields of medical and clinical research. This development is well illustrated by the articles in the present issue, including 13 original research papers and one review, covering a broad range of actual research topics in the field of radiopharmaceutical sciences.
Download or read book Current Aspects of Radiopharmaceutical Chemistry written by Peter Brust and published by MDPI. This book was released on 2018-09-04 with total page 218 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a printed edition of the Special Issue "Current Aspects of Radiopharmaceutical Chemistry" that was published in Molecules
Download or read book Anticancer Research written by and published by . This book was released on 1981 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book A History of Radionuclide Studies in the UK written by Ralph McCready and published by Springer. This book was released on 2018-04-25 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The British Nuclear Medicine Society celebrates its 50th Anniversary with this booklet, which reflects the research of many of the pioneers in the use of radionuclides for the diagnosis and therapy of human disease. Since 1949 there have been remarkable advances in radionuclide techniques and imaging equipment: from the first devices “home-made” in the many physics departments throughout the UK, to the sophisticated multimodality imagers now in everyday use in Nuclear Medicine. The BNMS has been instrumental in promoting the use of radionuclide techniques in the investigation of pathology by supporting and providing education, research and guidelines on the optimum use of radiation to help patients. The future of Nuclear Medicine is bright, thanks to improved imaging resolution, new radiopharmaceuticals, and new diagnostic and therapeutic techniques and procedures.
